Context in the Clinic: How Well Do Cognitive-BehavioralTherapies and Medications Work in Combination?Edna B. Foa, Martin E. Franklin, and Jason Moser Cognitive-behavioral therapy (CBT) and pharmacother- ety disorders. Because other articles in this special issue apy demonstrate efficacy across the anxiety disorders, but address neural pathways and pharmacotherapy, we focus recognition of the
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UntitledSection 1 - Chemical Product and Company Identification MSDS Name: Benzoyl cyanide
Catalog Numbers: AC152060100, AC152060250, AC152060500, AC152061000, AC383660250,
Synonyms: Phenylglyoxylonitrile; Benzeneacetonitrile, alpha-oxo-; Phenylglyoxynitrile; alpha-
Acros Organics N.V.
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
Section 2 - Composition, Information on Ingredients Chemical Name
Appearance: yellow solid. Flash Point: 84 deg C.
Warning! Harmful if swallowed, inhaled, or absorbed through the skin. Causes eye, skin, and
respiratory tract irritation. May cause central nervous system depression. Moisture sensitive.
Target Organs: Central nervous system.
Potential Health Effects
Eye: Causes eye irritation.
Skin: Causes skin irritation. Harmful if absorbed through the skin.
Ingestion: Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and
Inhalation: Causes respiratory tract irritation. Inhalation at high concentrations may cause CNS
depression and asphixiation. Harmful if inhaled.
Chronic: Exposure to small amounts of cyanide compounds over long periods of time is reported
to cause loss of appetite, headache, weakness, nausea, dizziness, and symptoms of irritation of
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting
the upper and lower eyelids. Get medical aid.
Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or
water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air
immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician: Treat symptomatically and supportively.
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-
demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode when heated.
Extinguishing Media: Do NOT get water inside containers. Use water spray, dry chemical,
carbon dioxide, or appropriate foam.
Flash Point: 84 deg C ( 183.20 deg F)
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 2; Flammability: 1; Instability: 0
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in
suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not get water inside containers.
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before
reuse. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Do not allow contact with water. Use only in a chemical fume hood. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in
a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible
substances. Store protected from moisture. Section 8 - Exposure Controls, Personal Protection
Engineering Controls: Facilities storing or utilizing this material should be equipped with an
eyewash facility and a safety shower. Use only under a chemical fume hood.
OSHA - Final PELs
OSHA Vacated PELs: Benzoyl cyanide: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI
Z88.2 requirements or European Standard EN 149 must be followed whenever workplace
Section 9 - Physical and Chemical Properties
Physical State: Solid
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 206 deg C @ 760 mmHg
Freezing/Melting Point:29-32 deg C
Decomposition Temperature:Not available.
Solubility: Slightly soluble.
Specific Gravity/Density:Not available.
Chemical Stability: Stable under normal temperatures and pressures. Moisture sensitive.
Conditions to Avoid: Ignition sources, dust generation, moisture, excess heat.
Incompatibilities with Other Materials: Strong oxidizing agents, strong reducing agents,
strong acids, strong bases.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
CAS# 613-90-1 unlisted.
CAS# 613-90-1: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology: No information available.
Teratogenicity: No information available.
Reproductive Effects: No information available.
Mutagenicity: No information available.
Neurotoxicity: No information available.
Ecotoxicity: Bacteria: Phytobacterium phosphoreum: EC50 = 3.29-6.28 mg/L; 5,15,30 min;
Microtox test at 15 C
Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
CAS# 613-90-1 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313 No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA. CAS# 613-90-1 is listed as a Priority Pollutant under the Clean Water Act. CAS# 613-90-1 is listed as a Toxic Pollutant under the Clean Water Act. None of the chemicals in this product are considered highly hazardous by OSHA.
CAS# 613-90-1 can be found on the following state right to know lists: California, (listed as Cyanides, inorganic salts), New Jersey, (listed as Cyanide anion), New Jersey, (listed as Cyanides, inorganic salts), Pennsylvania, (listed as Cyanide anion), Massachusetts, (listed as Cyanide anion).
California Prop 65
California No Significant Risk Level: None of the chemicals in this product are listed.
European Labeling in Accordance with EC Directives
R 23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
S 24/25 Avoid contact with skin and eyes. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
WGK (Water Danger/Protection)
CAS# 613-90-1: 3
Canada - DSL/NDSL
CAS# 613-90-1 is listed on Canada's NDSL List.
Canada - WHMIS
This product has a WHMIS classification of D1A, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations. Canadian Ingredient Disclosure List
CAS# 613-90-1 (listed as Cyanides, inorganic salts) is listed on the Canadian Ingredient
MSDS Creation Date: 6/03/1999
Revision #4 Date: 9/07/2006
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.
MHRA UK Public Assessment Report Efficacy of progestogens in the maintenance of early pregnancy in women with threatened miscarriage or recurrent miscarriage February 2008 Executive Glossary EXECUTIVE SUMMARY This Public Assessment Report reviews evidence for the efficacy of progesterone and dydrogesterone in the maintenance of pregnancy in women with threatened mis