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Btpnews.comBiological Therapies in Psychiatry Newsletter 2010 Please circle the answer to each question. There is only one answer to each question.
1. What characteristic of asenapine (Saphris) makes it unique among 10. Which of the second-generation antipsychotics is most likely to increase antipsychotics currently available in the United States? A. It causes weight loss during acute treatment. B. It increases the risk of hyperprolactinemia.
C. It must be administered sublingually.
D. It is associated with cerebrovascular adverse events in elderly patients.
2. Diacetylmorphine, the active ingredient in heroin, has been studied as a 11. At steady state, a 300-mg dose of olanzapine long-action injection “treatment of last resort” for what condition? (Zyprexa Relprevv) every 2 weeks produces blood levels similar to those achieved with what daily dose of oral olanzapine? C. Alcohol addiction D. Heroin addiction 12. Fluvoxamine has the greatest affinity for which of the following cytochrome P450 isoenzymes? 3. Second-generation antipsychotics have enhanced abilities to improve cognitive function in patients with schizophrenia compared with first- 4. How long should patients be observed after every injection of the 13. A 2010 study by Kish and colleagues found reduced brain serotonin extended-release suspension preparation of olanzapine (Zyprexa Relprevv) transporter binding in chronic users of what illicit drug? to ensure they do not have a post-injection delirium sedation syndrome? A. 1 hour B. 2 hours C. 3 hours D. 4 hours 5. Which of the following treatments shows the best long-term risk-to- benefit ratio for chronic insomnia? A. Cognitive behavioral therapy 14. Because it prolongs the cardiac QT interval, ziprasidone (Geodon) increases the risk of what life-threatening cardiac adverse event? 6. What percentage of patients taking clozapine (Clozaril and others) experience sialorrhea? A. < 5% B. 20% C. 35% D. > 50% 15. In 2008, the US Food and Drug Administration concluded that, compared with patients taking placebo, patients taking anticonvulsant 7. What percentage of pregnant women have depression? medications had an increased risk of what? A. 0% to 10% B. 10% to 20% C. 20% to 30% D. 30% to 40% A. Gastrointestinal bleeding B. Hyperprolactinemia 8. What were the first two second-generation antipsychotic medications to be approved by the US Food and Drug Administration for the treatment of schizophrenia and bipolar disorder in children and adolescents? A. Aripiprazole (Abilify) and risperidone (Risperdal and others) 16. In veterans with posttraumatic stress disorder (PTSD), how much B. Clozapine (Clozaril and others) and olanzapine (Zyprexa) greater is the risk of developing dementia than in veterans without PTSD? C. Haloperidol (Haldol and others) and iloperidone (Fanapt) D. Quetiapine (Seroquel) and ziprasidone (Geodon) 9. What medication has been studied the most for the treatment of borderline personality disorder? A. Aripiprazole (Abilify) 17. Of patients experiencing their first episode of schizophrenia, approximately what percentage has a sustained recovery lasting 2 years or 18. If a woman who is taking valproic acid (Depakote, Depakene, and 22. Which of the following antipsychotics is a potent muscarinic others) for the treatment of bipolar disorder plans to become pregnant, what is the most appropriate course of action? A. Decrease the valproic acid dose by half B. Add carbamazepine (Tegretol and others) 23. Abbott Laboratories withdrew the “diet pill” sibutramine (Meridia 19. Delirium in elderly inpatients is associated with a greater than 12-fold and others) from the US market because the SCOUT trial found a higher frequency of what in sibutramine-treated patients? A. Depression B. Mania C. Schizophrenia D. Dementia A. Movement disorders B. Cognitive dysfunction 20. What kind of episode rules out a diagnosis of bipolar II disorder? A. Depressive B. Manic C. Hypomanic D. Mixed 21. The US Food and Drug Administration discontinued trials of 24. What antidepressant is most likely to cause weight LOSS during S-adenosyl methionine (SAMe) because of problems with what? CONTINUING MEDICAL EDUCATION ANSWER SHEET/CERTIFICATE REQUEST Sponsored by the University of Arizona Col ege of Medicine at the Arizona Health Sciences Center Name ________________________________________________________ Title _______ Specialty ____________________________________ Address _____________________________________________________________ City _____________________________________________ State ____________________________ Zip ______________ Phone ___________________ Email __________________________________ This educational activity has been designated for a maximum of Complete the assessment questions/program evaluation and send
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