Tableau de bord mensuel des indicateurs tabac Bilan de l’année 2010 Tabagisme et arrêt du tabac en 2010 Les bilans annuels du tableau de bord tabac (www.ofdt.fr) donnent une vue synthétique de l’évolution récente des principaux indicateurs liés au tabagisme, à la prise en charge des fumeurs et aux actions de prévention et d’information. Ce bilan 2010 constitue la 7ème édit
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Business Plan 2006-2010
1. EXECUTIVE SUMMARY. 3
1.1. INTRODUCTION . 3 1.2. THE MARKET. 3 1.3. COMPETITORS. 3 1.4. TOTAL MARKET VALUE . 4 1.5. SEGMENTATION GRID WITH TOTALS . 4 1.6. BUSINESS OBJECTIVES. 5 1.7. BUSINESS OBJECTIVES GRAPH. 6 1.8. BUSINESS INSIGHT CONCLUSIONS . 6 2. BUSINESS INSIGHT . 8
2.1. MARKET SHARE. 8 2.1.1. MARKET SHARE GRAPH: INDEX YEAR . 8 2.2. COMPETITORS. 9 2.2.1. COMPETITOR RANKING. 9 2.2.2. COMPETITOR RANKING GRAPH. 10 2.2.3. COMPETITOR BENCHMARKING . 10 2.2.4. COMPETITOR BENCHMARKING GRAPH. 11 2.3. CUSTOMERS. 12 2.3.1. CUSTOMERS. 12 2.3.2. CUSTOMERS OBJECTIVES GRAPH OUR SHARE . 12 2.4. TRENDS . 13 2.5. SWOT . 14 3. BUSINESS DESIGN . 15
3.1. BUSINESS OBJECTIVES. 15 3.2. VISION . 16 3.3. MISSION. 16 3.4. STRATEGIC CHALLENGES . 16 3.5. STRATEGY: OFFENSIVE. 16 3.6. SUPPORTING STRATEGIES . 16 1. Executive Summary
The objective of this case is to gain an understanding of AirFlow’s current business environment and to draw up future objectives. Historically Pharma UK Ltd has been strong in the field of animal health, but corporate strategy determined its expansion into other areas of business, particularly pharmaceuticals, both organically through investment in research and manufacturing technology, and through strategic acquisition and alliances with other companies. With regards to the respiratory market prices are predicted to increase slightly until 2007. However with many drugs coming off patent in 2008, generic products will enter the market and prices are expected to fall. Pharma UK must take advantage that AirFlow is one of the few products specifically approved for COPD (chronic obstructive pulmonary disease) and that it has a 24 hour efficacy with once-daily dosing compared with many competitive products that need twice daily dosing. Over the next couple of years Pharma UK must seek to gain a strong foothold on the UK market and build Airflow into a strong established brand. 1.2. The Market
The respiratory market is defined to include: asthma, COPD and allergic rhinitis. COPD caused around 2.7 million deaths in 2000 - making it the world's fourth biggest killer disease. The condition, caused mainly by smoking, is set to rise to be the third biggest killer by 2020. Around 3 million people suffer from the condition in the UK, with 30,000 dying each year. The British Thoracic Society (BTS) says respiratory disease kills one in five people in the UK and costs the health service more than 6 billion pounds every year. The market for COPD treatments in UK is currently worth around 5 million Euro and is expected to grow to approximately 10 million Euro in 2010. Awareness of the condition is low among the general population. 1.3. Competitors
Principal competitors are other international pharmaceutical companies that also sell branded, patent-protected, prescription medicines. Like these other companies Pharma UK will increasingly have to compete with generic pharmaceuticals, mainly on price as the generic companies do not bear the high cost of research. The industry's intellectual property base is increasingly being challenged by generic manufactures looking to make an early entry into large markets, which puts pressure on product lifecycles. GSK's Seretide is the world’s biggest respiratory drug, and is licensed for asthma and COPD. In England, the NHS spent 39.5 million pounds on Symbicort (AstraZeneca) in 2004, compared with 177.3 million pounds on Seretide. Merck and AstraZeneca should close the gap between GSK and other companies involved in the respiratory market by 2010. Of the six key respiratory launches predicted before 2010, one of the most significant will be Alvesco, co-marketed by Altana and Sanofi-Aventis. Altana will be propelled into the top ten respiratory key players by 2010 due to the sales of Alvesco and the PDE 4 inhibitor Daxas (roflumilast), due to launch by the end of 2004. Respiratory disease is one of the few areas in which Pfizer does not have a strong presence, but new partnerships have made it a player in the field almost overnight e.g. co-marketing of Boehringer Ingelheim Spiriva, collaboration with Altana on the asthma/COPD drug Daxas. 1.4. Total Market Value
The Total Market Value of “Respiratory – AirFlow” is 542.114,34 in 1.000 Euro. 1.5. Segmentation Grid with totals
SBU: Demo Case 1: Pharma UK - Products 6 September - Human Pharmaceuticals - Products - Prescription Medicine - New Product - Respiratory - AirFlow Prescription
Priority A: Of high strategic importance 1.6. Business Objectives
1.7. Business Objectives Graph
1.8. Business Insight Conclusions
AirFlow is expected to be one of the leading products within 5 years. The British Thoracic Society (BTS) says respiratory disease kills one in five people in the UK and costs the health service more than 6 billion pounds every year. Around 3 million people suffer from the condition in the UK, with 30,000 dying each year because of COPD (chronic obstructive pulmonary disease status). Commercial companies increasingly run primary care services. 2. Financial
Efforts to increase the cash generation and growth potential of the businesses has put the company in a strong position for the future. AirFlow does not have a strong brand identity compared to competitive products. Developing a strong brand position is crucial to creating continued demand from both clinicians and patients - strong branding is the key to extending the lifecycle of a product, even line extensions should be based on the brand. 4. Products
5 products have gained COPD status. Spiriva and AirFlow the only products specifically for COPD (maintenance treatment). The other products are traditional asthma treatments which have gained the additional indication. AirFlow can justify charging a slightly higher price as only our product and Boehringer's have been specifically designed for COPD treatment. We also have the advantage of once a day dose. 5. Communication
Communication strategy should be assessed to include more mild and moderate patients. Key opinion leader links should be strengthened. Reap the benefits of the recent reports which confirm AirFlow as first in line treatment. Patients are becoming better informed - knowledgeable. 2. Business Insight
2.1. Market Share
2.1.1. Market Share Graph: Index Year
Operating Profit before
2.2.2. Competitor Ranking Graph
Market Share in %
Simulated Actual Market Difference
2.2.4. Competitor Benchmarking Graph
2.3.2. Customers Objectives Graph Our Share
GP (General Practitioners)
Short term definition: 2006-2007
Low diagnosis rates for COPD. Many existing patients are not diagnosed and treated. The respiratory market is highly competitive. In the pharmaceutical industry outsourcing has never enjoyed greater popularity and all available indicators show that this trend is set to continue over the next few years. Further pricing pressures have been placed on the industry through legislation not only in major established markets, but Doctors remain principal decision makers, but as the economic burden of funding increases, payers, incl. governments, managed care organisations, patients etc. are increasingly influencing the choices doctors make.
Long term definition: 2008-2010
There will be increased interest and competition in the COPD market as the asthma market is saturated. COPD set to rise to be the third biggest killer by 2020. Increase in smog will result in respiratory problems (growing market). The emergence of a more knowledgeable patient base, who access an increasing amounts of information means that the dynamics are changing and consumer brand loyalty is starting to exert a definite pull. The changing regulatory and policy landscape enables companies to have the status of their products changed from prescription medicine to OTC medicine. The health services seek to transfer the true costs of drugs from their own prescribing budgets to the patient's budget. For this to work well the brand heritage must be in place. The traditional GP practice is increasingly coming under threat - a clear trend towards appointing commercial companies to The market is evolving in response to the changing shape of the world economy. Developing economies are driving growth in healthcare provision as GDP rises, creating exciting new opportunities for the pharmaceutical industry. Developing economies such as China are fast expanding the number of patients who can benefit from medicines. With significant changes occurring in clinical outsourcing practice and an emphasis on partnerships and creating a win-win situation, the focus will be on how companies create successful agreements and pricing arrangements with each other. All COPD drugs except for short actings and teophyllins are expected to be delisted from the reimbursement list. Specialists and IMs will be able to prescribe reimbursed drugs. 2.5. SWOT
1. 24 hour efficacy with once-daily dosing - many competitive 1. Traditionally not as strong as competitors in the respiratory 2. Key opinion leaders recently positioned AirFlow as an 2. Our strategic alliances have previously resulted in co- 3. Efforts to increase cash generation and growth potential 3. Lack of brand identity, AirFlow is up against strong brands. have put AirFlow in a strong position for the future. 4. AirFlow is still relatively new on the market - no wide patient 4. Pharma UK has a couple of drugs at phase III development and are stepping up investments in development and pre-marketing to support all these late stage pipeline 5. Traditionally Pharma UK has not been very customer or 5. Fewer side effects than competitive products. 6. Availability of data, business information, smoke signals. 6. AirFlow is expected to be one of the leading products within 8. No/limited experience in generic competition. Opportunities
1. Under diagnosed market - many existing patients are failing to be diagnosed and treated. Add-on potential in the market.
2. Lack of effective therapies will continue to hamper attempts 2. The market for COPD treatments is currently worth around 5 million Euro and is expected to grow to approximately 10 million Euro in 2010. 3. The industry's intellectual property base is increasingly being challenged by generic manufacturers looking to make 3. New national standards for the treatment in the UK have an early entry into large markets, - puts pressure on product been launched, with a pledge from the government to improve patient care and tackle inequalities. Awareness of the condition among the general population is low - but set 4. With many drugs coming off patent in 2008, - generic companies are formulating their strategies for attacking these patents. 4. An increasing tendency to let commercial companies run primary care services. Must establish strong links with this 5. Strong competitors, they have brand in place and money available to reinforce market awareness of their brands. 5. Patient becoming better informed - patient pull. Pharma UK offers a product with a daily dosing many of our competitors 8. The reputation of the pharmaceutical industry has been in 6. Sales of Seretide could be hit by new safety warnings decline (drug safety, some companies perceived to be 7. COPD is mainly diagnosed by pulmonologists and not GPs 9. Strong competitors blur difference between asthma and who widely lack the proper tools and knowledge for the task.
3. Business Design
3.1. Business Objectives
Pharma UK Ltd. is committed to discovering and delivering novel, high-value medicines, - medicines that make a real difference in
important areas of healthcare. The company is committed to realise new ideas that will help to inspire the lives of their stakeholders.
It is possible to sum up what Pharma UK Ltd believes in and strives for in a single phrase: "Value through Innovation"
This recognises that in a competitive and fast-changing world, the values of products, services and companies are constantly changing. In order for things to have real value to the customer, they have to be superior to any other offering - and therefore better than they were before. In today's global markets, real customer value can only be created by Pharma UK constantly finding ways of doing new things well, or doing what we are currently doing even better. 3.4. Strategic Challenges
Co-marketing efforts and strengthening the pipeline through appropriate external targeted acquisition, licensing and Increase awareness of COPD and the difference between COPD and asthma among the general population. Provide clearly defined segments of each customer group. To carry out relevant marketing and sales programmes for Build relationship with Key Opinion Leaders and the new privately run companies that will increasingly take over the GPs Step up investments in development and pre-marketing to support late stage pipeline opportunities and to build a strong 3.5. Strategy: Offensive
Expansion: Protecting and Growing Current Rx Base. 3.6. Supporting Strategies
Promote AirFlow as the "First Choice" in COPD treatment. Among inhaled treatments differentiate Airflow - once daily usage! Maximise sales growth by releasing the full potential of our marketed brands throughout their lifecycle. Growing our position in existing markets Expanding our presence in key emerging markets Vigorously defending our legitimate intellectual property rights. Exceed competitors' coverage and frequency. 3. Communication
Help to educate the general public - too many still not seeking treatment. Provide Internists (specialists in internal diseases) and GPs with treatment knowledge and motivation. Emphasise asthma and COPD differentiation. Key opinion leader and patient group relationship building. 4. Product
Deliver a portfolio of differentiated medicines that meet patient needs by successfully delivering the next wave of products in development. Rigorous management of our portfolio of products in development, to mitigate risks associated with new innovative products Further improving the productivity and efficiency of our drug discovery and development. Strengthening the pipeline through appropriate external targeted acquisition, licensing and partnership opportunities. 5. Company
People Management: increase company ability focusing on field force efficiency and efficient product management. Leading and developing people to improve business competence in all functions.
A review of enhanced recovery for thoracic anaesthesia andsurgeryN. L. Jones,1 L. Edmonds,2 S. Ghosh1 and A. A. Klein11 Consultant, Anaesthesia and Intensive Care, 2 Library and Knowledge Services Manager, Papworth Hospital,Cambridge, UKSummaryDuring the past decade, there has been a dramatic increase in the number of thoracic surgical procedures carried outin the UK. The current ﬁnancial cli