Rapid Pre-formulation Screening of Drug Salts for Dry Powder Inhalers H. Harris1, J.Shur1, J. Clarke2, E. French2 and R Price1 1Pharmaceutical Surface Science Research Group, Department of Pharmacy and Pharmacology, University of 2Pfizer Global R&D, Sandwich, Kent, CT13 9NJ, UK. Summary Salt formation is a simple means of endowing a molecule with properties to overcome some un
- A |
J |K |
U |V |
PhonphemCase 002 defendant likely ‘unfit’
August 31, 2011
A physician who has examined Khmer Rouge “First Lady” Ieng Thirith said in court
yesterday that she would have “great difficulty” testifying in her own defence, casting
further doubt on her fitness to stand trial during hearings at Cambodia’s war crimes
New Zealand geriatrician John Campbell made the comment when asked by co-defence
lawyer Diana Ellis whether Ieng Thirith would be able to testify in her own defence and
stand up to cross-examination in her pending trial for war crimes and genocide.
“My assessment at this stage is that she would have difficulty instructing her counsel and
participating fully in the trial,” he said. Campbell said his conclusions should not be
considered final until “all possible measures have been tried” to improve her condition.
“Until we’ve explored all possibilities and tried all measures to try and improve function,
we cannot be definite that she will not be able to participate in her own defence,” he said.
Ieng Thirith has “significant cognitive impairment” from a number of possible causes,
Campbell testified on Monday, including an “underlying dementing illness” due “most
likely” to Alzheimer’s disease.
Ieng Thirith had been taking three psychotropic medications since 2006 that he said may
be contributing to her condition. She stopped taking bromazepam and clonazepam last
week and has begun a reduction in quetiapine, described by Campbell as a “major
Campbell recommended a three-month trial period for a different drug to address
memory-loss symptoms associated with Alzheimer’s or dementia, once Ieng Thirith has
stopped taking quetiapine. He said improvement in her condition was “possible, but
unlikely”, and noted that “around a third” of patients see improvement.
Anne Heindel, a legal advisor at the Documentation Centre of Cambodia, said the two
days of hearings suggested so far that it was “very likely that she’s going to be found
unfit” for trial.
Ellis introduced reports in yesterday’s hearing from the head of the detention centre
documenting 50 outbursts by Ieng Thirith in which she “insulted” co-defendant Brother
No 2 Nuon Chea, guards or S-21 jailer Duch over a nine-month period starting in late
2008. Campbell testified that when he asked her in a meeting for the date, Ieng Thirith incorrectly gave her birthday. She later – also incorrectly – provided that same date for her wedding day. Yet when Campbell asked her for the actual date of her birthday, she could not answer. The KR Social Action Minister was “unable to answer the questions about where she was and the purpose of the [detention centre] and why she was there”, Campbell said, and failed to perform “very basic tests”, such as writing a complete sentence of her own choice and following a series of three instructions. People who had observed Ieng Thirith said she “sometimes talks to herself, usually about the past and her youth” and “can become lost within the detention centre and on occasions does not recognise her own room”, according to Campbell’s report. Campbell said he had yet to receive “a proper account from her of what family she had and where they were and how many grandchildren she had”. Campbell said he was “very conscious” of the possibility that Ieng Thirith was attempting to deceive him, but said he “did not feel that she was deliberately trying to mislead” and was in fact “frustrated by her inability to understand what was going on” during the assessment.
Neurocritical Care Copyright © 2004 Humana Press Inc. All rights of any nature whatsoever are reserved. ISSN 1541-6933/04/3:XXX–XXX Translational Research Multimodality Monitoring in Severe Traumatic Brain Injury The Role of Brain Tissue Oxygenation Monitoring Jamin M. Mulvey,1*, Nicholas W.C. Dorsch,2 Yugan Mudaliar,1 and Erhard W Lang,2 1Department of Intensive Care, Univers