Nanowires can detect molecular signs of cancer, scientists find Brightsurf Science News
Ads by Google PSA Blood Test Elevated PSA
Brightsurf RSS Science

Nanowires can detect molecular signs of
Search Brightsurf Science
cancer, scientists find
Science News Article
Resource Directory
Use of minuscule devices to spot cancer markers could lead to ultra-powerful new diagnostics CAMBRIDGE, Mass. — Harvard University researchers have found that molecular markers indicating the presence of cancer in the body are readily detected in blood scanned by special arrays of silicon nanowires — even when these cancer markers constitute only one hundred-billionth of the protein present in a drop of blood. In addition to this exceptional accuracy and PSA Testing - Prostate
sensitivity, the minuscule devices also promise to pinpoint the exact type of cancer present with a speed not currently available to clinicians. A paper describing the work will appear in October in the journal Nature Biotechnology and is now posted on the journal’s web site. “This is one of the first applications of nanotechnology to healthcare and offers a clinical technique that is significantly better than what exists today,†says author Charles M. Lieber, Mark Hyman Jr. Professor of Chemistry in Harvard’s Faculty of Arts and Sciences. “A Diagnosed with
nanowire array can test a mere pinprick of blood in just minutes, providing a nearly instantaneous scan for many different cancer markers. It’s a device that could open up substantial new possibilities in the diagnosis of cancer and other complex diseases.†Lieber and his colleagues linked slender nanowires conducting a small current with antibody receptors for certain cancer markers — such as prostate specific antigen (PSA), PSA-a1-antichymotrypsin, carcinoembryonic antigen and mucin-1. When these telltale proteins come into contact with a receptor, it sparks a momentary change in conductance that gives a clear Prostate Clinical Trial
indication of the marker’s presence. The detectors differentiate among various cancer markers both through the specific receptors used to snag them and because each binds its receptor for a characteristic length of time before dislodging. “Our results show that these devices are able to distinguish among molecules with near- perfect selectivity,†Lieber says, adding that the risk of false readings is minimized by the incorporation of various control nanowires. The scientists also fitted some nanowires in the arrays with nucleic acid receptors for telomerase, Prostate Cancer
an enzyme inactive in most of the body’s somatic cells but active in at least 80 percent of known human cancers. In testing of extracts from as few as 10 tumor cells, these receptors allowed real-time monitoring of telomerase binding and activity. Lieber says nanowire arrays could easily be scaled up to detect many different cancer markers — more of which are being found all the time, thanks to the current boom in proteomics. Widespread use of these cancer markers in healthcare will ultimately depend upon the development of techniques that allow rapid detection of many markers with high selectivity and sensitivity. Prostate Cancer
“Genomics and proteomics research has elucidated many new biomarkers that have the potential to greatly improve disease diagnosis,†the scientists write. “The availability of multiple biomarkers is believed to be especially important in the diagnosis of complex diseases like cancer, for which disease heterogeneity makes tests of single markers inadequate. Patterns of multiple cancer markers might, however, provide the information necessary for robust diagnosis of disease … [and] detection of markers associated with different stages of disease Shop@Brightsurf
pathogenesis could further facilitate early detection.†While initial rounds of cancer testing today identify only whether or not cancer is present, Books, Music, DVD
nanowire arrays have the potential to immediately fill in details on exactly what type of cancer is present. Nanowires could also track patients’ health as treatment progresses. Because the arrays detect molecules suspended in fluids, drops of blood could be tested directly, in a physician’s office, without any need for biochemical manipulation. Lieber’s co-authors are Gengfeng Zheng, Fernando Patolsky, Yi Cui and Wayne U. Wang, all of Harvard’s Department of Chemistry and Chemical Biology, Biophysics Program and Division Nanowires can detect molecular signs of cancer, scientists find of Engineering and Applied Sciences. The work was supported by the Defense Advanced Research Projects Agency and the National Cancer Institute. Electronics & Office
Print this page
E-mail this page to a friend
More articles about " cancer markers "
Kids & Baby
Related Reading

Cancer Markers: Diagnostic and Developmental Significance (Contemporary
Home & Garden

Marker may signal metastasis to bone of prostate, breast Ca. (Preliminary Findings).
: An article from: Internal Medicine News

Polyamines as biochemical markers of normal and malignant growth (Progress in
cancer research and therapy)

Breath test may detect breast cancer risk: markers of oxidative stress.(Clinical
Rounds) : An article from: Internal Medicine News

Elevation of the tumor marker CA125 in right heart failure.(Case Report) : An article
from: Southern Medical Journal

A Proactive Strategy Toward Terrorism and Transnational Crime

On Deceiving Terrorists

AMPLIFICATION: Blood Test Detects Breast Cancer Marker. : An article from: Analytic
Separations News

Surrogate markers for prostate cancer death needed too.(Clinical Records) : An
article from: Family Practice News


What Is Cholesterol-Lowering Medicine? If your doctor has decided that you need to take medicine to reduce high cholesterol, it’s because you’re at high risk for heart disease or stroke. Usual y the treatment combines diet and medicine. Most heart disease and many strokes are caused by a buildup of fat, cholesterol and other substances cal ed plaque in the inner wal s of your arteries. Th

Summary No Country of one’s own An advisory report on treaty protection for stateless persons in the Netherlands Worldwide, an estimated 12 million people have no nationality. In other words, they are stateless. Statelessness is a problem because possessing a nationality means that there is at least one country where one has the right to reside. Nationality confers a number of othe

Copyright © 2010-2014 Medical Articles