Girl Power: Estrogen Promotes HSC Self-Renewal
Esther and Susan 1Immune Receptors of the Innate and Adaptive System Team, Institut d’Investigacions Biome`diques August Pi i Sunyer, Centre EstherKoplovitz, Rossello´, 149À153, 08036 Barcelona, Spain2Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA*Correspondence:
Although some hematopoietic cell types are known to respond to sex hormones, hematopoietic stem cells(HSCs) are generally thought to function similarly in both sexes. Recently in Nature, show that HSCs respond to higher levels of estrogen in females, resulting in enhanced self-renewal andincreased erythropoiesis.
and increase their self-renewing divisions
nificant increase in HSC and MPP cycling.
levels of estrogens in females, particularly
during pregnancy, lead to sex differences
diol. Alternately, increased HSC division
males. HSCs do express low levels of pro-
gesterone receptor (PR), but injection of
in contrast, estradiol stimulates dendritic
cycling is not driven by testosterone in fe-
their progression to erythroid cells. This
Esr1) and the more selectively expressed
in erythroid cell precursors by inhibiting
ERb (Esr2). Nakada et al. show that female
GATA-1; however, it is possible that eryth-
and male HSCs express Esr1, but not
Esr2. ERa is necessary for the estradiol-
more BrdU-labeled HSCs after 10 days.
ERa and use of germline Esr1-deficient
correlates with increases in spleen cellu-
specific estriol may promote this process.
HSC cycling to levels seen in males.
estradiol administration. Rigorous pheno-
1 week and yielding serum estradiol levels
recent achievement, and this is the first
subsets. One intriguing possibility is that
Cell Stem Cell 14, February 6, 2014 ª2014 Elsevier Inc. 137
S.K. was supported by NIH AI92511. E.C. wassupported by a BIOTRACK postdoctoral fellow-
genitors that retain long-term repopulat-
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ability to give rise to long-term self-renew-
ing HSCs upon serial transplantation.
Copley, M.R., Beer, P.A., and Eaves, C.J. (2012).
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of TGFb have been implicated in the regu-
strate if estradiol alters this property of
Illing, A., Liu, P., Ostermay, S., Schilling, A., de
HSCs, an earlier report showed that rela-
Haan, G., Krust, A., Amling, M., Chambon, P.,
Schinke, T., and Tuckermann, J.P. (2012). Haema-tologica 97, 1131–1135.
in estradiol-treated mice is less quiescent
and yields superior immune reconstitution
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sooner, since their serial transplant even-
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tually leads to reduced numbers of granu-
M.I., Payne, K.J., and Kincade, P.W. (2001).
allow subsequent MEP differentiation.
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138 Cell Stem Cell 14, February 6, 2014 ª2014 Elsevier Inc.
Journal of the American Medical Informatics Association Volume 9 Number 3 May / Jun 2002Factors Associated withSuccess in Searching MEDLINE and ApplyingEvidence to Answer Clinical QuestionsWILLIAM R. HERSH, MD, M. KATHERINE CRABTREE, RN, DNSC, DAVID H. HICKAM, MD, MPH, LYNETTA SACHEREK, MLS, CHARLES P. FRIEDMAN, PHD, PATRICIA TIDMARSH, JD, CRAIG MOSBAEK, DALE KRAEMER, PHD A b s t r a c t Object
Wine is the difference between eating and dining I look forward to a glass of wine while preparing supper, was, in fact, a sense of dread as mealtime approached, be-and at least another with the evening meal. My husband cause what I used to look forward to — the combinationCaffeine-free and I eat well, and dinner is our night’s entertainment. And of two of my favourite thing
Girl Power: Estrogen Promotes HSC Self-Renewal
Esther and Susan 1Immune Receptors of the Innate and Adaptive System Team, Institut d’Investigacions Biome`diques August Pi i Sunyer, Centre EstherKoplovitz, Rossello´, 149À153, 08036 Barcelona, Spain2Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA*Correspondence:
Although some hematopoietic cell types are known to respond to sex hormones, hematopoietic stem cells(HSCs) are generally thought to function similarly in both sexes. Recently in Nature, show that HSCs respond to higher levels of estrogen in females, resulting in enhanced self-renewal andincreased erythropoiesis.