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Soumission #4860 | université de toulouse – les universités et grandes écoles de toulouse midi-pyrénées

Soumission #4860 | Université de Toulouse – Les universités e.
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Soumission #4860
Title of the thesis :
Role of estrogen receptor (ER) alpha-signaling in regulatory T cel s on the protective
action of estradiol in CNS autoimmunity
Thesis supervisor :
Dr Jean-Charles Guéry, PhD, DR2 INSERM
e-mail address :
[email protected]
PhD school name :
Biology, Health and Biotechnologies (BSB)
Research laboratory :
Laboratory website :
Subject short description :
Clinical remissions in multiple sclerosis (MS) patients are frequently observed during
pregnancy suggesting that steroid hormones, particularly estrogens, could be protective.
Indeed, administration of estrogen (17ß-estradiol, E2) inhibits experimental autoimmune
encephalomyelitis (EAE) in mice, the animal model of MS. We recently showed that
E2-mediated inhibition of encephalitogenic T cel priming and EAE protection was
dependent on estrogen receptor ! (ER!) expression in the hematopoietic compartment.
Using tissue-specific ER!KO mouse models, we demonstrated that ER!-signaling in T
lymphocytes, but not myeloid cel s, was required for sustained EAE protection. The goal of
this proposal is now to investigate whether E2 act directly in vivo on encephalitogenic
Th1/Th17 cel s or indirectly on regulatory T lymphocytes or their precursors to promote
their capacity to inhibit pathogenic CD4+ T cel responses through a trans-acting
mechanism of suppression. To achieve this goal we wil develop new models of ER!
mutant mice, including mice selectively ER! in Foxp3+ T cel s. This project wil help to
understand the pathophysiological mechanisms implicated in the modulation of MS by
female sexual hormones and may lead to new therapeutic strategies.
Scientific domain :
Two major publications in the domain of PhD :
Lélu K, Laffont S, Delpy L, Paulet PE, Périnat T, Tschanz SA, Pel etier L, Engelhardt B,
and Guéry JC. Estrogen receptor !-signaling in T lymphocytes is required for estradiol-
mediated inhibition of Th1 and Th17 cel differentiation and protection against EAE. J.
Immunol. 2011 Sep 1;187(5):2386-93.
Lélu K, Delpy L, Robert V, Foulon E, Laffont S, Pel etier L, Engelhardt B, Guéry JC.
Endogenous estrogens, through estrogen receptor !, constrain autoimmune inflammationin female mice by limiting CD4+ T-cel homing into the CNS. Eur J Immunol. 2010Dec;40(12):3489-98.


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