British Journal of Cancer (2004) 90, 1176 – 1183 All rights reserved 0007 – 0920/04 $25.00 Survival of patients with nonseminomatous germ cell cancer: areview of the IGCC classification by Cox regression and recursivepartitioning MR van Dijk*,1, EW Steyerberg1, SP Stenning2, E Dusseldorp3 and JDF Habbema1 Department of Public Health, Erasmus MC – University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands; 2Medical Research Council, Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK; 3Data Theory Group, Department of Education, Leiden University, PO Box 9555, 2300 RB Leiden, The Netherlands The International Germ Cell Consensus (IGCC) classification identifies good, intermediate and poor prognosis groups among patients with metastatic nonseminomatous germ cell tumours (NSGCT). It uses the risk factors primary site, presence of nonpulmonary visceral metastases and tumour markers alpha-fetoprotein (AFP), human chorionic gonadotrophin (HCG) and lactic dehydrogenase (LDH). The IGCC classification is easy to use and remember, but lacks flexibility. We aimed to examine the extent of any loss in discrimination within the IGCC classification in comparison with alternative modelling by formal weighing of the risk factors. We analysed survival of 3048 NSGCT patients with Cox regression and recursive partitioning for alternative classifications. Good, intermediate and poor prognosis groups were based on predicted 5-year survival. Classifications were further refined by subgrouping within the poor prognosis group. Performance was measured primarily by a bootstrap corrected c-statistic to indicate discriminative ability for future patients. The weights of the risk factors in the alternative classifications differed slightly from the implicit weights in the IGCC classification. Discriminative ability, however, did not increase clearly (IGCC classification, c ¼ 0.732; Cox classification, c ¼ 0.730; Recursive partitioning classification, c ¼ 0.709). Three subgroups could be identified within the poor prognosis groups, resulting in classifications with five prognostic groups and slightly better discriminative ability (c ¼ 0.740). In conclusion, the IGCC classification in three prognostic groups is largely supported by Cox regression and recursive partitioning. Cox regression was the most promising tool to define a more refined classification.
British Journal of Cancer (2004) 90, 1176 – 1183. doi:10.1038/sj.bjc.6601665 Keywords: Cox regression; recursive partitioning; germ cell cancer; prognostic classifications Testicular germ cell tumours (seminomatous and nonseminoma- combining the main prognostic factors for progression-free tous) are the most common cancers among young adult men. Since survival (PFS) and overall survival (Bajorin et al, 1988, 1991; the 1970s, long-term cure rates of patients with germ cell tumours Mead et al, 1992). The coexistence of classifications differing in have increased to over 80%, because of the ability of cisplatin- type, complexity and ability to separate good from poor prognosis based chemotherapy to cure advanced disease (Bosl and Motzer, complicated international collaboration in randomised trials and 1997; Hartmann et al, 1999; Steele et al, 1999; Sonneveld et al, made comparison of nonrandomised studies impossible. Interna- 2001). Owing to the high overall cure rate, interest has shifted from tional collaboration by the International Germ Cell Cancer increasing the overall cure rate to reducing treatment-related Collaborative Group resulted in the development of the Interna- toxicity for patients with a good prognosis (de Wit et al, 2001). On tional Germ Cell Consensus Classification (IGCC classification), the other hand, high-risk patients, eligible for more intensive which is widely applied and easy to use and remember (IGCCCG, treatment, for example, stem-cell support or high-dose chemother- apy, should be identified (Bokemeyer et al, 1999, 2002).
For the IGCC classification, readily available risk factors were Several classifications have been proposed in the past to selected from a wider set following Cox regression analyses, distinguish patients according to prognosis, by identifying and namely primary site, presence of nonpulmonary visceral metas-tases (NPVM) and elevation of the tumour markers alpha-fetoprotein (AFP), human chorionic gonadotrophin (HCG) and *Correspondence: MR van Dijk; E-mail: [email protected] lactic dehydrogenase (LDH). All variables were categorical, since Presented in part at Third Joint meeting of the International Society for no major differences in performance were found compared to Clinical Biostatistics and the Society for Clinical Trials, London, UK, 20 – using continuous variables (McCaffrey et al, 1998). In Table 1, how the risk factors were combined into three prognostic groups for Received 6 November 2003; revised 17 December 2003; accepted 17 patients with nonseminomatous germ cell tumours (NSGCT) with December 2003; published online 24 February 2004 either good, intermediate or poor prognosis are shown. The good A review of the development of the IGCC classificationMR van Dijk et al International Germ Cell Consensus Classification for nonsemi- Centres participating in the International Germ Cell Collaborative Group provided retrospective data of 5202 adult male patients with NSGCT. All patients were treated between 1975 and 1990 with cisplatin-based chemotherapy. Data were collected on age, primary AFP good ¼ 0 and HCG good ¼ 0 and LDH good ¼ 0 site, date of diagnosis, levels of serum AFP, HCG and LDH, nodal disease in the abdomen, mediastinum, and neck, lung metastases,spread to other visceral sites like liver, bone and brain and on treatment details like previous therapy. For the development of the IGCC classification, patients without missing data on the risk factors primary site, NPVM, tumour markers AFP, HCG and LDH and the outcome survival were selected (n ¼ 3048) (IGCCCG, AFP intermediate ¼ 1 or HCG intermediate ¼ 1 or LDH intermediate ¼ 1 The outcome measures were PFS and overall survival from the start of the chemotherapy. The risk factors in the IGCC classification were primary site (testis/retroperitoneal vs medias- AFP poor ¼ 2 or HCG poor ¼ 2 or LDH poor ¼ 2 tinum), presence of NPVM (yes/no) and tumour markers AFP, HCG and LDH. Each tumour marker had three categories; good, Tumour markers AFP/HCG/LDH: Good – AFP o1000 ng mlÀ1, HCG o5000 iu lÀ1, intermediate and poor with specific cutoff points on the LDH o1.5 Â upper limit of normal; Intermediate – AFP 1000 – 10000 ng mlÀ1, HCG continuous tumour markers (see Table 1) (IGCCCG, 1997). The 5000 – 50000 ng mlÀ1, LDH 1.5 – 10 Â N; Poor – AFP 410000 ng mlÀ1, HCG same risk factors and categories were used to construct the alternative classifications based on Cox regression and recursivepartitioning.
prognosis group is characterised by the absence of adverse riskfactors. The intermediate prognosis group is defined by the The IGCC classification makes no clear distinction between the presence of any intermediate tumour marker, that is, one or more intermediate tumour markers and between the poor risk factors intermediate tumour markers are present. The poor prognosis and is represented by a max score. One way to assess this group is characterised by the presence of any of the poor risk assumption is by evaluating whether the weights in the IGCC factors mediastinal primary site, NPVM, AFP poor, HCG poor or classification were optimally allocated to the risk factors. We LDH poor, that is, one or more poor risk factors are present. The hereto varied the IGCC weights (1/2) over the levels of the risk classification can be seen as a max function where the good, factors and compared all possible combinations with respect to intermediate and poor prognosis groups have a maximum score of performance. Performance was quantified by the difference in minus twice the log likelihood (model w2) (Clayton and Hills, In the IGCC classification, all intermediate tumour markers and all poor risk factors were required only to be sufficiently bad to be We used the Cox regression to study the univariable and classified as intermediate and poor prognosis, respectively, that is, multivariable effects of the IGCC risk factors on the overall differences in importance between intermediate tumour markers survival, expressed as Hazard ratios and regression coefficients.
and differences in importance between poor risk factors are not The Cox regression model formed the basis of classification ‘5R’.
taken into account. Furthermore, no distinction is made between We multiplied the multivariate regression coefficients by 10 and the number of intermediate tumour markers in the intermediate rounded them to obtain weights. A sum score was calculated by prognosis group and the number of poor risk factors in the poor multiplying the weights with individual patient characteristics and prognosis group. Better discrimination might be achieved by adding the resulting individual scores (Assmann et al, 2002). We incorporating differences in predictive strength and testing calculated the estimated 5-year survival rate for each score.
The IGCC classification can be viewed as implying that the risk Furthermore, it is difficult to adjust the current classification for factors are strongly dependent, that is, that there are interactions changes in treatment strategy. A more flexible scoring system between risk factors. There is, for example, no distinction made could more easily identify subgroups for the identification of very between patients with one poor risk factor or three poor risk high risk patients eligible for novel chemotherapy approaches such factors. To test whether and which interactions were present, we as high-dose chemotherapy or the use of novel cytotoxic agents added all two-way interactions between the IGCC risk factors in a (Bokemeyer et al, 1999; Kollmannsberger et al, 2000). We however Cox regression model. Important interactions were selected note that an important consideration in developing the IGCC through stepwise backward selection (Po0.05). Since interactions classification was that all the prognostic groups should be large based on small number of patients give unreliable regression enough to make randomised trials of new treatments for each coefficients, the interaction terms were defined as linear. The prognostic group feasible (IGCCCG, 1997).
resulting model forms the basis of classification ‘5Ri’. A sum score The aim of this study was to reconsider steps taken in the based on a regression model with interactions is, however, more development of the IGCC classification, and to investigate difficult to calculate and interpret. Therefore, a table was alternative classifications based on Cox regression and recursive constructed with 5-year survival estimates for all possible partitioning (Breiman et al, 1984) that may discriminate better and combinations of the IGCC risk factors based on the Cox regression be more suitable to identify more subgroups.
model with linear interactions. The number of patients on which British Journal of Cancer (2004) 90(6), 1176 – 1183 A review of the development of the IGCC classification each survival estimate was based is given to indicate the reliability validated by taking random bootstrap samples (100) (Efron and Tibshirani, 1993; Harrell et al, 1996).
An alternative and visually more attractive way of exploring and presenting interactions between risk factors is by growing a treethrough recursive partitioning (Breiman et al, 1984; Segal and Bloch, 1989; Ahn and Loh, 1994) that we used to constructclassification ‘5T’. A binary tree is built by the following process: The median follow-up time of surviving patients was 50 months.
first the risk factor that best splits the data into two groups, leading Disease progression occurred in 680 patients, and 533 patients to the largest decrease in prediction error, is determined (recursive died. The 5-year PFS was 78% (95% CI 76 – 79%) and the 5-year partitioning or splitting method). Splitting continues until the overall survival 82% (95% CI 81 – 84%). Most patients had as subgroups reach a minimum size or until no improvement can be primary site testis or retroperitoneum (97%), no NPVM (92%), made (stopping rule). The full tree, which is often too complex and and good AFP, HCG and LDH levels (84, 87 and 67%, respectively) overfit, is pruned using crossvalidation. All trees within one (Table 2). All risk factors were predictors of survival as indicated standard error of the lowest crossvalidated prediction error are by the Hazard ratios ranging from 2.1 to 6.2, where the tumour considered as equivalent. From these equivalent trees, the simplest marker AFP was the weakest risk factor in the univariable analysis.
is chosen as final tree (Breiman et al, 1984).
As a splitting method, the exponential scaling method was used (Therneau et al, 1990; LeBlanc and Crowley, 1992). The splittingprocess stopped when a minimum of five patients per groups was The regression-based weights of the risk factors in classification reached or when there was no further decrease in prediction error.
5R, and the cutoff points on the resulting sum score are presented We used 10-fold crossvalidation to determine the optimal tree size.
in Table 3, with the weights and cutoff points of the IGCC Modelling was performed with S-plus version 2000 using the RPART library that contains a recursive partitioning method for The weights suggest that differences between risk factors were present. Tumour marker AFP had a much lower weight in the The RPART library (rpart2.zip) and manual (rpart2doc.zip) can multivariate analysis than tumour markers HCG and LDH. As a be found at http://www.stats.ox.ac.uk/pub/SWin.
result, a poor AFP level (score 3) is not sufficient to be classified aspoor prognosis in classification 5R. Also, the combination of twoor three intermediate tumour markers, which would lead to an intermediate prognosis in the IGCC classification, results in a scoreof over 10 and thus in classification in the poor prognosis group in In all classifications, three prognostic groups were identified using classification 5R. The presence of risk factor NPVM (score 7) alone the estimated 5-year survival by sum score (classification 5R), was not sufficient to be classified as poor prognosis, in contrast combination of risk factors (5Ri) or binary tree (5T). Subgroups with the IGCC classification. Patients would only be classified as with a 5-year survival higher than 90% were considered as good poor prognosis when other risk factors besides NPVM or AFP are prognosis, between 65 and 89% as intermediate prognosis, and We identified four significant interactions in the Cox regression Furthermore for each classification, we explored the possibility model; between AFP and primary site (Po0.001), AFP and NPVM of identifying more subgroups. For the IGCC classification, this (Po0.01), HCG and NPVM (Po0.003) and HCG and LDH was carried out by allowing weights to vary from zero to four(instead of zero to two), and comparing all possible combinationson performance. For classifications 5R, 5Ri and 5T, we changed the Characteristics of 3048 NSGCT patients on the IGCC risk cutoff points on estimated 5-year survival. A 5-year survival rate higher than 90% was considered as good prognosis, 75 – 89% asintermediate prognosis, 60 – 74% as good-poor prognosis, 40 – 59% as intermediate-poor prognosis, and lower than 40% as poor-poorprognosis (Kollmannsberger et al, 2000). Survival of the five groups of the IGCC classification and classifications 5R, 5Ri and 5T was presented by Kaplan – Meier curves.
The classifications were evaluated by their ability to distinguishbetween patients differing in survival. An indication of the discriminative ability is the difference in 5-year survival rates between the good, intermediate and poor prognosis groups. A c- statistic was also calculated for both the three and five group classifications. For binary outcomes, the c-statistic is similar to the area under the ROC curve (Harrell et al, 1984). The c-statistic for survival data indicates the probability that for a randomly chosen pair of patients, the one having the higher predicted survival is the one who survives longer (Harrell et al, 1984). Overall performanceof the three and five group classifications was measured by model w2. When a model is developed and evaluated on the same data, the performance of the model is usually too optimistic. The optimism can be quantified with statistical methods, known as internal validation techniques (Steyerberg et al, 2001). To estimate and correct for the optimism in discriminative ability, the steps takenin the Cox regression and recursive partitioning were internally NPVM ¼ nonpulmonary visceral metastases.
British Journal of Cancer (2004) 90(6), 1176 – 1183 A review of the development of the IGCC classificationMR van Dijk et al Weights, coding of variables, and cutoff on the max function of the IGCC classification and the sum score of the regression-based The final tree fitted by recursive partitioning, using the exponential scaling method. The 5-year survival rates, events and total number of observations per subgroup are given. The resulting subgroups are displayed in rectangulars and determine classification 5T.
Classifications 5Ri did show a statistically significant increase in overall performance over the IGCC classification (model w2 422, 2 d.f.). Classification 5T had a worse overall performance with a NPVM ¼ nonpulmonary visceral metastases.
(Po0.01). The regression coefficients all had negative signs, indicating that the effect of the risk factors together was smaller Within the max score, different weights did not lead to an than the sum of their separate effects. For all 108 combinations of improvement in overall performance over the weights of the IGCC the IGCC risk factors, we present 5-year survival estimates from classification (model w2 402, 2 d.f.). The following weights were the Cox regression model with interactions (Appendix). Patients allocated to derive a max function with five prognostic groups in with testis as primary site and good or intermediate tumour the IGCC classification with the score varying between 0 and 4; markers had the highest estimated survival (55 – 92%). Patients primary site mediastinum (4), NPVM (3), AFP good/intermediate/ with mediastinum as primary site and NPVM had the worst poor (0/1/2), HCG good/intermediate/poor (0/2/3) and LDH good/ estimated survival (0 – 64%). Since the number of patients with intermediate/poor (0/1/3). The 5-year survival varied from 37 to more than one poor risk factor was limited, the survival estimates 92% for the five groups of the IGCC classification, from 34 to 92% for these patients were less reliable. Recursive partitioning resulted for classification 5R, from 36 to 92% for classification 5Ri and from in a tree with seven subgroups with 5-year survival ranging from 35 to 91% for classification 5T (Table 5). The cutoff points on the 35 to 91% (Figure 1), forming the basis of classification 5T.
sum score for the five groups of classification 5R are also given in Tumour marker LDH was the principal determinant of 5-year Table 5. The difference in survival between the prognostic groups survival, making a split between good LDH (N ¼ 2036) and for each classification is illustrated in Figure 2. The c-statistic for intermediate/poor LDH (N ¼ 1012). The majority of the ‘good the five groups of the IGCC classification and classifications 5R LDH’ subgroup consists of patients with no risk factors (N ¼ 1865) and 5Ri was slightly higher than for the three group classifications with an observed 5-year survival of 91% (95% CI 90 – 93%).
(0.739, 0.741 and 0.744, respectively) and with a small amount of Furthermore, a subgroup of 29 patients with primary site optimism (0.002) for the Cox regression models. The increase of mediastinum had a 5-year survival of 55% (95% CI 34 – 72%) the c-statistic for the five groups of classification 5T was very and patients with intermediate or poor HCG (N ¼ 142) had a 5- limited (0.722) with an optimism of 0.011. The increase in model w2 year survival of 70% (95% CI 61 – 77%). Within the subgroup was more substantial; 422 for the extended IGCC classification, 446 intermediate/poor LDH, four further subgroups were identified for classification 5R, 450 for classification 5Ri. The increase in with the risk factors NPVM, primary site and HCG, with 5-year model w2 for classification 5T (383) was less substantial.
The 5-year survival rates for the good, intermediate and poor The discriminative ability of classifications derived through Cox prognosis groups were comparable for the IGCC classification and regression and recursive partitioning was in concordance with the classifications 5R, 5Ri and 5T (Table 4). The c-statistic of the IGCC IGCC classification and therefore supports the validity of the IGCC classification was 0.732. The apparent c-statistics of classifications classification. We did, however, find that not all intermediate 5R, 5Ri and 5T were 0.732, 0.735 and 0.718, respectively. Validation tumour markers and poor risk factors were equally important, and showed minor optimism in the c-statistic in the Cox regression that taking these differences into account does affect the models (0.002). More optimism was present in the classification classification of patients. In Cox regression-based classifications, 5T, with the c-statistic decreasing from 0.718 to 0.709. Classifica- especially risk factors NPVM and AFP had less impact compared tion 5R did not show an improvement in model w2 compared to the to the other risk factors. That AFP is of less importance than the IGCC classification (model w2 402 and 401, respectively, 2 d.f.).
other risk factors is confirmed by recursive partitioning where AFP British Journal of Cancer (2004) 90(6), 1176 – 1183 A review of the development of the IGCC classification Survival of the IGCC classification, the regression-based classifications 5R and 5Ri and classification 5T based on recursive partitioning Survival of subgroups within the IGCC classification, the regression-based classifications 5R and 5Ri and classification 5T based on recursive Surv ¼ 5-year survival. Cutoff points on sum score classification 5R: Good 0, Intermediate 2 – 9, Good – poor 10 – 16, Intermediate – poor 17 – 22, Poor – poor 422.
Survival curves for the five groups of the IGCC classification (A) and classifications 5R (B), 5Ri, (C) and 5T (D).
was not selected in the final tree. Furthermore, not all risk factors allow for more flexible classifications with more subgroups, had statistical interactions. In classifications 5Ri and 5T, only a leading to a small improvement in discriminative ability and 5- limited number of interactions were included. Combining several year survival of 34% for the poorest risk patients.
risk factors led to differences in 5-year survival, that is, patients It appears that the maximum discriminative ability might have with one poor risk factor had a better chance of survival than been reached with the current IGCC risk factors and coding, patients with three risk factors. These deviations from the weights making further improvement in discriminative ability difficult.
used by the IGCC classification did, however, not lead to The risk factors selected for the IGCC classification are in improvements in discriminative ability, in contrast with what we agreement with risk factors used in other studies on identifying expected. The use of Cox regression and recursive partitioning did good and poor prognosis patients with NSGCT (Bajorin et al, 1991; British Journal of Cancer (2004) 90(6), 1176 – 1183 A review of the development of the IGCC classificationMR van Dijk et al Mead et al, 1992). Some other potentially useful risk factors The IGCC dataset suffers from a number of limitations. First, include age, lung metastases and abdominal mass size. However, not all data were used for the multivariable regression adding these three risk factors to the Cox model had no substantial models because of missing data. When patients with missing effect on discriminative ability (c increased from 0.73 to 0.74). One data differ from the other patients on prognosis, this causes a bias could also consider using continuous codings of tumour markers, in the regression coefficients and the estimated 5-year survival but this would lead to an undesirable increase in complexity and rates (Little, 1992; van Buuren et al, 1999; Clark and Altman, 2003). Secondly, we could not internally validate the IGCC The division into more prognostic groups is similar to another classification, because the exact steps taken in the modelling division by recursive partitioning of poor prognosis patients process (selection and categorisation of risk factors) were not (Kollmannsberger et al, 2000). Kollmannsberger et al identified defined. The IGCC classification was applied to a 30% validation three prognosis groups: a good-poor, intermediate-poor and poor- set (IGCCCG, 1997), and although the proportion of patients in poor risk group with 2-year survival rates of 84, 64 and 49%, each prognostic group was similar, the 5-year survival for respectively. These survival rates are higher than the survival rates poor prognosis patients was higher (57%). We did internally of the good-poor, intermediate-poor and poor-poor risk groups validate the modelling steps of the Cox regression models and identified in the IGCC dataset. This may be due to the difference in found minor optimism in discriminative ability. Classification 5T, survival for the poor prognosis patients (72 vs 50%), and remains based on recursive partitioning, however, showed optimism in when the difference in follow-up time is taken into account (2 vs 5 discriminative ability, as might be expected from a more data- years). The data in Kollmannsberger et al (2000) are more recent driven method. This, in combination with the poorer performance, and improvements in treatment may have led to the difference in suggests that recursive partitioning is less suitable for the construction of prognostic classifications. It can be useful, The lack of improvement in discriminative ability in both the however, for exploratory analyses in finding interactions between classifications with three and five groups might also be explained by the dominance of the good prognosis group, which has a similar The survival estimates of the IGCC classification were also survival for all classifications and contains more than half of all externally validated with more recent data from an MRC/EORTC patients. We therefore examined whether discriminative ability trial (N ¼ 300). The 2-year PFS outcome largely corresponded with increased within the poor prognosis group of each classification.
the IGCC estimates (IGCCCG, 1997). To gain further insight in the Discriminative ability increased from 0.50 to 0.60, 0.63, 0.64 and generalisability of the Cox regression models as well as the IGCC 0.65 for the three poor prognosis groups of classifications 5T, classification, further external validation is necessary, in larger IGCC, 5R and 5Ri, respectively. Hence, some improvement was recent datasets with longer follow-up.
noted within the IGCC poor prognosis group. Furthermore, even In conclusion, the IGCC classification appears to be a valid way though the c-statistic is often used and easy to interpret, it is not to classify patients with NSGCT in three prognostic groups.
suitable for detecting small differences in discriminative ability Recursive partitioning is less suitable for the construction of (Harrell et al, 1996; Steyerberg et al, 2000).
prognostic classifications, because of its poorer performance.
Although the use of Cox regression and recursive partitioning Although Cox regression did not lead to a clear improvement in did not have a major effect on discriminative ability, they can still performance, it gave a more flexible and transparent scoring be useful tools in the construction of future prognostic classifica- system without much loss in simplicity. We therefore recommend tions when other criteria are taken into account. One of the the use of regression-based weights in the development of future advantages of classifications such as the IGCC classification is its simplicity. Classification 5T is reasonably simple with only a fewsubgroups and the survival probability readily available. Classifi-cation 5R is slightly more complicated because of the sum scorethat has to be calculated. Finally, classification 5Ri is not so much complicated as visually unattractive. Furthermore, survival esti-mates for infrequent combinations of risk factors are not reliable This work was supported by the Netherlands Organisation for and therefore provide little information on the prognosis of Scientific Research and by the Royal Netherlands Academy of Arts and Sciences. We thank the members of the IGCCCG (Medical A disadvantage of the IGCC classification is its inflexibility.
Research Council (MRC): GM Mead (Royal South Hants Hospital, More groups could be defined, but not in a straightforward Southampton, Hampshire, UK), P Cook (MRC Clinical Trials Unit, manner. Classification 5R and classification 5Ri are very London), SD Fossa (Norwegian Radium Hospital, Montebello, flexible with many possible cutoff points. Classification 5T is Oslo, Norway), A Horwich, SB Kaye (Royal Marsden Hospital, less flexible due to the limited number of subgroups, but Surrey, England), RTD Oliver (St Bartholomew’s Hospital, London, flexibility could be increased by putting fewer restrictions on the England). European Organisation for the Research and Treatment recursive partitioning allowing for more subgroups to be of Cancer (EORTC): PHM de Mulder (Academic Hospital Nijmegen, The Netherlands), R de Wit and G Stoter (Rotterdam The IGCC classification considered not just discrimination but Cancer Institute, The Netherlands), RJ Sylvester (EORTC Data also simplicity and the size of the resulting prognostic groups and Center, Brussels Belgium). USA: DF Bajorin, GJ Bosl, M Mazumdar was chosen by consensus from a shortlist of possible models, (Memorial Sloan-Kettering Cancer Center, New York). CR Nichols which balanced these considerations. Consequently, in the IGCC (Indiana University Hospital, Indianapolis). R Amato (University classification there is a lack of transparency; it is unclear how the of Texas MD Anderson Cancer Center, Houston, Texas). Italy: G classification was constructed statistically because statistical Pizzocaro (Istituto Nazionale per lo studio e la Cura dei Tumori, considerations were not the only criteria used to derive the Milan). France: JP Droz (Centre Leon Benard, Lyon), A Kramar classification. Classification 5T shows very clearly how the (CRLC Val d’Aurelle, Montpellier). Denmark: G Daugaard subgroups were derived from the successive splits in the risk (Rigshospitalet, Copenhagen). Spain: H Cortes-Funes and L Paz- factors. Classification 5R shows the difference in importance Ares (Hospital Doce de Octubre, Madrid). Australia: JA Levi between the risk factors and how the risk factors are combined in a (Royal North Shore Hospital, Sydney). New Zealand: BM Colls sum score. Classification 5Ri could be presented in a similar way as (Christchurch Hospital, Christchurch), VJ Harvey (Auckland classification 5R, but interpretation of the main and interaction Hospital, Auckland). Canada: C Coppin (Fraser Valley Cancer Centre, Vancouver, British Columbia) and their colleagues (see British Journal of Cancer (2004) 90(6), 1176 – 1183 A review of the development of the IGCC classification below) for kindly providing their data for the analyses in this Netherlands). USA: R Motzer (Memorial Sloan-Kettering Cancer Center, New York), L Finn (University of Texas MD Anderson MRC: N Aass (Norwegian Radium Hospital, Oslo, Montebello, Cancer Center). Italy: R Salvioni and L Mariani (Istituto Nazionale Norway), PI Clark (Clatterbridge Hospital, Liverpool, England), Tumori, Milan). Spain: P Lianes Barragan (Hospital doce de MH Cullen (Queen Elizabeth Hospital, Birmingham, England), D Octubre, Madrid). Denmark: S Werner Hansen (Rigshospitalet, Dearnaley (Royal Marsden Hospital, Surrey, England), SJ Harland (Middlesex Hospital, London, England), WG Jones (Yorkshire Montpellier), J Bouzy (Institut Gustave Roussy, Villejuif).
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Source: http://www.elisedusseldorp.nl/pdf/vandijk2004BJCsurvival.pdf

Mcneil consumer healthcare recalls four product lots of benadryl® allergy ultratab™ tablets, 100 count, and one product lot of extra strength tylenol® rapid release gels, 50 count

Mcneil Consumer Healthcare Recalls Four Product Lots of Benadryl® Allergy Ultratab™ Tablets, 100 Count, and One Product Lot of Extra Strength Tylenol® Rapid Release Gels, 50 Count Contact: Bonnie Jacobs 215-273-8994 Marc Boston 215-273-7649 FOR IMMEDIATE RELEASE - Fort Washington, PA - June 15, 2010 - McNeil Consumer Healthcare, Division of McNEIL-PPC, Inc., is recalling


Statistics Concentration)M. S. (Applied Statistics)University of the Philippines at Diliman, 1985Department of BiostatisticsUniversity of Alabama at Birmingham, Oct 2008 – presentCenter for Cardiovascular BiologyUniversity of Alabama at Birmingham, November 2010 – presentCenter for AIDS ResearchUniversity of Alabama at Birmingham, May 2008 – presentDepartment of BiostatisticsUniversity

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