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The European Society for the Study of Diabetes (EASD) Natal, Rio Grande do Norte, Brazil, May 8-11, 2011 Scientific Program


17h00 -18h30 - Registration
18h45 - Welcome and opening remarks
Chairs - Carlos Boschero; Décio Eizirik

19h00 - Keynote Lecture
Genetics of type 2 diabetes- are we getting any closer?
Leif Groop, Lund University Diabetes Centre, Malmö, Sweden
20h00 – Welcome Cocktail


09h00 – 10h10 - Lectures
1 - Epigenetics and alternative splicing of beta cells in diabetes
Chairs - Leif Groop; Rui Curi
09h00 – 09h25 - The epigenome of pancreatic islets in health and disease –
François Fuks - Laboratory of Cancer Epigenetics, Université Libre de Bruxelles, (ULB),Belgium
09h35 – 10h00 - Alternative splicing in pancreatic beta cel s –
Decio L. Eizirik - Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Belgium
10h00 – 10h25 - Coffee break

10h25 – 11h45 - Short Talks
(8 min presentation + 4 min discussion)
OC.01
Functional and epigenetic alterations induced by palmitate in the insulin secreting clonal β cel line INS-1
832/13
Malmgren SM1; Nagorny CL1; Spegél P1; Dekker-Nitert M1; Ling C1; Mulder H1 - 1Lund University - Clinical
science, Malmö
OC.02
Relationships between pancreatic islets and clinical characteristics
Marselli L1; Suleiman M1; Bugliani M1; Marchetti P1 - 1University of Pisa - Department of Endocrinology
and Metabolism
OC.03
EFFECTS OF ANTI- AND PRO-INFLAMMATORY CYTOKINES ON THE EXPRESSION OF PRDX 6 IN INSULIN–
PRODUCING RINm5F CELLS
Paula FMM1; Souza KL2; Boschero AC3 - 1Department of Anatomy, Cel ular Biology and Physiology and
Biophysics - Institute of Biology, UNICAMP, Campinas, SP, Brazil; 2Institute of Biophysics Carlos Chagas
Filho - UFRJ, RJ, Brazil; 3Department of Anatomy, Cellular Biology and Physiology and Biophysics -
Institute of Biology, UNICAMP, Campinas, SP

OC.04
Non-obese diabetic mice deficient in the pro-apoptotic BH3-only protein Bid are protected from Fas-
induced beta cel destruction but not diabetes
Mol ah Z1; Kay T1; Thomas H1 - 1St Vincents Institute - Immunology and Diabetes
OC.05
Global gene expression profiling to identify the mechanisms involved in the protective effects of 1,25-
dihydroxyvitamin D3 against cytokine-induced damage of islets of Langerhans.
Wolden-Kirk H1; Overbergh L2; Van Lommel L3; Naamane N4; Gysemans C2; Brusgaard K1; Christesen
HB1; Thorrez L5; Schuit F3; Eizirik DL4; Mathieu C2 - 1University of Southern Denmark - Inst. of Clinical
Research; 2Catholic University of Leuven - Experimental Medicine; 3K.U.Leuven - Gene Expression
Unit; 4Université Libre de Bruxelles - Experimental Medicine; 5Catholic University of Leuven - Stem Cell
Institute Leuven
OC.06
Differential Role of GPRC5B and GPRC5C Receptors in the Regulation of Pancreatic β-cel Function
Soni A1; stefan A2; Sarheed JM3; P Rorsman4; Salehi A1 - 1Lund university - Clinical Science; 22The Oxford
Centre for Diabetes - Endocrinology & Metabolism, Oxford University, UK; 3Lund University -
Department of Clinical Science, UMAS, Clinical Research Center, University of Lund, Sweden; 4The
Oxford Centre for Diabetesm, Oxford University, UK - Endocrinology & Metabolism
11h45 – 13h00 – Poster Session

PT.01

Islet changes induced by increased fructose intake: increased β-cel apoptosis and islet fat deposit.
Rebol edo OR1; Marra CA2; Del Zotto H3; Borel i MI4; Maiztegui B5; Gagliardino JJ6 - 1Facultad de Ciencias
Médicas UNLP - CENEXA (UNLP-CONICET; 2Facultad de Ciencias Médicas UNLP - INIBIOLP (UNLP-
CONICET; 3CENEXA (UNLP-CONICET LA PLATA) - Fac. Cs. Médicas UNLP; 4Universidad Nacional de La
Plata - Centro de Endocrinología Experimental y Aplicada (CENEXA); 5CENEXA - Facultad de Ciencias
Medicas; 6CENEXA (UNLP-CONICET) - Facultad de Ciencias Médicas UNLP
PT.02
Islet Neogenesis-Associated Protein (INGAP): Its Positive Physiological Modulatory Role in Insulin
Secretion
Flores LE1; Del Zotto H1; Raschia MA1; Borel i MI1; Barbosa HC2; Boschero AC3; Gagliardino JJ1 - 1CENEXA
(UNLP-CONICET LA PLATA) - Fac. Cs. Médicas UNLP; 2UNICAMP - Departamento de Fisiologia e
Biofísica; 3IB - UNICAMP - Fisiologia e Biofísica
PT.04
Placental VEGF, COX-2 and CASPASE-3 in pregnancies complicated by diabetes or mild gestational
hyperglycemia, relation with hyperglycemia and umbilical PI
Saito FH1; Calderon IMP1; Carvalho-Silva SAL1; Moreli JB1; Amorin RL2; Damasceno DC1; Rudge MVC1 -
1Botucatu Medical School/UNESP - Gynecology and Obstetrics; 2School of Veterinary Medicine and
Animal Sciences/UNESP - Pathology
PT.05
Reduction of SIRT4 protein expression impairs glucose-stimulated insulin secretion in islets from both
control and restricted rats
Alves P L1; Vanzela EC2; Ribeiro RA2; Barbosa HC2; Amaral MEC1 - 11Centro Universitário Hermínio
Ometto, Programa de Pós Graduação em Ciências Biomédicas, UNIARARAS - NUCISA; 2UNICAMP -
Fisiologia e Biofísica
PT.06
Effect of Azadirachta indica (Neem) seed oil on maternal-fetal outcomes, lipid profile and oxidative
stress in streptozotocin-induced diabetic rats
Iessi IL1; Dal aqua B2; Saito FH3; Corvino SB4; Piculo F1; Calderon IMP5; Lima PHO6; Rudge
MVC7; Rodrigues T8; Damasceno DC9 - 1Unesp - Botucatu - Ginecologia e Obstetrícia; 2Unesp - Botucatu -
Ginecologia e Obstetricia; 3Faculdade de Medicina de Botucatu - UNESP - Ginecologia e
Obstetrícia; 4Faculdade de Medicina de Botucatu - Ginecologia e Obstetrícia; 5FMBotucatu/UNESP -
Ginecologia e Obstetrícia; 6UNESP - Faculdade de Medicina de Botucatu/ UNOESTE-Universidade do
Oeste Paulista - Ginecologia e Obstetrícia/ FACLEPP; 7UNESP - Ginecologia e Obstetrícia; 8Universidade
de Mogi das Cruzes - Centro Interdisciplinar de Investigação Bioquímica; 9Faculdade de Medicina de
Botucatu, Unesp, São Paulo, Brasil - Programa de Pós-Graduação em Ginecologia, Obstetrícia e
Mastologia
PT.07
KNOCKDOWN OF 5-HT2B RECEPTOR DECREASE GLUCOSE STIMULATED INSULIN SECRETION IN A CLONAL
(INS (832/13) BETA-CELL LINE
Bennet H1; Nagorny CL2; Wierup N3; Dekker-Nitert M4; Lernmark A1; Fex M1 - 1Clinical science, Malmö -
The unit of Diabetes and Celiac disease; 2Clinical science, Malmö - Molecular Metabolism; 3Clinical
science, Malmö - Neuroedocrine Cel Biology; 4Clinical science, Malmö - Diabetes and Endocrinology
PT.08
ARHGAP21 expression in MIN6 cel s and neonatal pancreatic islets: possible participation on the
mechanism of insulin secretion
Ferreira SM1; Barbosa HC2; Rezende LF3; Bigarella CL4; Saad ST5; Boschero AC6 - 1Universidade Estadual
de Campinas - Anatomia, Biologia Celular e Fisiologia e Biofísica; 2UNICAMP - Departamento de
Fisiologia e Biofísica; 3Universidade Estadual de Campinas - UNICAMP - Departamento de Anatomia,
Biologia Celular e Fisiologia e Biofísica; 4UNICAMP - Hemocentro; 5UNICAMP - Centro de Hematologia e
Hemoterapia; 6IB - UNICAMP - Fisiologia e Biofísica
PT.09
Calcium signaling alteration is associated with mitochondrial dysfunction and increased ROS generation
in the islets of Langerhans from senescent rats
Coelho F. M.1; Sinigaglia-Coimbra R2; Hirata AE3; Jurkiewicz A4; Smaili SS5; Lopes GS4 - 1UNIFESP -
Departamento de Farmacologia; 2Universidade Federal de São Paulo - Medicina; 3UNIFESP - EPM -
Fisiologia ; 4UNIFESP - EPM - Farmacologia; 5UNIFESP - EPM - Farmacologia - MAD
PT.10
Evaluation of azadirachtin effect in streptozotocin-induced diabetic rats during pregnancy
Damasceno DC1; Dal aqua B2; Iessi IL3; Saito FH4; Bueno A5; Netto AO6; Sinzato YK7; Marini G6; Rudge
MVC7; Rodrigues T8 - 1FM - UNESP - Botucatu - Ginecologia e Obstetrícia; 2Unesp - Botucatu -
Ginecologia e Obstetricia; 3UNESP - Ginecologia e Obstetricia; 4Faculdade de Medicina de Botucatu -
UNESP - Ginecologia e Obstetrícia; 5Faculdade de Medicina de Botucatu UNESP - Ginecologia e
Obstetrícia; 6Faculdade de Medicina de Botucatu - Ginecologia e Obstetrícia; 7UNESP - Ginecologia e
Obstetrícia; 8Universidade de Mogi das Cruzes - Centro Interdisciplinar de Investigação Bioquímica
PT.11
GLUCOSE TOLERANCE, INSULIN SECRETION AND CA2+ HANDLING IN ISLETS FROM LDL RECEPTOR
KNOCKOUT MICE (LDLR-/-) FED HIGH-FAT-DIET (WESTERN-TYPE)
Souza JC1; Vanzela EC1; Ribeiro RA1; Machado-de-Oliveira CAM2; Oliveira HCF1 - 1UNICAMP - Anatomia,
Biologia Celular, Fisiologia e Biofísica; 2Unifesp - Biociências
PT.12
Chronology of appearance of INGAP-positive cells and its relationship with the increase in B-cel mass
during the pre and postnatal periods
Madrid V1; Borel i MI2; Maiztegui B1; Boschero AC3; Barbosa HC4; Gagliardino JJ2; Del Zotto H1 - 1CENEXA
(UNLP-CONICET LA PLATA) - Fac. Cs. Médicas UNLP; 2Universidad Nacional de La Plata - Centro de
Endocrinología Experimental y Aplicada (CENEXA); 3IB - UNICAMP - Fisiologia e Biofísica; 4UNICAMP -
Departamento de Fisiologia e Biofísica
PT.13
Effects of Fatty Acids Withdrawal in Culture Medium on RINm5F Cel s Death Susceptibility
Rosim MP1; Nunes, V. A.2; Lenzen S3; Curi R4; Azevedo-Martins AK5 - 1Universidade de São Paulo -
ICB; 2Universidade de São Paulo - Escola de Artes, Ciências e Humanidades; 3MHH-Hannover - Klinische
Biochemie; 4ICB - USP - Fisiologia e Biofísica; 5Universidade de São Paulo - Escola de Artes Ciências e
Humanidades
PT.14
PROTEIN RESTRICTION DURING PREGNANCY DID NOT MODIFY PRO-APOPTOTIC GENES EXPRESSION,
BUT IMPAIRED THE EXPANSION OF PANCREATIC ISLETS AREA
Ramalho AFS1; Salvatierra CB2; Reis SRL1; Lemes SF1; Veloso RV1; Marise ABReis3; Arantes VC1; Latorraca
MQ4 - 1Universidade Federal de Mato Grosso - Departamento de Alimentos e Nutrição; 2UNEMAT -
Departamento de Engenharia de Alimentos; 3Universidade Federal de Mato Grosso - Departamento de
Ciências Básicas em Saúde - FCM/UFMT; 4Universidade Federal de Mato Grosso, Faculdade de Nutrição -
Departamento de Alimentos e Nutrição
PT.15
Proteomic Approach to Search for Differential y Expressed Proteins in Human Pancreatic Islets and
Human Insulinomas.
Terra L. F.1; Teixeira PC2; Wailemann R. A.1; Zelanis A.3; Palmisano G.4; Cunha-Neto E2; Kalil J2; Sogayar
MC1; Labriola L1 - 1Instituto de Química - USP - Bioquímica; 2InCor - FM - USP - Clínica Médica - Disciplina
de Imunologia Clínica e Alergia / Lab de Imunologia; 3Instituto Butantã - CAT- CEPID; 4University of
Southern Denmark - Biochemistry and Molecular Biology
PT.16
CaMK4/CREB pathway-mediated β-cel proliferation
Barbosa HC1; Rodrigues de Ledesma AM1; Liu B1; Jones PM1; Persaud SJ1; Mul er DS1 - 1King Col ege
London - Diabetes and Nutritional Sciences Division
PT.17
CYTOTOXICITY AND CYTOPROTECTIVE EFFECTS OF FLAVONOIDS RUTIN, HESPERIDIN, NARINGIN,
NEOHESPERIDIN ON INSULIN-SECRETING CELLS BRIN-BD11.
FELIPE ET1; MAESTRI JS1; KANUNFRE CC2; GRASSIOLLI S2; Curi R3; Newsholme P4; Carpinelli AR5; Oliveira-
Emilio HR2 - 1Universidade Estadual de Ponta Grossa - Mestrado em Biologia Evolutiva; 2Universidade
Estadual de Ponta Grossa - Biologia Geral; 3ICB - USP - Fisiologia e Biofísica; 4University Col ege Dublin -
School of Biomolecular and Biomedical Science; 5USP - Fisiologia e Biofísica
PT.18
MORPHOMETRY OF ENDOCRINE PANCREAS IN THE MSG-OBESE RAT
Lubaczeuski, C1; Vettorazzi JF2; Ferreira, LE1; Ribeiro RA4; Bonfleur ML3; Balbo SL1 - 1UNIOESTE -
CCBS; 2Unicamp - Anatomia, Biologia celular e Fisiologia e Biofísica; 3UNIOESTE - Centro de Ciências
Biológicas e da Saúde; 4Universidade Estadual de Campinas - Fisiologia e Biofísica
PT.19
CONDITIONAL EXPRESSION OF CONSTITUTIVELY ACTIVE EGF-R IN BETA CELLS
Hakonen E1; Ustinov J1; Miettinen P1; Otonkoski T1 - 1University of Helsinki - Biomedicum Stem Cell
Center and Hospital for Children and Adolescents
PT.20
Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cel s and mouse islets.
MARROQUI L1; Vieira E1; Gonzalez A1; Nadal A1; Quesada I1 - 1Universidad Miguel Hernández, Spain. -
Instituto de Bioingeniería.
PT.21
NADPH oxidase plays an active role in the changes induced by fructose upon islet function
Borel i MI1; Flores LE1; Raschia MA2; Román L2; Rebol edo OR2; Gagliardino JJ3 - 1CENEXA (UNLP-CONICET
LA PLATA) - Fac. Cs. Médicas UNLP - ARGENTINA; 2CENEXA (UNLP-CONICET LA PLATA) - Fac. Cs. Médicas
UNLP - ARGENTNA; 3CENEXA (UNLP-CONICET LA PLATA) - Fac. Cs. Médicas UNLP - ARGENTINA

PT.22
Intrauterine Growth Retardation together with High Fat Diet in Rats Markedly Disturbs Islet Morphology
without Loss of Beta-cel Mass or Induction of Diabetes
Delghingaro-Augusto V1; Madad L1; Simeonovic C1; Dahlstrom JE1; Nolan C1 - 1Australian National
University - Medical School
PT.23
Participation of NAD(P)H oxidase on insulin secretory process of BRIN-BD11 beta cel s.
Hirata AE1; Morgan D2; Graciano MFR3; Curi R4; Carpinel i AR3; Flatt, PR5; Newsholme P6 - 1UNIFESP -
EPM - Fisiologia; 2USP - Fisiologia e Biofísca; 3USP - Fisiologia e Biofísica; 4ICB - USP - Fisiologia e
Biofísica; 5University of Ulster - School of Biomedical Sciences; 6University College Dublin - School of
Biomolecular and Biomedical Science
PT.24
Protzek AOP1; Costa Júnior JM1; Purificação TA1; Rafacho A2 - 1State University of Campinas - Unicamp -
Department of Anatomy Physiology and Biophysics, Institute of Biology; 2Universidade Federal de
Uberlândia - Faculdade de Ciências Integradas do Pontal
13h00 – 15h00 – Lunch time
May , Monday 9th
15h30 – 17h15 - Lectures
2 - Cross talk between beta-cells and other cells/-tissues
Chairs - Anders Tengholm; Jens Nielsen
15h30 – 15h55 - Connecting cel s within the islets
Paolo Meda – University of Geneva School of Medicine, Switzerland
16h05 – 16h30 - Hypothalamic inflammation connecting obesity to pancreatic islet failure –Lício
Augusto Velloso
– School of Medical Sciences (UNICAMP), Campinas, SP, Brazil
16h40 – 17h05 - Modulation of pancreatic β-cel metabolism and insulin secretion by IL-6 released from
skeletal muscle
Philip Newsholme UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, UCD
Dublin, Dublin 4, Ireland
17h15 – 17h30 h - Coffee break

17h30 – 18h30 h - Short Talks
(8 min presentation + 4 min discussion)
OC.07
Functional changes of pancreatic beta cel s by high a glucose diet and hyperfunction of adipocytes
Velasco M1; Larque C1; MHiriart-Urdanivia2 - 1Instituto de Fisiologia Celular, UNAM - Neurodevelopment
and Physiology; 2Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, UNAM -
Neurodevelopment and Physiology
OC.08
The use of proteomics to elucidate the protective effects of glucagon-like peptide-1 on cytokine-
mediated beta-cel dysfunction and death.
Overbergh L1; Bugliani M2; De Hertog W1; Verdrengh E1; Masini M3; Waelkens E4; Marchetti P5; Mathieu
C1 - 1Catholic Unversity of Leuven - Laboratory of Experimental Medicine and Endocrinology; 2 -
3University of Pisa - Endocrinology and Metabolism; 4Catholic Unversity of Leuven - Laboratory of
Protein Phosphorylation and Proteomics; 5University of Pisa - Dept. Endocrinology and Metabolism
OC.09
Lipotoxic ER stress-induced DP5 and PUMA expression contributes to mitochondrial beta-cel apoptosis
Cunha DA1; Gurzov EN1; Germano C2; Naamane N1; Eizirik DL1; Cnop M1 - 1Université Libre de Bruxel es -
Experimental Medicine; 2Faculdade de Medicina de Ribeirão Preto - Clínica Médica
OC.10
The role of GPR40 in type 2 diabetes and obesity in animal models
Balhuizen A1; Kumar R2; Salehi A3 - 1Lund university, Sweden - Clinical Science; 2Lund university - Clinical
Science; 3Lund University - Clinical Sciences
OC.11
Role of the Ubiquitin-Proteasome System (UPS) in Type 2 Diabetes (T2D) Beta Cell Dysfunction.
Bugliani M1; R Liechti2; Cheon H3; Marsel i L4; Suleiman M1; Xenarios I2; Lee M.S.3; Marchetti P1 -
1University of Pisa - Dept. Endocrinology and Metabolism; 2Swiss Institute of Bioinformatics - Vital-It group; 3Samsung Biomedical Center - Department of Medicine; 4University of Pisa - Department of Endocrinology and Metabolism
09h00 – 10h45 h - Lectures
3 - The role for diabetes candidate genes in pancreatic beta cells
Chairs - Miriam Cnop; Fumihiko Urano
09h00 – 09h25- From genotype to pancreatic β-cel phenotype in humans –
Piero Marchetti, Cisanel o Hospital, Pisa - Italy
09h35 – 10h00 - Translating genome wide association signals into molecular mechanisms for diabetes in
human pancreatic islets
Anna L Gloyn - Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, UK
10h10 – 10h35 Impact of natural y occurring severe activating glucokinase mutation gene in human
islets –
Antonio Luís Cuesta Muñoz - Center for the Study of Pancreatic Beta-cell Diseases-DRI-Málaga, IMABIS-
Carlos Haya Foundation, Malaga, SPAIN
10h45 – 11h00 - Coffee break

11h00 – 11h50 - Short Talks
(8 min presentation + 4 min discussion)
OC.12
Differential usage of NF-kB activating signals by IL-1β and TNF-α in pancreatic beta cel s
Ortis F1; Miani M2; Col i ML2; Cunha DA2; Gurzov EN2; Allagnat F2; Eizirik DL2 - 1Université Libre de
Bruxel es, Brussels, Belgium - Experimental Medicine - Institute of Biology, State University of Campinas
(UNICAMP), Campinas, SP, Brazil - Anatomy, Cel ular Biology and Physiology and Biophysics; 2Université
Libre de Bruxelles, Brussels, Belgium - Experimental Medicine
OC.13
Role of melatonin receptors in pancreatic islets
Nagorny CL1; Bennet H1; Stamenkovic J1; Sathanoori R1; Fex M1; Wierup N1; Mulder H1 - 1Lund
University - Clinical Sciences Malmö
OC.14
Growth arrest specific protein 6 impinge on the β-cell mass in the newborn rat
Haase TN1 - 1University of Copenhagen - Department of Biomedical Sciences
OC.15
Mechanisms of expansion of the beta-cell mass in pregnancy
Gaarn LW1; Nielsen JH1 - 1Faculty of Health Sciences, University of Copenhagen - Department of
Biomedical Sciences
11h50 – 13h30 – Poster Session 2
PT.25
Plasma membrane Ca2+-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum
Ca2+ stores and triggers apoptosis in pancreatic b-cel s.
Herchuelz A1 - 1Laboratoire de Pharmacodynamie - ULB, Belgium
PT.26
Effect of INGAP-PP upon islet glucokinase activity and glucose metabolism
Maiztegui B1; Borelli MI1; Gagliardino JJ1 - 1CENEXA (UNLP-CONICET La Plata) - Facultad de Ciencias
Médicas-UNLP
PT.27
Identification of a novel GPCR mediating anti-diabetic effects of AAT
Kumar R1; Balhuizen A2; Soni A1; Salehi A1 - 1Lund university - Clinical Science; 2Lund University, Sweden -
Clinical Sciences
PT.28
Tumor necrosis factor-alpha and interferon-gamma induce pancreatic beta cel apoptosis through
STAT1-mediated Bim activation
Gurzov EN1; Barthson J1; Germano C2; Moore F1; Eizirik DL1 - 1Université Libre de Bruxelles -
Experimental Medicine; 2Faculdade de Medicina de Ribeirão Preto - Clínica Médica
PT.29
Maternal protein restriction leads functional changes in pancreatic islets M2/3 subtype of muscarinic
receptor (mAChR) from adult rats.
de Oliveira JC1; Barel a LF2; Branco RCS2; Miranda RA2; Bataglini LA2; Lepri ER3; Mel o EVSL3; Gravena
C2; Mathias PCF2 - 1Universidade Estadual de Maringá - UEM - Biogia Celular e Genética; 2Universidade
Estadual de Maringá - UEM - Biologia Celular e Genética; 3Universidade Estadual de Maringá - UEM -
Histologia
PT.30
Impaired insulin secretory response in obese rats involves reduced muscarinic receptor function of
pancreatic islets and high parasympathetic activity
Branco RCS1; Grassiol i S2; Bataglini LA3; Miranda RA4; Gravena C3; Mello E5; Lepri ER5; Mathias PC3; de
Oliveira JC6 - 1Universidade Estadual de Maringa - Biologia Celular e Genetica; 2UEM - DBC; 3UEM -
Biologia Celular e Genética; 4UEM - Biologia Celular; 5UEM - Histologia; 6Universidade Estadual de
Maringá - Biologia Celular e Genética
PT.31
BISPHENOL-A EXPOSURE DURING PREGNANCY DISRUPTS GLUCOSE HOMEOSTASIS IN MOTHERS AND
ADULT MALE OFFSPRING
Alonso-Magdalena P1; García-Arévalo M1; Vieira E1; Soriano S1; Menes L2; Burks D2; Quesada I1; Nadal A1
- 1Universidad Miguel Hernández - Instituto de Bioingeniería; 2Instituto Principe Felipe - CSIC
PT.32
MALNUTRITION AFTER WEANING IMPAIRS THE PROTECTIVE EFFECT OF TAURINE (TAU)
SUPPLEMENTATION UPON ENERGY BALANCE, GLUCOSE HOMEOSTASIS AND INSULIN SECRETION (IS) IN
MICE FED A HIGH FAT DIET (HFD)
Camargo RL1; Cappel i APG2; Batista TM2; MR Silva P3; Ribeiro RA4; Zoppi CC5; Carneiro EM5 -
1Universidade Estadual de Campinas - UNICAMP - Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica; 2Unicamp - Fisiologia e Biofísica; 3Unicamp - Fisiologia; 4Universidade Estadual de
Campinas - Fisiologia e Biofísica; 5UNICAMP - Anatomia, Biologia Celular e Fisiologia e Biofísica
PT.33
Reduction of plasma lipids improves insulin secretion in insulin resistant rats.
Destro M1; Bosqueiro JR1 - 1FC - UNESP - Bauru - Educação Física
PT.35
Endoplasmic Reticulum Stress: a potential candidate for the gestational diabetes pathogenesis
Nunes, V. A.1; Araujo MS2; Rosim MP3; Curi R4; Azevedo-Martins AK5 - 1Universidade de São Paulo -
Escola de Artes, Ciências e Humanidades; 2UNIFESP - Bioquímica; 3Universidade de São Paulo - Fisiologia
e Biofísica; 4ICB - USP - Fisiologia e Biofísica; 5Universidade de São Paulo - Escola de Artes Ciências e
Humanidades
PT.36
SNARE COMPLEX FORMATION IN PANCREATIC ISLETS OF RATS SUBMITTED TO PROTEIN MALNUTRITION
Lopes BV1; Bertuol AEM1; Dotto RP1; Sílvia RLReis2; Arantes VC3; Latorraca MQ4; Marise ABReis5 -
1Universidade Federal de Mato Grosso - Departamento de Alimentos e Nutrição; 2Universidade Federal
de Mato Grosso - Laba; 3UFMT - Alimentos e Nutrição; 4Universidade Federal de Mato Grosso, Faculdade
de Nutrição - Departamento de Alimentos e Nutrição; 5Universidade Federal de Mato Grosso -
Departamento de Ciências Biológicas da Saúde - Fisiologia
PT.37
DIFFERENTIAL IMPACT OF CHRONICALLY ELEVATED GLUCOSE AND PYRUVATE LEVELS ON THE
MITOCHONDRIAL AND PLASMA MEMBRANE IN BETA CELLS
Goehring I1; Malmgren SM1; Mulder H1; Nichol s D2 - 1Lund University Diabetes Centre - Department of
Clinical Sciences, Malmö, Sweden; 2Buck Institute for Age Research - Novato, United States
PT.38
TNF-α AND ADIPONECTIN LEVELS RELATED TO BODY MASS INDEX IN MILD GESTATIONAL
HYPERGLYCEMIA
Bueno A1; Sinzato YK2; Lima PHO3; Moreli JB4; Caetano M5; Gelaleti RB6; Morceli G7; Damasceno
DC8; Calderon IMP9; Rudge MVC2 - 1Faculdade de Medicina de Botucatu UNESP - Ginecologia e
Obstetrícia; 2UNESP - Ginecologia e Obstetrícia; 3UNESP - Faculdade de Medicina de Botucatu/
UNOESTE-Universidade do Oeste Paulista - Ginecologia e Obstetrícia/ FACLEPP; 4Faculdade de Medicina
de Botucatu- Unesp-Botucatu - Ginecologia Obstetrícia e Mastologia; 5Universidade Estadual Paulista -
UNESP - Ginecologia e obstetrícia; 6UNESP - FMB - Ginecologia e Obstetrícia; 7Faculdade de Medicina de
Botucatu-Júlio de Mesquita Filho/FMB/UNESP - Departamento de Ginecologia e Obstetrícia; 8Faculdade
de Medicina de Botucatu, Unesp, São Paulo, Brasil - Programa de Pós-Graduação em Ginecologia,
Obstetrícia e Mastologia ; 9FMBotucatu/UNESP - Ginecologia e Obstetrícia
PT.39
TAURINE AMELIORATES GLUCOSE HOMEOSTASIS AND PANCREATIC ISLET FUNCTION IN OBESE (ob/ob)
MICE
Santos-Silva, JC1; Ribeiro RA1; Cotrim, BB1; Carneiro EM1 - 1State University of Campinas - Department of
Anatomy, Cel Biology and Physiology and Biophysics
PT.40
EFFECTS OF EXERCISE TRAINING AND INTERLEUKIN 6 UPON INSULIN SECRETORY MACHINERY PROTEINS:
EVIDENCE FOR A POSSIBLE CONTRACTING SKELETAL MUSCLE AND PANCREATIC β-CELLS CROSSTALK
MODULATION
Zoppi CC1; Costa Jr. JM1; Paula FMM1; Machado-de-Oliveira CAM2; Silveira LR3; Carneiro EM4 - 1State
University of Campinas - Anatomy, Cel ular Biology and Physiology and Biophysics; 2Unifesp -
Biociências; 3USP - Ribeirão Preto - Escola de Ed Física; 4UNICAMP - Fisiologia e Biofísica
PT.41
EARLY SWIM TRAINING MODULATES GLUCOSE AND CHOLINERGIC RESPONSES IN PANCREATIC ISLETS
FROM MSG-OBESE RATS
Borck, P.C.1; Rickli, S.2; Barros, V.B.3; Franco, A.H.3; Alípio, J.C. de L.2; Venturel i, A.C.3; Machado,
M.J.R.2; Leite, N. de C.3; Gonçalves, D.C.de O.N.1; Mathias PCF4; Grassiol i S5 - 1UEPG - Farmácia; 2UEPG -
Enfermagem; 3UEPG - Educação Física; 4UEM - Biologia Celular e Genética; 5UEPG - DeBio
PT.42
Alpha 1-antitrypsin protects mouse islets from LPS induced inflammation
Nal a AA1; Nielsen JH1; Nal a A1; Bil estrup N1; Frøkiær H2; Metzdorff S2; Petersen M2; Mehlsen A2; Shah
F3 - 1Faculty of Health Sciences, University of Copenhagen - Biomedical Institute; 2Faculty of Life
Sciences, University of Copenhagen - Biochemistry; 3DTU Nanotech, Lyngby - Department of Micro- and
Nanotechnology
PT.43
CILIARY NEUROTROPHIC FACTOR (CNTF) IMPROVES INSULIN SECRETION AND HALF-LIFE AND INCREASES
INSULIN SENSITIVITY IN NON-OBESE DM2 MICE
Rezende LF1; Santos GJ2; Santos-Silva, JC2; Boschero AC2 - 1State Universiy of Campinas - Department of
Anatomy, Cel Biology and Physiology and Biophysics; 2State University of Campinas - Department of
Anatomy, Cel Biology and Physiology and Biophysics
PT.44
EFFECT OF THE PHYSICAL EXERCISE IN THE MECHANISMS OF THE SECRETION INSULIN IN MSG-OBESE
MICE
EFFECT OF THE PHYSICAL EXERCISE IN THE MECHANISMS OF THE SECRETION INSULIN IN MSG-
OBESE MICE

Picinato MC1 - 1USP - Departamento de Fisiologia e Biofísica
PT.45
Insulin Secretion in Obese and Diabetic Animals Induced by High Fat Diet (HFD): The Role of Interleukin
10 (IL-10).
Cintra DE1; Pauli JR1; Ropelle ER1; Morarij J2; Contin Moraes J3; Araujo EP4; de Souza CT5; Batista
TM6; Carneiro EM6; Saad MJA7; Velloso LA7 - 1Universidade Estadual de Campinas - Faculdade de
Ciências Aplicadas; 2Unicamp - Faculdade de Ciências Médicas; 3Universidade Estadual de Campinas -
Faculdade de Ciências Médicas; 4FCM UNICAMP - Enfermagem; 5FCM - UNICAMP - Clínica
Médica; 6Unicamp - Fisiologia e biofísica; 7UNICAMP - Clínica Médica
PT.46
LOW PROTEIN DIET DURING FETAL LIFE AND NUTRITIONAL RECOVERY AFTER BIRTH WITH HIGH-FAT
DIET IN RATS: EFFECTS ON INSULIN SECRETION
Silva HBF1; CARDOSO KB2; CARLI AP3; Reis SRL2; Souza LMI4; Marise ABReis5; Latorraca MQ6; Milanski
M7; Arantes VC2 - 1Universidade Federal de Mato Grosso - Pós-Graduação em Biociências; 2Universidade
Federal de Mato Grosso - Departamento de Alimentos e Nutrição, Faculdade de
Nutrição; 3Universdidade Federal de Mato Grosso - Pós-graduação em Biociências; 4Universidade
Estadual de Campinas - Programa de Pós Graduação em Fisiopatologia Médica; 5Universidade Federal de
Mato Grosso - Departamento de Ciências Básicas, Faculdade de Ciências Médicas; 6Universidade Federal
de Mato Grosso, Faculdade de Nutrição - Departamento de Alimentos e Nutrição; 7Unicamp -
Departamento de Clínica Médica
PT.47
DUODENAL-JEJUNAL BYPASS IMPROVES GLUCOSE HOMEOSTASIS IN OBESE RATS
Araujo, ACF1; Balbo SL2; Ribeiro RA3; Nardel i TR4; Vettorazzi JF4; Bonfleur ML5 - 1UNIOESTE -
CCMF; 2UNIOESTE - CCBS; 3Universidade Estadual de Campinas - Fisiologia e Biofísica; 4Unicamp -
Anatomia, Biologia celular e Fisiologia e Biofísica; 5UNIOESTE - Centro de Ciências Biológicas e da Saúde
PT.48
Dexamethasone treatment increases AS160 activity in rat pancreatic islets through AMPK and AKT
pathways
Purificação TA1; Paula FM1; Rezende LF1; Protzek AO1; Rafacho A2 - 1Unicamp – State University of
Campinas - Department of Anatomy Physiology and Biophysics, Institute of Biology; 2Federal University
of Santa Catarina - bDepartment of Physiological Sciences, Center of Biological Sciences
13h30 – 15h00 – Lunch time


15h30 – 17h15 - Lectures
4 - New developments in the regulation of islet cell function
(chair - André Herchuelz; Ângelo Carpinel i)
15h30 – 15h55 - Metabolic regulation of glucagon secretion –
Quan Zhang– The Oxford Centre for diabetes, Oxford, UK
16h05 – 16h30- The clock gene Rev-erb-alpha regulates beta cel function: modulation by high fat diet
and leptin
Elaine Vieira - Instituto de Bioingeniería, Universidad Miguel Hernandez, Elche, Spain
16h40 – 17h05 - Rho GTPases in insulin secretion
Anjan Kowluru – Department of Pharmaceutical Sciences and Internal Medicine, Wayne State University
and John D Dingel VA Medical Center, Detroit, MI48201, USA
17h15 – 17h30 - Coffee break

17h30 – 18h20 - Short Talks
( 8 min presentation + 4 min discussion)
OC.16
The Ca2+-activated cation channel TRPM5 as a positive regulator of insulin release.
Colsoul B1; Schraenen A2; Gilon P3; Nilius B1; Schuit F2; Vennekens R1 - 1K.U.Leuven - Laboratory of Ion
Channel Research; 2K.U.Leuven - Gene Expression Unit; 3UCL - Pôle d’Endocrinologie, Diabète et
Nutrition
OC.17
AMPK-UCP2 pathway may be involved in the reduced insulin secretion by pancreatic islet of low protein
fed mice
de Oliveira CA1; Rezende LF2; Vanzela EC2; Santos GJ2; Souza JC2; Calegari VC2; Costa Júnior JM2; Protzek
AO2; Carneiro EM2 - 1Universidade Federal de São Paulo - Unifesp - Departamento de
Biociências; 2Universidade Estadual de Campinas - UNICAMP - Departamento de Anatomia, Biologia
Celular e Fisiologia e Biofísica
OC.18
Regulation of Epac2 localization in β-cel s by cAMP and Ca2+-mediated activation of Ras
Tengholm A1; Ideval -Hagren O1 - 1Uppsala University - Department of Medical Cell Biology
OC.19
Simvastatin treatment inhibits glucose-stimulated insulin secretion in INS-1E cel s
Zúñiga JP1; Rebelato ELO2; Abdulkader F3 - 1Instituto de Ciências Biomédicas, Universidade de São
Paulo - Fisiologia e Biofísica; 2ICB - USP - Fisiologia e Biofísica; 3ICB-USP - Fisiologia e Biofísica

08h00 – 09h45 - Lectures
5 - Beta cell proliferation & regeneration
chairs - Sigurd Lenzen; Anna Gloyn
08h00 – 08h25 - Role of the EGF receptor in pancreatic beta cell growth and differentiation
Timo Otonkoski - Biomedicum Stem Cel Center and Children’s Hospital, University of Helsinki, Helsinki,
Finland
08h35 – 09h00 - Beta cel neogenesis in the postnatal pancreas
Luc Bouwens, Cel Differentiation Lab, Vrije Universiteit Brussel (Free University Brussels), Brussels,
Belgium.
09h10 – 09h35 - Regulation of beta cel mass: lessons from pregnancy and birth –
Jens Høiriis Nielsen, Department of Biomedical Sciences, University of Copenhagen, Denmark
09h45 – 10h00 - Coffee break

10h00 – 11h45 - Lectures
6 - Islet pathophysiology in diabetes
Chairs Decio Eizirik; Lício Vel oso
10h00 – 10h25- Peroxisomal stress and the role of free radicals in β-cel lipotoxicity –
Sigurd Lenzen - Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany
10h35 – 11h00 - Molecular mechanisms of lipotoxic beta cel demise –
Miriam Cnop – Université Libre de Bruxelles (ULB), Brussels, Belgium
11h10 – 11h35 - The binary switch between life and death of ER stressed beta cel s –Fumihiko Urano
University of Massachusetts Medical School, USA
11h45 – 12h00 - Closing remarks
Chair – Anders Tengholrn
12h00 – 12h00 Assembly of the ISG Society
Departure

Source: http://www.eventus.com.br/islet2011/imagens/programa_ilhotas.pdf

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Enalapril Enalapril is used to treat mild, moderate or severe heart failure and high blood pressure and is usually used in combination with other medications. It is available as 2.5mg, 5mg, 10mg and 20mg tablets. The usual dose for dogs is 0.25mg/pound by mouth given once a day. (sold per tablet) What is Enalapril? Enalapril is used to treat mild, moderate, or severe heart failure

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