1. Name of the medical Product: 4.6 Pregnancy and lactation Udenafil is not indicated for use in women. 2. Qualitative and Quantitative Composition: In the embryo fetal development study performed in rats and rabbits, only high doses of Udenafil (300 mg/kg/day and 240 mg/kg/day) showed skeletal variations and ossific retardations in fetuses. In the study for the effects of udena
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GinsanaStandardised Ginseng Extract G115
Bibliographic Index of published studies
J.F. Cui: Identification and quantification of ginsenosides in various commercial ginseng H. Yamada et al.: Fractionation and characterization of anticomplementary and mitogenic substances from Panax ginseng G115. J.F. Cui et al.: Analysis of ginsenosides by chromatography and mass spectrometry: Release of 20 S-protopanaxadiol and 20 S-protopanaxatriol for quantitation. F. Soldati, O. Tanaka: Panax ginseng C.A. Meyer – relation between age of plant and H.R. Schulten, F. Soldati: Identification of ginsenosides from Panax ginseng in fractions obtained by HPLC, by FD-MS, MIR-IR, and TLC. O. Sticher, F. Soldati: HPLC separation and quantitative determination of ginsenosides from Panax ginseng, Panax quinquefolium and from ginseng drug preparations. Communication 1: Planta Med 36(1): 30-42 (1979) Communication 2: Planta Med 39(4): 348-357 (1980) O. Sticher et al.: Mass spectrometric investigation of ginsenoside Rg2. Biochemistry
I.A.L. Persson, L. Dong, K. Persson: Ef ect of Panax ginseng extract (G115) on angiotensin-converting enzyme (ACE) activity and nitric oxide (NO) production. J. Van Kampen, H. Robertson, T. Hagg, R. Drobitch: Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson’s disease. K. Yamasaki et al.: Ef ects of the standardized ginseng extract G115 on the D-glucose transport of Ehrlich ascites tumour cells. A.C. Realini: G115, a novel stimulator of poly (ADP-ribose) polymerase, stimulates Poly(ADP-Ribosyl)ation: a Protein Shuttle Mechanism in Chromatin, Thesis, Univ A.H. Bit les et al.: The effects of oral ginseng administration on the activities and isoenzyme profiles of murine lactate dehydrogenases. Biochem Pharmacol 33(9): 1571-1573 (1984) G.T.W. Shia et al.: The effects of ginseng saponins on the growth and metabolism of V. Petkov: Ef ects of ginseng on the brain biogenic monoamines and 3‘,5‘-AMP-system. Arzneimit elforschung 28(3), 388-393 (1978) J. Schole: Influence of Panax ginseng saponins on the glutathione system of rat‘s liver. In: Schole J., Harisch G., Sallmann H.P. (Eds.) Belastung, Ernährung und Resistenz - Fortschrit e in der Tierphysiologie und Tierernährung 9. Verlag Paul Parey, Hamburg. Pharmacology / Toxicology
A.M.A.S. Goda: Ef ect of dietary ginseng herb (Ginsana® G115) supplementation on growth, feed utilization, and hematological indices of Nile tilapia, Oreochromis niloticus J World Aquacult Soc 39(2), 205-214 (2008) T.L. Eriksson, S.P.S. Svensson, I. Lundstroem, K. Persson, T.P.M. Andersson, R.G.G. Andersson: Panax ginseng induces anterograde transport of pigment organelles in M. Pannacci, V. Lucini, F. Col eoni, C. Martucci, S. Grosso, P. Sacerdote, F. Scaglione: Panax ginseng C.-A. Mayer G115 modulates pro-inflammatory cytokine production in mice throughout the increase of macrophage toll-like receptor 4 expression during A.C. Cabral de Oliveira, A.C. Perez, J.G. Prieto, I.D.G. Duarte, A.I. Alvarez: Protection of Panax ginseng in injured muscles after eccentric exercise. J. Voces, A.C. Cabral de Oliveira, J.G. Prieto, L. Vila, A.C. Perez, I.D.G. Duarte, A.I Alvarez: Ginseng administration protects skeletal muscle from oxidative stress induced Braz J Med Biol Res 37(12), 1863-1871 (2004) G.D. Anderson, G. Rosito, M.A. Mohustsy, G.W. Elmer: Drug interaction potential of soy G. Merino, A.J. Molina, J.L. Garcia, M.M. Pulido, J.G. Prieto, A.I. Alvarez: Ginseng increases intestinal elimination of albendazole sulfoxide in the rat. Comp Biochem Physiol Toxicol Pharmacol 136 , 9-15 (2003) A.C. Cabral de Oliveira et al.: Protective effects of Panax ginseng on muscle injury and Comp Biochem Physiol Part C 130(3), 369-377 (2002) N.V. Provalova, E.G. Skurikhin, O.V. Pershina, N.I. Suslov, M.Y. Minakova, A.M. Dygai, E.D. Gol’dberg: Mechanism underlying the effects of adaptogens on erythropoiesis Bull Exp Biol Med 133(5), 428-432 (2002) N.V. Provalova, E.G. Skurikhin, N.I. Suslov, A.M. Dygai, E.D. Gol’dberg: Effects of adaptogens on granulocytopoiesis during paradoxical sleep deprivation. Bull Exp Biol Med 133(3), 261-264 (2002) C.H. Wu et al.: The preventive effects of G115 on balloon injury-induced neointima R. Maffei Facino et al.: Panax ginseng administration in the rat prevents myocardial ischemia-reperfusion damage induced by hyperbaric oxygen: Evidence for an J. Voces et al.: Ef ects of administration of the standardized Panax ginseng extract G115 on hepatic antioxidant function after exhaustive exercise. Comp Biochem Physiol Part C 123, 175-184 (1999) A. Ferrando et al.: Ef ects of ginseng extract on various haematological parameters A. Ferrando et al.: Ef ects of a standardized Panax ginseng extract on the skeletal muscle of the rat: A comparative study in animals at rest and under exercise. C.Y. Kwan: Dif erential vascular ef ects of Panax ginseng and Panax quinquefolius In: H.C. Weber, D. Zeuske, S. Imhof (Eds.): Ginseng in Europe. Proceedings of the 1st European Ginseng Congress, Marburg, Germany. 1998. p. 45-53 S. Rimar et al.: Pulmonary protective and vasodilator effects of a standardized Panax ginseng preparation following artificial gastric digestion. V.D. Petkov et al.: Behavioral effects of stem-leaves extract from Panax ginseng C.A. Acta Physiol Pharmacol Bulg 18(2): 41-48 (1992) V.P. Dixit, P. Jain, K. Bhandari, A.K. Purohit: Effects of Ginseng (G-115) on serum lipids of hyperlipidaemic rhesus monkeys (Macaca mulatta). H.S. Kim et al.: Antinarcotic effects of the standardized ginseng extract G115 on V. Petkov: Ginseng as a remedy regulating aging processes in brain (experiments on “Recent Advances in Ginseng Studies”. Proceedings International Ginseng Seminar, Sanjo Kaikan, Univ Tokyo. April 1, 1989; 83-98 V.D. Petkov, A.H. Mosharrof: Ef ect of standardized extract from ginseng on the C R Acad Bulg Sci 40(12): 113-116 (1987) M.B. Lasarova et al.: Ef ects of piracetam and standardized ginseng extract on the electroconvulsive shock-induced memory disturbances in „step-down“ passive Acta Physiol Pharmacol Bulg 13(2): 11-17 (1987) V.D. Petkov, A.H. Mosharrof: Effects of standardized ginseng extract on learning, V.D. Petkov, A.H. Mosharrof: Age- and individual-related specificities in the effects of standardized ginseng extract on learning and memory (experiments on rats). T.B. Ng, W.W. Li, H.W. Yeung: Ef ects of ginsenosides, lectins and Momordica charantia insulin-like peptide on corticosterone production by isolated rat adrenal cells. M.M. Hassan Samira et al.: Ef ect of the standardized ginseng extract G115 on the metabolism and electrical activity of the rabbit‘s brain. V.K. Singh et al.: Immunomodulatory activity of Panax ginseng extract. V.K. Singh et al.: Combined treatment of mice with Panax ginseng extract and interferon F.G. Hess et al.: Ef ects of subchronic feeding of ginseng extract G115 in beagle dogs. F.G. Hess et al.: Reproduction study in rats of ginseng extract G115. A.H. Bit les et al.: The effect of ginseng on lifespan and stress responses in mice. K.H. Rueckert: A new study that proves the great effectiveness of a special extract made from first class Korean ginseng roots. Proc Int Ginseng Symp, Seoul, Sep 1974, 59-64 (1974) W. Sterner, A.M. Kirchdorfer: Vergleichende Leistungsprüfungen an Mäusen mit standardisiertem Ginseng-Extrakt und einem ginsenghaltigen Gerotherapeutikum. Pharmacokinetics / Metabolism (Ginsenosides)
CT. Yu, J. Chen, X.W. Teng V. Tong, T.K.H. Chang: Lack of evidence for induction of CYP2B1, CYP3A23, and CYP1A2 gene expression by Panax ginseng and Panax quinquefolius extracts in adult rats and primary cultures of rat hepatocytes. M.A. Tawab, U. Bahr, M. Karas, M. Wurglics, M. Schubert-Zsilavecz: Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos 31(8), 1065-1071 (2003) T.K.H. Chang, et al.: In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1. J.F. Cui et al.: Gas chromatographic-mass spectrometric determination of 20(S)- protopanaxadiol and 20(S)-protopanaxatriol for study on human urinary excretion of ginsenosides after ingestion of ginseng preparations. J Chromatogr B Biomed Appl 689: 349-355 (1997) J.F. Cui et al.: Determination of aglycones of ginsenosides in ginseng preparations sold in Sweden and in urine samples from Swedish athletes consuming ginseng. Scand J Clin Lab Invest 56(2): 151-160 (1996) M. Karikura et al.: Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI . Comparison of the decomposition modes of ginsenoside Rb1 and M. Karikura et al.: Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of M. Karikura et al.: Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large Chem Pharm Bull 38(10): 2859-2861 (1990) J. Stroembom et al.: Studies on absorption and distribution of ginsenoside Rg1 by whole-body autoradiography and chromatography. E. Jenny, F. Soldati: Pharmacokinetics of ginsenosides in the mini-pig. In: Chang H.M., Yeung H.W., Tso W.W., Koo A. (Eds.) Advances in Chinese Medicinal Materials Research. World Scientific Publishing Co. Pte. Ltd., Singapore. 1985. p. 499- T. Odani et al.: Decomposition of ginsenosides Rg1 and Rb1 in the digestive tract of rats. Chem Pharm Bull 31(10): 3691-3697 (1983) T. Odani et al.: The absorption, distribution and excretion of ginsenoside Rb1 in the rat. T. Odani et al.: The absorption, distribution and excretion of ginsenoside Rg1 in the rat. R.J. Sawchuck et al.: Pharmacokinetics of ginsenosides in the rabbit. Eur J Drug Metab Pharmacokinet 5(3): 161-168 (1980) AI. Ferrando, A. Alvarez, J. del Estal, J. Prieto: Mechanism of intestinal absorption of
Congreso de Medicina del Deporte de Euskadi, April 28, 1980 S. Cañigueral, R. Tschopp, L. Ambrosetti, A. Vignutelli, F. Scaglione, O. Petrini: The development of herbal medicinal products. Quality, safety and efficacy as key factors. F. Scaglione, M. Pannacci, O. Petrini: The standardised G115® Panax ginseng C.A. Meyer extract. A review of its properties and usage. Evid Based Integrative Med 2(4), 195-206 (2005) F. Soldati: Ginseng, Asian (Panax ginseng). Encyclopedia of Dietary Supplements. New York, Marcel Dekker, 2005. 265-277 D.O. Kennedy, A.B. Scholey: Ginseng: potential for the enhancement of cognitive Pharmacol Biochem Behav 75 , 687-700 (2003) C.N. Gil is: Panax ginseng pharmacology. A nitric oxide link? R.T. Owen: Ginseng in the nineties – more than a roborant? C. Chinna: Phytochemical and preclinical advances with Panax ginseng. Oesterr Apoth Ztg 46(31/32): 650-652 (1992) C. Chinna: Current clinical aspects of ginseng research. Oesterr Apoth Ztg 46(19): 377-381 (1992) E. Sprecher: Ginseng – miracle drug or phytopharmacon? Oesterr Apoth Ztg 37(51/52): 1022-1027 (1983) R.T. Owen: Ginseng a pharmacological profile.
Threadworms Threadworms are common but are not usually serious. Threadworms infect the gut and lay eggs around your anus which causes itch. Treatment usually includes medication plus hygiene measures. Medication kills the worms, but not their eggs, which can survive for two weeks. Therefore, you also need strict hygiene measures for two weeks after taking medication to prevent you from swal