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LOMBARDIA :

Milano

Denominazione del Centro : Centro Studi Aterosclerosi
Anno di costituzione : 1991
Direttore : Prof. Alberico L. CATAPANO
Collaboratori :

Struttura ospitante : Ospedale “Bassini” – Via M. Gorki 50
20092 Cinisello Balsamo
Tel. 02 6173 276 / 02 6659 4231 Fax 02 6659 4941
Tel. 02 503 18302 Fax 02 503 18386
Tel. 02 503 8302 fax 02 503 18386
E-mail : [email protected] / [email protected]
Referente : Prof. A. L. CATAPANO
Principali scopi ed attività cliniche e di ricerca :
Terapia delle dislipemie. Lipemia post-prandiale ed aterosclerosi.
Disfunzione endoteliale
Riconoscimenti a livello regionale : Centro di Coordinamento – Network regionale
Partecipazione a progetti nazionali/internazionali : UE, Coordinamento Centri
regionali
Pubblicazioni più significative dalla costituzione :
Corsini A, Mazzotti M, Fumagalli R, Catapano AL, Romano L, Romano C “Poor response to
simvastatin treatment in hypercholesterolaemic patients with familial defective apo B-100”
,
Lancet 1991, 337:305
Grignaffini P, Roma P, Galli C, Catapano AL “Protection of low density lipoprotein from
oxidation by 3,4-dihydroxyphenylethanol”
Lancet 1994, 343: 11296-1297
Rinaldi M, Catapano AL, Parrella P, Ciaffrè SA, Signori E, Seripa D, Uboldi P, Antonini R, Ricci
G, Farace MG, Fazio VM “Treatment o f severe hypercolesterolemia in apolipoprotein E-
deficient mice by intramuscolar injection of plasmid DNA”
Gene Therapy (2000) 7, 1795-1801
“Efficacy and safety of a combination of fluvastatin and bezafibrate in patients with mixed
hyperlipidemia”
The FACT Study Centers ; Atherosclerosis 2000;150: 429-436
“Effects of fluvastatin and bezafibrate combination on plasma fibrogen, t-plasminogen activator
inhibitor and C reactive protein level in coronary artery disease patients with mixed
hyperlipidemia”
The FACT Study Centers, Thrombosis and Haemostasis 2000; 83(4): 549-553
Pubblicazioni recenti più significative dal 2007:

GD. Norata, P. Marchesi, S. Passamonti, A. Pirillo, F.Violi, AL. Catapano “Anti-inflammatory
and anti-atherogenic effetcs of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E
deficient mice”
Atherosclerosis . 2007 Apr;191(2):265-271,Epub 2007)
GD. Norata, L. Grigore, S. Raselli, L. Redaelli, A. Hamsten, F. Maggi, P.Eriksson, AL. Catapano
“Post-prandial endothelial dysfunction in hypertriglyceridemic subjects :molecular mechamisms
and gene expression studies”
Atherosclerosis ,193 (2007) 321-327
GD. Norata, M. Omgari, K. Garlaschelli, S. Raselli, L. Grigore, AL.Catapano “Plasma resistin
levels correlate with determinants of the metabolic syndrome”
Europ J Endcrinol ,vol. 15 n.2-
February 2007 : 279-284
B. Mattioli, GD. Norata, MG Quaranta, L. Giordani, AL. Catapano, M. Viora “Effect of native
and modified HDL on peripheral blood mononuclear cells and endothelial cells”
Ist. Superiore
di Sanità – rapporti ISTISAN 06/50, 2006:0206
GD. Norata, AL. Catapano “ Moleculaar mechanism responsible for the anti-inflammaroty and
protective effect of High Density Lipoprotein on the endotheliium”
High Blood Pressure §
Cardiovascular Prevention ,2007, 14(1) 21-31
GD. Norata, M. Ongarik, K. Garlaschelli, G. Tibolla, L. Grigore, Rasell SI. Baragetti, D. Noto, G.
Buccianti, M. Averna, AL. Catapano “Effect ofthe 420C/G variant of the resistin gene promoter
on metabolic syndrome, obesity, myocardial infarction and kydney dysfunction”
J InterMed
2007 Jul;262(1); 104-112
AL. Catapano, TR. Pedersen, G.de Backer “Averting a pandemic health crisis in Europe by 2020
: what physicians need to know regrading cholesterol management”
Europ J. Cardiovasc
Prevention Rehabil 2007, Apr; 14(2):340-345
G. Favato, P. Mariani, W. Mills Roger, A. Capone, M. Pelagatti, V. Pieri, A. Marcobelli, MG.
Trotta, A. Zucchi, AL. Catapano “ASSET (Age/Sex standardised Estimates of Treatment) : A
Research Model to Improve the Governaance of Prescribing Funds in Italy”
PLoS ONE ,
2007Jul,4;2(7): e592
AL. Catapano “Why many at risk are not reaching their low-density lipoprotein cholesterol goals
the need for alternative therapies”
European Cardiovascular Disease 2007 issue 1;26-32
I. Baragetti, S. Raselli, A. Stucchi, V, Terraneo, S. Furiani,L. Buzzi, K. Garlaschelli, E. Alberghini,
AL.Catapano, G.Buccianti “Improvement of endothelial function in uraemic patients on
peritoneal dialysis : a possible role for 5-MTHF administration”
Nephrol Dial Transplant 2007
Nov;22(11):3292
A. Pirillo, P. Uboldi, G. Pappalardo, H. Kuhn,AL. Catapano “Modification of HDL(3) by mild
oxidative stress increases ATP-binding cassette transporter 1-mediated cholesterol efflux”

Cardiovasc Res 2007 Aug 1;75(3):566-574
L. Gregore, GD. Norata, AL. Catapano “Inhibition of synthesis and absorption of cholesterol: a
new option in managing hypercholesterolemia”
Intl.Congress Series 1303 (2007) 121-128
GD. Norata, AL. Catapano “Triglyceride-rich liporproteins: From normotrygliceridemic subjects
and hyperlipidemic patients differently affect endothelial cell activation and gene expression
patterns”
Circ Res 2007 Apr13;100(7):e81
GD. Norata, AL. Catapano “Trygliceride-rich lipoproteins and endothelial dysfunction :
molecular mechanism and gene expression studies”
Future Medicina – Future Lipidology (2007)
2(2) 119-122
E. Tragni, A. Filippi, G. Mazzaglia, E. Sessa, C. Cricelli, AL. Catapano “Monitoring statin safety
in primary care”
Pharmacoepidemiol Drug Saf. 2007 Jun;16(6):652-657
L. Colombo, M. Argaglione, N. Colombo, A. Russo, AL.Catapano “Genetic polymorphism in an
aged population-comparisons with large population of subjects and with young survivors of
myocardial infarction”
High Blood Pressure§ Cardiovascular Prevention 14(2);99-101, 2007
AL. Catapano “The pharmacological elegance of inhibiting cholesterol absorption and synthesis
while providing a homeostatic balance”
Fundam Clin Pharmacol. 2007 Nov;21(s2):21-26
GD. Norata, S. Raselli, L. Grigore, K. Garlaschelli, E. Dozio, P. Magni, AL. Catapano “Leptin-
adiponectin ratio is an independent predictor of intima media thickness of the common carotid
artery”
Stroke 2007Oct;38(10):2844-2846
A. Stucchi, V. Terranno, I. Baragetti, G. Tibolla, S. Vettoretti, S. Raselli, GD. Norata, L. Buzzi, AL.
Catapano, G. Buccianti “ Associazione tra polimorfismo-374T/A del RAGE e gravità della
disfunzione renale in pazienti affetti da insufficienza renale cronica (IRC)”
Il Bassini
2007;XXVII:12-17
E. Signori, M. Rinaldi, M. Fioretti, S. Iurescia, D. Seripa, G.Perrone, GD.Norata, AL. Catapano, G.
Buccianti “ApoE gene delivery inhibits severe hypercholesterolemia in newborn ApoE-KO mice”
Biochem Biophys Res Commun 2007 Sep 21,361(2):543-548
I. Baragetti, GD. Norata, S. Raselli, A. Stucchi, V. Terranno, AL. Catapano, G. Buccianti “Il
tessuto adiposo come possibile bersaglio di danno cardiovascolare in corso di disfunzione renale”

Il Bassini,volume XXVII Luglio-Dicembre 2007;9-13
DP. Mikhailidis, GC. Sibbring,CM. Ballantyne, GM. Davies, AL. Catapano “Meta-analysis of the
cholesterol-lowering effect of ezetimibe added to ongoing statin theraphy”
Curr Med Res Opin
2007 Aug; 23(8):2009-20026
A. Poli, F. Marangoni, R. Paoletti, E. Mannarino, G. Lupattelli, A. Notarbartolo, P. Aureli, F.
Bernini, A. Cicero, A.Gaddi, AL.Catapano, C. Cricelli, M. Gattone, W. Marrocco, M. Porrrini, R.
Stella, A.Vanotti, M. Volpe, R. Volpe, C. Cannella, A. Pinto, E. Del Toma, C. LaVecchia, A.
Tavani, E. Manzato, G. Riccardi, C. Sirtori, A. Zambon “Non-pahrmacological control of plasma
cholesterol levels”
Nutr Metab Cardiovasc Dis 2008 Feb;18(2):S1-16
GD. Norata, P. Marchesi, A. Pirillo, P. Uboldi, G. Chiesa, V. Maina, C. Garlanda, A. Mantovani,
AL. Catapano “Long pentraxin 3,a key component of innate immunity, is modulated by high-
density lipoproteins in endothelial cells”
Arterioscler Thromb Vasc Biol 2008;28:925-931
A: Bonetti, F. Tirelli, A. Catapano, D. Dazzi, A. Dei Cas, F. Solito, G. Ceda, C. Reverberi, C.
Monica, S. Pipitone, G. Elia, M. Spattini, G. Magnati “Side effetcs of anabolic androgenic
steroids abuse”
Intl J Sports Med 2008 Aug;29(8):679-687
AL. Fracanzani, L. Burdick, S. Raselli, P. Pedroti, L. Grigore, G. Santorelli, L. Valenti, A.
Maraschi, A. Catapano, S. Fargion “Carotid artery intima-media thickness in non-alcoholic fatty
liver disease”
Am J Med 2008 Jan;121(1):72-78
I. Baragetti, S. Raselli, A. Stucchi, V. Terranno, S. Furiani, L. Buzzi, K. Garlaschelli, E. Alberghini,
AL. Catapano, G. Buccianti “Hyperhomocysteinemia and endothelal dysfunction in dyalisis
patients: what should be treated first ?
Nephrol Dialysis Transplantation 2008;223(3):1069-1071
G. Favato, P. Mariani, CF. Print, A. Capone, M. Pelagatti, V. Pieri, A. Marcobelli, E. Tragni, MG.
Trotta, A. Zucchi, AL. Catapano “Effetto dei fabbisogni terapeutici sesso ed età-correlati sui
costi di prescrizione nella medicina generale”
Pharma Economics – Italian Resarch Articles 2008;
10(2):89-98
GD. Norata, K. Garlaschelli, L. Grigore, G. Tibolla, S.Raselli, G. Buccianti, AL. Catapano
“Circulating soluble receptor for advanced glycation end products is inversely associated with
body mass index and waist/hip raito in the general population”
Nutr Metab Cardiovasc Dis 2009
Feb;1982):129-134
L. Grigore, GD. Norata, AL. Catapano “Combination therapy in cholesterol reduction : focus on
ezetimibe and statins”
Vasc Health Risk Manag 2008;4(2):267-278
N. Abate, AL. Catapano, CM. Ballantyne, MH. Davidson, A. Polis, SS. Smugar, AM. Tershakovec
“Effectc of ezetimibe/simvastatin versus atorvastatin or rosuvastatin on modifying ipid profiles in
patients with diabetes, metabolic syndrome, or neither : results of two subgroup analyses”
J Clin
Lipidology (2008)2: 91-105
R. Hobbs, T. McCormack C. Cricelli, AL. Catapano, KA. Fox “Cardiovascular disease risk
prevention across Europe”
Report Cardiovascular Dis Prevetnton 2008 Marzo, 14-19
A. Pirillo, P. Uboldi, C. Bolego, H. Kuhn, AL. Catapano “The 15-llipoxygenase-modified high
density lipoproteins 3 fail to inhibit the TNFa-induced inflammatory response in human
endothelial cells”
J Immunol 2008 Aug;181:2821-2830
GD. Norata, P. Magni, AL. Catapano “ The relationship betweeen leptin-adiponectin ratio and
carotid intima-media thickness in asympomatic females –Response to letter by Kotani et al.”

Stroke 2008;39:e34
I. Baragetti, L. Buzzi, A. Stucchi, C. Sarcina,G.Buccianti, AL. Catapano, GD. Norata “La
microalbuminuria è un marcatore indipendentedi danno cardiovascolare sublinico in soggetti
affetti da disfunzione renale cronica”
Il Bassini,volume XXVIII Gennaio-Giugno 2008;26-31
MH. Davidson, N. Abate, CM. Ballantyne, AL. Catapano, Xia Xu, Jianxin Lin, E. Rosenberg, AM.
Tershakovec “Ezetimibe/simvastatin compared with atorvastatin or rosuvastatin in lowering to
specified levels both LDL-C and each of five other emerging risk factors for coronary heart
disease : non-HDL-cholesterol, TC/HDL-C, apolipoprotein B, apo-B/apo-A-I, or C-reactive
protein”
J Clin Lipidology (2008) 2:436-446
AL. Catapano “Perspectives on low-density lipoprotein cholesterol goal achievement” Current
Medical Research and Opinions,vol. 25 no. 2, 2009:434-447
V. Atella, A. Brady, AL. Catapano, J. Critchley, IM. Graham, FD. Hobbs, J. Leal, P.Lindgren, D.
Vanuzzo, M.Volpe, D.Wood, R. Paoletti “Bridging science and health policy in cardiovascular
disease : focus on lipid management. A report from a Session held during the 7th International
Symposium on Multiple Risk Factors in Cardiovascular Diseases : Prevention and
Intervention”
Health Policy, in Venice, Italy, on 25 October, 2008, Atherosclerosi Supp. 2009 Jun
10;10(1):3-21
GD. Norata, P. Marchesi, Vivek Krishna Pulakazhi Venu, F. Pasuqalini, A. Anselmo, F. Moalli, I.
Pizzitola, C. Garlanda, A. Mantovani, AL. Catapano “Deficiency of the long pentraxin PTX3
promotes vascular inflammation and atherosclerosis”
Circulation J Am Heart Association 2009,
13Agosto (700-709 / Circulation 2009 aug 25;120(8):699-708. Epub 2009 Aug 10
GD. Norata, S. Raselli, L. Grigore, K. Garlaschelli, D.Vianello, S. Bertocco, A. Zambon, AL.
Catapano “Small dense LDL and VLDL predict commmon carotid artery IMT and elicit an
inflammatory response in peripheral blood mononuclear and endothelial cells”
Atherosclerosis
2009 Oct;206(2):556-562: Epub 2009 Mar 25
GD. Norata, K. Garlaschelli, L. Gregore, S. Raselli, S. Tramontana, F. Meneghetti, R. Artali, D.
Noto, AB. Cefalù, G. Buccianti, M. Averna, AL. Catapano “Effects of PCSK9 variants on
common carotid artery intima media thickness and relation to ApoE alleles”
Atherosclerosis
2010 Jan;208(1):177-182
P. Lucotti, L. Monti, E. Setola, G. La Canna, A. Castiglioni, A. Rossodivita, MG. Pala, F. Formica,
G. Paolini, AL. Catapano, E. Bosi, O. Alfieri, P. Piatti “Oral L-arginine supplementation
improves endothelial function and ameliorates insulin sensitivity and inflammation in
cardiopathic nondiabetic patients after an aortocoronary bypass”
Metabolism 2009
Sep;58(9):1270-1276. Epub 2009 Jul 9
GD. Norata, K. Garlaschelli, L. Grigore, G. Tibolla, S. Raselli, L. Redaelli, G. Buccianti, AL.
Catapano “Circulating soluble receptor for advanced glycationend products is inversely
associated with body mass index and waist/hip ratio in the general population”
Nutr Metab
Cardiovasc Dis 2009 Feb;19(2):129-134. Epub 2008 Jul 2
GD. Norata, I. Baragetti, S. Raselli, A. Stucchi, K. Garlaschelli, S. Vettoretti, G. Piloni, G.
Buccianti, AL. Catapano “Plasma adiponectin levels in chronic kidney disease patients : relation
with molecular inflammatory profile and metabolic status”
Nutr Metab Cardiovasc Dis 2010
Jan;20(1):56-63
G. Tbolla, GD.Norata, C. Meda, L. Arnaboldi, P. Uboldi, F. Piazza, C. Ferrarese, A. Corsini, A.
Maggi, E. Vegeto, AL. Catapano “Increased atherosclerosis and vascular inflammation in APP
transgenic mice wiwth apolipoprotein E deficiency”
Atherosclerosis 2010 May;210(1):78-87
AB. Polis, N. Abate, AL. Catapano, CM. Ballantyne, MH Davidson, SS. Smugar, AM.Tershakovec
“Low-density lipoprotein cholesterol reduction and goal achievement with ezetimibe/simvastatin
versus atorvastatin or rosuvastatin in patients with diabetes, metabolic syndrome, or neither
disease, stratified by National Cholesterol Education Program risk category”
Metab Syndr Relat
Disord 2009 Dec;7(6):601-610
A. Filippi, M. Casula, E. Tragni,O. Brignoli,C. Cricelli, A. Poli, AL.Catapano ;for the CHECK
Study Group “Blood pressure and antihypertensive therapy according to the global
cardiovascular risk level in Italy : the CHECK Study”
EurJ Cardiovasc Prev Rehabil 2010 Mar
19. Epub
G. Corrao, V. Conti, L. Merlino, AL. Catapano, G. Mancia “Results of a retrospective database
analysis of adherence to statin theraphy and risk of nonfatal ischemic heart disease in daily
clinical practice in Italy”
Clin Ther 2010 Feb;32(2):300-310
MW. Lorenz, H. Bickel, ML. Bots, MMB. Breteler, AL. Catapano, M.Desvarieux, B. Hedblad, B.
Iglseder, SH. Johnsen, M.Juraska, S. Kiechl, EB. Mathiesen, GD. Norata, L. Grigore, J. Polak, H.
Popper, M.Rosvall, T. Rundek, Rl. Sacco, D. Sander, M. Sitzer, H. Steinmetzl, E. Stensland, J.
Willeit,J. Witeman, D. Yanez, SG. Thompson.The PROG-IMT Study Group “Individual
progression of carotid intima media thickness as a surragate for vascular risk (PROG-IMT) –
rationale and design of a meta-analysis project”
Am Heart J 2010 May;159(5):730-736.e2
GD. Norata, C. Garlanda, AL. Catapano “The long pentraxin PTX3 : a modulator of the
immunoninflammatory response in atherosclerosis and cardiovascular diseases”

Cardiovascular Medicine,TCM vol. 20, n. 2,2010:35-40
GD. Norata, AL. Catapano “Lecithin : cholesterol acyltransferase and vascular disease”
Clinical Lipidology 2010

Source: http://www.gruppostudioaterosclerosi.it/public/bassini.pdf

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