Biochemical and Biophysical Research Communications 336 (2005) 1144–1149Induction of tamoxifen resistance in breast cancer cellsRainer Girgert a,*, Hartmut Schimming b, Wolfgang Ko¨rner c, Carsten Gru¨ndker a,a Department of Obstetrics and Gynecology, University of Go¨ttingen, D-37099 Go¨ttingen, Germanyb Facility for Electronic Equipment, University of Ulm, D-89075 Ulm, Germanyc Bava
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Corel office documentFish oil appears to help against heart failure
By MARIA CHENG –– Aug. 31, 2008
MUNICH, Germany (AP) —— Fish oil supplements may work slightly better than a popularcholesterol-reducing drug to help patients with chronic heart failure, according to new researchreleased Sunday.
Chronic heart failure is a condition that occurs when the heart becomes enlarged and cannotpump blood efficiently around the body.
With few effective options for heart failure patients, the findings could give patients a potentialnew treatment and could change the dietary recommendations for them, said Dr. Jose GonzalezJuanatey, a spokesman for the European Society of Cardiology, who was not connected to theresearch.
"This reinforces the idea that treating patients with heart failure takes more than just drugs,"Juanatey said.
The study findings were published online in the medical journal The Lancet on Sunday. Theywere simultaneously announced at a meeting of the European Society of Cardiology in Munich.
"With a lot of these patients, you have no other choice," said Dr. Helmut Gohlke, a cardiologistat the Heart Centre in Bad Krozingen, Germany. "They've tried other treatments and are at theend of the road." Italian researchers gave nearly 3,500 patients a daily omega-3 pill, a prescription-formulationpill derived from fish oils, produced by Norway's Pronova BioPharma.
But doctors said people should get the same benefits from taking cheaper options like fish oilsupplements —— or just eating more oily fish like salmon.
Roughly the same number of patients were given placebo pills. Patients were followed for anaverage of four years.
In the group of patients taking the fish oil pills, 1,981 died of heart failure or were admitted tothe hospital with the problem. In the patients on placebo pills, 2,053 died or were admitted to thehospital for heart failure.
In a parallel study, the same team of Italian doctors gave 2,285 patients the drug rosuvastatin,also known as Crestor, and gave placebo pills to 2,289 people. Patients were then tracked forabout four years. The doctors found little difference in heart failure rates between the twogroups.
Comparing the results from both studies, the researchers concluded that fish oil is slightly moreeffective than the drug because the oil performed better against a placebo than did Crestor.
"It's a small benefit, but we should always be emphasizing to patients what they can do in termsof diet that might help," said Dr. Richard Bonow, chief of cardiology at Northwestern University Hospital in Chicago and past president of the American Heart Association.
Both studies were paid for by an Italian group of pharmaceuticals including Pfizer Inc., SigmaTau SpA and AstraZeneca PLC.
Omega-3 fatty acids from fish such as salmon and tuna have long been proven to offer healthbenefits like protecting the heart and brain, though scientists aren't exactly sure how.
Bonow said that since cell membranes are made of fatty acids, fish oils may help to replace andstrengthen those membranes with omega-3.
Fish oils also are thought to increase the body's good cholesterol levels, as well as possiblystabilizing the electrical system in heart cells, to prevent abnormal heart rhythms.
In contrast, statins act on the body's bad cholesterol, which may not have a big impact on heartfailure.
Previous studies that investigated the benefits of omega-3 fatty acids have largely beenobservational, and have lacked a direct comparison to a placebo. It has also been unknownwhether taking fish oil supplements would be as good as eating fish.
"This study changes the certainty of the evidence we have about fish oils," said Dr. DouglasWeaver, president of the American College of Cardiology.
Weaver said that guidelines in the United States would likely change to recommend that moreheart patients eat more fish or take supplements. "This is a low-tech solution and could help allpatients with cardiovascular problems."
Program of the 9th Japan-China International Symposium on Health Sciences (The Auditorium, University of Shizuoka / October 14, 2010) Naohide Kinae (President, University of Shizuoka) Shen Zheng-rong (Deputy President, Zhejiang Academy of Medical Sciences) Chairperson: Toshiyuki Kan and Ye Yi-ping Professor, School of Pharmaceutical Sciences, University of Shizuoka Novel heart failure