Die Struktur von Tadalafil erlaubt eine selektive Bindung an die Bindungsstelle der PDE5 und minimiert gleichzeitig die Interaktion mit PDE6, was visuelle Nebenwirkungen einschränkt. Seine Verteilung im Organismus erfolgt breit, wobei das Verteilungsvolumen etwa 63 Liter beträgt. Über 90 % des Wirkstoffs sind an Plasmaproteine gebunden. Die Wirkung bleibt unabhängig von der Nahrungsaufnahme konstant. Der Abbauweg über CYP3A4 kann durch Hemmer wie Ritonavir oder Ketoconazol verlangsamt werden, was die Plasmakonzentrationen deutlich erhöht. In diesem Kontext wird cialis 20mg preis häufig in Bezug auf pharmakokinetische Wechselwirkungen erwähnt.

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Determination of resorcinol and salicylic acid content in cosmetics by reversed － phase high performance liquid chromatography GAO Xiao － xuan1 MU Min2 DONG Yin － mao1 HE Cong － fen1 ZHANG Peng － xiang1 YIN Jia － zhen1 WANG Shuo1 ZHAO Hua1 1． Beijing Technology and Business University Beijing 2． China Association of Fragrance Flavor and Cosmetic Industries Beijing Abstract A reversed － phase high performance liquid chromatography method for simultaneous determination of resorcinol and salicylic acid in cosmetics was established． The sample was analyzed on a Kromasil C column 250 mm × 4. 6 mm i． d． 5 μm with a detection UV wavelength of 275 nm． Gradient elution was carried out with mobile phase composed of methanol buffered with 0. 01 mol / L ammonium dihydro － phosphate at a flow rate of 1. 0 mL / min． Results showed that as the concentration of resorcinol and salicylic acid are in the same range of 0. 5 ～ 150 μg / mL the relationship between concentration and the corresponding peak area shows good linearity r = 0. 999 7 and 0. 999 8 respectively ． The regression equations can be expressed as A = 12 420 ρ － 6 301 and A = 15 500 ρ － 8 810 respectively and the recoveries of resorcinol and salicylic acid achieve 95. 9% ～ 103. 5% ． The RSD of the method is 0. 61% ～ 0. 88% ． Key words cosmetics high performance liquid chromatography resorcinol salicylic acid 13051236290 E － mail gaoxiaoxuan@ rocketmail． com。 010 68984949 E － mail zhaoh@ btbu． edu． cn。 Standard HPLC spectrum of resorcinol 7. 7 min Precision and recoveries of resorcinol and salicylic acid HAHN S KIELHORN J KOPPENHFER J et al． Concise internation- al chemical assessment document 71 － resorcinol R ． World Health YATES R L HAVERY D C． Determination of phenol resorcinol sali- cylic acid and α － hydroxy acids in cosmetic products and salon prepa- rations J ． Journal of Cosmetics Science 1999 50 315 － 325． DEPARTMENT FOR BUSINESS ENTERPRISE ＆ REGULATORY REFORM． URN 08 /689 consultation on the consolidation of the exist- ing regulations and implementation of 3 technical directives amending directive 76 /768 / eec on the safety of cosmetic products S ． London Consumer and Competition Policy Directorate 2008． KOO J CUFFIE C A TANNER D J et al． Mometasone furoate 0． 1% － salicylic acid 5% ointment versus mometasone furoate 0． 1% ointment in the treatment of moderate － to － severe psoriasis A multicenter study J ． Clinical Therapeutics 1998 20 2 ROSSO J D． The role of topical salicylic acid in the management of psoriasis vulgaris and other localized hyperkeratotic skin disorders Evaluation of a novel cream formulation J ． Journal of the American KLIGMAN A M． The growing importance of topical retinoids in clinical dermatology A retrospective and prospective analysis J ． Journal of the American Academy of Dermatology 1998 39 Suppl 2 Results of determination for product samples MIKAMI E GOTOA T OHNOA T et al． Simultaneous analysis of dehydroacetic acid benzoic acid sorbic acid and salicylic acid in cos- metic products by solid － phase extraction and high － performance liquid chromatography J ． Journal of Pharmaceutical and Biomedical PARHAM H RAHBARA N． Solid phase extraction － spectrophotomet- ric determination of salicylic acid using magnetic iron oxide nanoparti- cles as extractor J ． Journal of Pharmaceutical and Biomedical Analy- ALGAR S O MARTOS N R DIAZ A M． Fast and single solid phase fluorescence spectroscopic batch procedure for determination in drug formulations J ． Journal of Pharmaceutical and PISTONESIA M F DI NEZIOA M S CENTURINA M E et al． Deter- mination of phenol resorcinol and hydroquinone in air samples by syn- chronous fluorescence using partial least － squares CHOCHOLOU P HOLIKA P ATINSKY D et al． A novel applica- tion of onyxTM monolithic column for simultaneous determination of sal- icylic acid and triamcinolone acetonide by sequential injection chroma- YEA G X LUA X P HAN P F et al． Application of ultrasound on J ． Chemical Engineering and Processing

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