NATIONAL COORDINATOR FOR AQUACULTURE INADs/NADAs1 Project Termination Report for the Period NCRAC FUNDING: $89,000 (July 15, 2004 to August 31, 2009) PARTICIPANT: REASON FOR TERMINATION PROJECT OBJECTIVES (6) Identify existing data and remaining (8) Encourage and seek opportunities for (10) Identify potential funding sources for (4) Seek the support and particip
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SermsGuideline Number 7: February 2011
Use of SERMs in Menopause
Apart from the uterus and breasts – the main reproductive organs, oestrogen also acts on other tissues of the liver, brain, heart and bones. It acts on target tissues by binding to the oestrogen receptors which are located in the cell nucleus. The estrogen-receptor complex then binds to specific DNA sites and then to coactivator proteins and nearby genes become active. The active genes produce molecules of messenger RNA, which guide the synthesis of specific proteins. These proteins can then influence cell behavior in different ways, depending on the cell type involved and the organ tissue involved. Thus it causes production of proteins in some tissues e.g.: liver and also causes cell proliferation in others e.g.: breast and endometrium. Hormone Replacement Therapy (HRT) offered to postmenopausal women for relief from menopausal symptoms and protection from long term consequences brought with it some undesirable complications in the form of Ca breast and Ca endometrium. The need for an ideal drug which proves beneficial in some organs and avoids the undesirable effects on other organs has resulted in the development of Selective Estrogen Receptor Modulators (SERMs) that could confer all the benefits of estrogen without any of its risks. These compounds exhibit selective agonistic or stimulatory effects (i.e. estrogenic) on one organ system and neutral or antagonistic (i.e. antiestrogenic) effects on other organ systems. TYPES of SERMs – Synthetic & natural SERMs are available.
Synthetic SERMs: Belong to 5 chemical groups: triphenylethylenes, benzothiophenes, tetrahydronaphtylenes, indoles
Natural SERMs: These are phytoestrogens, plant derived substances that are structurally and functionally similar to
estrogens and are found in many foods. They exhibit estrogenic activity in the body by acting on estrogen receptors.
They too have both weak estrogenic and anti- estrogenic activity.
Effects of Estradiol and SERMs
Brain Uterus Vagina Breast Bone Cardiovascular System
Pure antiestrogen —
SERMs widely used:
1. Clomiphene - which is used for ovulation
2. Tamoxifen - used for the treatment of ER-positive breast cancer and chemoprotection for women at risk of
3. Toremifene - a Tamoxifen derivative, indicated for the treatment of ER-positive breast cancer
4. Raloxifene - used for the prevention and treatment of osteoporosis.
SERMs in Menopause Management
As the risk of osteoporosis increases once women reach menopause, prevention as well as treatment is necessary for them. Raloxifene is a first-line drug for prevention and treatment of postmenopausal osteoporosis.1 Osteoporosis is predominantly a disease of women. The burden of morbidity from osteoporosis has significant medical, social and financial implications. In addition, fractures of hip are associated with 20% excess mortality. Though osteoporotic fractures are preventable, they are often diagnosed only after the event. The effective treatment strategies currently available for this disease mandate that osteoporosis be diagnosed and treated much before the occurrence of complications like fracture. By conservative estimates India has nearly 30 million women with osteoporosis.2 Identifying Women at risk
It is essential to evaluate the risk of osteoporosis in all postmenopausal women for the development of osteoporosis. The World Health Organization (WHO) defines osteoporosis as bone density 2.5 SD below the mean for young adult women. It is recommended that treatment for osteoporosis should be initiated according to the results of the 10-year absolute fracture risk assessment.3 The risk factors help determine which patients should be evaluated for osteoporosis with Bone Densitometry. These are Adults with vertebral, rib, hip or distal forearm fractures Early menopause or surgical menopause before age 40 Older patients who lose a significant amount of body weight (i.e. 5%) Those women found to be at risk should be evaluated by performing Bone Densitometry by Dual-Energy X-ray Absorptiometry (DEXA). Prophylaxis needs to be planned for women with BMD T-scores below -2.0 SD in the absence of risk factors and in women with T-scores below -1.5 SD if other risk factors are present. Women aged older than 70 years and who have multiple risk factors (especially those with previous fractures) are at enough risk for fracture to begin treatment without BMD testing. Treatment with Raloxifene
Raloxifene has been approved for the prevention of postmenopausal osteoporosis in 1997 and the treatment of
postmenopausal osteoporosis in 1999.
The Multiple Outcomes of Raloxifene Evaluation (MORE) trial found that treatment with raloxifene 60 and 120 mg/ day for 3 years significantly reduced vertebral fracture risk by 30% and 50% compared with placebo respectively, in postmenopausal women with osteoporosis. The MORE trial showed that among women who had no fractures at the start of the study 4 years earlier, Raloxifene produced a 49% reduction in vertebral fractures. In the cohort with existing vertebral fractures at study entry, there was a 34% reduction.4 Apart from its skeletal effects, Raloxifene also provides some other beneficial effects too- Action on uterus - A big advantage lies in the fact that Raloxifene does not stimulate endometrial proliferation which is
beneficial for women with a uterus. In studies, a statistically significant increase in endometrial thickness was seen with
raloxifene compared with placebo after 3 years of therapy in the MORE trial, although there was no increase in the risk of
Action on breast tissue- In the MORE Study of 5,129 postmenopausal women with osteoporosis treated with raloxifene,
a 76% overall reduction of breast cancer and a 90% reduction in estrogen receptor-positive breast cancer were noted in
comparison with placebo.5
A head-to-head comparative Study of Tamoxifen and Raloxifene(STAR) showed that the drug raloxifene, currently used to
prevent and treat osteoporosis in postmenopausal women, works as well as tamoxifen in reducing breast cancer risk for
postmenopausal women at increased risk of the disease.6
Action on Lipids and Cardiovascular System : In an analysis of MORE data, raloxifene decreased total cholesterol
(8.5%) and LDL cholesterol (15%) without significant changes in HDL and triglycerides. Homocysteine and lipoprotein a
(Lp(a)) levels were also found to decrease significantly.7
The Raloxifene Use and The Heart (RUTH) study was designed to investigate possible cardioprotective effects of raloxifene in elderly women with CAD or at risk for CAD. Results demonstrated a neutral effect on CAD risk during 5.6 years of follow-up.8 Action on brain - Its beneficial effects on the brain, such as the cognitive benefits associated with estrogen use are yet
unknown, although raloxifene does not appear to impair cognition or affect mood in postmenopausal women.
Adverse Effects: Raloxifene may induce hot flushes and leg cramps. It is not beneficial for vaginal atrophy.
Raloxifene increases the risk of Deep Vein Thrombosis (DVT) to a degree similar to that observed with estrogen. Venous thromboembolic events occurred in 1.0% of women who received Raloxifene, compared with 0.3% of women who received placebo.4 Contra-indications
Post-menopausal women with vasomotor symptoms
Women who have had thrombophlebitis/DVT
Hepatic & renal impairment
Dose : A single oral dose of 60mg/day. It can be taken with or without food. Use should be commenced at least one year
after the menopause.
Efficacy and safety have been determined for up to 40 months. Conclusion : Raloxifene is a useful drug in the prevention and treatment of osteoporosis in postmenopausal women who
do not have vasomotor symptoms. In addition, it has beneficial effects on reducing the occurrence of breast cancer.
1. Action plan Osteoporosis. Consensus Statement of the Expert Group Meeting convened by the Osteoporosis 2. Shah R.S, Savardekar L S. Post Menopausal Osteoporosis in India: Growing Public Health Concern. Symposium 3. Clinician's Guide to Prevention and Treatment of Osteoporosis. Washington, DC: National Osteoporosis 4. Ettinger B, Black DM, Mitlak BH, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple outcomes of raloxifene evaluation (MORE) investigators. JAMA. 1999; 282(7):637-645. 5. Cummings SR, Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA, et al. The effect of raloxifene on risk of breast cancer in postmenopausal women: Results from the MORE randomized trial. JAMA 1999; 281:2189-97. 6. Vogel VG, Costantino JP, et Al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2Trial. JAMA. 2006. 7. Vincenzo De Leo, et al. Randomized control study of the effects of raloxifene on serum lipids and homocysteine in older women. Am J Obstet Gyn. 2001;184:350–3. 8. Pines A. Lessions from RUTH. Climacteric. 2006;9(5):323–4.
CURRÍCULUM VITAE ANTECEDENTES PERSONALES Apellido: Cueto Rua Nombres: Eduardo Angel Fecha de Nacimiento: 6/3/1947 Estado Civil: Casado Hijos: 4 Domicilio Calle: 56 Teléfono/Fax: 0221-4838662 Matricula Provincial: 12.996 E-Mail: ESTUDIOS REALIZADOS Y TITULOS OBTENIDOS Médico 25 de Marzo de 1971 Otorgado por la Facultad de Ciencias Médicas de la Universidad Nacional d