Yellow Fever Vaccine YF-VAX ¨ Caution: Federal (USA) law prohibits dispensing without prescription. DESCRIPTION YF-VAX¨, Yellow Fever Vaccine, for subcutaneous use, is prepared by culturing the 17D strain of yellow fever virus in living avian leukosis virus-free (ALV-free) chicken embryos. The vaccine, containing sorbitol and gelatin as a stabilizer, is lyophilized, and hermetically seal
Bardzo tanie apteki z dostawą w całej Polsce kupic viagra i ogromny wybór pigułek.
Bju_4798-4801.fmBlackwell Science, LtdOxford, UKBJUBJU International1464-4096BJU InternationalMay 2004937 A little more than 10 years has passed since TRAINING AND MENTORING IN UROLOGY: THE ‘LAP’ GENERATION
Clayman and Kavoussi performed the first S.V. BARIOL and D.A. TOLLEY – Scottish Lithotriptor Centre, Western General Hospital,
techniques have flourished in the few units dedicated to laparoscopic endeavour, the Accepted for publication 10 February 2004 problem of training a generation of urologists in laparoscopy, a technique that is rapidly becoming the standard of care, remains.
achieving operative competence is the use of simulators or tools to select applicants, based The wide use of laparoscopy in many other on aptitude. At present, those who train surgical specialities means the junior trainee The pathway described above is more suited further in laparoscopy are those who have has often had considerable previous exposure to speciality registrars, who are able to chosen to do so. Tools such as the Advanced to laparoscopy with associated development incorporate the programme into their period Dundee Endoscopic Psychomotor Tester  of spatial awareness and appropriate motor of training. Mentoring trained urologists and Minimally Invasive Surgical Trainer – skills. Nevertheless an integrated programme requires the cooperation of the mentor and trainee, as well as their respective hospital adequately validated to justify their expense competency is essential. To this end BAUS and . The testing of airline pilots, often used the Specialist Advisory Committee in urology as a model for surgical training, has used simulators for selection and training for pathway to facilitate the acquisition of decades. There is little doubt that similar tests laparoscopic skills, like most endo-urological will play a role for laparoscopists of the future modular training and mentoring. Once the competence as an endpoint. The programme minimum of skills have been acquired for safe Consideration of future service provision also tissue handling, the trainee can be guided by needs to be considered in selecting urologists complemented by assisting and observing at a mentor and video feedback used to facilitate for further training in laparoscopy. The various laparoscopic urological procedures, number of urologists offering laparoscopy in and independent practice on bench models, a geographical area should be limited to followed by an advanced skills course that Videotape recording can be a double-edged maintain the highest technical standards. This might otherwise be compromised by dilution laparoscopic surgeon is placed is intense and follows until independent practice appears far exceeds that of conventional ‘scalpel’ The laparoscopic approach is of proven benefit in laparoscopic nephrectomy and However, the number of cases required to nephroureterectomy, in terms of blood loss achieve satisfactory performance varies and techniques should not be under-emphasized as a method of improving laparoscopic skills, affecting oncological control (Bariol SV, independent of mentor or apprentice, and although it is recognized that laparoscopy is a Stewart G, MacNeil SA, Tolley DA, Oncological technique that applies across the breadth of urology rather than to a subspeciality. Wide certification. However, the Endourological experience with endoscopic surgery facilitates unpublished), but its role in radical pelvic Society, among other criteria, requires at least the development of spatial awareness and the surgery has yet to be firmly established. 40 laparoscopic procedures to be undertaken However, as laparoscopy in urology increases or assisted in a 1-year period for a fellowship to be recognized. The European Society of maintain a system for training in laparoscopic Urotechnology, a full participant in the There is as yet no recognized way to select those suitable for laparoscopic training. A their early experience with new techniques. has espoused the British model, also wishes conspicuous omission from the pathway to This can easily be incorporated into current 2 0 0 4 B J U I N T E R N A T I O N A L | 9 3 , 9 1 3 – 9 1 8 | doi:10.1111/j.1464-410X.2004.04798–04801.x training programmes for speciality registrars, Macmillan AI, Cuschieri A. Assessment
of innate ability and skills for endoscopic Therapy Trial compared doxazosin, finasteride and combination therapy with placebo . Results from both trials (each at 1-year) with open surgery must submit themselves Predictive and concurrent validity. Am J showed no benefit in the use of combined Surg 1999; 177: 274–7
Failure to do so risks a decrease in the Wilson MS, Middlebrook A, Sutton C,
standard of care offered to patients with Stone R, McCloy RF. MIST-VR: a virtual
urological conditions, or at the very least reality trainer for laparoscopic surgery to the possibility of the patient being treated by assess performance. Ann R Coll Surg Eng effect of medical therapy on the clinical the non-urologist with appropriate technical 1997; 79: 403–4
Paisley AM, Baldwin PJ, Paterson-
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were significantly lower with combined therapy.
Accepted for publication 10 February 2004 Over a mean follow-up of 4.5 years the rate of overall clinical progression (the primary endpoint) among men in the placebo group standard surgical treatment for symptomatic was 4.5 per 100 person years. Compared with placebo, doxazosin significantly reduced the was related to the normal ageing process risk of progression by 39% (P < 0.001) and finasteride reduced it by 34% (P = 0.002). 1895 bilateral orchidectomy was proposed Therefore the reduction in risk between the drugs, used as a single agent, did not differ completely effective it is not surprising significantly. For combined therapy the risk of overall clinical progression was reduced by commonplace, and their value has been well 66% (P < 0.001), a significantly greater documented. Short-to-moderate clinical trials showed the effectiveness of a-blockers for amongst older men, and which fundamentally relieving symptoms and improving urinary flow rate [2–5]. Until recently, trials reduced the need for invasive therapy, with urinary symptoms. While a small proportion combining the two classes of drugs showed the magnitude of the reduction similar to that little superiority in alleviating symptoms and in previous trials with 5a-reductase inhibitors absolute indications, e.g. acute urinary improving urinary flow rate. The Veterans retention (AUR) or UTI, most have traditionally Affairs Cooperative Studies Benign Prostatic had surgery to relieve the bothersome urinary symptoms and improve their quality of life finasteride and combination therapy with slightly, but over the duration of the trial 2 0 0 4 B J U I N T E R N A T I O N A L failed to reduce the risk of AUR and invasive Trial study: a one-year study of terazosin Therapy (PREDICT) trial. Urology 2003; 61:
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The efficacy of terazosin, finasteride or 11 Roehrborn CG. The Agency for
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finasteride, alone or in combination, in 12 Speakman MJ, Kirby RS, Joyce A
et al. Guideline for the primary care is published in this issue of the BJU International . The new guideline places symptoms. BJU Int 2004; 93: in press
GPs firmly in the front rank for the initial The new guideline is for both GPs and patients, and reflects the high degree COGNITIVE EFFECTS OF HORMONAL TREATMENT FOR PROSTATE
CANCER A. KOUPPARIS, A. RAMSDEN and R. PERSAD – Department of
implementation. This guideline will hopefully Urology, Bristol Royal Infirmary, Bristol, UK offer real practical advice to both doctors and other healthcare professionals, and the many Accepted for publication 10 February 2004 patients suffering from symptomatic BPH.
Hormonal manipulation is a well established were subjectively apparent to individuals. Fortunately, these adverse effects appear to be reversible with oestrogen-replacement primary-care level with the BAUS guidelines troublesome side-effects. Recently, interest may reduce the number of patients requiring has turned to the possible adverse effects It would be reasonable to assume that LHRH agonists have similar effects in men. Substantial declines in testosterone levels REFERENCES
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this field are obviously required, both to Altered cognitive function in men treated in all patients, and this was associated formulate a standardized and reproducible with a wide range of effects on cognitive memory, attention and executive functions control trial. BJU Int 2002; 90: 427–32
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Several possibilities exist for the differences between male and female study populations. The duration of androgen suppression was shorter in patients with prostate cancer than EARLY REHABILITATION OF ERECTILE FUNCTION AFTER
in women, particularly in those after bilateral NERVE-SPARING RADICAL PROSTATECTOMY: WHAT IS
salpingo-oophorectomy. The possibility arises THE EVIDENCE?
P. GONTERO and R. KIRBY – St George’s Hospital, London, UK
that the degree and type of cognitive effects are related to the period of treatment.
Accepted for publication 10 February 2004 There are inherent differences in neuropsychological function between men INTRODUCTION
and women; the latter excel in verbal abilities abilities . This observation seems to be prophylaxis for erectile function after nerve- Comparing sexual function after normal (no related to the influences that different sparing radical prostatectomy (NSRP) was nerve sparing) and NSRP, Gralnek et al.  androgen levels in the sexes have on brain recently stressed by Montorsi and Burnett . reported that the latter had significantly organization during prenatal development. Despite that the patient compliance with better quality-of-life scores for both sexual Oestrogen and testosterone continue to be erectile rehabilitation protocols may be and physical function. The negative effect of suboptimal, as documented by the relatively sexual bother on quality of life may become areas of the brain which subserve verbal even more marked with a longer time after and visual-spatial functions, respectively. discontinue treatment for sexual dysfunction the procedure. In the study by Penson et al.  Therefore, their suppression during hormonal . It seems appropriate therefore to attempt manipulation could result in the selective determinant of worse general health-related currently proposed rehabilitative protocols in terms of cost-efficiency and quality of life.
2 0 0 4 B J U I N T E R N A T I O N A L treatment (27%) also had better nocturnal between sexual dysfunction and quality of erections recorded a year after surgery. Unfortunately that study did not address the recovery of sexual function an important prevalence of nocturnal erections over the issue for patients surgically treated for Spontaneous erectile function is absent for 9 months for all the patients in the treatment most patients soon after NSRP, but there is a arm compared with those in the placebo arm. progressive return over 2 years in a variable It is possible that sildenafil and the other proportion of them. This observation led to currently available PDE-5 inhibitors, e.g. the hypothesis of the so-called ‘neuropraxia’ effective in the early phase of nerve healing, cavernosal nerves which would abolish any as documented by the lack of clinical efficacy The proportion of men who have a complete form of erection. The low oxygen tensions in a of sildenafil in the first 9 months after NSRP recovery of erectile function after bilateral constantly flaccid penis may initiate severe anatomical preservation of neurovascular fibrotic changes in the cavernosal tissue. In a recent experimental model, penile tissue from reported to be up to 20% for patients under debate, but probably is less than half overall. rats which had undergone bilateral incision of Differences in surgical technique, patient cavernosal nerves 3 months earlier showed a significant overexpression of hypoxia-related Three-monthly intracavernosal injections substances like TGF-b and collagen I and III with prostaglandin E1 starting in the first compared with the same tissue from a control month after surgery significantly enhanced almost all the reported studies there is no compared with sildenafil alone started after 4 undergone specific erectile rehabilitation trabecular smooth muscles is replaced by months. At the 6-month follow-up, 82% of treatment during the follow-up. However, collagen, the caverno-occlusive mechanism is patients in the combination arm responded to lost, with subsequent venogenic erectile subsequent sildenafil, vs only 52% in the sildenafil-only arm . Intracavernosal therapy produces a high erectile response in patients after standard (not nerve-sparing) RP surgery gave the best results of potency and therefore it may be the treatment of recovery at 2 years . By contrast, in the support in the initial year after surgery choice in soon after NSRP. Similarly, the use of study of Katz et al.  patients were revealed a progressive incidence of venous the vacuum constrictor device may facilitate deliberately asked not to use any erectile leakage, varying from 14% at 4 months to early sexual intercourse and potentially an rehabilitation after laparoscopic RP, and 50% at >12 months . Similarly, in the early return of natural erections, although no study of Montorsi et al. , eight of 15 controlled study has been carried out to test alprostadil in the first 4 months after surgery had a colour Doppler diagnosis of venous postoperative erectile treatment rely on very leakage, compared with only two of 12 of the CONCLUSIONS
treatment group. These findings corroborate Montorsi et al.  recovery of spontaneous the hypothesis that erectile rehabilitation Erectile dysfunction may significantly affect the quality of life of patients who have had erectile dysfunction during the process of NSRP, and every effort should be made to improve sexual outcomes of these procedures. The current scientific evidence supporting the patients taking sildenafil at bedtime for early postoperative use of erectile aids is at present based mainly on indirect proof of The ideal treatment designed to promote the temporary postoperative ‘erectile silence’.
restoration of erectile function after NSRP it is possible that the erectile rehabilitation acceptable tolerability. Nocturnal penile intracavernosal injections or a vacuum device should be offered as a first-line option for the ‘healing’ time of potency rather than 8 months after NSRP . The early intake of first few months after the procedure, as their mechanism of action does not require intact failure. Larger randomized trials with at inhibitor sildenafil at bedtime has been sildenafil, or equivalent PDE-inhibitor therapy, before a definite conclusion can be drawn nocturnal erections. In the preliminary study may be a reasonable choice for those patients on the true efficacy of rehabilitative sexual from Padma-Nathan et al.  patients who who can achieve at least a partial erection. A regained sexual function after 9 months of PDE-5 inhibitor may not be effective when 2 0 0 4 B J U I N T E R N A T I O N A L spontaneous erections are absent. Possibly, as Penson DF, Feng Z, Kuniyuri A et al.
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10 Leungwattanakij S, Bivilacqua TJ, Usta
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the current level of knowledge about the 11 Mulhall JP, Slovick R, Hotaling J
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2 0 0 4 B J U I N T E R N A T I O N A L
Publications (Dr. Gijs H. Goossens) Top 5 publications 1. Goossens GH, Petersen L, Blaak EE, Hul G, Arner P, Astrup A, Froguel P, Patel K, Pedersen O, Polak J, Oppert J-M, Martinez A, Sørensen TIA, Saris WHM, and the NUGENOB Consortium. Several gene polymorphisms but not FTO variants modulate resting energy expenditure and fat-induced thermogenesis in obese subjects: The NUGENOB Study