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Publikationen PD. Dr. med. Christian Jacob
Originalarbeiten in Zeitschriften mit Gutachtersystem

108.Weber H, Scholz CJ, Jacob C, Heupel J, Kittel-Schneider S, Erhardt A, Hempel
S, Schmidt B, Kiel T, Gessner A, Lesch KP, Reif A. SPOCK3, a risk gene for adult ADHD and personality disorders. Eur Arch Psychiatry Clin Neurosci. 2013 Nov 29. [Epub ahead of print] (Impact Factor 2012: 3.200) 107.Jacob C, Weber H, Retz W, Kittel-Schneider S, Heupel J, Renner T, Lesch KP, Reif A. Acetylcholine-metabolizing butyrylcholinesterase (BCHE) copy number and deficit/hyperactivity syndrome. J Psychiatr Res. 2013 Dec;47(12):1902-8. doi:
10.1016/j.jpsychires. 2013. 08.006. Epub 2013 Aug 30. (Impact factor 2012:
106.Groß-Lesch S, Dempfle A, Reichert S, Jans T, Geissler J, Kittel-Schneider S, Nguyen TT, Reif A, Lesch KP, Jacob C. Sex- and Subtype-Related Differences in the Comorbidity of Adult ADHDs. J Atten Disord. 2013 Nov 6. [Epub ahead of print] (Impact factor 2012: 0) Impact Factor 2012:2.16) 105.Weber H, Klamer D, Freudenberg F, Kittel-Schneider S, Rivero O, Scholz CJ, Volkert J, Kopf J, Heupel J, Herterich S, Adolfsson R, Alttoa A, Post A, Grußen-
dorf H, Kramer A, Gessner A, Schmidt B, Hempel S, Jacob C, Sanjuán J, Moltó
MD, Lesch KP, Freitag CM, Kent L, Reif A. The genetic contribution of the NO
system at the glutamatergic post-synapse to schizophrenia: Further evidence and
meta-analysis. Eur Neuropsychopharmacol. 2013 Sep 27. doi:pii: S0924-
977X(13)00271-X. 10.1016/j.euroneuro.2013.09.005. [Epub ahead of print] (Im-
pact factor 2012: 4.60)
104.Philipsen A, Graf E, Jans T, Matthies S, Borel P, Colla M, Gentschow L, Langner D, Jacob C, Groß-Lesch S, Sobanski E, Alm B, Schumacher-Stien M, Roesler M, Retz W, Retz-Junginger P, Kis B, Abdel-Hamid M, Heinrich V, Huss M, Korn-mann C, Bürger A, van Elst LT, Berger M. A randomized controlled multicenter trial on the multimodal treatment of adult attention-deficit hyperactivity disorder: enrollment and characteristics of the study sample. Atten Defic Hyperact Disord. 2013 Oct 17. [Epub ahead of print] (Impact factor 2012: 0) 103.Lin MK, Freitag CM, Schote AB, Pálmason H, Seitz C, Renner TJ, Romanos M, Walitza S, Jacob C, Reif A, Warnke A, Cantor RM, Lesch KP, Meyer J. Haplotype co-segregation with attention deficit-hyperactivity disorder in unrelated German multi-generation families. Am J Med Genet B Neuropsychiatr Genet. 2013 Sep 3. doi: 10.1002/ajmg.b.32192. [Epub ahead of print] (Impact factor 2012: 2.23) 102.Fallgatter AJ, Ehlis AC, Dresler T, Reif A, Jacob C, Arcos-Burgos M, Muenke M, Lesch KP. Influence of a Latrophilin 3 (LPHN3) risk haplotype on event-related
potential measures of cognitive response control in attention-deficit hyperactivity
disorder (ADHD). Eur Neuropsychopharmacol. 2012 Dec 11. doi:pii: S0924-
977X(12)00310-0. 10.1016/j.euroneuro.2012.11.001. [Epub ahead of print] (Im-
pact factor 2012: 4.60)
101.Weißflog L, Scholz CJ, Jacob C, Nguyen TT, Groß-Lesch S, Renner TJ, Ro- manos M, Rujescu D, Kneitz S, Lesch KP, Reif A. KCNIP4 as a candidate gene
for personality disorders and adult ADHD. Eur Neuropsychopharmacol. 2012
Sep 13. pii: S0924-977X(12)00214-3. doi: 10.1016/j.euroneuro.2012.07.017.
[Epub ahead of print] (Impact factor 2012: 4.60)
100.Jans T, Graf E, Jacob C, Zwanzger U, Groß-Lesch S, Matthies S, Perlov E, Hennighausen K, Jung M, Rösler M, Schulte-Altedorneburg M, von Gontard A, Hänig S, Sobanski E, Alm B, Poustka L, Bliznak L, Colla M, Gentschow L, Burghardt R, Salbach-Andrae H, Becker K, Holtmann M, Freitag C, Warnke A, Philipsen A. A randomized controlled multicenter trial on the treatment for ADHD in mothers and children: enrolment and basic characteristics of the study sample. Atten Defic Hyperact Disord. 2013 Mar;5(1):29-40. doi: 10.1007/s12402-012-0092-4. Epub 2012 Oct 16. (Impact factor 2013: 0) 99. Gajewska A, Blumenthal TD, Winter B, Herrmann MJ, Conzelmann A, Mühlberger A, Warrings B, Jacob C, Arolt V, Reif A, Zwanzger P, Pauli P, Deckert J, Dom-schke K. Effects of ADORA2A gene variation and caffeine on prepulse inhibition – a multi-level risk model of anxiety. Prog Neuropsychopharmacol Biol Psychia-try. 2013 Jan 10;40:115-21. doi: 10.1016/j.pnpbp.2012.08.008. Epub 2012 Aug 23. (Impact factor 2012: 3.55) 98. Heinzel S, Dresler T, Baehne CG, Heine M, Boreatti-Hümmer A, Jacob C, Ren- ner, TJ, Reif A, Lesch K-P, Fallgatter AJ, Ehlis AC. COMT x DRD4 epistasis im-pacts deficit/hyperactivity disorder (ADHD) and healthy controls. Cereb Cortex. 2013 Jun;23(6):1453-62. doi: 10.1093/cercor/bhs132. Epub 2012 May 22.(Impact fac-tor 2012: 6.83)
97.Reif A, Weber H, Domschke K, Klauke B, Bauman C, Jacob C, Ströhle A, Gerlach
A, Alpers GW, Pauli P, Hamm A, Kircher T, Arolt V, Wittchen HU, Binder EB. Er-hardt A, Deckert J. Meta-analysis of MAOA-uVNTR in panic disorder in four European populations. Am J Med Genet B Neuropsychiatr Genet. 2012 Oct;159B(7):786-93. doi: 10.1002/ajmg.b.32085. Epub 2012 Aug 22. (Impact fac-tor 2012: 2.23) 96. Unterecker S, Müller P, Jacob C, Riederer P, Pfuhlmann B. Therapeutic Drug Monitoring of Antidepressants in Haemodialysis Patients. Clin Drug Investig. 2012 Aug 1;32(8):539-45. doi: 10.2165/11633560-000000000-00000. (Impact factor 2012: 1.92) 95. Klauke B, Winter B, Gajewska A, Zwanzger P, Reif A, Herrmann MJ, Dlugos A, Warrings B, Jacob C, Mühlberger A, Arolt V, Pauli P, Deckert J, Domschke K. Af-fect-Modulated Startle: Interactive Influence of Catechol-O-Methyltransferase Val158Met Genotype and Childhood Trauma. PLoS One. 2012;7(6):e39709. Epub 2012 Jun 22. (Impact factor 2012: 3.73) 94. Jacob C, Nguyen TT, Weißflog L, Liedel S, Groß-Lesch S, Müller T, Lesch KP, Reif A. PPP2R2C as a candidate gene of a temperament and character trait based endophenotype of ADHD. Atten Defic Hyperact Disord. 2012 Sep;4(3):145-52. doi: 10.1007/s12402-012-0080-8. Epub 2012 Jun 5. (Impact factor 2012: 0) 93. Weber H, Scholz CJ, Domschke K, Baumann C, Klauke B, Jacob C, Maier W, Fritze J, Bandelow B, Lang T, Fehm L, Ströhle A, Hamm A, Gerlach AL, Alpers GL, Kircher T, Wittchen HU, Arolt V, Pauli P, Deckert J, Reif A. Gender differences in associations of glutamate decarboxylase 1 gene (GAD1) variants with panic dis-order. PLoS One. 2012;7(5):e37651. Epub 2012 May 25. (Impact factor 2012: 3.73) 92. Conzelmann A, Reif A, Jacob C, Weyers P, Lesch KP, Lutz B, Pauli P. A polymor- phism in the gene of the endocannabinoid degrading enzyme FAAH (FAAH
C385A) is associated with emotional-motivational reactivity. Psychopharmacol-
ogy (Berl). 2012 Dec;224(4):573-9. doi: 10.1007/s00213-012-2785-y. Epub 2012
Jul 10. (Impact factor 2012: 4.06)
91. Molochnikov L, Rabey JM, Dobronevsky E, Bonucelli U, Ceravolo R, Frosini D, Grünblatt E, Riederer P, Jacob C, Aharon-Peretz J, Bashenko Y, Youdim MB,
Mandel S. A molecular signature in blood identifies early Parkinson’s disease.
Mol Neurodegener. 2012 May 31;7:26. doi: 10.1186/1750-1326-7-26. (Impact
factor 2012: 4.01)
90. Ribasés M, Sánchez-Mora C, Ramos-Quiroga JA, Bosch R, Gómez N, Nogueira M, Corrales M, Palomar G, Jacob C, Gross-Lesch S, Kreiker S, Reif A, Lesch KP, Cormand B, Casas M, Bayés M. An association study of sequence variants in the forkhead box P2 (FOXP2) gene and adulthood attention-deficit/hyperactivity disorder in two European samples. Psychiatr Genet. 2012 Aug;22(4):155-60. doi: 10.1097/YPG.0b013e328353957e. (Impact factor 2012: 2.37) 89. Grünblatt E, Geissler J, Jacob C, Renner T, Müller M, Bartl J, Deckert J, Riederer P, Lesch KP, Walitza S, Gerlach M, Schmitt A. Pilot study: mRNA biomarkers for adult Attention-Deficit Hyperactivity Disorder in whole blood, Atten Defic Hyperact Disord. 2012 Jun;4(2):77-84. Epub 2012 May 6. (Impact factor 2012: 0) 88. Domschke K, Klauke B, Winter B, Gajewska A, Herrmann MJ, Warrings B, Mühl- berger A, Wosnitza K, Dlugos A, Naunin S, Nienhaus K, Fobker M, Jacob C, Arolt
V, Paul P, Reif A, Zwanzger P, Deckert J. Modification of caffeine effects on the
affect-modulated startle by neuropeptide S receptor gene variation. Psy-
chopharmacology (Berl)
. 2012 Aug;222(3):533-41. Epub 2012 Mar 8. (Impact
factor 2012: 4.06)
87. Domschke K, Gajewska A, Bernward W, Herrmann MJ, Warrings B, Mühlberger A, Wosnitza K, Glotzbach E, Conzelmann A, Dlugos A, Fobker M, Jacob C, Arolt
V, Reif A, Pauli P, Zwanzger P, Deckert J. ADORA2A gene variation, caffeine
and emotional processing – a multi-level interaction on startle reflex. Neuropsy-
, 2012 Feb;37(3):759-69. doi: 10.1038/npp.2011.253. Epub
2011 Oct 19. (Impact factor 2012: 8.68)
86. Christiansen H, Hirsch O, Philipsen A, Oades RD, Matthies S, Hebebrand J, Uekermann J, Abdel-Hamid M, Kraemer M, Wiltfang J, Graf E, Colla M, Sobanski E, Alm B, Rösler M, Jacob C, Jans T, Huss M, Schimmelmann BG, Kis B. German validation of the Conners Adult ADHD Rating Scales – self-report (CAARS-S): confirmation of factor structure in a large sample of subjects with ADHD. J Atten Disord. 2012 Mar 21. [Epub ahead of print] (Impact factor 2012: 0) 85. Schecklmann M, Ehlis AC, Plichta MM, Dresler T, Heine M, Boreatti-Hümmer A, Jacob C, Pauli P, Fallgatter AJ. Working memory and response inhibition as one integral endophenotype of adult attention deficit hyperactivity disorder? A behavi-oural and imaging correlational investigation. J Atten Disord. 2013 Aug;17(6):470-82. doi: 10.1177/1087054711429702. Epub 2012 Feb 8. (Impact factor 2012: 0) 84. Jain M, Vélez JI, Acosta MT, Palacio LG, Balog J, Roessler E, Pineda D, Londo- ño AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Hakonarson H, Seitz C, Freitag
CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A,
Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Castellanos FX, Bailey-
Wilson JE, Arcos-Burgos M, Muenke M. A cooperative interaction between
LPHN3 and 11q doubles the risk for ADHD. Mol Psychiatry. 2012 Jul;17(7):741-
7. doi: 10.1038/mp.2011.59. Epub 2011 May 24. (Impact factor 2012: 14.90)
83. Christiansen H, Kis B, Hirsch O, Matthies S, Hebebrand J, Ueckermann J, Abdel- Hamid M, Kraemer M, Wiltfang J, Graf E, Colla M, Sobanski E, Alm B, Rösler M, Jacob C, Jans T, Huss M, Schimmelmann BG, Philipsen A. German validation of the Conners Adult ADHD Rating Scales (CAARS) II: Reliability validity, diagnostic sensitivity and specificity. Eur Psychiatry. 2012 Jul;27(5):321-8. doi: 10.1016/j.eurpsy.2010.12.010. Epub 2011 Mar 9. (Impact factor 2012: 3.70)
82. Reif A, Nguyen TT, Weißflog L, Jacob C, Romanos M, Schäfer H, Renner T, But-
tenschon HN, Kittel-Schneider S, Gessner A, Weber H, Neuner M, Groß-Lesch
S, Boreatti-Hümmer A, Kreiker S, Heine M, Palmason H, Seitz C, Asherson P,
Warnke A, Fischer G, Grabe HJ, Meyer J, Freitag CM, Mors O, Cormand B,
Haavik J, Franke B, Lesch KP. DIRAS2 is associated with adult ADHD and re-
lated personality traits. Neuropsychopharmacology. 2011 Oct;36(11):2318-27.
doi: 10.1038/npp.2011.120 Epub 2011 Jul 13. (Impact factor 2011: 7.99)
81. Weber H, Kittel-Schneider S, Gessner A, Domschke K, Neuner M, Jacob C, But- tenschon HN, Boreatti-Hümmer A, Volkert J, Herterich S, Baune BT, Gross-
Lesch S, Kopf J, Kreiker S, Nguyen TT, Weissflog L, Arolt V, Mors O, Deckert J,
Lesch KP, Reif A. Cross-Disorder Analysis of Bipolar Risk Genes: Further Evi-
dence of DGKH as a Risk Gene for Bipolar Disorder, but also Unipolar Depres-
sion and Adult ADHD. Neuropsychopharmacology. 2011 Sep;36(10):2076-85.
(Impact factor 2011: 7.99)
80. Sánchez-Mora C, Ribasés M, Casas M, Bayés M, Bosch R, Fernàndez-Castillo N, Brunso L, Jacobsen KK, Landas E, Lundervold AJ, Gross-Lesch S, Kreiker S, Jacob C, Lesch KP, Buitelaar J, Hoogman M, Kiemeney LALM, Kooij JJS, Mick E, Asherson P, Faraone SV, Franke B, Reif A, Johansson S, Haavik J, Ramos-Quiroga JA, Cormand B. Exploring DRD4 and its interaction with SLC6A3 as possible risk factors for adult ADHD: a meta-analysis in four European popula-tions. Am J Med Genet B Neuropsychiatr Genet. 2011 Jul;156(5):600-12. (Impact factor 2011: 3.23) 79. Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld PG, Ripke S, Kohli MA, Kloi- ber S, Ising M, Heck A, Ellgas A, Pfister H, Lieb R, Puetz B, Uhr M, Hohoff C, Mai-
er W, Bandelow B, Domschke K, Jacob C, Deckert J, Landgraf R, Bettecken T,
Keck ME, Müller-Myhsok B, Holsboer F, Binder EB. TMEM132D, a new candi-
date for anxiety phenotypes: evidence from human and mouse studies. Mol Psy-
. 2011 Jun;16(6):647-63. (Impact factor 2011: 13.67)
78. Lesch KP, Selch S, Renner TJ, Jacob C, Nguyen TT, Hahn T, Romanos M, Walitza S, Shoichet S, Dempfle A, Heine M, Boreatti-Hümmer A, Romanos J,
Gross-Lesch S, Zerlaut H, Wultsch T, Heinzel S, Fassnacht M, Fallgatter A,
Allolio B, Schäfer H, Warnke A, Reif A, Ropers HH, Ullmann R. Genome-wide
copy number variation analysis in attention-deficit/hyperactivity disorder: associa-
tion with neuropeptide Y gene dosage in an extended pedigree. Mol Psychiatry.
2011 May;16(5):491-503. (Impact factor 2011: 13.67)
77. Reif A, Schecklmann M, Eirich E, Jacob C, Jarczok TA, Kittel-Schneider S, Lesch KP, Fallgatter AJ, Ehlis AC. A functional promoter polymorphism of neuronal ni-
tric oxide synthase moderates prefrontal functioning in schizophrenia. Int J Neu-
, 2011 Aug;14(7):887-97. (Impact factor 2011: 4.78)
76. Domschke K, Reif A, Weber H, Richter J, Hohoff C, Ohrmann P, Pedersen A, Jochen Bauer J, Suslow T, Kugel T, Baumann C, Klauke B, Jacob C, Maier W, Fritze J, Bandelow B, Krakowitzky P, Rothermundt M, Erhardt A, Binder E, Holsboer F, Gerlach A, Kircher T, Lang T, Alpers G, Ströhle A, Fehm L, Gloster A, Wittchen U, Arolt V, Pauli P, Hamm A, Deckert J. Neuropeptide S receptor (NPSR)gene –converging evidence for a role in panic disorder. Mol Psychiatry.
2011 Sep;16(9):938-48. (Impact factor 2011: 13.67)
75. Conzelmann A, Woidich E, Mucha RF, Weyers P, Jacob C, Lesch KP, Pauli P. Methylphenidate normalizes emotional processing in adult patients with Attention
Deficit Hyperactivity Disorder: Preliminary findings. Brain Res. 2011 Mar
24;1381:159-66. (Impact Factor 2011: 10.34)
74. Lazary J, Juhasz G, Anderson IM, Jacob C, Nguyen TT, Lesch KP, Reif A, De- akin JF, Bagdy G. Epistatic interaction of CREB1 and GIRK2 on rumination and
negative emotionality. Eur Neuropsychopharmacol. 2011 Jan;21(1):63-70. (Im-
pact factor 2011: 4.41)
73. Schecklmann M, Schenk E, Maisch A, Kreiker S, Jacob C, Warnke A, Gerlach M, Fallgatter AJ, Romanos M. Altered Frontal and Temporal Brain Function during Olfactory Stimulation in Adult Attention-Deficit/Hyperactivity Disorder. Neuropsy-chobiology. Neuropsychobiology. 2011;63(2):66-76. (Impact factor 2011: 2.68)
72. Grünblatt E, Zehetmayer S, Bauer P, Jacob C, Müller T, Jost WH, Riederer P.
Peripheral biomarkers for diagnosing Parkinson’s disease. J Neural Transm. 2010 Dec;117(12):1387-93. (Impact factor 2010: 2.60) 71. Philipsen A, Graf E, van Elst LT, Jans T, Warnke A, Hesslinger B, Ihorst G, Lesch KP, Gerlach M, Matthies S, Colla M, Jacob C, Sobanski E, Alm B, Rösler M, Kis B, Huss M, Lieb K, Schlander M, Berger M. Evaluation of the efficacy and effectiveness of a structured disorder tailored psychotherapy in ADHD in adults: study protocol of a randomized controlled multicentre trial. Atten Defic Hyperact Disord. 2010 Dec;2(4):203-12. (Impact factor 2010: 0) 70. Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, Domené S, Vélez JI, Karkera JD, Balog J, Berg K, Kleta R, Gahl WA, Roessler E, Long R,
Lie J, Pineda D, Londoño AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Ha-
konarson H, Johansson S, Knappskog PM, Haavik J, Ribases M, Cormand B,
Bayes M, Casas M,Ramos-Quiroga JA, Hervas A, Maher BS, Faraone SV, Seitz
C, Freitag CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U,
Warnke A, Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Vortmeyer A,
Bailey-Wilson JE, Castellanos FX, Muenke M. A common variant of the latrophilin
3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of
stimulant medication. Mol Psychiatry. 2010 Nov;15(11):1053-66. (Impact factor
2010: 15.47)
69. Dresler T*, Ehlis AC*, Heinzel S, Renner TJ, Reif A, Baehne CG, Heine M, Bore- atti-Hümmer A, Jacob C, Lesch KP, Fallgatter AJ. Dopamine Transporter (DAT)
genotype impacts neurophysiological correlates of cognitive response control in
an adult sample of patients with ADHD. Neuropsychopharmacology. 2010
Oct;35(11):2193-202. (Impact factor 2010: 6.69)
68. Hohoff C, Mullings LE, Heatherley SV, Freitag C, Neumann L, Domschke K, Kra- kowitzky P, Rothermundt M, Keck ME, Erhardt A, Binder EB, Jacob C, Fritze J,
Bandelow B, Maier W, Holsboer F, Rogers PJ, Deckert J. Adenosine A(2A) recep-
tor gene: Evidence for association of risk variants with panic disorder and anx-
ious personality. J Psychiatr Res. 2010 Oct;44(14):930-7. (Impact factor 2008:
67. Romanos M, Ehlis AC, Baehne CG, Jacob C, Renner TJ, Storch A, Briegel W,Walitza S, Lesch KP, Fallgatter AJ. Reduced NoGo-anteriorisation during con-
tinuous performance test in deletion syndrome 22q11.2. J Psychiatr Res. 2010
Sep;44(12):768-74. (Impact factor 2008: 4.679)
66. Conzelmann A, Pauli P, Mucha RF, Jacob C, Gerdes ABM, Romanos J, Bähne CG, Heine M, Boreatti-Hümmer A, Alpers GW, Fallgatter AJ, Warnke A, Lesch KP,
Weyers P. Early attentional deficits in an attention-to-prepulse paradigm in ADHD
adults. J Abnorm Psychol. 2010 Aug;119(3):594-603. (Impact factor 2008:
65. Johansson S, Halmøy A, Mavroconstanti T, Jacobsen KK, Landaas E, Reif A, Jacob C, Boreatti-Hümmer A, Kreiker S, Lesch KP, Kan CC, Kooij JJS, Lamber-tus A Kiemeney JK, Buitelaar F, Ribasés M, Bosch R, Bayés M, Casas M, Ramos-Quiroga JA, Cormand P, Knappskog P, Haavik J. Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1636 adult cases and 1923 controls from four European populations. Am J Med Genet B Neuropsychiatr Genet. 2010 Jul;153B(5):1008-15. (Impact factor 2008: 2.696) 64. Landaas ET, Johansson S, Jacobsen KK, Ribasés M, Bosch R, Sanchez-Mora C, Jacob C, Boreatti-Hümmer A, Kreiker S, Lesch KP, Kiemeney JK, Kooij JJS, Kan
CC, Buitelaar F, Faraone SV, Halmøy A, Ramos-Quiroga JA, Cormand P, Reif A,
Franke B, Mick E, Knappskog P, Haavik J. An international multicenter associati-
on study of the serotonin transporter gene in persistent ADHD. Genes Brain Be-
. 2010 Jul;9(5):449-58. (Impact factor 2010: 4.06)
63. Jacob C, Nguyen TT, Dempfle A, Heine M, Windemuth-Kieselbach C, Baumann K, Jacob F, Prechtl J, Wittlich A, Herrmann MJ, Gross-Lesch S, Lesch KP, Reif A. A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/ hyper-activity disorder. Eur Arch Psychiatry Clin Neurosci. 2010 Jun;260(4):317-26. (Impact factor 2010: 2.75) 62. Scholz CJ, Jacob C, Buttenschon HN, Kittel-Schneider S, Boreatti-Hümmer A, Zimmer M, Walter U, Lesch KP, Mors O, Kneitz S, Deckert J, Reif A. Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):967-72. (Impact factor 2008: 2.696) 61. Retz-Junginger P, Rösler M, Jacob C, Alm B, Retz W. Lack of Gender Differ- ences in Self- and Investigator-Rated Psychopathology in Adult Attention Deficit-/Hyperactivity Disorder. Atten Defic Hyperact Disord. 2010 Jun;2(2):93-101. (Im-pact factor 2010: 0) 60. Sánchez-Mora C, Ribasés M, Ramos-Quiroga JA, Casas M, Bosch R, Boreatti- Hümmer A, Heine M, Jacob C, Lesch KP, Fasmer OB, Knappskog PM, Kooij JJ, Kan C, Buitelaar JK, Mick E, Asherson P, Faraone SV, Franke B, Johansson S, Haavik J, Reif A, Bayés M, Cormand B. Meta-analysis of brain-derived neurotro-phic factor p.Val66Met in adult ADHD in four European populations. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):512-23. (Impact factor 2008: 3.932) 59. Franke N, Vasquez AA, Johansson S, Hoogman M, Romanos J, Boreatti-Hümmer A, Heine M, Jacob C, Lesch KP, Casas M, Ribasés M, Bosch R, Sánchez-Mora C, Gómez-Barros N, Fernàndez-Castillo N, Bayés M, Halmøy A, Halleland H, Lan-daas ET, Fasmer OB, Knappskog PM, Heister AJGAM, Kiemeney LA, Kooi JJS, Boonstra M, Kan C, Asherson P, Faraone SV, Buitelaar J, Haavik J, Cormand B, Ramos-Quiroga JA, Reif A. Meta-analysis of the SLC6A3/DAT1 VNTR haplotype in adult ADHD suggests differential involvement of the gene in adult and child-
hood ADHD. Neuropsychopharmacology. 2010 Feb;35(3):656-64. (Impact fac-
tor 2010: 6.69)
58. Tarantino V, Ehlis AC, Baehne C, Boreatti-Huemmer A, Jacob C, Bisiacchi P, Fallgatter AJ. The time course of temporal discrimination: An ERP study. Clin Neurophysiol. 2010 Jan;121(1):43-52. (Impact factor 2010: 2.79) 57. Pauli P, Conzelmann A, Mucha RF, Weyers P, Bähne CG, Fallgatter AJ, Jacob C, Lesch KP. Affect-modulated startle reflex and dopamine D4 receptor gene varia-tion. Psychophysiology. 2010 Jan 1;47(1):25-33. (Impact factor 2010: 3.26) 56. Herrmann MJ, Mader K, Schreppel T, Jacob C, Heine M, Boreatti-Hummer A, Ehlis AC, Scheuerpflug P, Pauli P, Fallgatter AJ. Neural correlates of perform-ance monitoring in adult patients with attention-deficit/ hyperactivity disorder (ADHD). World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):457-64. (Impact factor 2010: 2.05)
55. Fallgatter A, Bähne C, Ehlis AC, Plichta M, Richter MM, Herrmann MJ, Conzel-
mann A, Pauli P, Jacob C, Lesch KP. Impact of COMT genotype on prefrontal brain functioning in aduld ADHD in response control task. Human cognitive Neu-rophysiology, im Druck. (gegründet 2008) 54. Herrmann MJ, Schreppel T, Biehl T, Jacob C, Heine M, Boreatti-Hümmer A, Mühlberger A, Fallgatter AJ. Emotional deficits in adult ADHD patients: an ERP study. Soc Cogn Affect Neurosci. 2009 Dec;4(4):340-5. (Impact factor 2008: 2.913) 53. Ribasés M, Bosch R, Hervás A, Ramos-Quiroga JA, Bielsa A, Gastaminza X, Gui- jarro-Domingo S, Nogueira M, Gómez-Barros N, Kreiker S, Groß-Lesch S, Jacob
C, Lesch KP, Reif A, Johansson S, von Plessen K, Knappskog PM, Haavik J, Es-
tivill X, Casas M, Bayés M, Cormand B. Case-controll study of six genes asym-
metrically expressed in the cerebral hemispheres: evidence of association of
BAIAP2 with adulthood attention-deficit hyperactivity disorder. Biol Psychiatry.
2009 Nov 15;66(10):926-34. (Impact factor 2009: 8.93)
52. Wolf RC, Plichta MM, Sambataro F, Fallgatter AJ, Jacob C, Lesch KP, Herrmann MJ, Schönfeldt-Lecuona C, Connemann BJ, Grön G, Vasic N. Regional brain ac-
tivation changes and abnormal functional connectivity of the ventrolateral pre-
frontal cortex during working memory processing in adults with attention-
deficit/hyperactivity disorder. Hum Brain Mapp. 2009 Jul;30(7):2252-66. (Impact
factor 2009: 6.26)
51. Hohoff C, Neumann A, Domschke K, Jacob C, Meier W, Fritze J, Bandelow B, Krakowitzky P, Rothermundt M, Arolt V, Deckert J. Association analysis of RGS 2/13 variants with panic disorder. J Neural Transm. 2009 Nov;116(11):1523-8. (Impact factor 2009: 2.26) 50. Bähne CG, Ehlis AC, Plichta MM, Conzelmann A, Pauli P, Jacob C, Gutknecht L, Lesch KP, Fallgatter AJ. TPH2 gene variants modulate response control proc-
esses in adult ADHD patients and healthy individuals. Mol Psychiatry. 2009
Nov;14(11):1032-9. (Impact factor 2009: 15.09)
49. Herrmann M, Würflein H, Schreppel T, Koehler S, Mühlberger A, Reif A, Canli T, Romanos M, Jacob C, Lesch KP, Fallgatter AJ. Catechol-O-methyltransferase val158met genotype affects neuronal correlates of aversive stimuli processing. Cogn Affect Behav Neurosci. 2009 Jun;9(2):168-72. (Impact factor 2008: 3.132) 48. Conzelmann A, Mucha RF, Jacob C, Weyers P, Romanos J, Gerdes AB, Baehne CG, Boreatti-Hümmer A, Heine M, Alpers GW, Warnke A, Fallgatter AJ, Lesch KP, Pauli P. Abnormal Affective Responsiveness in Attention Deficit/Hyperactivity
Disorder: Subtype Differences. Biol Psychiatry. 2009 Apr 1;65(7):578-85. (Im-
pact factor 2009: 8.93)
47. Grünblatt E, Bartl J, Zehetmayer S, Ringel TM, Bauer P, Riederer P, Jacob C. Gene expression as peripheral biomarkers for sporadic Alzheimer's disease. J
Alzheimers Dis
. 2009 Mar;16(3):627-34. (Impact factor 2008: 5.101)
46. Rösler M, Fischer R, Ammer R, Ose C, Retz W; on behalf of the study group (Jacob C). A randomised, placebo-controlled, 24-week, study of low-dose ex-tended-release methylphenidate in adults with attention-deficit/hyperactivity dis-order. Eur Arch Psychiatry Clin Neurosci. 2009 Feb;259(2):120-129. (Impact fac-tor 2009: 2.75) 45. Hess C, Reif A, Strobel A, Boreatti-Hümmer A, Lesch KP, Jacob C. A functional dopamine-β-hydroxylase (DBH) gene promoter polymorphism is associated with impulsive and hostile personality, but not with affective disorders. J Neural Transm. 2009 Feb;116(2):121-30. (Impact factor 2009: 2.26) 44. Reif A, Jacob C, Rujescu D, Herterich S, Lang S, Gutknecht L, Bähne C, Strobel A, Freitag CM, Giegling C, Romanus M, Hartmann A, Rösler M, Renner TJ, Fall-
gatter AJ, Retz W, Ehlis AC, Lesch KP. Genetic variation determining neuronal
nitric oxide synthase expression affects externalizing behaviors in humans. Arch
Gen Psychiatry
. 2009 Jan;66(1):41-50. (Impact factor 2009: 12.26)
43. Plichta MM, Vasic N, Wolf C, Lesch KP, Brummer D, Jacob C, Fallgatter AJ, Grön G. Neural hypo- and hyper-responsiveness on immediate and delayed reward
processing in adult ADHD. Biol Psychiatry. 2009 Jan;65(1):7-14. (Impact factor
2009: 8.93)
42. Koehler S, Lauer P, Schreppel T, Jacob C, Heine M, Boreatti-Hümmer A, Fall- gatter AJ, Herrmann MJ. Increased EEG power density in alpha and theta bands in adult ADHD patients. J Neural Transm. 2009 Jan;116(1):97-104. (Impact factor 2009: 2.26)
41. Eisenbarth H, Alpers GW, Conzelmann A, Jacob C, Weyers P, Pauli P. Psycho-
pathic traits in adult ADHD patients. Personality and Individual Differences. 2008 468-472. (Impact factor 2008: 1.598) 40. Schecklmann M, Ehlis AC, Plichta MM, Jacob C, Fallgatter AJ. Diminished pre- frontal oxygenation with normal and above-average verbal fluency performance
qin aduld ADHD: the first scientific observation of hyperfocussing. J Psychiatr
. 2008 Dec;43(2):98-106. (Impact factor: 4.679)
39. Zhou K, Dempfle A, Arcos-Burgos M, Bakker SC, Banaschewski T, Biederman J, Buitelaar Jan, Castellanos FX, Doyle A, Ebstein RP, Ekholm J, Forabosco P, Franke B, Freitag C, Friedel S, Gill M, Hebebrand J, Hinney A, Jacob C, Lesch KP, Loo SK, Lopera F, McCracken JT, McGough JJ, Meyer J, Mick E, Miranda A, Muencke M, Mulas F, Nelson SF, Nguyen TT, Oades RD, Ogdie MN, Palacio JD, Pineda D, Reif A, Renner T, Roeyers H, Romanos M, Rothenberger A, Schäfer H, Sergeant J, Sinke RJ, Smalley SL, Sonuga-Barke E, Steinhausen HC, van der Meulen E, Walitza S, Warnke A, Lewis CM, Faraone SV, Asherson P. Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2008 Dec;147B(8):1392-1398. (Im-pact factor: 3.932) 38. Lesch KP, Timmesfeld N, Renner TJ, Halperin R, Röser C, Nguyen TT, Craig DW, Romanos J, Heine M, Meyer J, Freitag C, Warnke A, Romanos M, Schäfer H, Walitza S, Reif A, Stephan DA, Jacob C. Molecular genetics of adult ADHD: con-verging evidence from genome-wide association and extended pedigree linkage studies. J Neural Transm. 2008 Nov;115(11):1573-85. (Impact factor: 2.514) 37. Ehlis AC, Bähne CG, Jacob C, Herrmann MJ, Fallgatter AJ. Reduced lateral pre- frontal activation in adult patients with attention-deficit/hyperactivity disorder (ADHD) during a working memory task: A functional near-infrared spectroscopy (fNIRS) study. Psychiatr Res. 2008 Oct;42(13):1060-7. (Impact factor: 2.666) 36. Domschke K, Hohoff C, Jacob C, Maier W, Fritze J, Bandelow B, Krakowitzky P, Kästner F, Rothermundt M, Arolt V, Deckert J. Chromosome 4q31-34 Panic Dis-order Risk Locus: Association of Neuropeptide Y Y5 Receptor Variants. Am J Med Genet B Neuropsychiatr Genet. 2008 Jun;147B(4):510-6. (Impact factor: 3.932) 35. Romanos M*, Freitag C*, Jacob C*, Craig DW, Dempfle A, Nguyen TT, Halperin R,Walitza S, Renner TJ, Seitz C, Romanos J, Palmason H, Reif A, Heine M,
Windemuth-Kieselbach C, Vogler C, Sigmund J, Warnke A, Schäfer H, Meyer J,
Stephan DA, Lesch KP. Genome-wide linkage analysis of ADHD using high-
density SNP arrays: novel loci at 5q13.1 and 14q12. Mol Psychiatry. 2008
May;13(5):522-30, *contributed as equal. (Impact factor: 12.537)
34. Renner TJ, Walitza S, Dempfle A, Eckerl L, Romanos M, Gerlach M, Schäfer H, Warnke A, Lesch KP, Jacob C. Allelic variants of SNAP25 and ADHD in a ger-man family-based sample. J Neural Transm. 2008 Feb;115(2):317-21. (Impact factor: 2.514) 33. Herrmann MJ, Langer JB, Jacob C, Ehlis AC, Fallgatter AJ. Reduced prefrontal oxygenation in Alzheimer’s disease during verbal fluency tasks. Am J Geriatr
. 2008 Feb;16(2):125-35. (Impact factor: 4.022)


32. Philipsen A, Richter H, Peters J, Alm B, Sobanski E, Colla M, Münzebrock M,
Scheel C, Jacob C, Perlov E, van Elst LT, Hesslinger B. Efficacy of a Structured Group Psychotherapy in Adults with Attention Deficit Hyperactivity Disorder – Results of a Multicenter Study. J Nerv Ment Dis. 2007 Dec;195(12):1013-9. (Im-pact factor: 1.863) 31. Reif A, Rösler M, Freitag CM, Schneider M, Eujen A, Kissling C, Wenzler D, Jacob C, Retz-Junginger P, Thome J, Lesch KP, Retz W. Nature and nurture
predispose to violent behavior: serotonergic genes and adverse childhood envi-
ronment. Neuropsychopharmacology. 2007 Nov;32(11):2375-83. (Impact fac-
tor: 6.157)
30. Reif A, Melchers M, Strobel A, Jacob C, Herterich S, Lesch KP, Zimmer M. FZD3 is not a risk gene for schizophrenia: a case-control study in a Caucasian sample. J Neural Transm Suppl. 2007;(72):297-301. (Impact factor: 1.356) 29. Jacob C, Romanos J, Dempfle A, Heine M, Windemuth-Kieselbach C, Kruse A, Reif A, Walitza S, Romanos M, Strobel A, Brocke B, Schafer H, Schmidtke A, Boning J, Lesch KP. Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center. Eur Arch Psychiatry Clin Neurosci. 2007 Sep;257(6):309-17. (Impact factor: 2.809) 28. Gutknecht L*, Jacob C*, Strobel A*, Müller J, Reif A, Mössner R, Zeng Y, Gross
C, Brocke B, Lesch KP. Tryptophan hydroxylase-2 gene variation influences per-
sonality traits and related disorders. Int J Neuropsychopharmacol. 2007
Jun;10(3):309-20. *contributed as equal. (Impact factor: 4.895)
27. Selch S, Haderlein J, Strobel A, Meyer J, Jacob C, Schmitt A, Lesch KP, Reif A. MLC1 polymorphisms are specifically associated with periodic catatonia, a sub-
group of chronic schizophrenia. Biol Psychiatry. 2007 May 15;61(10):1211-4.
(Impact factor: 8.456)
26. Richter MM, Ehlis AC, Jacob C, Fallgatter AJ. Cortical excitability in adult patients with attention-deficit/hyperactivity disorder (ADHD). Neurosci Lett. 2007 May 29;419(2):137-41. (Impact factor: 2.085) 25. Jacob C, Koutsilieri E, Bartl J, Neuen-Jacob E, Arzberger T, Zander N, Ravid R, Roggendorf W, Riederer P, Grunblatt E. Alterations in expression of glutamater-
gic transporters and receptors in sporadic Alzheimer's disease. J Alzheimers
. 2007 Mar;11(1):97-116. (Impact factor: 4.081)

24. Brocke B, Armbruster D, Muller J, Hensch T, Jacob C, Lesch KP, Kirschbaum C,
Strobel A. Serotonin transporter gene variation impacts innate fear processing:
acoustic startle response and emotional startle. Mol Psychiatry. 2006
Dec;11(12):1106-12. (Impact factor: 11.804)
23. Jacob C, Lesch KP. The Wuerzburg research initiative on adult attention-deficit hyperactivity disorder (WURIN-AADHD): Multi-layered evaluation of long-term course. Eur. Arch Psychiatry Clin Neurosci. 2006; 256 Suppl 1:112-20. (Impact factor: 3.042) 22. Mossner R, Walitza S, Geller F, Scherag A, Gutknecht L, Jacob C, Bogusch L, Remschmidt H, Simons M, Herpertz-Dahlmann B, Fleischhaker C, Schulz E,
Warnke A, Hinney A, Wewetzer C, Lesch KP. Transmission disequilibrium of po-
lymorphic variants in the tryptophan hydroxylase-2 gene in children and adoles-
cents with obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2006
Aug;9(4):437-42. (Impact factor: 5.184)
21. Mossner R, Freitag CM, Gutknecht L, Reif A, Tauber R, Franke P, Fritze J, Wag- ner G, Peikert G, Wenda B, Sand P, Rietschel M, Garritsen H, Jacob C, Lesch KP, Deckert J. The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder. J Psychopharmacol. 2006 Jul;20(4):547-52. (Impact factor: 3.255) 20. Reif A, Herterich S, Strobel A, Ehlis AC, Saur D, Jacob C, Wienker T, Topner T, Fritzen S, Walter U, Schmitt A, Fallgatter AJ, Lesch KP. A neuronal nitric oxide
synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal
cortex function. Mol Psychiatry. 2006 Mar;11(3):286-300. (Impact factor:
19. Richter MM, Ehlis A-C, Bähne CG, Scheuerpflug, P, Jacob C, Fallgatter AJ. In- hibitorische Hirnfunktionen bei ADHS im Erwachsenenalter. Nervenheilkunde. 2006;25: 657-61. (Impact factor: 0.396) 18. Herrmann MJ, Reif A, Jabs B, Jacob C, Fallgatter AJ. Facial affect decoding in Schizophrenia: An ERP study. Psychiatry Res. 2006 Mar 30;141(3):247-52. (Im-pact factor: 2.31) 17. Reif A, Strobel A, Jacob C, Herterich S, Freitag CM, Topner T, Mossner R, Fritzen S, Schmitt A, Lesch KP. A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorder. Int J Neuropsychopharma-
. 2006 Feb;9(1):13-20. (Impact factor: 5.184)
16. Leonhard C, Reif A, Beck M, Jacob C, Lesch KP. Reversible ischaemic neurolo- gical deficit associated with short-term methylphenidate medication. Int J Neuro-
. 2006 Feb;9(1):129-30. (Impact factor: 5.184)

15. Herrmann MJ, Ehlis AC, Wagener A, Jacob C, Fallgatter AJ. Near-infrared optical
topography to assess activation of the parietal cortex during a visuo-spatial task.
Neuropsychologia. 2005;43(12):1713-20. (Impact factor: 4.118)
14. Ehlis AC, Zielasek J, Herrmann MJ, Ringel T, Jacob C, Fallgatter AJ. Beneficial effect of atypical antipsychotics on prefrontal brain function in acute psychotic disorders. Euro Arch Psychiatry Clin Neurosci. 2005 Oct;255(5):299-307. (Impact factor: 2.264) 13. Jacob C, Muller J, Schmidt M, Hohenberger K, Gutknecht L, Reif A, Schmidtke A, Mossner R, Lesch KP. Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. Neuropsychopharmacology. 2005 Sep;30(9):1711-8. (Impact factor: 3.637) 12. Schumacher J, Abou Jamra R, Becker T, Klopp N, Franke P, Jacob C, Sand P, Fritze J, Ohlraun S, Schulze TG, Rietschel M, Illig T, Propping P, Cichon S,
Deckert J, Nothen MM. Investigation of the DAOA/G30 locus in panic disorder.
Mol Psychiatry. 2005 May;10(5):428-9. (Impact factor: 9.335)
11. Ehlis AC, Zielasek J, Herrmann MJ, Ringel T, Jacob C, Wagener A, Fallgatter AJ. Evidence for unaltered brain electrical topography during prefrontal response control in cycloid psychoses. Int J Psychophysiol. 2005 Feb;55(2):165-78. (Im-pact factor: 2.584)

10. Hosing VG, Schirmacher A, Kuhlenbaumer G, Freitag C, Sand P, Schlesiger C,
Jacob C, Fritze J, Franke P, Rietschel M, Garritsen H, Nothen MM, Fimmers R, Stogbauer F, Deckert J. Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder. J Neural Transm Suppl. 2004;(68):147-56. (Im-pact factor: 1.449) 9. Domschke K, Freitag CM, Kuhlenbumer G, Schirmacher A, Sand P, Nyhuis P, Jacob C, Fritze J, Franke P, Rietschel M, Garritsen HS, Fimmers R, Nothen MM,
Lesch KP, Stegbauer F, Deckert J. Association of the functional V158M catechol-
O-methyl-transferase polymorphism with panic disorder in women. Int J Neuro-
. 2004 Jun;7(2):183-8. (Impact factor: 4.128)
8. Rothe C, Gutknecht L, Freitag C, Tauber R, Mossner R, Franke P, Fritze J, Wag- ner G, Peikert G, Wenda B, Sand P, Jacob C, Rietschel M, Nothen MM, Garrit-
sen H, Fimmers R, Deckert J, Lesch KP. Association of a functional -1019C>G 5-
HT1A receptor gene polymorphism with panic disorder with agoraphobia. Int J
. 2004 Jun;7(2):189-92. (Impact factor: 4.128)
7. Jacob C, Strobel A, Hohenberger K, Ringel T, Gutknecht L, Reif A, Brocke B, Lesch KP. Association between allelic variation of serotonin transporter function and neuroticism in anxious cluster C personality disorders. Am J Psychiatry.
2004 Mar;161(3):569-72. (Impact factor 2004: 7,61)
6. Ringel TM, Heidrich A, Jacob C, Fallgatter AJ. Sensory gating deficit in a subtype of chronic schizophrenic patients. Psychiatry Res. 2004 Mar 15;125(3):237-45. (Impact factor 2004: 1,99)
5. Luckhaus C, Jacob C, Reif A. Mirtazapine completely relieves severe insomnia in
a patient with Lewy body dementia. Int J Psychiat Clin. 2003;7:139-41. (Impact factor: 0.191) 4. Luckhaus C, Jacob C, Zielasek J, Sand P. Olfactory reference syndrome mani- fests in a variety of psychiatric disorders. Int J Psychiat Clin. 2003;7:41-44. (Im-pact factor: 0.191) 3. Herrmann MJ, Jacob C, Unterecker S, Fallgatter AJ. Reduced response- inhibition in obsessive-compulsive disorder measured with topographic evoked potential mapping. Psychiatry Res. 2003 Oct 15;120(3):265-71. (Impact factor: 2.778) 2. Luckhaus C, Jacob C. Venlafaxine withdrawal syndrome not prevented by maprotiline, but resolved by sertraline. Int J Neuropsychopharmacol. 2001 Mar;4(1):43-4. (Impact factor: 3.9)
1. Sulz S, Gräff U, Jacob C. Persönlichkeit und Persönlichkeitsstörung. Eine empri-
sche Untersuchung der VDS-Persönlichkeitsskalen. Psychotherapie in Psychiat-rie, Psychotherapeutischer Medizin und Klinischer Psychologie. 1998;1: 46-56.
Eingereichte Manuskripte

13. Domschke K, Winter B, Gajewska A, Unterecker S, Warrings B, Dlugos A, Not-
zon S, Nienhaus K, Markulin F, Gieselmann A, Jacob C, Herrmann M, Arolt V, Mühlberger A, Reif A, Pauli P, Deckert J, Zwanzger. Multilevel Impact of the Do-pamine System on the Emotion-Potentiated Startle Reflex. 12. Jans T, Jacob C, Warnke A, Zwanzger U, Matthies S, Borel P, Hänig S, Sobanski E, Colla M, Becker K, Holtmann M, Freitag C, Graf E, Ihorst G, Philipsen A. A randomised controlled trial on trans-generational Attention-Deficit/Hyperactivity Disorder (ADHD) in mothers and children (AIMAC) - outcome of treatment. 11. Philipsen A, Jans T, Graf E, Matthies S, Borel P, Colla M, Gentschow L, Langner D, Jacob C, Groß-Lesch S, Sobanski E, Alm B, Schumacher-Stien M, Roesler M, Retz W, Retz-Junginger P, Kis B, Abdel-Hamid M, Heinrich V, Huss M, Korn-mann C, Bürger A, Perlov E, Berger M, Tebartz van Elst L. Multimodal treatment of adult attention-deficit/hyperactivity disorder - a randomised controlled multicen-tre trial (COMPAS). 10. Fleck K*, Jacob C*, Philipsen A, Graf E, Weyers P, Warnke A, Freitag C, Soban- ski E, Schumacher-Stien M, Becker K, Holtmann M, Kappel V, Jaite C, Jans T. Child impact on family functioning: a multivariate analysis in multiplex families with children and mothers both affected by Attention-Deficit/Hyperactivity Disor-der (ADHD). 9. Jacob C, Gross-Lesch S, Reichert S, Jahns T, Kittel-Schneider S, Nguyen TT, Romanos M, Reif A, Dempfle A*, Lesch KP*. Sex- and subtype-related differ- ences of personality disorders (axis-II) and personality traits in persistent atten-tion-deficit/ hyperactivity disorder. 8. Conzelmann A, Woidich E, Mucha RF, Weyers P, Müller M, Lesch KP, Jacob C, Pauli P. Methylphenidate and Emotional-Motivational Processing in Attention-Deficit/Hyperactivity Disorder. 7. Weber H, Scholz CJ, Jacob C, Heupel J, Kittel-Schneider S, Hempel S, Schmidt B, Geßner A, Domschke K, Zwanzger P, Wittchen HU, Pauli P, Hamm A, Deckert J, Lesch KP, Reif A. Cross-disorder analysis of SPOCK3, a risk gene for adult ADHD, personality and panic disorder. 6. Biehl SC, Gschwendtner KM, Guhn A, Müller LD, Reichert S, Heupel J, Reif A, Deckert J, Herrmann MJ, Jacob C. Does adult ADHD interact with COMT val158met genotype to influence working memory performance? 5. Jacob C, Groß-Lesch S, Jans T, Dempfle A, Reif A, Lesch KP. Internalizing symp- 4. Freitag CM, Nguyen TT, Lempp T, Waltes R, Jacob C, Weißflog L, Romanos M, Renner TJ, Warnke A, Walitza S, Rujescu D, Lesch KP, Reif A. The role of ASTN2-variants in childhood and persistent ADHD, comorbid disorders and per-sonality traits. 3. Weber H, Kittel-Schneider S, Gessner A, Domschke K, Neuner M, Jacob C, But- tenschon HN, Boreatti-Hümmer A, Volkert J, Herterich S, Groß-Lesch S, Kopf J, Kreiker S, Nguyen TT, Weißflog L, Walter U, Mors O, Deckert J, Lesch KP, Reif A. Cross-disorder analysis of bipolar risk genes: exclusion of ANK3 and CACNA1C, but replication of DGKH as a risk gene for bipolar disorder as well as unipolar depression and persisting ADHD. 2. Vasic N, Plichta MM, Wolf RC, Lesch KP, Jacob C, Fallgatter AJ, Sosic-Vasic Z, Grön G. Reduced neural error signaling in left inferior prefrontal cortex in adults with ADHD. 1. Jacob C, Reif A, Gross-Lesch S, Lesch KP. Influence of personality disorders and environmental factors on the course of attention-deficit/ hyperactivity disorder in adults.

10. Jacob C. Peter Riederer ‘‘70th birthday’’ Neurobiological foundations of modern
10.1007/s00702-012-0886-8. Epub 2012 Aug 19.PMID: 22903349 [PubMed - in process]
9. Herrmann MJ, Biehl S, Jacob C, Deckert J. Neurobiological and psychophysio-
logical correlates of emotional dysregulation in ADHD patients. Atten Defic Hy-peract Disord. 2010 Dec;2(4):233-9. Epub 2010 Nov 30. 8. Jacob C, Domscke K, Gajewska A, Warrings B, Deckert J. Neurogenetics of panic disorder - focus on association studies. Expert Rev Neurother. 2010 Aug;10(8):1273-84.
7. Fallgatter A, Jacob C. Sucht und Aufmerksamkeitsdefizit/ Hyperaktivitätsstörun-
gen. Nervenarzt. 2009 Sep;80(9):1015-21.
6. Jacob C, Philipsen A, Ebert D, Deckert J. Multimodale Therapie bei adulten Auf-
merksamkeitsdefizit/ Hyperaktivitätsstörungen. Nervenarzt. 2008 Jul;79(7):801-8.
5. Jacob C, Lesch KP. Genetik des Alkoholmissbrauchs und -abhängigkeit bei adul-

4. Kamolz S, Jacob C, Lesch KP, Pfuhlmann B, Reif A, Keller H, Wiesbeck GA. Die
posttraumatische Belastungsstörung- Teil 1- Eine Übersicht. Krankenhauspsy-chiatrie. 2003;14: 113-118. 3. Jacob C, Pfuhlmann B. Die konfabulatorische Paraphrenie. Krankenhauspsychi-
2. Jacob C. Delinquenz und Persönlichkeitsstörungen. Krankenhauspsychiatrie.
1. Jacob C. Psychopharmakotherapie von Zwangsstörungen. ZNS & Schmerz.

3. Jans T, Jacob C. ADHD in Families, in ADHD in Adults, A Practical Guide to
Evaluation and Management, Editor: Craig B.H. Surman, Springer, Current Clinical Psychiatry 2013, ISBN: 978-1-62703-247-6 (Print) 978-1-62703-248-3 (Online).
2. Domschke K, Jacob C, Gajewska A, Deckert J. Genetik von Angststörungen,
Angststörungen. Klinik, Forschung, Therapie, Hrsg. Rupprecht R, Kellner M, Kohlhammer Verlag. 2012.
1. Jacob C, Lesch KP. Neurobiologie der Komorbidität des ADHS, ADHS und Ko-
morbidität im Kindes- und Erwachsenenalter. Kohlhammer Verlag. 2007.


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1. To clarify the indications for erectile dysfunction. 2. To prescribe the formulary choice vardenafil (Levitra®). Vardenafil, sildenafil (Viagra®) and tadalafil (Cialis®) are phosphodiesterase type-5 (PDE5) inhibitors and are licensed for the treatment of erectile dysfunction. Sildenafil was first introduced in the UK in 1998 and since then, the treatment options have expanded by the introd

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