Bardzo tanie apteki z dostawą w całej Polsce kupic levitra i ogromny wybór pigułek.

Waterproofing polyurethane primer single-component.
Formula number:

Manufacturer: Soprema

Distributors: Soprema
1675 Haggerty Street
44955 Yale Road West
310 Quadral Drive
Drummondville (Quebec) J2C 5P7
Chilliwack (B.-C.) V2R 4H3
Wadsworth (Ohio) 44281
Tel.: 819 478-8163
Tel.: 604 793-7100
Tel.: 1 800 356-3521
In case of emergency:
SOPREMA (8:00am to 5:00pm): 1 800 567-1492
CANUTEC (Canada) (24h.): 613 996-6666
CHEMTREC (USA) (24h.): 1 800 424-9300
Caution! Combustible liquid and vapours. The vapours are heavier than air and may spread long distances to a distant ignition source (such as a pilot light, and
any object that sparks, such as an electric motor) and flash back.
Harmful if inhaled. May cause irritation to eyes, skin and respiratory tract. Harmful or fatal if swallowed. Ingestion of the product can cause severe lung injury
when aspirated. May cause cancer. This product contains isocyanates. May cause allergic or asthmatic symptoms or breathing difficulties if inhaled. May cause
allergic skin reaction. Irritating and/or toxic gases or fumes may be generated by thermal decomposition or combustion.
Dipropylene glycol methyl
ether acetate (DPMA)
diisocyanate (MDI)
propyl] trimethoxysilane
Benzoyl Chloride
(3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: Vapour generated at
ambient temperature should not cause any harmful health effect at short Effects of Short-Term (Acute) Exposure
term. Nevertheless this product can form methanol in case of hydrolysis. Vapours of methanol may cause dizziness, drowsiness, INHALATION
No adverse effects are anticipated from single exposure to
visual troubles and also tingling, numbing and lancinating pains to hands and forearms. This product may cause a sensitization by MDI: MDI has a very low vapour pressure. Therefore, airborne
exposures are unlikely to occur unless MDI is heated or forms an SKIN CONTACT
aerosol or mist during pouring, frothing or spraying operations. Short- DPMA:. DPMA is a non-irritant based on animal information. (1)
term inhalation exposure to isocyanates can cause respiratory and DPMA:. Prolonged exposure not likely to cause significant skin
mucous membrane irritation. Symptoms include eye and nose irritation, dry or sore throat, runny nose, shortness of breath, wheezing and laryngitis. Coughing with chest pain or tightness may also occur, MDI: MDI can cause moderate irritation. Isocyanates, in general, can
frequently at night. These symptoms may occur during exposure or cause skin discolouration (staining) and hardening of the skin after may be delayed several hours. Some people may become sensitized to repeated exposures. Skin sensitization, resulting in dermatitis, may MDI (see Effects of Long-term (Chronic) Exposure for information). occur in some individuals. Skin contact is not expected to result in the High aerosol concentrations could cause inflammation of the lung tissue (chemical pneumonitis), chemical bronchitis with severe asthma- (3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: This product causes
like wheezing, severe coughing spasms and accumulation of fluid in the a minor irritation. It causes the following effects: local malaise and lungs (pulmonary oedema), which could prove fatal. Symptoms of redness. An increase of skin pigmentation can occur. (2) pulmonary oedema may not appear until several hours after exposure and are aggravated by physical exertion. (1) Alsan Trafik HP 510 LO
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Benzoyl Chloride: Benzoyl chloride is corrosive to skin based on
animal information and because it reacts violently with moisture to MDI: Respiratory sensitization has developed in people working with
produce heat, benzoic acid and hydrogen chloride gas, and with air to MDI. The sensitization is usually caused by a very large exposure or by form corrosive fumes. Corrosive materials are capable of producing multiple exposures. Although varying periods of exposure (1 day to severe burns, blisters, ulcers and permanent scarring, depending on the years) may elapse before sensitization occurs, it develops more often concentration of the solution and the duration of contact. No human during the first few months of exposure. Sensitized individuals react to very low levels of MDI (as low as 0.0014 ppm) that have no effect on unsensitized people. At first, the symptoms may appear to be a cold or SKIN ABSORPTION
mild hay fever. However, severe asthmatic symptoms can develop and DPMA: Prolonged skin contact with very large amounts may cause
include wheezing, chest tightness, shortness of breath, difficulty breathing and/or coughing. Fever, chills, general feelings of discomfort, (3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: Prolonged and
headache and fatigue can also occur. Symptoms may occur extended should not cause absorption of potentially harmful amounts of immediately upon exposure, within an hour or several hours after exposure or both and/or at night. Typically the asthma improves with removal from exposure (e.g. weekends and vacations) and returns, in EYE CONTACT
some cases, in the form of an "acute attack", on renewed exposure. DPMA:. DPMA is a mild irritant based on animal information. (1)
Sensitized people who continue to work with MDI may develop DPMA : DPMA may cause slight temporary eye irritation. Corneal
symptoms sooner after each exposure. The number and severity of symptoms may increase. Following removal from exposure, some workers may continue to have persistent respiratory problems such as MDI: Contact with MDI liquid, mist and aerosols may cause slight
asthmatic symptoms, bronchial problems and hypersensitivity to MDI. irritation with tearing and discomfort. (1) Others may recover fully and may gradually lose their sensitivity (3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: This product causes
within several years. MDI may also cause hypersensitivity a light irritation. It causes the following effects: malaise, pain, pneumonitis, another allergic lung disease, which is characterized by excessive blinking of the eyes, watering of the eyes, excessive and symptoms such as shortness of breath, fever, tiredness, non-productive m rked redness at the conjunctiva, swelling at the conjunctiva. (2) cough, and chills. Several studies have shown that continued exposure to low levels of MDI and other isocyanates may cause impaired lung Benzoyl Chloride: Benzoyl chloride is corrosive to eyes based on
function, such as diminished respiratory capacity. Other studies have animal information and because it reacts violently with moisture to shown that extremely low levels of MDI (e.g. less than 0.003 ppm) do produce heat, benzoic acid and hydrogen chloride gas, and with air to not decrease lung function. Cross-sensitization between different form corrosive fumes. Corrosive materials are capable of producing isocyanates may occur. People sensitized to toluene diisocyanate (TDI) severe eye burns, and permanent injury, including blindness, depending or hexamethylene diisocyanate (HDI) may show sensitization to MDI, on the concentration of the solutions and duration of contact. No human aving previous exposure to this chemical. (1) SKIN SENSITIZATION
MDI: Allergic contact dermatitis has developed from occupational
DPMA: Very low toxicity if swallowed. Harmful effects not
contact with MDI. It has been proposed that a break-down (hydrolysis) anticipated from swallowing small amounts. (2) people showed reaction to MDA as well as MDI, while one showed MDI: There have been no reports of human ingestion of MDI. Animal
studies indicate that the toxic effects of the ingestion of MDI are slight. CARCINOGENICITY
Ingestion could result in irritation and corrosion of the mouth, throat, MDI: The risk of cancer associated with exposure to isocyanates has
been examined in 4 human population studies. No strong association or (3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: This product
consistent pattern has been observed. There is one isolated report of a hydrolyses in the stomach to form methanol. May cause nauseas, non-smoking painter who developed lung cancer after being exposed to abdominal pains, vomiting, headaches, dizziness, shortness of breath, MDI and TDI for 15 years. He also had a 10-year history of lung weakness, fatigue, leg cramps, agitation, confusion, and behaviour of disease thought to be caused by exposure to MDI and TDI. It is not drunk person, visual troubles, drowsiness, coma and death. There can possible to draw any conclusions from this case report. The have a delay of many hours between ingestion of methanol and International Agency for Research on Cancer (IARC) has determined appearance of signs and symptoms. The observed effects were partly there is inadequate evidence for the carcinogenicity of MDI or caused by the acidosis and partly by cerebral oedema. The visual polymeric MDI in humans. There is limited evidence for the effects consist of: a blurred vision, a diplopia, a change in the colour carcinogenicity of a mixture containing MDI and polymeric MDI in perception, a restriction of the visual field and a total blindness. experimental animals. IARC has concluded that this chemical is not Ingestion of moderate amounts of methanol also produces a metabolic classifiable as to its carcinogenicity to humans (Group 3). The acidosis. Appearance of symptoms can occur 48 hours after ingestion. American Conference of Governmental Industrial Hygienists (ACGIH) A dose of 60-200 ml of methanol is fatal for most of adults. Ingestion has not assigned a carcinogenicity designation to this chemical. The US of amounts as low as 10 ml caused blindness. Massive overdoses can National Toxicology Program (NTP) has not listed this chemical in its cause liver, kidney and myocardium injuries. (2) Effects of Long-Term (Chronic) Exposure
Benzoyl Chloride: Small human population studies have shown an
increase in lung cancers in employees with combined exposure to INHALATION
benzoyl chloride and alpha-chlorinated toluenes. IARC has determined (3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: Long-term repeated
that there is limited evidence for the combined exposure of overexposure at concentrations of methanol vapours of 3000 ppm or alphachlorinated toluenes and benzoyl chloride to humans. There is more may cause a cumulative effect causing nausea, vomiting, inadequate evidence for the carcinogenicity of benzoyl chloride to headaches, buzzing ears, insomnia, trembling, unsteady gait, dizziness, experimental animals. IARC has concluded that this chemical is blurred vision and diplopia. Liver and/or kidney injuries can occur. probably carcinogenic to humans (Group 2A). Combined exposures to Prolonged overexposure to concentrations of 800 and 1000 ppm can apha-chlorinated toluenes and benzoyl chloride. ACGIH has designated cause severe ocular injuries on certain persons. (2) this chemical as not classifiable as a human carcinogen (A4). NTP has LUNGS/RESPIRATORY SYSTEM
not listed this chemical in its report on carcinogens. (1) MDI: Exposure to isocyanates is likely to cause aggravation to
individuals with existing respiratory disease, such as chronic bronchitis MDI: No human or animal information is available. (1)
Alsan Trafik HP 510 LO
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MDI: No human or animal information is available. (1)
Evacuate area. Wear self-contained breathing apparatus and appropriate protective clothing in accordance with standards. Approach fire from MUTAGENICITY
upwind and fight fire from maximum distance or use unmanned hose MDI: In one case report, MDI caused DNA damage in human white
holders or monitor nozzles. Always stay away from containers because blood cells after inhalation exposure to 5 to 20 ppb. This report of the high risk of explosion. Stop leak before attempting to put out the provides insufficient information for determining the mutagenicity of fire. If leak cannot be stopped, and if there is no risk to the surrounding MDI. No other human or animal in vivo studies have been reported. area, let the fire burn itself out. Move containers from fire area if this MDI induced chromosome aberrations in cultured human lymphocytes, can be done without risk. Cool containers with flooding quantities of with and without metabolic activation. It only marginally increased sister chromatid exchanges at a high dose, with and without metabolic EXTINGUISHING MEDIA
2, foam. Use of water spray when fighting fire may be inefficient because of the low flash point of the product. MDI: No information was located. (1)

MDI: MDI can enter the body by inhalation or ingestion. It is probably
metabolized to 4,4’-methylene dianiline, which is metabolized further Ventilate area. Wear appropriate protective equipment during cleanup. Eliminate all sources of ignition. Shut off source of leak if you can do it HEALTH COMMENTS
without risk. Contain the spill. Absorb or cover with dry earth, sand or MDI: In many reports it is not clear whether pure MDI or polymeric
other non-combustible material and transfer to containers. Sweep or MDI (PMPPI [polymethylene polyphenyl isocyanate], commonly about shovel into containers with lids, use clean non-sparking tools (sp.: 50% MDI) was being used. In addition, problems with common plastic) to collect absorbed material. Cover and remove to appropriate airborne MDI sampling methods may affect the interpretation of well ventilated area until disposal. Do not touch or walk through spilled laboratory and workplace exposure studies. (1) material. Wash spill area with soap and water. Prevent entry into waterways, sewers, basements or confined areas. Dispose of material SECTION IV: FIRST AID MEASURES
according to the local environmental regulations.
Remove contaminated clothing. Wash thoroughly with soap and water. HANDLING
I rritation persists, get medical attention. This product and its vapours are combustible and toxic. Avoid contact EYE CONTACT
with eyes, skin and clothing. Do not ingest. Avoid breathing mist, Flush thoroughly with water for at least 15 minutes. If irritation vapour or dust. Wash hands thoroughly after handling. Before handling, it is very important that ventilation controls are operating and protective equipment requirements are being followed. People working INHALATION
with this product should be properly trained regarding its hazards and In case of gas or vapour inhalation, move victim to fresh air. If its safe use. Eliminate all ignition sources (e.g. sparks, open flames, hot breathing is difficult, give oxygen. If breathing stops, give respiratory surfaces). Keep away from heat. Ground transfer containers to avoid static accumulation. Tightly reseal all partially used containers. Do not SWALLOWING
Do not induce vomiting. Immediately contact local poison control centre. Should vomiting occur, be sure to keep the victim’s head below Store in a cool well-ventilated area out of direct sunlight and away hips to avoid aspiration of vomit into the lungs. Maintain the victim at from heat and ignition sources. Keep storage areas clear of combustible rest and obtain immediate medical attention. materials. No smoking near storage area. Store away from incompatible materials. Store the product according to occupational health and safety SECTION V: FIRE-FIGHTING MEASURES
regulations and fire and building codes. Storage area should be clearly identified, clear of obstruction and accessible only to trained and FLAMMABILITY:
authorized personnel. Inspect periodically for damage or leaks. Have EXPLOSION DATA: Sensitivity to mechanical impact: No
appropriate fire extinguishers and spill clean-up equipment near storage area. Inspect all containers to make sure they are properly labelled. FLASH POINT:
FLAMMABILITY LIMITS IN AIR: (% in volume) Not available
HANDS: Wear gloves made from polyvinyl alcohol (PVA) or nitrile.
This product and its vapours may ignite by heat, sparks or flames. RESPIRATORY: If the TLV is exceeded, if use is performed in a
Vapours may form explosive mixtures with air. Vapours are heavier poorly ventilated confined area, use an approved respirator in than air and may travel a considerable distance to a source of ignition and flash back to a leak or open container. The product may ignite on EYES: Wear chemical safety goggles in accordance with standards.
contact with strong oxidizing agents. Do not cut, puncture or weld OTHERS: Eye bath and safety shower.
CONTROL OF VAPOURS: Local exhaust is needed to control
vapour and dust level to below recommended limits. Irritating and/or toxic gases or fumes may be generated by thermal SECTION IX: PHYSICAL AND CHEMICAL PROPERTIES
decomposition or combustion. Toxic and/or irritating gases or fumes can emanate from empty containers when submitted to high PHYSICAL STATE: Liquid
temperatures. Combustion of this product may release: gaseous ODOUR AND APPEARANCE: Transparent liquid with strong odour
hydrocarbons, hydrogen fluoride, hydrogen chloride, carbon oxides, ODOUR THRESHOLD: Not
formaldehyde, acetaldehyde, methylglyoxal, nitrogen oxides, hydrogen VAPOUR DENSITY (air = 1): 6.24
cyanide, silicon oxides, phosgene, hydrochloric acid and other irritating EVAPORATION RATE (Butyl acetate = 1): Not
BOILING POINT (760 mm Hg): Not
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Benzoyl Chloride: (1)
100 Centipoises (Visco Brookfield, 25°C) SECTION X: STABILITY AND REACTIVITY
DPMA: DPMA (mixed isomers) is a mild irritant. (1)
STABILITY: This material is stable at handling and storage
conditions recommended under the Section VII. MDI: MDI has been reported to cause slight eye irritation in
CONDITIONS OF REACTIVITY: Avoid excessive heat. MDI is
readily dimerized and trimerized by heat. Exposed to high Benzoyl Chloride : Benzoyl chloride is corrosive. Application of 0.1 of
temperatures, this product can emit dangerous decomposition products benzoyl chloride was corrosive in rabbits. No scoring information was such as fumes, carbon oxide, nitrogen oxide, trace of hydrocyanic acid, trace of formaldehyde, trace of hydrochloric acid. SKIN IRRITATION

INCOMPATIBILITY: Keep away from oxidizing agents and from
DPMA: DPMA (mixed isomers) is a non-irritant. (1)
highly acid and basic materials to avoid exothermic reactions. MDI: Application of 0.5 ml MDI (under a cover for 24 hours) caused
Strong oxidizing agents – Reacts violently with fire or explosion risk.
slight (92 to 94% MDI) to moderate irritation (95% MDI) in rabbits. (1) Water – Reacts non-violently at room temperature with release of heat
to form carbon dioxide and inert material made up of polyureas which Benzoyl Chloride: Prolonged exposure (24-hour) to benzoyl chloride
could rupture closed containers. Toluenendiamine is formed as an caused corrosion. Application of 0.5 ml benzoyl chloride, under a cover intermediate product in the reaction. Above 50°C, the reaction becomes for 24 hours, was corrosive to the ears of rabbits. No scoring Amines, alcohols, acids, or bases – May react violently with
Effects of Short-Term (Acute) Exposure
generation of heat and flammable compounds. Metal compounds (e.g. organometallic catalysts, such as organotin
compounds) – May polymerize with the generation of heat and MDI: MDI has a very low vapour pressure and it is difficult to achieve
vapour concentrations necessary for inhalation toxicity testing. Alkaline metals – The reaction is exothermal and flammable
Therefore, inhalation toxicity studies have focused on the effects of the aerosol. No significant effects were found when rats were exposed to 2, Halogens – The reaction is exothermal and flammable compounds can
5 and 15 mg/m³ of MDI aerosol for 6 hours/day, 5 days/week for 2 weeks. The overall effect was a decline in respiratory rate which was Amides, phenols, mercaptans, urethanes, ureas and surface active
determined to be due mainly to MDI’s action as a pulmonary irritant. agents (surfactants, e.g. non ionic detergents) – May react vigorously
The RD50 (concentration required to reduce the respiratory rate by or violently with the generation of heat. HAZARDOUS DECOMPOSITION PRODUCTS: This product
reacts with water and causes an emanation of carbonic gas which would (3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: Irritating. Moderate
lead to pressure increasing in closed containers. Peroxides can also EYE CONTACT
(3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: Irritating. Severe
uncontrolled exothermic polymerization upon contact with incompatible materials, especially strong bases, such as triethylamine INGESTION
and sodium hydroxide, trialkyl phosphines, potassium acetate, many MDI: Rats were given daily doses of 4.3 to 5 g/kg for 5 days. The only
metal compounds soluble in organic media, or if heated above 204°C. effect was a slight enlargement of the spleen in 2 of 5 rats. (1) The resulting pressure build-up could rupture closed containers. Effects of Long-Term (Chronic) Exposure
very reactive compounds and are highly reactive toward a large number INHALATION
of compounds with active hydrogens, particularly at high temperatures (3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: In rats, the repeated
exposure to a breathable aerosol of an hydrolysate of this product did not cause any injury to the respiratory tract and did not show any sign SECTION XI: TOXICOLOGICAL INFORMATION
MDI: The sensitizing potency of MDI was investigated using the
DPMA: (1)
mouse ear-swelling test (MEST). The dose required to sensitize 50% of the animals was 0.73 mg/kg. In this test, MDI was less potent than hexamethylene diisocyanate (HDI) and dicyclohexylmethane diisocyanate (HMDI), but more sensitizing than toluene diisocyanate MDI: (1)
(TDI). Cross reactivity was observed between MDI and HDI, HMDI
(3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: Negative results in a
test of mark in human (Human Patch Test). (2) TERATOGENICITY, EMBRYOTOXICITY, FETOTOXICITY
(3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: (2)
(3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: In a study of toxicity
on the development during which the product was given by a stomach tube to rats during the period of organogenesis, the only effect noticed was a very slight fetotoxicity at 3000 mg/kg/day (ossification reduced on one side) in presence of maternal toxicity but no embryotoxic or Alsan Trafik HP 510 LO
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teratogenic effect. No effect has been noticed at 500 and 1500 HMIS (USA):

MDI: It is not possible to conclude that MDI is mutagenic. There are
Reactivity (water)
Reactivity (water)
no studies available using cultured animal cells. MDI has produced Protective equipment
Specific hazard
mostly negative results in short-term bacteria tests. (1) SECTION XVI: OTHER INFORMATION
(3-[2,3-Epoxypropoxy] propyl) trimethoxysilane: Ester of organosilane
shows to be slightly mutagenic in the following in vitro procedures: Glossary:
Ames test, test on mouse lymphoma and test of sister chromatid exchange. It is unlikely that this product presents an important American Society for Testing and Materials genotoxic hazard, because there were no local oncogenic reactions following the repeated chronic application on mouse skin. (2) Department of Transportation (United States) CARCINOGENICITY
Environmental Protection Agency (United States) MDI: There is no animal information on the carcinogenicity of MDI
itself. IARC has determined there is limited evidence for the LD50/LC50: Less high lethal dose and lethal concentration published
carcinogenicity of a mixture containing monomeric and polymeric MDI National Fire Protection Association (United States) Occupational Safety & Health Administration (United Benzoyl Chloride: Small numbers of skin tumours have been observed
following the skin application of benzoyl chloride to mice. Inhalation Resource Conservation and Recovery Act (United exposure has produced no significant increase in tumour incidence in mice. IARC has concluded that there is inadequate evidence for the carcinogenicity of benzoyl chloride to experimental animals. (1) TLV-TWA: Threshold Limit Value – Time-weighted average
Workplace Hazardous Materials Information System SECTION XII: ECOLOGICAL INFORMATION
Do not allow product or runoff from fire control to enter storm or (1) CHEMINFO (2009) Canadian Centre of Occupational Health and sanitary sewers, lakes, rivers, streams, or public waterways. Block off drains and ditches. Provincial and federal regulations may require that environmental and/or other agencies be notified of a spill incident. Spill area must be cleaned and restored to original condition or to the Code of MSDS:
satisfaction of authorities. May be harmful to aquatic life. This MSDS has been prepared by: Michel
For more information: 1-800-567-1492
The Material Safety Data Sheets of SOPREMA Canada are available This product is listed as hazardous waste. Consult local, state, provincial or territory authorities to know disposal methods. Also listed as hazardous waste by the RCRA (USA); waste disposal as to follow Justification of the update:
EPA regulations. Do not dispose of waste with normal garbage or This MSDS contains all the information required by ANSI Z-400.1-1998 SECTION XIV: TRANSPORT INFORMATION
standard (United States), by regulation 29 CFR Part 1910.1200 of the Hazard Communication Standard of OSHA, and is in accordance with standard CLASSIFICATION (TDG – DOT): Not regulated.

To the best of our knowledge, the information contained herein is accurate.
SHIPPING NAME: Not applicable.
However, neither the above named supplier nor any of its subsidiaries
PACKING GROUP: Not applicable.
assumes any liability whatsoever for the accuracy or completeness of the
information contained herein. Final determination of suitability of any
material is the sole responsibility of the user. All materials may present
unknown hazards and should be used with caution. Although certain
hazards are described herein, we cannot guarantee that these are the only
WHMIS: Class
B3: Combustible liquid (flash point between hazards that exist.
Class D2A: Very toxic material causing other effects. Class D2B: Toxic and infectious material - Other effects – Toxic (MDI: skin irritation, skin sensitization) All constituents of this product are included on the Domestic Substances List (DSL – Canada) TSCA: All constituents of this product are included on the Toxic
Substances Control Act Inventory (TSCA – United States). Alsan Trafik HP 510 LO
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Page 5 of 5


capítulo 8 • Mitos y realidades, dudas y críticasExiste una serie de mitos y conceptos falsos acerca del uso clínico del litio. Éstos no solamente circulan entre los pacientes sino entre muchos profesionales. Actualmente el litio sigue siendo un fárma-co fundamental para el tratamiento de los trastornos bipolares, de la agresividad y de la suicidalidad. En todas las guías o algoritmos d

Pii: s1471-4906(01)01985-8

Research Update TRENDS in Immunology Vol.22 No.8 August 2001the sphingosine kinase pathway. Proc. Natl. Acad. 4 Kwak, B. et al. (2000) Statins as a newlyrecognized type of immunomodulator. Nat. Med. specificity and produce side-effects. 5 Proudfoot, A.E. et al. (2000) The strategy ofblocking the chemokine system to combat disease. 6 Reedquist, K.A. et al. (2000) The small GTPase,

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