Die Struktur von Tadalafil erlaubt eine selektive Bindung an die Bindungsstelle der PDE5 und minimiert gleichzeitig die Interaktion mit PDE6, was visuelle Nebenwirkungen einschränkt. Seine Verteilung im Organismus erfolgt breit, wobei das Verteilungsvolumen etwa 63 Liter beträgt. Über 90 % des Wirkstoffs sind an Plasmaproteine gebunden. Die Wirkung bleibt unabhängig von der Nahrungsaufnahme konstant. Der Abbauweg über CYP3A4 kann durch Hemmer wie Ritonavir oder Ketoconazol verlangsamt werden, was die Plasmakonzentrationen deutlich erhöht. In diesem Kontext wird cialis 20mg preis häufig in Bezug auf pharmakokinetische Wechselwirkungen erwähnt.

Macular.org

MEDICATIONS TO USE WITH CAUTION
No summary can take the place of careful discussions with your health care professionals. Few patients consider visual symptoms as being related to their medicine. However, when you realize that your eyes are really just an extension of your brain, an organ which is extremely sensitive to many drugs, it is not surprising that vision can be impaired by a host of medications. The National Registry of Drug-Induced Ocular Side Effects has published the following list of drugs which might be associated with macular degeneration. The drugs with more tenuous links to macular degeneration are followed by a question (?) mark. The generic name is in bold type and followed by various proprietary names from around the world. If you have any questions or want more information about any drug on this list and its possible links to macular degeneration, talk to your prescribing physician and/or ophthalmologist. You may also want to discuss whether the use of a drug on this list outweighs the increased risk of side effects compared with other treatments. Be sure to mention any prescribed or over the counter medications and other supplements you're taking. Describe any side effects you may have experienced. Remember, no summary can take the place of careful discussions with your health care professionals. Macular Edema
Acetazolamide
Defiltran (Fr.), Diamox, Diazol (S. Afr.), Didoc (Jap.), Diuramid (Pol.), Glaucomide
(Austral.), Glaupax (Swed.), Hydrazol
Allopurinol (?)
Bloxanth (Canad.), Epidropal (Germ.), Foligan (Germ.), Lopurin, Urosin (Germ.),
Zyloprim, Zyloric (G.B.)
Aluminum Nicotinate
Nicalex
Betaxolol (?)
Betoptic
Broxyquinoline
Colipar (Fr.), Fenilor (Belg., Germ.)
Chymotrypsin (?)
Alpha Chymar, Alphacutanee (Fr.), Alphlozyme (Fr.), Catarase, Chymar (G.B.), Chymar-
Zon (G.B.), Enzeon, Kimopsin (Austral., Jap.), Quimotrase (Canad.), Zolyse, Zonulyn
(Canad.), Zonulysin (G.B.)
Diclorphenamide
Daranide, Oralcon (Swed.), Oratrol
Dipivefrin (?)
Propine
DPE (?)
Propine
Epinephrine
Adremad (Fr.), Adrenalin, Adrenaline (G.B.), Adrenatrate, Asmatane, Asmolin, Asthma
Meter, Bronkaid, Dysne-Inhal (Canad.), Dyspne (Austral.), Glin-Epin (Austral.),
Glycirenan (Germ.), Intranefrin (Canad.), Liadren (Ital.), Medihaler-Epi, Micronefrin,
Primatene, Suprarenin, Sus-Phrine, Vaponefrin, Adrenaline (G.B.), El/2, E2, Epifrin,
Epinal, Epitrate, Eppy, Glaucon, Glauconin (Swed.), Glaufrin (Swed.), Lyophrin (G.B.),
Mistura E, Mytrate, Simplene (G.B.)
Ethoxzolamide
Ethamide
Griseofulvin
Fulcin (G.B.), Fulvicin-P/G, Fulvicin-U/F, Grifulvin V, Grisactin, Grisefuline (Fr.),
Grisovin (G.B.), Grisowen, Gris-PEG, Lamoryl (Swed.), Likuden M (Germ.)
Hexamethonium
Hexamethonium
Indomethacin (Indometacin) (?)
Amuno (Germ.), Confortid (Swed.), Imbrilon (G.B.), Inacid (Span.), Indacin (Jap.),
Indocid (G.B.), Indocin, Indomee (Swed.), Infrocin (Canad.), Metindol (Pol.), Mezolin
(Jap.)
Iodide and Iodine Solutions and Compounds
Aqueous Iodine Solution (G.B.), Compound Iodine Solution, Iodex (G.B.), Jodex
(Germ.), Lugol's Solution, Pima, Solute Iodo-Iodure Fort (Fr.), Strong Iodine Solution,
Teinture d'Iode (Fr.), Trivajodan (Germ.), Weak Iodine Solution (G.B.), Iodine Solution
Iodochlorhydroxyquin
Budoform (Austral.), Chinoform (G.B.), Clioquinol (G.B.), Enteroquin (Austral.),
Enteritan (Ital.), Entero-Valodon (G.B.), Entero-Vioform (G.B.),
Iodochlorhydroxyquinoline (Ind.), Vioform
Iodoquinol (Diiodohydroxyquinoline)
Diiodohydroxyquin, Diodoquin, Direxiode (Austral., Fr.), Embequin (G.B.), Floraquin,
Florequin (Swed.), Ioquin (Fr.), Moebiquin, Panaquin, Vaam-DHQ (Austral.), Yodoxin
Iothalamate Meglumine and/or Sodium
Angio-Conray, Cardio-Conray (Austral., G.B.), Conray, Contrix (Belg., Fr.), Cysto-
Conray, Gastro-Conray (Austral., G.B.), Retro-Conray (Austral., G.B.), Sombril (Span.),
Vascoray
Iothalamic Acid
Conray
Levobunolol (?)
Betagan
Methazolamide
Neptazane
Naproxen (?)
Anaprox, Naprosyn, Naxen (Mex.), Proxen (Aust., Germ., Switz.)
Niacin (Nicontic Acid)
Acidemel (S. Afr.), Diacin, Efacin, Niac, Nicangin (Swed.), Nico-400, Nicobid, Nicocap,
Nicolar, Niconacid (Germ.), Ni Cord, Nico-Span, Nicotinex, Nicyl (Fr.), NiSpan, SK-
Niacin, Span Niacin, Vasotherm, Wampocap
Niacinamide
Nicamid (Switz.), Nicobion (Fr., Germ.), Nicotamide (Fr.)
Nicotinyl Alcohol
Roniacol
Phenylephrine (?)
Neo-Synephrine, Ak-Dilate, Ak-Nefrin, Alcon-Efrin, Degest (Austral., Canad.), Dilatair,
Efricel, I-Care (Austral.), Isopto Frin, Isopto Phenylephrine (Austral.), Mistura D,
Mydfrin, Neo-Synephrine, Ocu-Phrin, Ocugestrin, Prefrin, Tear-Efrin
Quinine
Bi-quinate (Austral.), Coco-Quinine, Dentojel (Canad.), Quinamm, Quinate (Austral.),
Quinbisan (Austral.), Quine, Quinsan (Austral.)
Radioactive iodides
Iodotope I-125, Iodotope I-131, Iodotope Therapeutic, Sodium Iodide (I-125), Sodium
Iodide (I-131)
Tamoxifen
Nolvadex
Timolol (?)
Betim (G.B., Neth., Scand.), Blocadren, Blocanol (Fin.), Proflax (Arg.), Temserin
(Germ., Gr.), Timacor (Denm., Fr.), Timoptic, Timoptol (Austral., Fr., G.B., Neth., N.Z., S. Afr.) Macular or Paramacular Degeneration
Allopurinol (?)
Bloxanth (Canad.), Epidropal (Germ.), Foligan (Germ.), Lopurin, Urosin (Germ.),
Zyloprim, Zyloric (G.B.)
Amodiaquinne
Basoquin (G.B.), Camoquin, Flavoquine (Fr.)
Broxyquinoline
Colipar (Fr.), Fenilor (Belg., Germ.)
Chloroquine
Aralen, Arechin (Pol.), Avoclor (G.B.), Chlorocon, Chlorquin (Austral.), Malaquin
(Austral.), Malarex (Denm.), Malarivon (G.B.), Nivaquine (G.B.), Resochin (G.B.),
Roquine, Siragan (Aust.), Tresochin (Swed.)
Clonidine (?)
Catapres, Catapresan (Germ., Swed.), Catapressan (Fr.), Dixarit (G.B.) Isoglaucon
(Germ.)
Griseofulvin (?)
Fulcin (G.B.), Fulvicin-P/G, Fulvicin-U/F, Grifulvin V, Grisactin, Grisefuline (Fr.),
Grisovin (G.B.), Grisowen, Gris-PEG, Lamoryl (Swed.), Likuden M (Germ.)
Hydroxychloroquine
Ercoquin (Norw., Swed.), Plaquenil, Plaquinol (Port.), Quensyl (Germ.)
Ibuprofen (?)
Advil, Algofen (Ital.), Amersol (Canad.), Andran (Jap.), Anflagen (Jap.), Apsifen (G.B.),
Bluton (Jap.), Brufanic (Jap.), Brufen (Austral., Belg., Fr., G.B., Germ., Ital., Jap., Neth.,
S. Afr., Scand., Span., Swed., Switz.), Donjust B (Jap.), Ebufac (G.B.), Emodin (Arg.),
Epobron (Jap.), Focus (Ital.), IB-100 (Jap.), Ibu-Slo (G.B.), Ibuprocin (Jap.), Inflam
(Austral.), Inza (S. Afr.), Lamidon (Jap.), Liptan (Jap.), Medipren, Motrin, Mynosedin
(Jap.), Nagifen-D (Jap.), Napacetin (Jap.), Nobfelon (Jap.), Nobgen (Jap.), Nuprin,
Pantrop (Jap.), Rebugen (Ital.), Roidenin (Jap.), Rufen, Trendar
Indomethacin (Indometacin) (?)
Amuno (Germ.), Confortid (Swed.), Imbrilon (G.B.), Inacid (Span.), Indacin (Jap.),
Indocid (G.B.), Indocin, Indomee (Swed.), Infrocin (Canad.), Metindol (Pol.), Mezolin
(Jap.)
Iodochlorhydroxyquin
Budoform (Austral.), Chinoform (G.B.), Clioquinol (G.B.), Enteroquin (Austral.),
Enteritan (Ital.), Entero-Valodon (G.B.), Entero-Vioform (G.B.),
Iodochlorhydroxyquinoline (Ind.), Vioform
Iodoquinol
Diiodohydroxyquin, Diodoquin, Direxiode (Austral., Fr.), Embequin (G.B.), Floraquin,
Florequin (Swed.), Ioquin (Fr.), Moebiquin, Panaquin, Vaam-DHQ (Austral.), Yodoxin
Quinine
Bi-quinate (Austral.), Coco-Quinine, Dentojel (Canad.), Quinamm, Quinate (Austral.),
Quinbisan (Austral.), Quine, Quinsan (Austral.)
This List has been compiled by the
National Registry of Drug-Induced Ocular Side Effects
Oregon Health Sciences University
3181 S.W. Sam Jackson Park Road
Portland, Oregon 97201

Source: http://macular.org/sites/default/files/pictures/pdf/drugprint.pdf