Die Struktur von Tadalafil erlaubt eine selektive Bindung an die Bindungsstelle der PDE5 und minimiert gleichzeitig die Interaktion mit PDE6, was visuelle Nebenwirkungen einschränkt. Seine Verteilung im Organismus erfolgt breit, wobei das Verteilungsvolumen etwa 63 Liter beträgt. Über 90 % des Wirkstoffs sind an Plasmaproteine gebunden. Die Wirkung bleibt unabhängig von der Nahrungsaufnahme konstant. Der Abbauweg über CYP3A4 kann durch Hemmer wie Ritonavir oder Ketoconazol verlangsamt werden, was die Plasmakonzentrationen deutlich erhöht. In diesem Kontext wird cialis 20mg preis häufig in Bezug auf pharmakokinetische Wechselwirkungen erwähnt.

Microsoft word - mc_stockley_aug08_quarter_update.doc

What’s new in Stockley’s Drug Interactions
Changes for the August 2008 update

Stockley’s Drug Interactions is continually undergoing re-validation
and revision. Each quarter, new and revised sections will be
published on MedicinesComplete. This is a list of the changes made
since the last update.

Revised Chapters or Chapter Sections – the content has been
systematically re-validated and updated
Alcohol
Anorectics and Stimulants
New Monographs
Mifepristone + Miscellaneous
Paricalcitol + Miscellaneous
Sitaxentan + Miscellaneous
SNRIs; Venlafaxine + Atomoxetine
SNRIs; Venlafaxine + Sibutramine
SNRIs; Venlafaxine + Terbinafine
SSRIs + Methylphenidate
SSRIs + Terbinafine
Terbinafine + Miscellaneous
Selective Updates – monographs with some new, re-validated or
changed information (includes minor amendments)
5-HT3-receptor antagonists + Drugs that prolong the QT ACE inhibitors + Dialysis or Transfusion membranes ACE inhibitors + Diuretics; Potassium-sparing ACE inhibitors + NSAIDs ACE inhibitors and Angiotensin II receptor antagonists + Epoetin Alpha blockers + Aspirin or NSAIDs Alpha blockers + Beta blockers Alpha blockers + Calcium-channel blockers Alpha blockers + Cimetidine Alpha blockers + CYP3A4 or CYP2D6 inhibitors Alpha blockers + Diuretics Alpha blockers + Dutasteride or Finasteride Alpha blockers + Food Amfetamines and related drugs + Lithium Amfetamines and related drugs + Phenothiazines Amiodarone + Anaesthesia Amiodarone + Antihistamines Amiodarone + Beta blockers Amiodarone + Calcium-channel blockers Amiodarone + Disopyramide Amiodarone + Lithium Amiodarone + Macrolides Amiodarone + Oxygen Amiodarone + Protease inhibitors Amiodarone + Quinolones Amphotericin B + Antineoplastics Anaesthetics, general + Antihypertensives Anaesthetics, general + Methylphenidate Angiotensin II receptor antagonists + Aspirin or NSAIDs Angiotensin II receptor antagonists + Diuretics; Potassium-sparing Antidiabetics + Azoles; Miscellaneous Antidiabetics + Clonidine Antidiabetics + Disulfiram Antidiabetics + SSRIs Antiepileptics + Mefloquine Antiplatelet drugs + Aspirin Antiplatelet drugs + Food Antiplatelet drugs + NSAIDs Antipsychotics + SSRIs Azoles + Cola drinks Azoles + Food Azoles + H2-receptor antagonists Azoles + Proton pump inhibitors Azoles + Rifabutin Azoles + Rifampicin (Rifampin) and/or Isoniazid Benzodiazepines + Antiepileptics; Phenytoin Benzodiazepines + Modafinil Benzodiazepines + St John's wort (Hypericum perforatum) Benzodiazepines and related drugs + Protease inhibitors Benzodiazepines and related drugs + SNRIs Benzodiazepines and related drugs + SSRIs Beta blockers + Bupropion Beta blockers + Calcium-channel blockers; Verapamil Beta blockers + SSRIs Beta-agonist bronchodilators + Potassium-depleting drugs Bisphosphonates + Aspirin or NSAIDs Bisphosphonates + Polyvalent cations Bosentan + Azoles Bupropion + Antiepileptics Bupropion + Antiretrovirals Bupropion + Benzodiazepines and related drugs Bupropion + MAOIs and related drugs Bupropion + Miscellaneous Busulfan + Phenytoin Calcium-channel blockers + Diuretics Calcium-channel blockers + Grapefruit juice Calcium-channel blockers + Magnesium compounds Calcium-channel blockers + Protease inhibitors Calcium-channel blockers + Quinupristin/Dalfopristin Calcium-channel blockers + Rifampicin (Rifampin) Calcium-channel blockers + St John's wort (Hypericum perforatum) Calcium-channel blockers + Valproate Carbamazepine + Azoles Ciclosporin + Azoles Ciclosporin + Beta blockers Ciclosporin + Bosentan Ciclosporin + Fibrates Ciclosporin + Modafinil Ciclosporin + Protease inhibitors Ciclosporin + Sibutramine Ciclosporin + Terbinafine Clopidogrel + Miscellaneous Clozapine + Miscellaneous Corticosteroids + Azoles; Voriconazole Corticosteroids + Mifepristone Coumarins + Alpha blockers Coumarins + Antineoplastics; Fluorouracil and related prodrugs Coumarins + Antiplatelet drugs; Ticlopidine Coumarins + Azoles; Voriconazole Coumarins + Bosentan Coumarins + Broxuridine Coumarins + Calcium-channel blockers Coumarins + Foods; Mango fruit (Mangifera indica) Coumarins + Herbal medicines; St John's wort (Hypericum perforatum) Coumarins + Herbal medicines; Vitamin K1–rich Coumarins + Mefloquine Coumarins + Methylphenidate Coumarins + Phosphodiesterase type-5 inhibitors Coumarins + Protease inhibitors Coumarins + Proton pump inhibitors Coumarins + Sevelamer Coumarins + SNRIs Coumarins and related drugs + Antiplatelet drugs; Cilostazol Coumarins and related drugs + Antiplatelet drugs; Clopidogrel Coumarins and related drugs + Vitamin K substances Cyclophosphamide + Metronidazole Cycloserine + Ethionamide Digitalis glycosides + Alpha blockers Digitalis glycosides + Chinese herbal medicines Digitalis glycosides + Diuretics; Potassium-sparing Digitalis glycosides + Drugs that affect calcium Digitalis glycosides + Herbal medicines; St John's wort (Hypericum perforatum) Drugs that prolong the QT interval + Other drugs that prolong the QT interval Enteral feeds + Aluminium compounds and/or Sucralfate Eplerenone + CYP3A4 inducers Eplerenone + CYP3A4 inhibitors Eplerenone + Miscellaneous Ergot derivatives + Antidepressants Ergot derivatives + Macrolides Fibrates + Bile-acid binding resins Flecainide + Amiodarone Flecainide + SSRIs Furosemide + Sevelamer Halofantrine + Miscellaneous Haloperidol + Venlafaxine Heparin and LMWHs + Antiplatelet drugs Hormonal contraceptives + Modafinil Hormonal contraceptives + NNRTIs Hormonal contraceptives + Retinoids Hormonal contraceptives + St John's wort (Hypericum perforatum) Hormonal contraceptives + Terbinafine Hormonal contraceptives or HRT + Azoles Hormonal contraceptives or HRT + Bosentan Hormonal contraceptives or HRT + Protease inhibitors Hormonal contraceptives or HRT + Triptans Imatinib + CYP3A4 inducers Imatinib + CYP3A4 inhibitors Imatinib + Miscellaneous Inotropes and Vasopressors + Antimuscarinics Inotropes and Vasopressors + Ergometrine (Ergonovine) Inotropes and Vasopressors; Dopamine + Selegiline Irinotecan + Fluorouracil Isoniazid + Aminosalicylic acid Isoniazid + Disulfiram Isoniazid + Food Isoniazid + Rifamycins Levodopa + Antipsychotics Levodopa + MAO-B inhibitors Lithium + Antidepressants; SSRIs Lithium + Diuretics; Potassium-sparing Lithium + Herbal medicines Loop diuretics + Aspirin or other Salicylates Macrolides + H2-receptor antagonists Macrolides; Azithromycin + Food MAO-B inhibitors + Antidepressants MAO-B inhibitors + MAOIs or RIMAs MAO-B inhibitors + Pethidine (Meperidine) MAO-B inhibitors + Tyramine-rich foods MAO-B inhibitors; Selegiline + Hormonal contraceptives or HRT MAOIs + Opioids; Fentanyl and related drugs MAOIs + Opioids; Miscellaneous MAOIs or RIMAs + Benzodiazepines MAOIs or RIMAs + Dextromethorphan MAOIs or RIMAs + Opioids; Pethidine (Meperidine) MAOIs or RIMAs + Opioids; Tramadol MAOIs or RIMAs + SNRIs MAOIs or RIMAs + SSRIs MAOIs or RIMAs + Sympathomimetics; Directly-acting MAOIs or RIMAs + Sympathomimetics; Indirectly-acting MAOIs or RIMAs + Tyramine-rich foods Maraviroc + CYP3A4 inhibitors Mefloquine + Cardioactive drugs Mefloquine + Primaquine Mefloquine + Quinine and related drugs Mefloquine + Typhoid vaccine; Oral Mifepristone + Aspirin or NSAIDs Moclobemide + Cimetidine Nefazodone + Antidepressants Neuromuscular blockers + Antineoplastics NNRTIs + Antiepileptics; Enzyme-inducing NNRTIs + Azoles; Itraconazole NNRTIs + Azoles; Ketoconazole NNRTIs + Azoles; Voriconazole NNRTIs + Drugs that affect gastric pH NNRTIs + Food NNRTIs + Macrolides NNRTIs + NRTIs NNRTIs + Protease inhibitors NNRTIs + Rifamycins NRTIs + Atovaquone NRTIs + Co-trimoxazole or Trimethoprim NRTIs + Protease inhibitors NSAIDs or Aspirin + Prostaglandins Olanzapine + Miscellaneous Olanzapine + Quinolones Olanzapine + SSRIs Olanzapine + Tobacco Olanzapine + Tricyclic and related antidepressants Opioids + Antiepileptics; Enzyme-inducing Opioids + Baclofen Opioids + Glutethimide Opioids + Protease inhibitors Opioids + Quinidine Opioids; Fentanyl and related drugs + Azoles Opioids; Fentanyl and related drugs + Benzodiazepines Opioids; Fentanyl and related drugs + Macrolides Opioids; Fentanyl and related drugs + Protease inhibitors Opioids; Methadone + Protease inhibitors Paliperidone + Miscellaneous Parathyroid hormones; Teriparatide + Miscellaneous Phenobarbital + Azoles Phenytoin + Azoles Phenytoin + Calcium-channel blockers Phosphodiesterase type-5 inhibitors + Alpha blockers Phosphodiesterase type-5 inhibitors + Antihypertensives Phosphodiesterase type-5 inhibitors + Aspirin Phosphodiesterase type-5 inhibitors + Azoles Phosphodiesterase type-5 inhibitors + CYP3A4 inducers Phosphodiesterase type-5 inhibitors + Grapefruit juice Phosphodiesterase type-5 inhibitors + H2-receptor Phosphodiesterase type-5 inhibitors + Macrolides Phosphodiesterase type-5 inhibitors + Nitrates Phosphodiesterase type-5 inhibitors + Protease inhibitors Phosphodiesterase type-5 inhibitors; Sildenafil + Antidepressants Phosphodiesterase type-5 inhibitors; Sildenafil + Miscellaneous Phosphodiesterase type-5 inhibitors; Vardenafil + Miscellaneous Pimozide + SSRIs Potassium-sparing diuretics + NSAIDs Potassium-sparing diuretics + Potassium compounds Procainamide + Amiodarone Proguanil + Typhoid vaccine; Oral Propafenone + SSRIs Protease inhibitors + Antiepileptics; Carbamazepine Protease inhibitors + Antiepileptics; Phenytoin Protease inhibitors + Antiepileptics; Valproate Protease inhibitors + Atovaquone Protease inhibitors + Azoles; Fluconazole Protease inhibitors + Azoles; Itraconazole Protease inhibitors + Azoles; Ketoconazole Protease inhibitors + Azoles; Voriconazole Protease inhibitors + Drugs that affect gastric pH Protease inhibitors + Food Protease inhibitors + Grapefruit and other fruit juices Protease inhibitors + Macrolides Protease inhibitors + Miscellaneous Protease inhibitors + Protease inhibitors Protease inhibitors + Rifamycins Protease inhibitors + St John's wort (Hypericum perforatum) Protease inhibitors + Tenofovir Protease inhibitors; Fosamprenavir + Miscellaneous Proton pump inhibitors + Food or Drinks Quetiapine + CYP3A4 inducers Quetiapine + CYP3A4 inhibitors Quetiapine + Miscellaneous Quinidine + Amiodarone Quinolones + Opioids Raltegravir + Miscellaneous Ranolazine + Miscellaneous Reboxetine + Antidepressants Reboxetine + CYP3A4 inhibitors Reboxetine + Miscellaneous Risperidone + Lithium Risperidone + SSRIs Sirolimus + Azoles SNRIs + H2-receptor antagonists SNRIs + Propafenone SNRIs + St John's wort (Hypericum perforatum) SNRIs; Duloxetine + Antidepressants SNRIs; Duloxetine + Miscellaneous SNRIs; Venlafaxine + Antidepressants SNRIs; Venlafaxine + Miscellaneous Sodium oxybate + Miscellaneous SSRIs + Bupropion SSRIs + H2-receptor antagonists SSRIs + Nasal decongestants SSRIs + Protease inhibitors SSRIs + Rifampicin (Rifampin) SSRIs + Sibutramine SSRIs + SSRIs SSRIs + Tryptophan SSRIs; Fluoxetine + CYP2D6 substrates Statins + Azoles Statins + Protease inhibitors Sulphonylureas; Glibenclamide (Glyburide) + Bosentan Tacrolimus + Azoles Terbinafine + H2-receptor antagonists Tetracyclines + Sucralfate Thalidomide + Miscellaneous Theophylline + Sucralfate Theophylline + Tadalafil Thiazide diuretics + Calcium and/or Vitamin D Thyroid hormones + Amiodarone Ticlopidine + Miscellaneous Tizanidine + Antihypertensives Tizanidine + CYP1A2 inhibitors Tizanidine + Miscellaneous Trazodone + Antidepressants Tricyclic and related antidepressants + SSRIs Tricyclic antidepressants + Bupropion Tricyclic antidepressants + Modafinil Tricyclic antidepressants + Protease inhibitors Tricyclic antidepressants + SNRIs; Duloxetine Triptans + Beta blockers Triptans + Ergot derivatives Triptans + MAOIs Vaccines + Chloroquine or Hydroxychloroquine Vinca alkaloids + Azoles Vinca alkaloids + Macrolides Zolmitriptan + Cimetidine Zolmitriptan + Quinolones

Source: http://www.medicinescomplete.com/pdf/mc_stockley_Aug08_quarter_update.pdf