Die Struktur von Tadalafil erlaubt eine selektive Bindung an die Bindungsstelle der PDE5 und minimiert gleichzeitig die Interaktion mit PDE6, was visuelle Nebenwirkungen einschränkt. Seine Verteilung im Organismus erfolgt breit, wobei das Verteilungsvolumen etwa 63 Liter beträgt. Über 90 % des Wirkstoffs sind an Plasmaproteine gebunden. Die Wirkung bleibt unabhängig von der Nahrungsaufnahme konstant. Der Abbauweg über CYP3A4 kann durch Hemmer wie Ritonavir oder Ketoconazol verlangsamt werden, was die Plasmakonzentrationen deutlich erhöht. In diesem Kontext wird cialis 20mg preis häufig in Bezug auf pharmakokinetische Wechselwirkungen erwähnt.

Bcn quantity limits_jan 2007_112906.xls

Blue Care Network - January 2007
DOSE OPTIMIZATION PROGRAM
Antidepressants
Cymbalta (Nonformulary)*
Emsam (Nonformulary)
Paxil CR (Nonformulary)*
Pexeva (Nonformulary)*
Prozac Weekly (Nonformulary)*
Wellbutrin XL (Nonformulary)*
Antidiabetics
Actoplus Met (Nonformulary)*
Avandamet (Nonformulary)*
Byetta (Nonformulary)*
Duetact (Nonformulary)*
Antihypertensives
Atacand (Nonformulary)*
Avalide (Nonformulary)*
Avapro (Nonformulary)*
Diovan HCT (Nonformulary)*
Mavik (Nonformulary)
Micardis, HCT (Nonformulary)*
Lipotropics
Advicor (Nonformulary)*
Altoprev (Nonformulary)*
Caduet (Nonformulary)*
Crestor*
Lescol, XL (Nonformulary)*
Lipitor (Nonformulary)*
Vytorin (Nonformulary)*
Oxytrol (Nonformulary)
This does not apply to BCN Advantage members.
*Prior Authorization or Step Therapy may also be required.
Please refer to BCN's Quality Interchange Program available on the web at
www.bcbsm.com/providers/physicians/physicians_rx_bcn.shtml
90-Day at Retail program is now available. Commercial members may receive a 90-day supply of most maintenance medications at their
local pharmacy for only 2 copays (provided they have received a minimum 28-day supply prior to filling the 90-day).
Blue Care Network - January 2007
Quantity Restrictions
Anti-Infectives
Limit per Rx
Testosterone Replacement
Cipro XR (Nonformulary)*
Proquin XR (Nonformulary)*
Androgel Gel Pkt (Nonformulary)
Androgel Pump (Nonformulary)
Erectile Dysfunction Drugs
Xifaxan (Nonformulary)
Anti-Emetic Products
Limit per Rx
Edex (Nonformulary)*
Anzemet 100mg (Nonformulary)
Levitra (Nonformulary)*
Gastrointestinal
Amitiza (Nonformulary)*
Lotronex (Nonformulary)*
Zegerid (Nonformulary)*
Antifungals
Zelnorm (Nonformulary)*
Long-Acting Narcotics
Avinza (Nonformulary)
Anti-Migraine Products
Limit per Rx
Amerge (Nonformulary)
Fentora (Nonformulary)
Axert (Nonformulary)
Opana ER (Nonformulary)
Celebrex (Nonformulary)*
Frova (Nonformulary)
Osteoporosis
Boniva 150mg (Nonformulary)
Relpax (Nonformulary)
Daytrana (Nonformulary)
Antivirals
Humira (Nonformulary)*
Halflytely (Nonformulary)
Kineret (Nonformulary)*
Lyrica (Nonformulary)*
Neulasta (Nonformulary)
Estrogens/Combinations
Revlimid (Nonformulary)*
Pulmonary
Climara Pro (Nonformulary)
Combipatch (Nonformulary)
Smoking Cessation Products
Limit per 360 days
Chantix (Nonformulary)*
(Nonformulary)*
Femring (Nonformulary)
Menostar (Nonformulary)
Weight Reduction Products
Limit per Lifetime
Nuvaring (Nonformulary)
Meridia (Nonformulary)*
Seasonique (Nonformulary)
Tenuate (g)*
Xenical (Nonformulary)*
This does not apply to BCN Advantage members.
*Prior Authorization or Step Therapy may also be required.
Please refer to BCN's Quality Interchange Program available on the web at www.bcbsm.com/providers/physicians/physicians_rx_bcn.shtml

Source: http://www.mednetone.com/downloads/2007_Quantity_limits.pdf