4.1 Pharmaceutical Chemistry-V (Medicinal Chemistry-II including drug design)

1. Theoretical aspects of drug design: SAR Studies. 2. Structural features and pharmacological activity: Steric aspects. 3. Drug metabolism: Pathways of biotransformation, conjugation pathways. The following topics shall be treated as covering outline of synthetic procedures (of selected drugs) uses, SAR including physiochemical and steric aspects, metabolism & mode of action. 4. Cholinergics & methacholinesterases: Acetylcholines, methacholine, carbachol, bethanechol, psychostigmine, Neostigmine, Ditsopropyl fluorophosphates, parathion. 5. Adrenaline, salbutamol, noradrenaline, orciprenaline, isoprenaline, amphetamine, 6. Anticonvulsants: Phenobarbitone, metharbital, phenytoin, ethotoin, paramethadione, phensuximide, methosuximide, acetazolamide, phenscetride, primidone, diazepam, chlordiazepoxide, clonazepam, valproic acid, carbamazepine. 7. Analeptics: strychnine, picrotoxin, nikethamide, ethamivan, pentylene tetrazole, 8. Antipsychotics: chlorpromazine, prochlorperazine, haloperidol, chloroprothixene. 9. Antianxiety agents: chlordiazepoxide, diazepam, hydroxyzine, tybamate. 10. Muscle relaxants: Mephenesin, methocarbamol, carisoprodol, metaxalone, 11. Antiparkinsonism drugs: Benzfropine, procyclidine, biperiden, diphenhydramine, 12. Antispasmodics & antiulcer drugs: Atropine, hyoscyamine, scopolamine, homatropine, clidinium bromide, cyclopentolate, dicyclomine, glycopyrrolate, mepenzolate, oxyphency climine, propantheline, orphenadrine, isopropamide, procyclidine, ethopropazine. 13. Curariform drugs and ganglion blockers: d-tubocurarine, succinylcholine, decamethonium, gallamine, hexafluorenium, pancuronium. 14. Local anaesthetics: Cocaine, isobucaine, piperocaine, benzocaine, procaine, tetracaine, propoxycaine, lidocaine, prilocaine, etidocaine, phenacaine, diperodon, dyclonine. 15. Antiallergic agents: Diphenhydramine, doxylamine, pyrilamine, tripelennamine, pheniramine, chlorpheniramine, brompheniramine, triprolidine, promethazine, methdilazine, chlorcyclizine, phenindamine, cyproheptadine, buclizine. 16. Gastrointestinal agents: Bisacodyl, simethicone, docusate, metoclopramide. 17. Thyroid hormones & antithyroid drugs: Levothyroxine, liothyronine, propylthiouracil, methimazole, polypeptide & protein harmones. 18. Oxytocics: Oxytocin. 19. Diuretics: Mersalyl, urea, mannitol, chlormerodrin, ethacrynic acid, aminophylline, triamterene, amiloride, acetazolamide, dichlorphenamide, chlorothiazide, hydrochlorothiazide, bendroflumethiazide, furosemide, metolazone, closexolone, chlorthalidone, spironolactone. 20. Antihypertensive agents: Reserpine, guanethidine, diazoxide, hydralazine, minoxidil, methyldopa, prazosin, clonidine, pargyline. 21. Coagulants and anticoagulants: Heparin, Bishydroxycoumarine, warfarin, 22. Hypoglycemic agents: Insulin, phenformin, tolbutamide, chlorpropamide, 23. Plasma expanders and diagnostic agents: Iodohippurate, diatrizoate, iothalamate, metrizamide, iopanoid acid propyliodone, aminohippuric acid, ipodate, rosebengal, fluorescein, chlormerodin, metyrapone, evansblue.
Books Recommended:
1. Wilson & Gisvolds, Textbook of Organic Medicinal & pharmaceutical Chemistry,
2. W.O.Foye, Principles of Medicinal Chemistry. 3. M.E. Wolff, Burger’s medicinal chemistry, John Wiley & Sons. 4. Remingtons Pharmaceutical Sciences. PRACTICALS
Typical synthesis of drugs & drug intermediates by use of the following types of
reactions: (i) Benzoin condensation (ii) Benzilic acid rearrangement, (iii) Friedel
Crafts alkylation and acylation, (iv) Hoffmann- Bromamide reaction. (v) Perkin
condensation, (vi) Grignard reaction, (vii) Claisen condensation, (viii) MVP
reduction, (ix) Catalytic hydrogenation, (x) Skraup synthesis.

Books Recommended:
1. Vogals Textbook of practical organic chemistry, ELBS.
2. Mann & Saunders- Practical organic chemistry.


Microsoft word - 2012 flexscripts formulary.docx

2012 FlexScripts Administrators Preferred Formulary List The following is a list of the most commonly prescribed FORMULARY drugs only. It represents an abbreviated version of the drug list (formulary) that is at the core of your pharmacy benefit program. The list is not all-inclusive, does not guarantee coverage and is subject to change. In addition to using this list, you are encoura

Journal of Antimicrobial Chemotherapy (2003) 52 , 303–305 DOI: 10.1093/jac/dkg318 Advance Access publication 1 July 2003 Susceptibility to rifaximin of Vibrio cholerae strains from different geographical areas Maria Scrascia1, Maria Forcillo1, Francesco Maimone1,2 and Carlo Pazzani1,2* 1Dipartimento di Anatomia Patologica e di Genetica, Sezione di Genetica, Università di Ba

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