20100111 ummc_maric 1512.xls

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Agency Drop-Down List: 7529 - National Institutes of Health
Program Source (TAS) 75-0883-National Institute of Diabetes and
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Drop-Down List: Digestive and Kidney Diseases
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The overall goal of the parent grant is to examine some of the mechanisms by which estrogens protect the kidney in the setting of diabetes through the following specific aims: 1. 17B-estradiol (E2) regualtes teh renal renin-angiotensin system (RAS), 2. E2 and an estrogen metabolite 2-methoxyestradiol (2-ME) attenuate oxidative stress associated with diabetic nephropahty, 3. E2 and 2-ME attenuate inflammation associated with diabetic nephropathy, 4. E2 and 2-ME attenuate glomerulosclerosis and tubulointerstitial fibrosis associated with diabetic nephropathy. These aims are predominantly designed to examine the effects of estrogens on renal structural changes associated with diabetic renal disease (glomerulosclerosis and tubulointerstitial fibrosis) and also to examine some of the cellular mechanisms underlying these changes (oxidative stress and inflammation). Our additional observations arrising from studies funded by the parent grant strongly suggest that estrogens play an important role in regulating renal hemodynamics in the diabetic kidney. Specifically, E2 normalizes the increase in glomerular filtration rate (GFR) that characterizes later stages of diabetes. In addition, E2 decreases diabetes-induced albuminuria. Since both GFR and urine al Project Information
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Estrogen and Inflammation in Diabetic Nephropathy Number of Jobs*
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Activity Code Drop-Down 111219 - Other Vegetable (except Potato) and
List: Melon Farming
State Drop-Down List: AK - Alaska
Country Drop-Down List: US - United States
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Enter Activity Code: 111110
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Source: http://www.mmrs.state.ms.us/imported/Stim_Report/IHL/Univ_MS_Med_Cntr/20100111%20UMMC_MARIC%201512.pdf

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