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Fifth World Conference on The Future of Science
The DNA Revolution
Fondazione Cini, Venice, September 20-22, 2009
in collaboration with Italian Association for Cancer Research
The discovery of the structure of DNA, more than fifty years ago, and the realization that it encoded the genetic information that determines the nature of all living organisms, created a true revolution in our understanding of biology and medicine, whose impact on essentially every aspect of life continues and expands to this day. While genome sequencing of multiple organisms, from humans to bacteria, has revealed exciting new information about our genetic make-up and the mechanisms of disease − leading to what has been called the post-genomic era − the function and purpose of much DNA remains to be discovered. The Conference will assess the impact that the “DNA Revolution” has had and will continue to have on science, technology and the quality of human life. It will focus on the significance of the most recent genetic research to our understanding of evolution and natural selection, health and disease; on how the knowledge provided by DNA research has dramatically changed the practice of medicine, agriculture and the management of biological resources; and on the bioethical issues raised by such discoveries. Major topics to be discussed will be genes and genome evolution, the impact of recombinant DNA on biotechnology and pharmaceutics, the genetics of human diseases, gene therapy, and the molecular genetics of cancer. PRESIDENT Umberto Veronesi – VICE PRESIDENT Kathleen Kennedy Townsend – SECRETARY GENERAL Chiara Tonelli
ORGANISING COMMITTEE Pasquale Gagliardi, Pier Giuseppe Pelicci, Armando Peres, Lucio Pinto, Monica Ramaioli
SCIENTIFIC COMMITTEE Zhores Alferov, Peter Atkins, Jacques Bernier, J.Michael Bishop, Claudio Bordignon, Claude Cohen-Tannoudji, Daniel Dennett, Renato Dulbecco, Luc Montagnier, Rita
Levi Montalcini, Paul Nurse, Philip Pettit, Carlo Rubbia, Gian Tommaso Scarascia Mugnozza
PROGRAM COMMITTEE Claudio Basilico, Vittorio Bo, Edoardo Boncinelli, Chris Bowler, Guido Coggi, Maria Ines Colnaghi, Pier Paolo Di Fiore, Giulio Giorello, Telmo Pievani, Marcelo Sànchez
Sorondo, Amedeo Santosuosso
Organising Secretariat Fondazione Umberto Veronesi, +39 02 76018187 [email protected] -
The Dna Revolution
Fondazione Cini, Venice, September 20-22, 2009
CONFERENCE PROGRAM, September 7, 2009
Sunday, September 20 – Fondazione Cini
5.00 p.m. Opening Ceremony
Welcome Addresses
Umberto Veronesi
Giovanni Bazoli
Marco Tronchetti Provera
President Silvio Tronchetti Provera Foundation Kathleen Kennedy Townsend
Chiara Tonelli
James Watson
1962 Nobel Prize in Medicine (message) Renato Dulbecco
1975 Nobel Prize in Medicine (message) Opening Lectures
Human evolution between nature and culture
Luigi Luca Cavalli-Sforza
Molecular Medicine: a possible Future?
Pier Paolo Di Fiore
IFOM Foundation, The Firc Institute of Molecular Oncology; University of Synthetic Life
J. Craig Venter
7.30 p.m. Welcome Cocktail
Monday, September 21 – Fondazione Cini
9.00 a.m. – 1.00 p.m.: Genomes, Evolution, Biotechnology
Chairs: Paolo Costantino, Department of Genetics and Molecular Biology, University of Roma La Sapienza, Italy and Telmo Pievani, Department of Human Sciences for Education,
University of Milan Bicocca, Italy
Genes and Genomes through time
Edoardo Boncinelli
Racial catalogs and human biological diversity
Guido Barbujani
Department of Biology and Evolution, University of Ferrara, Italy Genomes from the Sea
Chris Bowler
Ecole Normale Supérieure, Paris, France 10.30 a.m. – 11.00 a.m. Coffee break
The diversity of the microbial world: a challenge for the future
Enrica Galli
Department of Biomolecular Sciences and Biotechnology, University of Crop Plant Genomics for Food Security
Michael Bevan
Nutritionally improved crops to alleviate malnutrition and Chiara Tonelli
Department of Biomolecular Sciences and Biotechnology, University of chronic diseases
Genomics Research in European Programmes
Timothy Hall
Biotechnologies, Agriculture and Food Research Directorate, European Commission 1.00 a.m. – 2.30 p.m. Lunch
2.30 p.m. – 6.00 p.m.: Stem Cells. DNA and Ethics
Chairs: Giulio Giorello, Department of Philosophy, University of Milan, Italy and Giuseppe Testa, Laboratory of Stem Cell Epigenetics, European Institute of Oncology, Milan, Italy
Stem cells: replacement therapy
Giulio Cossu
San Raffaele Scientific Institute; Department of Biology, University of Milan, Italy Unleashing the Genome: Maintaining, Reinstating and Oliver Brüstle
Exploiting Pluripotency
3.30 p.m. – 4.00 p.m. Coffee break
Bioethics and the Future of Science
John Harris
Institute for Science, Ethics and Innovation, School of Law, University of Should privacy be abolished in genetics?
Amedeo Santosuosso
Judge Court of Appeal of Milano; University of Pavia, Italy Truth, Good and Justice in Scientific Activities
Marcelo Sanchez Sorondo
Bioethics in public perception and media coverage
Massimiano Bucchi
Department of Sociology of Science, University of Trento, Italy 8.00 p.m. Concert at Scuola Grande di San Rocco
Tuesday, September 22– Fondazione Cini
9.00 a.m. – 12.30 a.m.: DNA, Human Health and Disease
Chairs: Claudio Basilico, Department of Microbiology, NYU School of Medicine, New York, USA and Guido Coggi, Department of Pathology, University of Milan, Italy
The Future of DNA Technology: transforming the material William Haseltine
Haseltine Foundation for Medical Sciences and the Arts, USA New insights into the mechanisms of human disease
Veronica van Heyningen
Human Genetics Unit, Institute of Genetics and Molecular Medicine, Learning Biology from the study of Genetic Diseases
Andrea Ballabio
Telethon Institute of Genetics and Medicine, Napoli, Italy 10.30 a.m. – 11.00 a.m. Coffee break
Gene Therapy for congenital and acquired disorders: Claudio Bordignon
University Vita Salute San Raffaele, Milan, Italy promoting the progress of clinical applications
Next Generation Microbial Genomics: The Human Microbiome George Weinstock
The Genome Center, Washington University, St. Louis, USA Longevity Genomics
Pier Giuseppe Pelicci
Experimental Oncology Department, European Institute of Oncology; 12.30 a.m. – 2.00 p.m. Lunch
2.00 p.m. – 5.00 p.m.: Italian Association for Cancer Research Symposium
Cancer Genetics
Chairs: Maria Ines Colnaghi, Italian Association for Cancer Research and Pier Paolo Di Fiore, IFOM Foundation, The Firc Institute of Molecular Oncology; University of Milan, Italy
Biomolecular mechanisms of cancer: the clinical perspective
Umberto Veronesi
European Institute of Oncology, Milan, Italy Common genetic variants, risk, and applications in cancer
Bruce Ponder
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, UK Linkages Between Genome Disorder and Breast Cancer
David Livingston
Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA Development
3.30 p.m. – 4.00 p.m. Coffee break
Cancer Stem Cells: Getting to the Root of Cancer
Dominique Bonnet
Cancer Research UK, London Research Institute, UK The Era of Genome-based Targeted Therapy of Cancer
Yosef Yarden
Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel


Manuscript of Review Article published in: MICROSCOPY RESEARCH and TECHNIQUE 2000; 48: 303-11 ROLE OF APOPTOSIS IN GASTRIC EPITHELIAL TURNOVER Axel von Herbay 1 , Jochen Rudi 2 1 Institute of Pathology, 2 Medizinische Klinik IV, University of Heidelberg, GermanyAddress for correspondance: Priv.-Doz. Dr. med. A. von Herbay, Pathologisches Institut,Universitätsklinikum, Im Neuenheimer F

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