Prhutson_uw_cv oct11.doc

1975 Biochemistry, U.C.L.A., Los Angeles, California 1976 Chemistry, University of Washington, Seattle, Washington 1979 Pharmacy, University of Washington, Seattle, Washington 1981 University of Tennessee Center for the Health Sciences, Memphis, Tennessee LICENSURE: Wisconsin (Pharmacist, #11276)
Board Certified in Oncology Pharmacy (BCOP) POSITIONS HELD:
1991-Present Associate Professor (CHS), School of Pharmacy, UW - Madison Assistant Professor (CHS), School of Pharmacy, UW – Madison 1988-Present Associate Member, University of Wisconsin Clinical Cancer Center 1988-Present Clinical Pharmacy Practitioner, University of Wisconsin Hospital and Clinics Clinical Pharmacist, Medical Oncology Consult Services, West Side VA Medical Clinical Pharmacist, Medical Oncology Ward, University of Illinois Hospital Assistant Professor, College of Pharmacy, University of Illinois at Chicago, Chicago, Instructor, School of Pharmacy, University of Tennessee Center for the Health Oncology Pharmacy Research Fellow, St. Jude Children's Research Hospital, Poison Information Pharmacist, Southern Poison Center, Memphis, Tennessee PROFESSIONAL ORGANIZATIONS AND SOCIETIES:
Sec/Treas, Pain & Palliative Care PRN 2007-08 Chair, Pain & Palliative Care PRN 2009-10 Hematology and Oncology Pharmacy Association RESEARCH PUBLICATIONS
Surles RL, Hutson PR, Valentine AL, Miles JP, Tanumihardjo SA. 3,4-didehydroretinol kinetics differ during lactation in sows on a retinol depletion regimen and the serum:milk 3,4-didehydroretinol:retinol ratios are correlated. J Nutr 2011; 141: 554-9. PMID: 21310863 Rose WE, Knier RM, Hutson PR. Pharmacodynamic effect of clinical vancomycin exposures on cell wall thickness in heterogeneous vancomycin-intermediate Staphylococcus aureus. J Antimicrob Chemother. 2010 Oct;65:2149-54. PMID: 20693174 Engle DB, Belisle JA, Gubbels JA, Petrie SE, Hutson PR, Kushner DM, Patankar MS. Effect of acetyl-l- carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin. Gynecol Oncol. 2009;112:631-6.
Lipinski RJ, Hutson PR, Hannam PW, Nydza RJ, Washington IM, Moore RW, Girdaukas GG, Peterson RE, Bushman W. Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse. Toxicol Sci. 2008;104:189-97. PMID: Hutson PR, Oettel K, Douglas J, Ritter M, Messing E, Staab MJ, Alberti D, Horvath D, Wilding G. Effect of medical castration on CYP3A4 enzyme activity using the erythromycin breath test. Cancer Chemother Pharmacol. 2008;62:373-7. PMID: 17922273 Sansone JM, Wilsman NJ, Leiferman EM, Conway J, Hutson P, Noonan KJ. The Effect of Fluoroquinolone Antibiotics on Growing Cartilage in the Lamb Model. J Ped Ortho 2008; 2009; 29: 189-95. PMID: Tremont-Lukats IW, Hutson PR, Backonja MM. A randomized, double-masked, placebo-controlled pilot trial of extended IV lidocaine infusion for relief of ongoing neuropathic pain. Clin J Pain. 2006;22: 266-71. Dubey S, Hutson P, Alberti D, Arzoomanian R, Binger K, Volkman J, Feierabend C, Wilding G, Schiller JH.
Phase I study of docetaxel and topotecan in patients with advanced malignancies. J Oncol Pharm Pract. 2005;11:131-8. PMID: 16595064.
Hutson PR, Love RR, Havighurst TC, Rogers E, Cleary JF., Effect of exemestane on tamoxifen pharmacokinetics in postmenopausal women treated for breast cancer. Clin Cancer Res 2005; 11: Love RR, Hutson PR, Havighurst TC, and Cleary JF. Endocrine effects of tamoxifen plus exemestane in postmenopausal women with breast cancer. Clinical Cancer Research 2005;11: 1500-3. PMID: Forouzannia A, Schiller J, Berlin J, et al. A phase I study of topotecan, as a radiosensitizer, for thoracic malignancies. Lung Cancer 2004;44:111-9. PMID: 15013589.
Hutson PR, Crawford ME, and Sorkness RL. Liquid chromatographic determination of hydroxyproline in tissue samples. J Chromatogr B Analyt Technol Biomed Life Sci 2003;791:427-30. PMID: 12798203.
Mould DR, Holford NH, Schellens JH, et al. Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors. Clin Pharmacol Ther 2002;71:334-48. PMID: 12011819.
Cleary J, Gordon DB, Hutson P, Ward S. Incidence and characteristics of naloxone administration in medical oncology patients with cancer pain. J Pharmaceutical Care Pain Symptom Control 2000; 8(2): 65-73.
Jolin JA, Hutson PR, Schink JC. Methotrexate sequestration in an ovarian cyst. Gynecol Oncol 72, 113-115 Hutson PR, Tutsch KD, Rago R, Arzoomanian R, Alberti D, Pomplun M, Church D, Marnocha R, Cheng AL, Kehrli N, Wilding. G. Renal clearance, tissue distribution, and CA-125 responses in a Phase I trial of suramin. Clin Ca Res 1998; 4(6) 1429-1436. PMID: 9626459.
Kanner AM, Bourgeois BF, Hasegawa H, and Hutson P. Rapid switchover to carbamazepine using pharmacokinetic parameters. Epilepsia 1998;39:194-200. PMID: 9578000 McCarthy DO,. Murray S, Galagan D,. Gern JE, Hutson PR. Meperidine attenuates the secretion but not the transcription of interleukin 1 beta in human mononuclear leukocytes. Nursing Research. 47(1):19-24, Glen VL, Hutson PR, Kehrli NJ, Boothman DA, Wilding G. Quantitation of beta-lapachone and 3-hydroxy-beta-lapachone in human plasma samples by reversed-phase high-performance liquid chromatography. Journal of Chromatography B: Biomedical Applications. 692(1):181-6, 1997. PMID: Berlin J, Tutsch KD, Hutson P, Cleary J, Rago RP, Arzoomanian RZ, Alberti D, Feierabend C, Wilding G. Phase I clinical and pharmacokinetic study of oral carboxyaminotriazole, a signal transduction inhibitor. J Clin Oncol 1997; 15: 781-789. PMID: 9053505.
Schiller JH, Kim KM, Hutson PR, DeVore R, Glick J, Stewart J, Johnson D. Phase II study of topotecan in patients with extensive-stage small cell carcinoma of the lung: An Eastern Cooperative Oncology Group Trial (E1592). J Clin Oncol 1996: 14: 2345-2352.
Planchon SM, Wuerzberger S, Frydman B, Witiak DT, Hutson P, Church DR, Wilding G, Boothman DA. Beta- lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: A p53-independent response. Cancer Res 1995; 55: 3706-3711. PMID : 7641180.
Vail DM, Elfarra AA, Panciera DL, Hutson PR. Pharmacokinetics and short-term clinicopathologic changes after intravenous administration of a high dose of methimazole in dogs. Am J Vet Res, 55:1597-1601,1994. PMID: 7879985.
McCarthy DO, Daun JM, Hutson, PR. Meperidine attenuates the febrile response to endotoxin and interleukin- 1 in rats. Nursing Res 1993; 42: 363-365. PMID: 8247820.
Hutson PR, Tutsch K, Spriggs D, Christian M, Rago R, Mutch R, Wilding G. Evidence of an absorption phase after short intravenous suramin infusions. Cancer Chemother Pharmacol 1993; 31:495-499. PMID: Mutch RS, Hutson PR. Intradermal carboplatin and ifosfamide extravasation in the mouse. Cancer 1992; Mutch RS, Hutson PR. Stability of a parenteral formulation of antipyrine and caffeine. Am J Hosp Pharm.
Hutson PR, Baumann TJ, Lavoie RR, Mullane MR. Morphine concentrations in plasma, ascites fluid, and nasogastric fluid during high-dose intravenous morphine infusion. Clin Pharm. 1988; 7:842-845. PMID: Shenep JL, Kalwinsky DK, Hutson PR, George SL, Dodge PK, Blankenship KR, Thornton D. Efficacy of oral sucralfate suspension in the prevention and treatment of chemotherapy-induced mucositis. J Pediat.
Manny RP, Hutson PR: Aminoglycoside volume of distribution in hematology-oncology patients. ClinPharm.
Sinkule JA, Hutson PR, Hayes FA, Etcubanas E, Evans WE: Pharmacokinetics of etoposide (VP-16) in children and adolescents with refractory solid tumors. Cancer Res 1984; 44:3109-3113. PMID: 6539169.
Evans WE, Stewart CF, Hutson PR, Cairnes DA, Bowman WP, Crom WR: Disposition of intermediate-dose methotrexate in children with acute lymphocytic leukemia. Drug Intell Clin Pharm 1982; 16:839-842. PMID: Evans WE, Crom WR, Sinkule JA, Yee GC, Stewart CF, Hutson PR: Clinical pharmacokinetics of antineoplastic drugs in children. Drug Metab Rev 1983; 14:847-886. PMID: 6197269.
Evans WE, Hutson PR, Stewart CF, Cairnes DA, Bowman WP, Rivera G, Crom WR: Methotrexate cerebrospinal fluid and serum concentrations following intravenous infusion of intermediate-dose methotrexate. Clin Pharmacol Ther 1983; 33:301-307. PMID: 6600662.
Mutch RS, Hutson PR. Levamisole in the Adjuvant Treatment of Colon Cancer. Clin Pharm. 1991; 10(2):95- Hutson PR. AIDS and the R.Ph.'s role in prevention/treatment. Drug Topics 1987; Dec. 14:104-111.
Hutson PR. Small cell lung cancer. Highlights on Antineoplastic Drugs 1986; 4(1):2-3, 10-11.
PSAP-VII Chapter Reviewer: Pancreatic Carcinomas and Endocrine Malignancies. 2010 Hutson PR. Red and white blood cell tests. In: Lee M, ed. Basic skills in interpreting laboratory tests.
American Society of Health-System Pharmacists, Bethesda, 4th ed. 2009.
Hutson PR. Red and white blood cell tests. In: Lee M, ed. Basic skills in interpreting laboratory tests.
American Society of Health-System Pharmacists, Bethesda, 3rd ed. 2004, 441-68.
Hutson PR, Tutsch KD, Wilding G. Pharmacokinetic analysis and adaptive control of suramin with ADAPT-II.
In: D'Argenio DZ, ed. Advanced Methods in Pharmacokinetics and Pharmacodynamics Systems Analysis.
Plenum Press. New York, 2nd ed. 1995, 177-188.
Hutson PR, Cobleigh MA. Squamous head and neck cancer. In: DiPiro JT, Talbert RL, Hayes PE, Yee GC, Posey LM, eds. Pharmacotherapy: A pathophysiologic approach. Elsevier Science. New York, 1989.
R. R. Love, S. A. Anderson, J. F. Cleary, P. R. Hutson. Lipid, lipoprotein, alkaline phosphatase, osteocalcin, and symptom effects of adding exemestane therapy in postmenopausal women taking adjuvant tamoxifen for breast cancer. Proc ASCO 22: 2003; 22: #236.
Hutson PR, Eickhoff JC, Anderson SA, Cleary JF, Love RR. Pharmacokinetic and pharmacodynamic interaction of adjuvant tamoxifen and exemestane in postmenopausal women treated for early stage breast cancer. Proc San Antonio Breast Cancer Symposium, 2002; 25: #260.
Stella, D Alberti, R Arzoomanian, K Binger, J Volkman, C Feierabend, K Hampton, P Hutson, K Tutsch, G Wilding, J H Schiller, University of Wisconsin Comprehensive Cancer Center, Madison, WI. Phase I Trial of Docetaxel and Topotecan in Patients with Advanced Malignancies. Proc ASCO 2001; #2880.
Afshin Forouzannia, Minesh P Mehta, Joan H Schiller, Paul R Hutson, Dona B Alberti, Christine A Feierabend, Nancy J Feierabend, Kimberly A Binger, Steven P Howard, Marcia L Pomplun, A S Wahamaki-Dresen, Thomas A McFarland, Rhoda Z Arzoomanian, George Wilding, Phase I Study of Topotecan and Thoracic Oettel KR, Hutson PR, Douglas JA, Bianco JA, Ritter MA, Staab MJ, Horvath DL, Miller KA, Alberti DB, VanUmmersen L, Hammes RJ, Wilding G. The effect of testosterone on drug metabolism in men with prostate cancer. Proc ASCO 2000; 19: #1477.
Hutson PR, Tutsch KD, Pomplun M, Robins HI, Tiffelaar CL, Alberti DB, Feierabend CA, Rieck N, Arzoomanian R, Wilding G. Carboplatin dosing in obese patients. Proc ASCO 2000; 19: #725.
Berlin JD, Schiller JH, Mehta MP, Hutson PR, Boothman DA, Alberti DB, Feierabend CA, Kehrli NJ, Kinger DA, Kavka JE, Pomplun ML, Wahamaki AS, Storer S, Arzoomanian RZ, Wilding G. Phase I study of topotecan and thoracic radiation. Proc ASCO 1999; 18: #670.
Tutsch KD, Berlin J, Arzoomanian RZ, Alberti D, Feierabend C, Simon K, Hutson P, Cleary J, Stewart J, Wilding G. Phase I clinical and pharmacokinetic trial of an oral micronized formulation of carboxyamido- triazole (CAI). Proc AACR 1996; 37:A1133.
Berlin J, Schiller JH, Hutson PR, Feierabend C, Simon K, Alberti D, Arzoomanian R, Boothman D, Glen V, Mehta M. Wilding G. Phase I clinical and pharmacokinetic study of daily topotecan with thoracic irradiation.
Cleary J, Tutsch KD, Berlin J, Arzoomanian RZ, Alberti D, Feierabend C, Simon K, Hutson P, Stewart J, Wilding G. Phase I and pharmacokinetic study of rebeccamycin analog (NSC 655649). Proc AACR Hutson PR, Kim K, Johnson D, Schiller JH. Pharmacodynamic evaluation of the response of extensive small cell cancer to topotecan. Proc ASCO 1995, #1481.
Wilding G, Arzoomanian RZ, Alberti D, Feierabend C, Rago R, Cleary J, Hutson P, Berlin J, Tutsch KD. Phase I clinical and pharmacokinetic study of oral carboxyamidotriazole (CAI). Proc ASCO 1995; 14: A1554.
Hutson PR, Kehrli N, Alberti D, Arzoomanian R, Feierabend C, Tutsch K, Wilding G. Suramin does not inhibit hepatic P450IID6 metabolism. Proc AACR 1994; 35:#1446.
Hutson PR, Tutsch KD, Rago R, Arzoomanian R, Alberti D, Feierabend C, Pomplun M, Spriggs D, Wilding G.
Suramin clearance prediction by limited sampling methods or by creatinine clearance. Proc AACR, 1993; Hutson PR, Rago R, Arzoomanian R, Alberti D, Tombes MB, Spriggs D, Wilding G. Use of probe drugs to evaluate the effect of suramin on P450 activity. Proc AACR, 1992, #3180.
Rago R, Tutsch K, Pomplun M, Hutson P, Wilding G. Human plasma and tissue levels of suramin. Proc AACR, Hutson P, Arzoomanian R, Tombes MB, Alberti D, Tutsch K, Mutch R, Rago R, Cheng AL, Spriggs D, Wilding G. Test dose guided rapid IV suramin infusions with weekly IV maintenance doses. Proc Proc Hutson PR, Mutch RS, Tormey D. Carboplatin and ifosfamide extravasation in the mouse. Proc AACR, 1991, Hutson PR, MacDonald L, Mutch RS. Pilot evaluation of nifedipine and urinary steroid excretion. ASHP Hutson PR, Horvath JM, Vasquez E. Ear densitometer vs. HPLC vs. colorimetry for analysis of indocyanine green in human plasma. Pharmacotherapy 1988; 8:126 (#54).
Hutson P, Evrard M, Cobleigh M, Lad T, McGuire WP, Cichock G: Pharmacokinetic and pharmacodynamic studies of spirogermanium in advanced non-small cell lung cancer. Proc ASCO 1985; 5:(149) 38.
Hutson PR, Sinkule JA, Hayes Fa, Evans WE: Pharmacokinetics of VP-16 in children with refractory solid tumors (ST). Drug Intell Clin Pharm 1983; 17:442.
Evans WE, Crom WR, Stewart CF, Hutson PR, Sinkule JA, Yee GC: Methotrexate clearance influences response to therapy in children with standard risk acute lymphocytic leukemia (ALL). Proc Amer Soc Clin Stewart CF, Crom WR, Bowman WP, Hutson PR, Evans WE: Influence of serum concentration on renal clearance of methotrexate in children with acute lymphocytic leukemia. Drug Intell Clin Pharm 1982; 16:483.
Evans WE, Crom WR, Stewart CF, Hutson PR, Cairnes DA, Rivera G, Bowman WP: Pharmacokinetics of intermediate-dose methotrexate (IDM) in children with leukemia. Proc Amer Soc Clin Oncol 1982; 1:11 (C- Evans WE, Hutson PR, Stewart CF, Cairnes DA, Bowman WP, Crom WR: Correlation of methotrexate "free" and total serum concentrations. Clin Pharmacol Ther 1982; 31:223.
American Journal of Health-System Pharmacy GRANT REVIEW COMMITTEES
Special Study Section - P20 Cancer Center CAM Program Grant (Feb 2001) Interactions of botanical drugs and drugs used to treat HIV” Susan G. Komen Breast Cancer Research Foundation. 2005.
Post-doctoral Fellowship pharmacology grants PROTOCOL REVIEW COMMITTEE MEMBERSHIP
UW ICTR Scientific Review Committee (formerly GCRC Protocol Review Committee) ECOG (Eastern Cooperative Oncology Group) 1992 – 2004 (Vice Chair, 2001 – 2004) UWCCC Experimental Therapeutics Disease-oriented Working Group UWCCC Palliative Care and Supportive Oncology Working Group DATA MONITORING COMMITTEE MEMBERSHIP
UW Center for Health Enhancement Systems Studies (CHESS) - UO1 Meditation and exercise for the prevention of upper respiratory infection" (MEPARI) – RO1 GRADUATE COMMITTEE MEMBERSHIP
Academic Staff Divisional Review Committee (2009 - Present) STUDENT GROUP ADVISING
(Christian Pharmacists Fellowship International) Phi Lambda Sigma (Pharmacy leadership fraternal group) SCHOOL OF PHARMACY AND UW HOSPITAL COMMITTEES (current)
Area 3 (Curriculum) (School of Pharmacy Reaccreditation review 2010-11) OTHER SERVICES / ACTIVITIES
Board Member. Edgewood Campus Grade School (2003 – 2006) CubMaster, West Middleton Cub Scout Pack 640 RECENT PRESENTATIONS (Date, Sponsor, and Location)
Practical Considerations in the use of Methadone for Analgesia November 2011 UW Extension Services in Pharmacy Population Pharmacokinetics in Clinical Research and Clinical Practice October 2011 American College of Clinical Pharmacy Use of Methadone for the Treatment of Pain January 2011 UW Pharmacy Extension Services Webinair Illustrations in Opioid Dosing in Chronic Cancer Pain Opioid Titration and Opioid Switching for Chronic Pain Medical Treatment of Secondary Lymphedema October 2008 UW Paul P Carbone Cancer Center Grand Rounds Dietary Supplements for the treatment of Lymphedema Getting Started in Practical Pharmacy Research Dietary Supplements in the Prevention and Adjuvant Treatment of Lung Cancer Dietary Supplements in the Prevention and Adjuvant Treatment of Breast Cancer Weight-based Dosing of Chemotherapy Agents Scientific evidence for medical opioid use Conference on Implementing a Modern and Balanced Opioid Legislation in Palliative Care Workshop for Medical Students Herbals and nutritional therapies – Men’s Health UW School of Medicine Clinical Investigator Preparatory Program (CIPP) Incorporating pharmacokinetics and pharmacodynamics in clinical studies Challenges of palliative care workshop: Sponsored by the UW Schools of Medicine and Nursing Using Complementary Therapies in Palliative Care Practical review of complementary and alternative therapies


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