Bardzo tanie apteki z dostawą w całej Polsce kupic levitra i ogromny wybór pigułek.

Microsoft word - publications based on the copenhagen mother.docx

Publications based on the Copenhagen Mother-Child Cohort
(last updated January 2014)

Original papers
1. Tinggaard J, Aksglaede L, Sørensen K, Mouritsen A, Wohlfahrt-Veje C, Hagen CP, Mieritz MG, Jørgensen
N, Wolthers OD, Heuck C, Petersen JH, Main KM, Juul A: The 2014 Danish references from birth to 20
years for height, weight and body mass index. Acta Paediatr 2014, in press
2. Wohlfahrt-Veje C, Tinggaard J, Winther K, Mouritsen A, Hagen CP, Mieritz MG, Tefre de Renzy-Martin K, Boas M, Petersen JH, Main KM: Body fat throughout childhood in 2647 healthy Danish children:
validity of skinfold measurements and BMI versus Dual enery X-ray Absortiometry (DXA). Eur J Clin
2014, in press
3. Wohlfahrt-Veje C, Audouze K, Brunak S, Antignac JP, Le Bizec B, Juul A, Skakkebaek NE, Main KM: Polychlorinated dibenzo-p-dioxins, furans and biphenyls (PCDDs/PCDFs, PCBs) in breast milk and early
childhood growth and IGF-I. Reproduction 2014, in press
4. Vesterholm DJ, Christensen JS, Virtanen HE, Skakkebaek NE, Main KM, Toppari J, Veje CW, Andersson AM, Nielsen F, Grandjean P, Jensen TK: No association between exposure to perfluorinated compounds
and congenital cryptorchidism: a nested case-control study among 215 boys from Denmark and Finland.
Reproduction 2014, in press
5. Frederiksen H, Jensen TK, Jørgensen N, Husby S, Skakkebaek NE, Main KM, Juul A, Andersson AM: Human urinary excretion of non-persistent Environmental chemicals: an overview of Danish data collected
2006-2012. Reproduction 2014 in press
6. Mouritsen A, Johansen ML, Wohlfahrt-Veje C, Hagen CP, Tinggaard J, Miertitz MG, Tefre de Renzy- Martin K, Soeborg T, Fallentin E, Juul A, Main KM: Determination of adrenal volume by MRI in healthy
children: associations to age, body size, pubertal stage and serum levels of adrenal androgens. Clin
2014 in press
7. Rantakokko P, Main KM, Wohlfahrt-Veje C, Kiviranta H, Airaksinen R, Vartiainen T, Skakkebaek NE, Toppari J, Virtanen HE: Association of Placenta Organotin Concentrations with congenital Cryptorchidism
and reproductive hormone levels in 280 Newborn Boys from Denmark and Finland. Human Reprod
2013; 28(6): 1647-1660
8. Juul A, Hagen C, Aksglæde L, Sørensen K, Mouritsen A, Frederiksen H, Main KM, Sloth-Mogensen S, Petersen AT. Endocrine evaluation of reproductive function in girls during infancy, childhood and adolescence. Endocr Dev 2012; 22: 24-39 9. Andersen HR, Wohlfahrt-Veje , Dalgård C, Christiansen L, Main KM, Nellemann C, Murata K, Jensen TK, Skakkebæk NE, Grandjean P: Paraoxonase 1 Polymorphism and Prenatal Pesticide Exposure Associated with Adverse Cardiovascular Risk Profiles at School Age. PLoS ONE 2012; 7: e36830 10. Wohlfahrt-Veje C, Andersen HR, Jensen TK, Granjean P, Skakkebaek NE, Main KM: Smaller genitals at school age in boys whose mothers were exposed to non-persistent pesticides in early pregnancy. Int J Androl 2012; 35: 265-272 11. Krysiak-Baltyn-K, Toppari J, Skakkebæk NE, Jensen TS, Virtanen HE, Schramm K-W, Shen H, Vartiainen T, Kiviranta H, Taboureau O, Audouze K, Brunak S, Main KM: Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex exposures. Int J Androl 2012; 35: 294-302 12. Virtanen HE, Koskenniemi JJ, Sundqvist E, Main KM, Kiviranta H, Tuomisto JT, Tuomisto J, Viluksela M, Vartiainen T, Skakkebæk NE, Toppari: Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta. Int J Androlog 2012; 35: 283-293 13. Hagen CP, Aksglæde L, Sørensen K, Mouritsen A, Andersson AM, Petersen JH, Main KM, Juul A: Individual serum levels of anti-Müllerian hormone in healthy girls persist through childhood and adolescence: a longitudinal cohort. Hum Reprod 2012; 27: 861-866 14. Wohlfahrt-Veje C, Andersen HR, Schmidt IM, Aksglæde L, Sørensen K, Juul A, Jensen TK, Grandjean P, Skakkebæk NE, Main KM: Early breast development in girls after prenatal exposure to non-persistent pesticides. Int J Androl 2012; 35: 273-282 15. Wohlfahrt-Veje C, Main KM, Schmidt IM, Boas M, Jensen TK, Grandjean P, Skakkebaek NE, Andersen HR. Lower birth weight and increased body fat at school age in children prenatally exposed to modern pesticides: A prospective study. Environ Health. 2011 Sep 20;10(1):79. 16. Aksglaede L, Christiansen P, Sørensen K, Boas M, Linneberg A, Main KM, Andersson AM, Skakkebaek NE, Juul A. Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism. Acta Paediatr. 2011 Jun;100(6):839-45. 17. Kristensen DM, Hass U, Lesné L, Lottrup G, Jacobsen PR, Desdoits-Lethimonier C, Boberg J, Petersen JH, Toppari J, Jensen TK, Brunak S, Skakkebaek NE, Nellemann C, Main KM, Jégou B, Leffers H. Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. Hum Reprod. 2011 Jan;26(1):235-44. 18. Aksglaede L, Sørensen K, Boas M, Mouritsen A, Hagen CP, Jensen RB, Petersen JH, Linneberg A, Andersson AM, Main KM, Skakkebæk NE, Juul A. Changes in anti-Müllerian hormone (AMH) throughout the life span: a population-based study of 1027 healthy males from birth (cord blood) to the age of 69 years. J Clin Endocrinol Metab. 2010 Dec;95(12):5357-64. 19. Hagen CP, Main KM, Kjaergaard S, Juul A. FSH, LH, inhibin B and estradiol levels in Turner syndrome depend on age and karyotype: longitudinal study of 70 Turner girls with or without spontaneous puberty. Hum Reprod. 2010 Dec;25(12):3134-41. 20. Hagen CP, Aksglaede L, Sørensen K, Main KM, Boas M, Cleemann L, Holm K, Gravholt CH, Andersson AM, Pedersen AT, Petersen JH, Linneberg A, Kjaergaard S, Juul A. Serum Levels of Anti- Mullerian Hormone as a Marker of Ovarian Function in 926 Healthy Females from Birth to Adulthood and in 172 Turner Syndrome Patients. J Clin Endocrinol Metab. 2010 Nov;95(11):5003-10. 21. Boas M, Frederiksen H, Feldt-Rasmussen U, Skakkebaek NE, Hegedüs L, Hilsted L, Juul A, Main KM. Childhood Exposure to Phthalates - Associations with Thyroid Function, Insulin-like Growth Factor I (IGF-I) and Growth. Environ Health Perspect. 2010 Oct;118(10):1458-64 22. Krysiak-Baltyn K, Toppari J, Skakkebaek NE, Jensen TS, Virtanen HE, Schramm KW, Shen H, Vartiainen T, Kiviranta H, Taboureau O, Brunak S, Main KM. Country-specific chemical signatures of persistent environmental compounds in breast milk. Int J Androl. 2010 Apr;33(2):270-8. 23. Boas M, Forman JL, Juul A, Feldt-Rasmussen U, Skakkebaek NE, Hilsted L, Chellakooty M, Larsen T, Larsen JF, Petersen JH, Main KM. Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women. Eur J Endocrinol. 2009 Dec;161(6):903-10. 24. Boas M, Hegedüs L, Feldt-Rasmussen U, Skakkebaek NE, Hilsted L, Main KM. Association of thyroid gland volume, serum insulin-like growth factor-I, and anthropometric variables in euthyroid prepubertal children. J Clin Endocrinol Metab. 2009 Oct;94(10):4031-5. 25. Wohlfahrt-Veje C, Boisen KA, Boas M, Damgaard IN, Kai CM, Schmidt IM, Chellakooty M, Suomi AM, Toppari J, Skakkebaek NE, Main KM. Acquired cryptorchidism is frequent in infancy and childhood. Int J Androl. 2009 Aug;32(4):423-8. 26. Damgaard IN, Jensen TK; Nordic Cryptorchidism Study Group, Petersen JH, Skakkebaek NE, Toppari J, Main KM. Risk factors for congenital cryptorchidism in a prospective birth cohort study. PLoS One. 2008 Aug 25;3(8):e3051. 27. Mau Kai C, Juul A, McElreavey K, Ottesen AM, Garn ID, Main KM, Loft A, Jørgensen N, Skakkebaek NE, Andersen AN, Rajpert-De Meyts E. Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number. Hum Reprod. 2008 Jul;23(7):1669-78. 28. Andersen HR, Schmidt IM, Grandjean P, Jensen TK, Budtz-Jørgensen E, Kjaerstad MB, Baelum J, Nielsen JB, Skakkebaek NE, Main KM. Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy. Environ Health Perspect. 2008 Apr;116(4):566- 72. 29. Shen H, Main KM, Andersson AM, Damgaard IN, Virtanen HE, Skakkebaek NE, Toppari J, Schramm KW. Concentrations of persistent organochlorine compounds in human milk and placenta are higher in Denmark than in Finland. Hum Reprod. 2008 Jan;23(1):201-10. 30. Main KM, Kiviranta H, Virtanen HE, Sundqvist E, Tuomisto JT, Tuomisto J, Vartiainen T, Skakkebaek NE, Toppari J. Flame retardants in placenta and breast milk and cryptorchidism in newborn boys. Environ Health Perspect. 2007 Oct;115(10):1519-26. 31. Bay K, Virtanen HE, Hartung S, Ivell R, Main KM, Skakkebaek NE, Andersson AM; Nordic Cryptorchidism Study Group, Toppari J. Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism. J Clin Endocrinol Metab. 2007 Oct;92(10):4020-7. 32. Teilmann G, Boas M, Petersen JH, Main KM, Gormsen M, Damgaard K, Brocks V, Skakkebaek NE, Jensen TK. Early pituitary-gonadal activation before clinical signs of puberty in 5- to 8-year-old adopted girls: a study of 99 foreign adopted girls and 93 controls. J Clin Endocrinol Metab. 2007 Jul;92(7):2538-44. 33. Mau Kai C, Main KM, Andersen AN, Loft A, Skakkebaek NE, Juul A. Reduced serum testosterone levels in infant boys conceived by intracytoplasmic sperm injection. J Clin Endocrinol Metab. 2007 Jul;92(7):2598-603. 34. Aksglæde L, Main KM, Skakkebæk NE, Juul A: High normal testosterone levels in infants with non-mosaic Klinefelters syndrome. Eur J Endocrinol 2007, 157: 345-50 35. Damgaard IN, Jensen TK, Petersen JH, Skakkebaek NE, Toppari J, Main KM. Cryptorchidism and maternal alcohol consumption during pregnancy. Environ Health Perspect. 2007 Feb;115(2):272-7. 36. Shen H, Main KM, Virtanen HE, Damggard IN, Haavisto AM, Kaleva M, Boisen KA, Schmidt IM, Chellakooty M, Skakkebaek NE, Toppari J, Schramm KW. From mother to child: investigation of prenatal and postnatal exposure to persistent bioaccumulating toxicants using breast milk and placenta biomonitoring. Chemosphere. 2007 Apr;67(9):S256-62. 37. Virtanen HE, Tapanainen AE, Kaleva MM, Suomi AM, Main KM, Skakkebaek NE, Toppari J. Mild gestational diabetes as a risk factor for congenital cryptorchidism. J Clin Endocrinol Metab. 2006 Dec;91(12):4862-5. 38. Kai CM, Main KM, Andersen AN, Loft A, Chellakooty M, Skakkebaek NE, Juul A. Serum insulin-like growth factor-I (IGF-I) and growth in children born after assisted reproduction. J Clin Endocrinol Metab. 2006 Nov;91(11):4352-60. 39. Damgaard IN, Skakkebaek NE, Toppari J, Virtanen HE, Shen H, Schramm KW, Petersen JH, Jensen TK, Main KM; Nordic Cryptorchidism Study Group. Persistent pesticides in human breast milk and cryptorchidism. Environ Health Perspect. 2006 Jul;114(7):1133-8. 40. Main KM, Toppari J, Suomi AM, Kaleva M, Chellakooty M, Schmidt IM, Virtanen HE, Boisen KA, Kai CM, Damgaard IN, Skakkebaek NE. Larger testes and higher inhibin B levels in Finnish than in Danish newborn boys. J Clin Endocrinol Metab. 2006 Jul;91(7):2732-7. 41. Main KM, Mortensen GK, Kaleva MM, Boisen KA, Damgaard IN, Chellakooty M, Schmidt IM, Suomi AM, Virtanen HE, Petersen DV, Andersson AM, Toppari J, Skakkebaek NE. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect. 2006 Feb;114(2):270-6. 42. Suomi AM, Main KM, Kaleva M, Schmidt IM, Chellakooty M, Virtanen HE, Boisen KA, Damgaard IN, Kai CM, Skakkebaek NE, Toppari J. Hormonal changes in 3-month-old cryptorchid boys. J Clin Endocrinol Metab. 2006 Mar;91(3):953-8. 43. Chellakooty M, Juul A, Boisen KA, Damgaard IN, Kai CM, Schmidt IM, Petersen JH, Skakkebaek NE, Main KM. A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding. J Clin Endocrinol Metab. 2006 Mar;91(3):820-6. 44. Boas M, Boisen KA, Virtanen HE, Kaleva M, Suomi AM, Schmidt IM, Damgaard IN, Kai CM, Chellakooty M, Skakkebaek NE, Toppari J, Main KM. Postnatal penile length and growth rate correlate to serum testosterone levels: a longitudinal study of 1962 normal boys. Eur J Endocrinol. 2006 Jan;154(1):125-9. 45. Schmidt IM, Chellakooty M, Boisen KA, Damgaard IN, Mau Kai C, Olgaard K, Main KM. Impaired kidney growth in low-birth-weight children: distinct effects of maturity and weight for gestational age. Kidney Int. 2005 Aug;68(2):731-40. 46. Shen H, Virtanen HE, Main KM, Kaleva M, Andersson AM, Skakkebaek NE, Toppari J, Schramm KW. Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas. Chemosphere. 2006 Jan;62(3):390-5. 47. Kaleva M, Virtanen H, Haavisto AM, Main K, Skakkebaek NE, Huhtaniemi I, Irjala K, Toppari J. Does variant luteinizing hormone (V-LH) predispose to improper testicular position in late pregnancy? Pediatr Res. 2005 Sep;58(3):447-50. 48. Mortensen GK, Main KM, Andersson AM, Leffers H, Skakkebaek NE. Determination of phthalate monoesters in human milk, consumer milk, and infant formula by tandem mass spectrometry (LC-MS-MS). Anal Bioanal Chem. 2005 Jun;382(4):1084-92. 49. Boisen KA, Chellakooty M, Schmidt IM, Kai CM, Damgaard IN, Suomi AM, Toppari J, Skakkebaek NE, Main KM. Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age. J Clin Endocrinol Metab. 2005 Jul;90(7):4041-6. 50. Shen H, Main KM, Kaleva M, Virtanen H, Haavisto AM, Skakkebaek NE, Toppari J, Schramm KW. Prenatal organochlorine pesticides in placentas from Finland: exposure of male infants born during 1997-2001. Placenta. 2005 Jul;26(6):512-4. 51. Kaleva M, Virtanen HE, Haavisto AM, Main KM, Reunanen M, Skakkebaek NE, Toppari J. Circannual rhythm in the incidence of cryptorchidism in Finland. Int J Androl. 2005 Feb;28(1):53-7. 52. Boisen KA, Kaleva M, Main KM, Virtanen H, Haavisto AM, Schmidt IM, Chellakooty M, Damgaard IN, Mau C, Reunanen M, Skakkebaek NE, Toppari J. [High and increasing prevalence of cryptorchidism in Denmark]. Ugeskr Laeger. 2004 Nov 22;166(48):4372-5. Danish. 53. Schmidt IM, Damgaard IN, Boisen KA, Mau C, Chellakooty M, Olgaard K, Main KM. Increased kidney growth in formula-fed versus breast-fed healthy infants. Pediatr Nephrol. 2004 Oct;19(10):1137-44. 54. Schmidt IM, Main KM, Damgaard IN, Mau C, Haavisto AM, Chellakooty M, Boisen KA, Petersen JH, Scheike T, Olgaard K. Kidney growth in 717 healthy children aged 0-18 months: a longitudinal cohort study. Pediatr Nephrol. 2004 Sep;19(9):992-1003. 55. Boisen KA, Kaleva M, Main KM, Virtanen HE, Haavisto AM, Schmidt IM, Chellakooty M, Damgaard IN, Mau C, Reunanen M, Skakkebaek NE, Toppari J. Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries. Lancet. 2004 Apr 17;363(9417):1264-9. 56. Chellakooty M, Vangsgaard K, Larsen T, Scheike T, Falck-Larsen J, Legarth J, Andersson AM, Main KM, Skakkebaek NE, Juul A. A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth. J Clin Endocrinol Metab. 2004 Jan;89(1):384-91. 57. Chellakooty M, Schmidt IM, Haavisto AM, Boisen KA, Damgaard IN, Mau C, Petersen JH, Juul A, Skakkebaek NE, Main KM. Inhibin A, inhibin B, follicle-stimulating hormone, luteinizing hormone, estradiol, and sex hormone-binding globulin levels in 473 healthy infant girls. J Clin Endocrinol Metab. 2003 Aug;88(8):3515-20. 58. Schmidt IM, Chellakooty M, Haavisto AM, Boisen KA, Damgaard IN, Steendahl U, Toppari J, Skakkebaek NE, Main KM. Gender difference in breast tissue size in infancy: correlation with serum estradiol. Pediatr Res. 2002 Nov;52(5):682-6. 59. Virtanen H, Kaleva M., Haavisto A-M, Main KM, Skakkebæk NE, Toppari J: The birth rate of hypospadias in the Turku area in Finland. APMIS, 2001, 109: 96-100

Reviews, editorials, and proceedings
1. Lindhardt Johansen M, Hagen CP, Johannsen TH, Main KM, Picard JY, Jørgensen A, Rajpert-De Meyts E,
Juul A: Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with special emphasis on disorders of sex
development. Int J Endocrinol 2013; 2013: 198698
2. Virtanen HE, Sadov S, Toppari J: Prenatal exposure to smoking and male reproductive health. Curr Opin Endocrinol Diabetes Obes 2012; 19: 228-232 3. Boas M, Feldt-Rasmussen U, Main KM. Thyroid effects of endocrine disrupting chemicals. J Mol Cell 4. Toppari J, Adamsson A, Boas M, Juul A, Main KM, Skakkebæk NE, Virtanen HE. Possible developmental early effects of endocrine disrupters on child health. WHO report 2012. Pages 1-83. ISBN 9789241503761 5. Bay K, Main KM, Toppari J, Skakkebæk NE: Testicular descent: INSL-3, testosterone, genes and the intrauterine milieu. Nature Rev Urol 2011; 8: 187-196 6. Juul A, Main KM, Skakkebæk NE: Disorders of sex development- the tip of the iceberg? Nature Rev 7. Feldt-Rasmussen U, Bliddal Mortensen AS, Rasmussen ÅK, Boas M, Hilsted L, Main KM: Challenges in interpretation of thyroid function tests in pregnant women with autoimmune thyroid disease. J Thyroid Res 2011; 10: 2011: 598712 8. Hartoft-Nielsen ML, Boas M, Bliddal S, Rasmussen AK, Main KM, Feldt-Rasmussen U: Do thyroid disrupting chemicals influence foetal development during pregnancy? J Thyr Res 2011; 2011: 342189 9. Main KM, Toppari J, Skakkebaek NE: Genital anomalies in boys and the Environment. Best Pract Res
Clin Endocrinol Metab 2010; 24(2): 279-289
10. Toppari J, Virtanen HE, Main KM, Skakkebaek NE: Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS) – Environmental connection. Birth Defects Res A Clin Mol Teratol 2010;
88(10): 910-919
11. Main KM, Skakkebaek NE; Toppari J: Cryptorchidism as part of the testicular dysgenesis syndrome: the Environmental connection. Endocr Dev 2009; 14: 167-173
12. Main KM: Phthalate monoesters and infant reproductive health. Gesundheitswesen 2008; 70 Suppl 1:
13. Toppari J, Kaleva M, Virtanen HE, Main KM, Skkakebæk NE: Luteinizing hormone in testicular descent. Mol Cell Endocrinol 2007; 269(1-2): 34-37
14. Toppari J, Virtanen H, Skakkebaek NE, Main KM: Environmental effects on hormonal regulation of testicular descent. J Steroid Biochem Mol Biol 2006; 102(1-5): 184-186
15. Lottrup G, Andersson AM, Leffers H, Mortensen GK, Toppari J, Skakkebaek NE, Main KM: Possible impact of phthalates on infant reproductive health. Int J Androl 2006; 29(1):172-180
16. Main KM, Jensen RB, Asklund C, Høi-Hansen CE, Skakkebaek NE: Low birth weight and male reproductive function. Horm Res 2006; 65 Suppl.3: 116-22
17. Main KM, Toppari J, Skakkebaek NE: Gonadal development and reproductive hormones in infant boys. Eur J Endocrinol 2006; 155 (Suppl 1): S51-S57


Pharmacogenomics: advent of personalized medicine

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