S U STA I N E D - R E L E AS E B U P RO P I O N VS. P L AC E B O FO R S M O K I N G C E S SAT I O N A COMPARISON OF SUSTAINED-RELEASE BUPROPION AND PLACEBO RICHARD D. HURT, M.D., DAVID P.L. SACHS, M.D., ELBERT D. GLOVER, PH.D., KENNETH P. OFFORD, M.S., J. ANDREW JOHNSTON, PHARM.D., LOWELL C. DALE, M.D., MOISE A. KHAYRALLAH, PH.D., DARRELL R. SCHROEDER, M.S., PENNY N. GLOVER, M.ED., C. ROLLYN
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Sargentwelch.comSafety Data Sheet
1. PRODUCT AND COMPANY IDENTIFICATION
Product Name: Colchicine
Synonyms/Generic Names: N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[alpha]heptalen-7-
SDS Number: 206.00
Product Use: For Educational Use Only
Manufacturer: Columbus Chemical Industries, Inc.
For More Information Contact: Ward's Science
5100 West Henrietta Rd. PO Box 92912-9012 Rochester, NY 14692 (800) 962-2660 (Monday-Friday 7:30-7:00 Eastern Time) In Case of Emergency Call: CHEMTREC - 800-424-9300 or 703-527-3887 (24 Hours/Day, 7 Days/Week)
2. HAZARDS IDENTIFICATION
OSHA Hazards: Target organ effect, Highly toxic by inhalation, Highly toxic by ingestion, Irritant, Teratogen
Target Organs: Liver, Kidney, Bone marrow, Nerves, Cardiovascular system
Signal Words: Danger
GHS Label Elements, including precautionary statements:
Do not breathe dust/fume/gas/most/vapors/spray. Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do so. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
Potential Health Effects
May be fatal if inhaled. Causes respiratory tract irritation. May be harmful if absorbed through skin. Causes skin irritation. Ingestion
3. COMPOSITION/INFORMATION ON INGREDIENTS
4. FIRST-AID MEASURES
Rinse with plenty of water for at least 15 minutes and seek medical attention immediately. Inhalation
Move casualty to fresh air and keep at rest. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Get medical attention immediately. Immediately flush with plenty of water for at least 15 minutes while removing contaminated clothing and wash using soap. Get medical attention immediately. Ingestion
Do Not Induce Vomiting! Never give anything by mouth to an unconscious person. If
conscious, wash out mouth with water. Get medical attention immediately.
5. FIRE-FIGHTING MEASURES
Suitable (and unsuitable)
Use water spray, alcohol-resistant foam, dry chemical, or carbon extinguishing media
Special protective equipment
Wear self-contained, approved breathing apparatus and full protective and precautions for firefighters
clothing, including eye protection and boots. Specific hazards arising from
Emits toxic fumes (carbon oxides, nitrogen oxides) under fire the chemical
conditions. (See also Stability and Reactivity section).
6. ACCIDENTAL RELEASE MEASURES
See section 8 for recommendations on the use of personal protective protective equipment and
Prevent spillage from entering drains. Any release to the environment may be subject to federal/national or local reporting requirements. Methods and materials for
Pick up and arrange disposal without creating dust. Sweep up and containment and cleaning up
shovel. Clean surfaces thoroughly with water to remove residual contamination. Dispose of all waste and cleanup materials in accordance with regulations.
7. HANDLING AND STORAGE
Precautions for safe handling
See section 8 for recommendations on the use of personal protective equipment. Use with adequate
ventilation. Wash thoroughly after using. Keep container closed when not in use. Avoid formation of dusts.
Conditions for safe storage, including any incompatibilities
Store in cool, dry well ventilated area. Keep away from incompatible materials (see section 10 for
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Occupational exposure controls: Contains no substances with occupational exposure limit values.
Wear chemical safety glasses or goggles with face shield. Inhalation
Provide local exhaust, preferably mechanical. If exposure levels are excessive, use an approved respirator. Wear nitrile or rubber gloves, full suit protecting against chemicals.
Provide eyewash stations, quick-drench showers and washing facilities accessible to areas of use and
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance (physical state, color, etc.) Upper/lower flammability or explosive limit
10. STABILITY AND REACTIVITY
Possibility of Hazardous Reactions
Conditions to Avoid
Hazardous Decomposition Products
11. TOXICOLOGICAL INFORMATION
Eyes – rabbit – Severe eye irritation – 3 hours Respiratory
No components of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. No components of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH. No components of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP. No components of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.
Signs & Symptoms of Exposure
Redness, tearing, itching, burning, conjunctivitis. Respiratory
Irritation of mucous membranes, coughing, wheezing, shortness of breath. Ingestion
Irritation and burning sensations of mouth and throat, nausea, vomiting, and abdominal pain. Chronic Toxicity
Laboratory experiments have shown teratogenic effects. Mutagenicity
Specific Target Organ Toxicity
12. ECOLOGICAL INFORMATION
Aquatic Invertebrate Not Available
Persistence and Degradability
Mobility in Soil
PBT and vPvB Assessment
Other Adverse Effects
13. DISPOSAL CONSIDERATIONS
Users should review their operations in terms of the applicable federal/national or local regulations and consult with appropriate regulatory agencies if necessary before disposing of waste products or residues. Users should review their operations in terms of the applicable federal/national or Containers
local regulations and consult with appropriate regulatory agencies if necessary before disposing of waste product container.
The information offered in section 13 is for the product as shipped. Use and/or alterations to the product may
significantly change the characteristics of the material and alter the waste classification and proper disposal
14. TRANSPORTATION INFORMATION
UN2811, Toxic solids, Organic, n.o.s., (Colchicine), 6.1, pg II UN2811, TOXIC SOLIDS, ORGANIC, N.O.S., (COLCHICINE), 6.1, pg II UN2811, TOXIC SOLIDS, ORGANIC, N.O.S., (COLCHICINE), 6.1, pg II UN2811, Toxic solids, Organic, n.o.s., (Colchicine), 6.1, pg II
15. REGULATORY INFORMATION
All ingredients are listed on the TSCA inventory. All ingredients are listed on the DSCL inventory. Class D-1A: Very toxic material causing immediate and serious toxic effects. Class D-2A: Very toxic material causing other toxic effects.
16. OTHER INFORMATION
Disclaimer: Columbus Chemical Industries, Inc. (“Columbus”) believes that the information herein is factual but is not intended to be all inclusive. The information relates only to the specific material designated and does not relate to its use in combination with other materials or its use as to any particular process. Because safety standards and regulations are subject to change and because Columbus has no continuing control over the material, those handling, storing or using the material should satisfy themselves that they have current information regarding the particular way the material is handled, stored or used and that the same is done in accordance with federal, state and local law. COLUMBUS MAKES NO WARRANTY, EXPRESS OR IMPLIED, INCLUDING (WITHOUT LIMITATION) WARRANTIES WITH RESPECT TO THE COMPLETENESS OR CONTINUING ACCURACY OF THE INFORMATION CONTAINED HEREIN OR WITH RESPECT TO FITNESS FOR ANY PARTICULAR USE.
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