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Microsoft word - shionogi claritin dry syrup 1 percent launched_2nd_080121_変更暦付き.doc

Long-acting selective H1 receptor antagonist for treatment of allergic Claritin® Dry Syrup 1% Launched
-Includes Pediatric Indication for Children Ages Three and Older- Schering-Plough K.K. (Headquarters: Osaka, President: Masao Torii) and Shionogi & Co., Ltd. (Headquarters: Osaka, President: Motozo Shiono) today launched Claritin® Dry Syrup 1% (generic name: Loratadine dry syrup 1%), a long-acting selective H1 receptor antagonist the two companies have been jointly developing as a treatment for Claritin® is an antihistamine for effectively treating allergic rhinitis (seasonal and perennial), urticaria, and itching associated with skin diseases (eczema, dermatitis, and pruritus cutaneous). Schering Plough Corporation of the United States created Claritin® and has marketed it for many years in more than 100 countries worldwide. Claritin® has been prescribed to over 400 million people. In Japan, Schering-Plough K.K. and Shionogi jointly market the prescription drugs Claritin® 10mg Tablet (launched September 2, 2002) and Claritin® RediTabs®, 10mg Tablet (launched November 15, 2004), and intend to jointly market Claritin® Dry Syrup 1% as well. Formulation Easy for Young Children to Take
Claritin® Dry Syrup 1% has been approved for pediatric use for children ages three and older. With sugar added to the odorless and tasteless active ingredient, the product has a slightly sweet flavor, which makes it easy for children to take. The formulation is also easy to dispense and use because the companies designed it to suspend readily in water In general, it is administered in solution as loratadine in once-daily oral doses of 5mg (dry syrup: 0.5g) for children age three to seven and 10mg (dry syrup: 1.0g) for children ages seven and older after a meal. Claritin® has also been recognized for its effectiveness and safety for adults as a non-sedating (non-drowsy) antihistamine that has little effect on concentration or scholastic performance. With medications for children under the age of seven, not only effectiveness and safety but also dosing frequency and being easy to take are considered important. Claritin® Dry Syrup 1% covers all these factors, and is therefore expected to make a significant contribution to The Claritin Family: A Broad Array of Products
Schering-Plough and Shionogi have also received approval for the additional indication for children age seven and older for Claritin® 10mg Tablet and Claritin® RediTabs®, 10mg Tablet. With the addition of Claritin® Dry Syrup 1% for children ages three and older, the Claritin® family of products is the first lineup of antihistamines in Japan that is available in three dosage forms. It therefore offers a variety of choices to an exceptionally broad range of patient age groups. Claritin® Dry Syrup 1% Product Overview
Inactive ingredients: Sugar, hydroxypropylcellulose, aqueous silicon Allergic rhinitis, urticaria, and itching associated with skin diseases (eczema, dermatitis, and pruritus cutaneous) Administration: Adults: Generally, one 10mg dose (dry syrup: 1g) as loratadine per day, administered orally in solution after a meal. The dose is adjusted based Children: Generally, one 5mg dose (dry syrup: 0.5g) as loratadine per day for children from the age of three to seven, and one 10mg dose (dry syrup: 1 g) per day for children ages seven and older, administered Packaging: Claritin® Dry Syrup 1%: 100g (0.5g x 150 packets) Characteristics: 1. Outstanding effectiveness in relieving allergic rhinitis, urticaria,
and itching associated with skin diseases
• For the first time in Japan, effectiveness against chronic allergic rhinitis was confirmed three days after administration. Alleviation of nasal symptoms was significantly better than with a placebo. • Symptoms of seasonal allergic rhinitis were significantly reduced compared with the placebo on the day of administration. Moreover, the effect continues until administration ceases. • For pediatric allergic rhinitis, lowered scores for the four nasal symptoms of sneezing, dripping, congestion and intranasal pruritus, which helps improve daily life. • Demonstrated high rates of improvement of 89.1% for urticarial pruritus and 87.5% for the appearance of macula. • Alleviated symptoms of pruritus associated with atopic dermatitis, including eczema, dermatitis, and pruritus cutaneous. • Significantly reduced symptoms of pruritus associated with atopic dermatitis compared with the placebo. (Source: overseas data) • Alleviated day- and night-time itching from pediatric atopic dermatitis from the day after administration began, and substantially lowered main pruritus scores. 2. Non-sedating
Little difference in the ability to drive compared with the placebo was observed during studies of the effects on driving. As a result, Claritin® has little effect on daily activities because it does not exhibit the same sedative effect as other antihistamines. 3. Sustained antihistamine action
Sustained action against wheal and erythema induced by histamines was observed during clinical trials. A single daily dosage offers excellent clinical effectiveness. 4. Easy to use and rapid action
• Single daily dosage ensures a high rate of dosing compliance.

Source: http://www.shionogi-inc.com/pdf/e_080121.pdf

Argumentaires pour le dossier grippe h1n

NOTE INTERNE SUR LA SITUATION DE L’EPIDEMIE DE GRIPPE H1N1 APPARITION DE LA MALADIE Dans l’état actuel de la connaissance du dossier, le virus de la grippe H1N1 qui circule au Mexique se transmet d’homme à homme. On se retrouve face à une épidémie de grippe humaine et c’est à tort que l’on parle de grippe porcine. L’origine de la maladie au Mexique n’est pas

Microsoft word - ve_200305986_se ridotta.doc

Il Tribunale Amministrativo Regionale per il Veneto, prima sezione, con l’intervento dei signori magistrati: Stefano Baccarini sul ricorso n. 891/2001, proposto da Elvis Elettronica Video Suono s.n.c. in proprio e quale mandataria dell’A.T.I. tra la medesima e Tecnocoop S.r.l., in persona del legale rappresentante pro tempore, rappresentato e difeso dall’avv. Umberto Costa, con domicilio

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