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Microsoft word - 5thsem(A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) 501 PHARMACEUTICAL CHEMISTRY-IV (MEDICINAL–II) Quantitative structure activity relationship (QSAR) studies, basic concepts of computer aided drug design, different drug design approaches, basic General Anaesthetics : Introduction, classification, mechanism of action, synthesis and therapeutic uses of halothane, ketamine, methohexital. Local Anaesthetics : Introduction, chemical classification, ideal requirements, mode of action, SAR, structures of important local anaesthetics, metabolism and synthesis of benzocaine, procaine, lidocaine, tetracaine and cinchocaine. Hypnotics and Sedatives – SAR of barbiturates, synthesis, metabolism and therapeutic uses of phenobarbital, amylobarbital, pentobarbital, cyclobarbitone calcium, thiopental, hexobarbital. chlordiazepoxide, diazepam, alprazolam. Anti-psychotics – SAR of phenothiazines, synthesis and therapaeutic uses of promethazine, Prochlorperazine, Fluphenazine, chlorpromazine, haloperidol, Anti– depressants: Synthesis and therapaeutic uses of amitryptaline, doxepine, iproniazid, isocarboxizide, trazodone, fluoxetin Anti – Anxietyagents : Synthesis and therapaeutic uses of nitrazepam, Anti-epileptics – Synthesis and therapaeutic uses of phenytoin, valproic acid, Drugs affecting adrenergic mechanism : Adrenergic receptors, biosynthesis of catecholamines, chemical classification along with structures, S.A.R of adrenergic drugs, adrenergic agonists, adrenergic blockers. Synthesis and therapeutic uses of phenylephrine, ephedrine, naphazoline, terbutaline, dopamine, amphetamine, phenoxybenzamine, propranolol, metaprolol, atenolol, Drugs affecting cholinergic mechanism: Introduction, SAR, cholinergic receptors, study of cholinergic agonists, indirectly acting cholinergic agonists, cholinergic blocking agents, neuromuscular blocking agents. Synthesis and therapeutic uses of methacholine, carbachol, neostigmine, pralidoxime, propantheline, dicyclamine, tropicamide, atropine, bipyridine. (A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) Cardiovascular Agents: Introduction, classification, mechanism of action of antianginal agentscalcium channel blockers, Anti-arrhythmic drugs, antihypertensive agents, antihyperlipidemic agents and anticoagulants. Synthesis and therapeutic uses of methyldopa, amlodipine, clonidine, hydralazine, verapamil, clofibrate, dicoumorol, Hypoglycaemics : General account on pancreatic malfunctions. chemical classification, S.A.R of hypoglycemics, Insulin preparations, a brief account on statin antidiabetics – phenformin, glipizide, chlopropamide, including a brief account on PPARγ inhibitors, meglitinide analogues, α-glucosidase inhibitors–Acarbose, miglitol. A brief account on thyroid and antithyroid drugs. Opoid Analgesics : Classification along with structures, mechanism of action, S.A.R of opioid analgesics, mixed agonists and mixed antagonists, central and peripheral acting anti tussive agents. Structure and therapeutic uses of morphine, codeine, diacetylmorphine, nalorphine, levalophan, noscapine, dextromethorphan. NSAIDS (Non-steroidal anti-inflamatory agents) : Introduction and types of pain and inflammation. Synthesis, metabolism and therapeutic uses of aspirin, paracetamol, ibuprofen, mefenamic acid, diclofenac, piroxicam. A brief account on Cox-2 inhibitors. DIURETICS : Introduction, chemical classification along with structures, mechanism of action, S.A.R, metabolism and synthesis of acetazolamide, benzthiazide, furosemide, ethacrynic acid chlorthiazide, hydrochlorthiazide and amiloride. Antihistaminic agents : Introduction, histamine receptors, biosynthesis of histamine, study of H1 and H2 antagonists. Chemical classification along with structures, mechanism of action, S.A.R, of antihistamines. Synthesis and metabolism of diphenhydramine, pyrilamine, mepyramine, cyclizine pheninramine, promethazine, antazoline, astimizole, cetrizine, Diagnostic agents : Introduction, structures and therapeutic uses of some important organic compounds as diagnostic agents. Synthesis of iopanoic acid, fluorescein, diatriazoic acid (A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) Assay of glipizide/frusemide tablets – I.P. Assay of paracetamol elixir/tablet – I.P. Assay of salicylic acid ointment – I.P. Synthesis of 7-hydroxy 4-methyl coumarin Synthesis of phenytoin (5, 5’ – diphenyl hydantoin) 1. Text book of Medicinal Chemistry by William O. Foye, Lea Febiger, Philadelphia. Wilson & Giswold’s Text book of organic Medicinal Chemistry and pharmaceutical chemistry by JH Block & JM Beale (Eds), 11th Ed, Lipcott, Raven, Philadelphia, 2004. 2. D. Abraham (Ed), Burger Medicinal chemistry ad Drug discovery, Vol. 1 & 2. John Wiley & Sons, New York 2003, 6th Ed. 3. Lippincott Williams and Wilkins: Remington Pharmaceutical Sciences; 20th 4. Bentley and Driver’s Textbook of Pharmaceutical Chemistry Ed: l. M. Atherden. Oxford University Press, Delhi. 5. B.N. Lads, MG.Mandel and F.I. way, Fundamentals of drug metabolism & disposition, William & welking co, Baltimore USA. 6. Hansch, Comprehensive medicinal chemistry, Vol 1 – 6 Elsevier pergmon press, 7. Rama Rao Nadendla, Principles of Organic Medicinal chemistry, Vol-I, New-Age International Publishers Pvt., limited, New Delhi, 2005 8. Daniel lednicer, Strategies For Organic Drug Synthesis And Design, John Wiley, 9. D. Lednicer, Organic drug synthesis, Vol, 1 – 6, J.Wiley N.Y. (A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) III/IV B.PHARMACY (5th Semester)
501 PHARMACEUTICAL CHEMISTRY-IV (MEDICINAL-II) (Theory) Add a note on different drug design approaches. Give a detailed Classify sedatives and hypnotics with suitable examples. Write the SAR and mode of action of Barbiturates. Outline the chemical classification of adrenergic drugs. Discuss What are oral hypoglycemic agents ? Classify them with examples Classify the non-steroidal anti inflammatory agents with examples and discuss their mode of action ? How do you synthesize diclofenac and Classify H1 antagonists with examples ? Discuss the SAR and Write short notes on Free Wilson analysis Outline the synthesis and therapeutic uses of phenytoin. Give the synthesis and mechanism of propantheline. Write short notes on antianginal agents. Discuss the mode of action of opioid analgesics Write the SAR and mode of action of thiazide diuretics. Add a note on synthesis and metabolism of cetrizine. III/IV B.PHARMACY (5th Semester)
502 PHARMACEUTICAL CHEMISTRY-IV (MEDICINAL-II) (A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) III/IV B.PHARMACY (5th Semester)
Formulation : Physical chemical and therapeutic factors in-volved in the formulation of dosage forms. Introduction to pre-formulation studies. Formulation additives in solid, semi-solid A study of the principles, formulation, manufacturing process and equipment and quality control of the following dosage forms. Liquid orals - Manufacture and quality control of solutions, emulsions and Semi-solids : Ointments, creams, pastes, Jellies - Definitions, Ideal requirements, Types of bases, selection of base, Typical examples. A study of the principles, formulation, manufacturing process and equipment and quality control of the following dosage forms. Solids: Compressed tablets Types - Formulation additives, Formulation, manufacture and quality control of tablets -Examples (I.P.) Processing Capsules : Hard and soft: Formulation, manufacture and their quality Tablet coating: Purpose - Sugar, film and enteric coating meth-ods. Parenterals : Definitions, Types, Formulation aspects, produc-tion facilities, lay out, manufacturing and quality control, Typi-cal examples from I.P. Ophtalmic preparations : Eye ointments, Eye drops, Ideal require-ments, Formulation, manufacture and quality control, Typical examples from I.P. Pharmaceutical Aerosols: Definitions, classification - formula-tion, propellents, pressurized packagings, applications Radiopharmaceuticals: Therapeutic and diagnostic uses. Pro-duction of radio Pharmaceuticals - Care in handling. Cosmetics: A Study of formulation manufacture and evaluation of cleaning creams, nail lacquers and nail polish removers, deodorants and antiperspirants, shampoos, hair bleaches and depilatories, shaving creams. (A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) Formulation of an anti-pyretic liquid oral for a child below ten years. Formulation of paediatric liquid oral of ibuprofen Formulation of paediatric liquid oral of amoxycillin Quality control tests of dummy lactose tablets Manufacture of calcium phosphate tablets Manufacture of ibuprofen-tablets by direct compression. Manufacture of sodium CMC lubricating jelly Manufacture of dextrose ampoules by terminal sterilization. Manufacture of NaNO ampoules by terminal sterilization. Disintegration test for different types of tablets. Formulation and evaluation of antidandruff shampoo. Theory and Practice of Inustrial Pharmacy by Lachman Pharmaceutical Dosage Forms – Tablets by H.A.Liberman Encyclopedia of Pharmaceutical technology by Swarbrick Cosmetic science and technology by Sagarin Cosmetics - Manufacture, Formulation and Quality control - (A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) III/IV B.PHARMACY (5th Semester)
Discuss the physico-chemical factors involved in the What are the ideal requirements of ointment bases ? Classify What are different methods used in manufacture of tablets ? Describe the facilities for commercial production of parenterals What are the advantages of aerosols. With a neat sketch. Explain the metering valve for pharmaceutical aerosols. Classify shampoos. Write down the ideal requirements of Write a note on additives used in tablet dosage forms. Explain the significance of the preformulation studies. Write a note on controlled flocculation. Explain the evaluation tests for emulsions. Write a note on opthalmic preservatives. Write any 2 evaluation tests for parenterals. Explain about handling of Radio pharmaceuticals. Write a note on evaluation tests for aerosols. Write a short notes on formulation of nail polish removers. III/IV B.PHARMACY (5th Semester)
(A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) III/IV B.PHARMACY (5th Semester)
505 PHARMACOGNOSY - I (Theory) (75 hrs.) Definitions, history, scope and development of pharmacognosy. Sources of natural drugs, organized and unorganized drugs. Different methods of Cultivation, collection, processing and storage of crude drugs. Factors influencing cultivation of medicinal plants. Types of soils and fertilizers of common use. Pest management and natural pest control agents. Plant hormones and their application. Polyploidy, mutation and hybridization with reference to medicinal plants. Quality control of crude drugs : Adulteration of crude drugs and their detection by organoleptic, microscopic, physical, chemical and biological methods of Systematic pharmacognostic study (microscopical characters, varieties, adulterants, substituents, principle constituents and uses) of the 1. Carbohydrates and derived products : Agar, guar gum, gum acacia, honey, isabgol, pectin, starch, sterculia and tragacanth 2. Proteins and enzymes: Gelatin, papain, yeast. 3. Tannins: Arjuna, black catechu, gambier catechu. Study of fibres used in pharmacy such as asbestos, cotton, glass- wool, nylon, Resin and Resin combinations : Asafoetida, balsam of peru, balsam of tolu, benzoin, cannabis, capsicum, ginger, guggel, jalap, myrrh, podophyllum, An introduction to biogenesis of primary and secondary metabolities of (A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) III/IV B.PHARMACY (5th Semester)
506 PHARMACOGNOSY – I (Practicals) (75 hrs.) Identification of Carbohydrates (Agar, Acacia, Starch, Honey, Tragacanth, Guargum, Pectin, Isabgol), Tannins (Black catechu), Resins (Benzoin, Asafoetida, storax, myrrh), Fibres (absorbent cotton, non-absorbent cotton, silk and wool) by general and specific chemical tests. Measurement of length and width of phloem fibres in powdered crude drugs, (Cinchona & Cinnamon) Measurement of starch grains (Ginger and Potatostarch) Measurement of calcium oxalate crystals (squill) Determination of stomatal number and stomatal index Determination of swelling factor of the given seeds (Isabgol) Identification of crude drug by organoleptic and morphological characters : Fibres (Cotton, Wool, Silk), Carbohydrates (Agar, Isapgol, acacia, tragacanth, Honey) , Proteins & Enzymes catechu, Arjuna), Resins (Benzoin, Myrrh, Asafoetida, Turmeric, Ginger, Determination of extractive value of crude drug Text book of Pharmacognosy by T.E.Wallis. Text book of Pharmacognosy by Trease and Evans Text book of Pharmacognosy by C.K.Kokate 04. Cultivation of Medicinal and Aromatic crops by A A Pharmacognosy and Phytochemistry by Dr.Vinod Rangari, Pharmacognosy and phytochemistry by Ashutoshkar. Essentials of Pharmacognosy by Dr.S.H.Ansari. Pharmacognosy and phytochemistry by Brady & Talyr Text book of Pharmacognosy by S.S.Handa and V.K.Kapoor. (A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) Define crude drug and write the differences between organized Write in detail about endogeneous factors affecting cultivation of Enumerate the physical methods of crude drug evaluation. Write the systematic pharmacognostic study of gum acacia. Write the applications of pharmaceutical fibres. Give an account of biosynthetic pathways for the formation of Write in brief about various sources of crude drugs. Write the chemical classification of crude drugs. Discuss the importance of sort and soil fertility in the cultivation of Classify plant harmones and write the applications of gibberellins Enumerate the methods of crude drug adulteration with examples. What is micrometry and write its significance in the evaluation of Define carbohydrates, write the biological source and uses of Write the chemical constituents and uses of gelatin and arjuna. Method of preparation of surgical cotton. Explain the biosynthesis of indole alkaloids. Write the biological source and chemical constituents of storax and (A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) General Pharmacology and pharmacodynamics : Factors influencing the effect of drugs. The Dose –effect relationship, Introduction to LD and ED , therapeutic index. General mechanism of drug action, Structure activity relationship, drug receptors, drug toxicity and drug allergy. Pharmacology of drugs acting on autonomic nervous system: Parasympathomimetics, parasympatholytics, sympathomimetics, sympatholytics, neuromuscular blocking agents and ganglionic blockers. Pharmacology of drugs acting on central nervous system : Synaptic transmission in the CNS; General anaesthetics, hypno-sedatives, analgesics, antipyretics and anti-Inflammatory agents. Pharmacology of drugs acting on central Nervous system : Antiepileptics, antiparkinsonian drugs, psycho- pharmacological agents, CNS stimulants, hallucinogens and drugs used in gout Pharmacology of drugs acting on Gastro –intestinal system : Purgatives, Antidiarrhoeal drugs, treatment of peptic ulcer, emetics and anti- emetics. Pharmacology of local anaesthetics and diuretics. Goodman and Gilman - The Pharmacological Basis of Therapeutics. Textbook of Pharmacology by Rang and Dale Quientessence of Medical Pharmacology by C.Chowdary. Lippincott’s illustrated reviews - Pharmacology by Richard D.Howland Essentials of medical pharmacology by K.D.Tripathi. Pharmacology and Pharmacotherapeutics by R.S.Satoskar, (A.N.U. B.PHARMACY SYLLABUS WITH EFFECT FROM 2012-13 ACADEMIC YEAR) III/IV B.PHARMACY (5th Semester)
Discuss the mechanisms of drug action with suitable examples. Classify cholinesterase inhibitors with suitable examples and discuss about the management of organophosphorous poisoning. Classify the anti inflammatory drugs with suitable examples and discuss the pharmacology of salicylates. Classify antidepressants. How do tricyclic antidepresants act ? Classify and discuss the various drugs that are used in peptic ulcer. Add a note on proton-pump inhibitors.’ 6. Classify diuretics with suitable examples and discuss the mechanism of action and adverse effects of furosemide ? Describe briefly dose-effect relationship. Write short notes on neuromuscular blocking drugs. Discuss the mechanism of action and therapeutic uses of Add a note on endogenous opioid peptides. Describe the mechanism of action and mention the therapeutic Write notes on pharmacology of allopurinol . Describe the mechanism of action and therapeutic uses of cocaine. Discuss different routes of administration of local anesthetics.
Girl Scouts of ____________ (Council Name) Health History and Medical Examination Form for Minors Health History: The more complete information you provide, the better we are able to work with your child to ensure she receives the care she needs. Medical Examination: A medical examination is completed for trips lasting more than three nights. The examination is completed by a lic