MGMS and RSC MMG Young Modellers’ Forum 2008 POSTER PRESENTATIONS Poster 1 Discarding Functional Residues from the Substitution Table Improves Predictions of Active Sites within Three-Dimensional Structures Sungsam Gong and Tom Blundell Dept. of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK Substitutions of individual amino a
Bardzo tanie apteki z dostawą w całej Polsce kupic cialis i ogromny wybór pigułek.
Microsoft word - case#xxxx ugx dm2 _6_.doc
NUTRITIONAL SUPPORT INCLUDING THE ULTRAGLYCEMX PLUS 360°
MEDICAL FOOD PROGRAM IN A PATIENT WITH TYPE 2 DIABETES
Initiate exercise plan at 150 minutes/week and To show how targeted nutritional support featuring Follow-up with FMRC nutritionist to report UltraGlycemX (with barley beta-glucans and chlorogenic progress and adjust dietary/exercise program acid) and UltraGlycemX PLUS 360° (with SKRMs*) may be useful in patients with type 2 diabetes. 4-Week Results
Patient’s Presentation and History
A 57-year-old Caucasian female presented with a The patient reported doing well with the LGLD. She was previous diagnosis of type 2 diabetes. She had a lifelong eating smaller, more frequent meals and exercising 1 challenge with food cravings, late-night eating, and hour 5 days/week, plus swimming and yoga 2 to 3 portion control, struggling with weight in high school and times/week. Fasting blood glucose was still around 120 further after 2 pregnancies (gestational diabetes during to 128 mg/dL, with 105 to 110 mg/dL at night. She felt both managed with diet). Weight loss trials had been better with more energy, but exercise had increased her unsuccessful; a loss of ~40 lb on a commercial meeting- arthritis symptoms. Lab tests revealed positive anti- centered program was regained within a year. A routine exam 2 years earlier revealed elevated blood glucose 8- through 14-Week Results
(~170 mg/dL) and she was placed on metformin. The dose was doubled in 6 months, at which time she noted At the 8-week visit, the patient was doing extremely well on the LGLD with a total weight loss of 12 lb. After 9 weeks, her fasting blood glucose was ranging 107 to 120 The patient also complained of migraines and joint pain in mg/dL. She reported a lot more energy and no migraines her knees, hands, low back, and shoulder. Her medical since starting the program. Lab tests were positive for history included recurrent kidney stones, ear infections, stool gluten sensitivity, and the patient was counseled on sinusitis (severe), hoarseness, dry mouth, ringing in ears, gluten elimination. At the 14-week visit, the patient had bronchitis, and irritable bowel syndrome (IBS). Surgeries lost a total of 17 lb and reported sustained energy and included removal of polyps, 2 stereotactic breast surgeries absence of headaches. Evening glucose measurements (fibrocystic breasts), and an adenotonsillectomy. She had continued to improve at ~105 mg/dL. A fall had injured a family history of heart failure, hypertension, type 2 her back and triggered some IBS-type symptoms. diabetes, thyroid problems, osteoporosis, and arthritis. Laboratory tests indicated an increase of hsCRP. The patient was advised to continue on UltraGlycemX and Patient’s Objective Information
the gluten-free diet and to add a soluble/insoluble fiber blend supplement at 1 scoop daily, along with a high HT: 66”; WT: 224 lb; BP 116/67; BMI: 36.2 kg/m2 potency L. acidophilus/B. lactis combination probiotic, 1 Exercise: yoga 2 times/week; aerobics 2 times/week 18- through 30-Week Results
Prescription medications and supplements included: levothyroxine sodium (thyroid), 0.50 mg daily; At 18 weeks, the patient had lost a total of ~21 lb. At the ezetimibe/simvastatin (cholesterol) 10/20 mg daily; 23-week visit, she noted more energy. Her fasting triamterene (hypertension), 50 mg daily; lisinopril glucose had been high at 107 to 127 mg/dL, with 2-hour (hypertension), 5 mg daily; calcium/magnesium/ postprandial at 105 to 110 mg/dL. She was instructed to zinc; fish oil; multivitamin/mineral; glucosamine/ replace UltraGlycemX with UltraGlycemX PLUS 360° Medical Food, 2 scoops twice daily, and continue the other prescribed nutraceuticals. At 25 weeks, her fasting glucose had improved with a maximum of 110 mg/dL. After 30 weeks, these values had sustained. Conclusion
Begin UltraGlycemX Medical Food, 2 scoops twice This case study suggests that targeted nutritional support that combines UltraGlycemX medical foods with LGLD Begin a Mediterranean-style, low-glycemic-load diet and aerobic exercise may help show improvement in clinical symptoms associated with type 2 diabetes. 9% Decrease in
After 30 weeks, the patient had a total loss of approximately 20 lb. A body composition analysis at 14 weeks confirmed an increase in lean muscle mass and decrease in fat mass. Excess body fat is associated with an increase in risk to insulin-related disorders 9% Decrease in
The patient’s body mass index (BMI)† was decreased from 36.2 (severely obese) to 33.1 (obese) in 30 weeks on the program. This result suggests a reduction in risk to lifestyle-related conditions. 13% Decrease in
Fasting glucose levels for the patient decreased 17% in 14 weeks to within a normal reference range (65 to 120 mg/dL) and remained comparable at the 30-week follow-up visit. These results suggest improved glucose metabolism. * Selective kinase response modulators—or SKRMs—are nutritional substances Financial support for this study was provided by Metagenics, Inc. This study was that can work to modulate kinase signaling and may help restore healthy signaling conducted at the Functional Medicine Research Center (FMRC), the clinical to genes, favorably affecting genetic expression, and thus helping to reverse some Case Study: Nutritional Support Including the UltraGlycemX PLUS 360° Medical †Body Mass Index (BMI) is computed by the weight (kg) divided by the square of Food Program in a Patient with Type 2 Diabetes. Metagenics, Inc.; 121DM507 the height (m). Note: The information provided in this case study describes the results of one patient under the care of a licensed healthcare practitioner and may not be a typical response. UltraGlycemX and UltraGlycemX PLUS 360° Medical Foods are to be used under the supervision of a physician or other licensed healthcare practitioner.
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