Die Struktur von Tadalafil erlaubt eine selektive Bindung an die Bindungsstelle der PDE5 und minimiert gleichzeitig die Interaktion mit PDE6, was visuelle Nebenwirkungen einschränkt. Seine Verteilung im Organismus erfolgt breit, wobei das Verteilungsvolumen etwa 63 Liter beträgt. Über 90 % des Wirkstoffs sind an Plasmaproteine gebunden. Die Wirkung bleibt unabhängig von der Nahrungsaufnahme konstant. Der Abbauweg über CYP3A4 kann durch Hemmer wie Ritonavir oder Ketoconazol verlangsamt werden, was die Plasmakonzentrationen deutlich erhöht. In diesem Kontext wird cialis 20mg preis häufig in Bezug auf pharmakokinetische Wechselwirkungen erwähnt.

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Use of prescribe and over-the-counter drugs can cause depletion of one or more vital nutrients in the body. The
drugs may interfere with the body's absorption of an essential nutrient or vitamin, or the body's production of an
important biochemical. Listed in this guide are many of the most frequently prescribe drugs, and the resulting
nutrients they deplete.
Acebutoltol (Sectral)
Captopril (Capoten)
Acetaminophen (Tylenol)(APAP)
Carbamazepine (Tegretol)
Acetazolamide (Diamox)
Carisoprodol (Soma) Compounds
Vitamin C, Sodium, Folic Acid, Iron, Potassium Acetohexamide (Dymelor)
Carvedilol (Coreg)
Albuterol (Proventil)
Celecoxib (Celebrex)
Calcium, Magnesium, Potassium,Phosphorous B Complex Vitamins, especially Folic Acid Amoxicil in (and most other antibiotics)
Chlorothiazide (Diuril and other Thiazide Diuretics)
Biotin, Calcium, Inositol, Magnesium, Potassium, Sodium, CoQ10, Zinc, Potassium, Phosphorous, Amiloride (Midamor)
Chlorotrianisene (Tace)
Amiloride and Hydrochlorothiaxide (Moduretic)
Chlorpromazine (Thorazine)
Chlorpropamide (Diabenese)
Amitriptyline (Elavil)
Chlolestyramine Resin (Questran)
Amphotericin B (Fungizone)
Vitamin D, Vitamin K, Zinc, Vitamin E, Phosphorous, Atenolol and Chlorthalidone (Tenoretic)
CoQ10, Magnesium, Phosphorous, Potassium, Cimetidine (Tagamet)
Zinc, Calcium, Folic Acid, Iron, Vitamin D, Atorvastatin (Lipitor)
Clomipramine (Anafranil)
Benazepril (Lotensin)
Clonidine (Catapres)
Betamethasone (Diprolene)
Calcium, Folic Acid, Magnesium, Potassium, Selenium, ColchicineVitamin C, Vitamin D, Zinc Vitamin B12, Sodium, Potassium, Calcium, Beta Bisoprolol (Zebeta)
Colestipol (Colestid)
Budesonide (Pulmicort)
Beta Carotene, Folic Acid , Iron, Vitamin A, Vitamin Folic Acid, Calcium Potassium, Magnesium, Selenium, B12,Vitamin D, Vitamin EVitamin C, Vitamin D, Zinc Cortisone (Catone)
Bumetanide (Bumex)
Vitamin C, Vitamin D, Zinc, Selenium, Potassium Vitamin C, B Complex Vitamins, Sodium, Potassium, Cyclosporine (Sandimmune, Neoral)
Potassium, Magnesium
Butabarbitol Sodium (Butalan)
Cyclothiazide (Anhydron)
Vitamin D, Vitamin K, Folic Acid, Calcium Sodium, Vitamin B6, Zinc, Potassium,
Phosphorous,Magnesium, CoQ10
Delavirdine (Rescriptor)
Butalbital Compounds
Folic Acid, Calcium, Biotin, Vitamin D, Vitamin K Desipramine (Norpramin)
Candesartan & Hydrochlorothiazide (Atacand)
CoQ10, Zinc, Potassium, Sodium, Phosphorous, Dexamethasone (Corticosteroid, Decadron)
Calcium, Folic Acid, Magnesium, Potassium Diclofenac and Misoprostol (Arthtotec)
Haloperidol (Haldol)
B Complex Vitamins (especial y Folic Acid) Didanosine (Videx)
Hydralazine (Apresoline) Compounds
CoQ10, Magnesium, Potassium, Vitamin B6, Zinc, Diethylstilbestrol (Stilphostrol)
Magnesium. B Complex Vitamins (especially B6) Hydrochlorothiazide (Microzide) Compounds
Digoxin (Lanoxin)
Sodium, Potassium, Zinc, Magnesium, Phosphorous, Hydrocodone Compounds
Enalapril (Vasotec) Compounds
Folic Acid, Iron, Vitamin C, Potassium, Magnesium, Folic Zinc, B Complex Vitamin, Sodium, Potassium Enoxacin (Penetrex)
Ibuprofen (Advil, Motrin, and most NSAIDS)
Potassium, B Complex Vitamins, Zinc, Magnesium, Imipramine (Tofranil)
Estradiol Compounds
B Complex Vitamins, Magnesium, Vitamin C, Zinc, Indapamide (Lozol)
CoQ10, Magnesium, Zinc, Sodium, Potassium, Estrogen and Medroxyprogesterone (Prempro)
B Complex Vitamin, Zinc, Vitamin C, Magnesium Irbesartan and Hydrochlorothiazide (Avapro HCTZ)
Estrogen (Conjugated, Premarin)
Sodium, Zinc, Magnesium, Phosphorous, Calcium, B Complex Vitamins(especially Vitamin B-6, Isoniazid (Laniazid) INH
Ethacrynic Acid (Edecrin)
Calcium, Magnesium, Potassium, Sodium, B Complex Lansoprazole (Prevacid)
Vitamins,
Levodopa (Dopar, Larodopa)
Ethyniyl Estradiol Compounds and most oral
contraceptives
Levodopa and Carbidopa (Sinemet)
B Complex Vitamins, Zinc, Magnesium, Vitamin C, Levonorgestrel (Norplant)
Ethosuximide (Zarontin)
B Complex Vitamins, Magnesium, Vitamin C, Zinc, Vitamin D, Vitamin K, Folic Acid, Calcium, Biotin Lisinopril (Prinivil, Zestril)
Famotidine (Pepcid)
Calcium, Folic Acid , Iron, B-12, Vitamin D, Zinc, Lithium (Lithobid)
Fenofibrate (Tricor)
Losartan and Hydrocholorothiazide (Hyzaar)
Flucytosine (Ancobon)
Sodium, Zinc, CoQ10, Magnesium, Phosphorous, Fluocinolone (Lidemol)
Lovastatin (Mevacor)
Zinc, Vitamin C, Vitamin D, Selenium, Potassium, Magnesium, Folic Acid, Calcium
Fluticasone (Flonase, Flovent) Compounds
Methocarbamol and Aspirin (Robaxisal)
Calcium, Folic Acid, Magnesium, Potassium Folic Acid, Iron, Potassium, Sodium, Vitamin C Methotrexate (Folex)
Glimepiride (Amaryl)
Methyldopa (Aldomet) Compounds
CoQ10, Magnesium, Phosphorous, Potassium,
Glipizide/Glyburide (and most anti-diabetic agents)
Methylprednisolone (Depo-Medrol)
CoQ10, Magnesium, Phosphorous, Zinc, Sodium, Calcium, Zinc, Folic Acid, Magnesium, Potassium, Pravatastin (Pravachol)
Metolazone (Zaroxolyn)
Prazosin and Polythiaziae (Minizide)
Potassium, Phosphorous, Magnesium, CoQ10, Metoprolol (Lopressor, Toprol)
Prednisolone (PredForte)
Metformin (Glucophage)
Magnesium, Vitamin C, Selenium, Potassium, Mineral Oil (Fleet-Enema)
Vitamin K, Vitamin D, Vitamin E, Vitamin A, Prednisone (Deltasone)
Vitamin C, Vitamin D, Zinc, Selenium, Potassium, Neomycin (Neo-Tabs)
Primidone (Deltasone)
Vitamin A, Beta Carotene, Calcium, Iron, Vitamin C, Vitamin D, Zinc, Selenium, Potassium, Lactobacillus, Acidophilus, Magnesium, Potassium, Magnesium, Folic Acid, CalciumVitamin B12, Primidone (Mysoline)
Vitamin B6, Sodium, Vitamin D, Vitamin K, Biotin, Calcium, Folic Acid, Vitamin D, Vitamin K Nevirapine (Viramune)
Prochlorperazine (Compazine)
Copper, Zinc, Folic Acid, Vitamin D, Iron, Vitamin CoQ10, B Complex Vitamins (especial y B2) Promazine (Sparine)
Norethindrome (Micronor and most oral
contraceptives)
Promethazine (Phenazine, Anergan)
Folic Acid, Magnesium, B Complex Vitamins, CoQ10, Magnesium, Phosphorous, Potassium, Nortriptyline (Pamelor)
Protriptyline (Vivactil)
CoQ10, B Complex Vitamins (especial y B2) Olsalazine (Dipentum)
Quinapril (Accupril and most ACE Inhibitors)
B Complex Vitamin, (especial y Folic Acid) Omeprazole (Prilosec)
Quinestrol (Estrovis)
Orlistat (Xenical)
Quinethazone (Hydromox)
Oxcarbazepine(Trileptal)
Rabeprazole (Aciphex)
Oxycodone (Oxycontine) Compounds
Raloxifene (Evista)
Folic Acid, Glutathione, Iron, Potassium, Sodium, Magnesium, B Complex Vitamins (especially B6) Ramipril (Altace)
Pantoprazole (Protonix)
Ranitidine (Zantac, Tritec) Compounds
Paraxetine (Paxil)
Folic Acid, Vitamin B12, Calcium, Iron, Vitamin D, Penicil amine (Depen, Cuprimine)
Repaglinide (Prandine)
Copper, Magnesium, Vitamin B6, Zinc, Sodium Phenobarbital (Luminal)
Rifampin/Rifabutin/Isoniazid
Calcium, Biotin, Folic Acid, Vitamin D, Vitamin K Vitamin D,B, Complex Vitamins, (especially B3 and
B6)
Rofecoxib (Vioxx)
Phenytoin (Dilantin)
B Complex Vitamins (especial y B9 and Folic Acid) Vitamin D, Vitamin K, B Complex Vitamins, Calcium, Sertraline (Zoloft)
Biotin
Phenelzine (Nardil)
Simvastatin (Zocor)
Polythiazide (Renese)
Sotatol (Betapace)
Stanozolol (Winstrol) Synthetic Anabolic Steroids
Trandolapril and Verapamil (Tarka)
Stavudine (Zerit) d4T
Triamcinolone (Azmacort, Aristocort)
Folic Acid, Potassium, Magnesium, Calcium, Sucralfate (Carafate)
Sulfasalazine (Azulfidine)
(Maxzide, Dyazide) Compounds
B Complex Vitamins (especial y Folic Acid) Trichormethiazide (Metahydrin)
(Synthetic Thyroid Hormones)
Zinc, Sodium, CoQ10, Magnesium, Phosphorous, Tacrolimus (Prograf)
Trifluoperazine (Stelazine)
B Complex Vitamins (especial y B2), CoQ10 Telmisartan and Hydrochlorothiazide (Micardis
Trimipramine (Surmontil)
Sodium, Zinc, Potassium, Phosphorous, Magnesium, Valproic Acid Compounds (Depakene)
CoQ10
Theophylline (Slo-Phyllin, Aerolate)
Valsartan and Hydrochlorothiazide (Diovan HCTZ)
B Complex Vitamins, (especially B1, B6), Potassium, Sodium. Zinc, CoQ10, Magnesium, Phosphorous, Magnesium Potassium
Zalcitabine (Hivid)
Copper, Zinc, Carnitine, Vitamin B12
Thioridazine (Mellaril)
Zidovudine (Retrovir) AZT related HIV Compounds
CoQ10, B Complex Vitamins (especial y B2) Timolol (Blocadren)
Zonisamide (Zonegran)
Folic Acid, Biotin, Calcium, Inositol, Thiamine Torsemide (Demadex)
Vitamin C, B Complex Vitamins (especially B 1 and

Source: http://www.trailcreekpharmacy.com/wp-content/themes/trailcreekp/pdfs/vitamin_drug_interaction.pdf