Biological Therapies in Psychiatry Newsletter 2010Please circle the answer to each question. There is only one answer to each question.
1. What characteristic of asenapine (Saphris) makes it unique among
10. Which of the second-generation antipsychotics is most likely to increase
antipsychotics currently available in the United States?
A. It causes weight loss during acute treatment.
B. It increases the risk of hyperprolactinemia.
C. It must be administered sublingually.
D. It is associated with cerebrovascular adverse events in elderly patients.
2. Diacetylmorphine, the active ingredient in heroin, has been studied as a
11. At steady state, a 300-mg dose of olanzapine long-action injection
“treatment of last resort” for what condition?
(Zyprexa Relprevv) every 2 weeks produces blood levels similar to those
achieved with what daily dose of oral olanzapine?
C. Alcohol addiction D. Heroin addiction
12. Fluvoxamine has the greatest affinity for which of the following cytochrome P450 isoenzymes?
3. Second-generation antipsychotics have enhanced abilities to improve
cognitive function in patients with schizophrenia compared with first-
4. How long should patients be observed after every injection of the
13. A 2010 study by Kish and colleagues found reduced brain serotonin
extended-release suspension preparation of olanzapine (Zyprexa Relprevv)
transporter binding in chronic users of what illicit drug?
to ensure they do not have a post-injection delirium sedation syndrome?
A. 1 hour B. 2 hours C. 3 hours D. 4 hours
5. Which of the following treatments shows the best long-term risk-to-
benefit ratio for chronic insomnia? A. Cognitive behavioral therapy
14. Because it prolongs the cardiac QT interval, ziprasidone (Geodon)
increases the risk of what life-threatening cardiac adverse event?
6. What percentage of patients taking clozapine (Clozaril and others)
experience sialorrhea? A. < 5% B. 20% C. 35% D. > 50%
15. In 2008, the US Food and Drug Administration concluded that, compared with patients taking placebo, patients taking anticonvulsant
7. What percentage of pregnant women have depression?
medications had an increased risk of what?
A. 0% to 10% B. 10% to 20% C. 20% to 30% D. 30% to 40%
A. Gastrointestinal bleeding B. Hyperprolactinemia
8. What were the first two second-generation antipsychotic medications to
be approved by the US Food and Drug Administration for the treatment of
schizophrenia and bipolar disorder in children and adolescents? A. Aripiprazole (Abilify) and risperidone (Risperdal and others)
16. In veterans with posttraumatic stress disorder (PTSD), how much
B. Clozapine (Clozaril and others) and olanzapine (Zyprexa)
greater is the risk of developing dementia than in veterans without PTSD?
C. Haloperidol (Haldol and others) and iloperidone (Fanapt)
D. Quetiapine (Seroquel) and ziprasidone (Geodon)
9. What medication has been studied the most for the treatment of
borderline personality disorder? A. Aripiprazole (Abilify)
17. Of patients experiencing their first episode of schizophrenia,
approximately what percentage has a sustained recovery lasting 2 years or
18. If a woman who is taking valproic acid (Depakote, Depakene, and
22. Which of the following antipsychotics is a potent muscarinic
others) for the treatment of bipolar disorder plans to become pregnant,
what is the most appropriate course of action?
A. Decrease the valproic acid dose by half
B. Add carbamazepine (Tegretol and others)
23. Abbott Laboratories withdrew the “diet pill” sibutramine (Meridia
19. Delirium in elderly inpatients is associated with a greater than 12-fold
and others) from the US market because the SCOUT trial found a higher
frequency of what in sibutramine-treated patients?
A. Depression B. Mania C. Schizophrenia D. Dementia
A. Movement disorders B. Cognitive dysfunction
20. What kind of episode rules out a diagnosis of bipolar II disorder?
A. Depressive B. Manic C. Hypomanic D. Mixed
21. The US Food and Drug Administration discontinued trials of
24. What antidepressant is most likely to cause weight LOSS during
S-adenosyl methionine (SAMe) because of problems with what?
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