Idiopathic thrombocytopenia purpura (itp) in children

Idiopathic Thrombocytopenia Purpura (ITP) in Children
What is ITP?
Idiopathic thrombocytopenia purpura (ITP) is a condition that causes low platelets. Platelets are
small cells that circulate in the blood that are responsible for preventing bleeding and bruising.
Patients with low platelets are at risk of bruising and rarely, serious bleeding.
What causes ITP?
We do not exactly know what causes ITP. We do know it involves the immune system; ITP likely is
caused by an abnormality in the immune response following a viral infection. One theory involves
the immune system becoming over-active after a viral infection - this leads to the immune system
being directed against platelets instead of the virus. These conditions are often called auto (or self)
immune disorders.
How common is ITP?

ITP in children is uncommon; it occurs in approximately 1 in every 25,000 children. This equals
about 200 – 300 cases of ITP in children each year in the state of Victoria.

What are the main problems with having ITP?

Platelets are small cells that stop bleeding and bruising. The normal level of platelets in the blood is
150 000 – 400 000 per ml of blood. These small cells become very sticky when there is a cut or
there is a bruise and stop the rest of the blood cells leaking; the platelets form a plug stopping
further bleeding.
If a patient has low platelets then they are at risk of increasing bruising or bleeding.
How high is the risk of bruising and bleeding?
Most patients with ITP experience only a mild increase in bruising. Some patients may develop
small pin point spots of bleeding on the skin called petechiae. Other patients may get more
extensive bruising and sometimes bleeding involving the lining of the mouth and nose (mucosal
bleeding). Rarely patients may have bleeding in the bowel. The most serious complication of ITP is
bleeding into the brain. The risk of bleeding into the brain is very low; an international study
involving 2000 patients there only two episodes of bleeding into the brain. One of these patients
was treated and fully recovered; the follow –up details of the other patient is not known.
Some girls who have ITP also have problems when they get their period.

Does ITP get better?
ITP in children usually gets better spontaneously in 6 – 8 weeks. Some patients however will have
a more prolonged illness. Somewhere between 5% and 20% of patients with ITP will have a course
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that is longer than 6 months; this is often referred to as chronic ITP. Many of these patients will
also get better but will take a lot longer for condition to settle.

What is the treatment for ITP?

Treatment is generally recommended when there is more significant bleeding; often bleeding from
the mouth or nose. This is always assessed on an individual basis and will need to be discussed
with your doctor. Treatment may also be needed for girls who are having heavier periods. The
treatment available is known to increase the platelet count BUT does not alter the underlying
condition. The two most common treatments are
1. Prednisolone – this is a steroid medication that is thought to act by slowing down the immune system. The medication is taken as a mixture or tablets. Treatment is often for a few days only. Most children tolerate prednisolone very well but side effects include increased appetite, sometimes sleep can be a bit disturbed and some children can experience some irritability. If prednisolone is used for a longtime (many weeks at a time), thinning of the bones may occur. 2. IVIG – this is a blood product consisting of concentrated antibodies. The antibodies are thought to work by tricking the patient’s immune system. IVIG has to be given by an intravenous infusion (through a drip) and takes a few hours. Patients need to be admitted to hospital for the day for this to take place. Side effects are uncommon but include feeling like having had the “flu”. This usually lasts for a day or two only.
Do I need to restrict my child’s activity?
Generally children with ITP are able to participate in all normal activities including going to school
and many sports. If the platelet count is very low and the patient has lots of bruising, playing rough
sports may be a problem – not so much for the bruising but because of the risk of trauma to the
brain causing bleeding. It is important however that you discuss this with your doctor –
participating in sports has lots of good effects and should be encouraged if at all possible.
What else do I need to do?
Regular blood tests and review with your doctor is generally all that is required – remember most
patients with ITP get better; it may just take a bit longer in some patients.

Resources used to produce this information sheet.
• Lilleyman, J “Medical nemesis and ITP” BJH 2003 123 586 – 589 • Bolton Maggs, P “Severe bleeding in idiopathic thrombocytopenia purpura” J Pediatr Hematol Oncol 2003 25 Suppl 1 S47 – S51 www.chrisbarnes.com.au
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Ph: 9345 4528 Fax: 9345 6588

Source: http://www.chrisbarnes.com.au/pdfs/itp-children.pdf