Suggested optimal values for an average sized person For tall and large, athletic subjects 10 to 25 % higher plasma values of anabolic hormones such as IGF-, DHEA sulfate, testosterone, dihydrotestosterone, and eventually estradiol and progesterone are probably more appropriate. For smaller and thin persons, the contrary should be true. The same is valid for 24- hour urine, where the urinary hormone levels should positively correlate with the urinary creatinine.(In patients without severe kidney disease)
• for a person of average size and body weight with normal( not exessive) activity and diet
Possible cause pathological (young adults deficiency
if pathologigal consequence if value →↓↑←± pathological Nutritional Ferritine Vitamin B 12 Folic acid erythrocytic Vitamin C Sodium NA+ Potassium K+ Magnesium erythrocytic Zinc 120 Cupper 120 < 90 Selenium 120 Vitamin E Vitamin A Vitamin D 25-OH Uric acid Hematocrite Ureum (BUN) transcortin, reference albumin,. values (& not borderline
to proteins may appear artificially high; high binding proteins may be caused by oral estrogen intake
Cholesterol
118 -180 mg/dl Hypothyroidism Acceptable
ENDOCRINE GH stimulated by GHRH, insulin, L- clondine, activity, . Somatomedin C 300- 350 (M) < 220 220 - 300 (W) < 180 IGF- BP- 3 TSH 1 > 2 Free T4 1,5 < 1,1 ATG 0 > 50 ATPO (or AMI) 0 TSI (or TBII) Thyroglobulin <
Goiter; * dessicated thyroid therapy→ ↑ thyroglobulin
Calcitonin 8 Phosphorus Parthormone 25 ACTH 40 < 20 or >80 ACTH-test cortisol > + 100 % Cortisol (total) (8h) Transcortin (CBG) Free cortisol Cortisol(total) (16 - Free cortisol- afternoon DHEA-Sulfate 250 -300(W)
DHEA deficiency, DHEA deficiency nephrotic syndrome
Androstenedione Aldosterone (standing or
secondary to hypocorticism or oral estrogen intake
Hemoglobulin A1c
progesterone deficiencies; synthetic ;progestogen
Prolactin
Prolactinome; hyper- prolactinemia secondary to hyperthyroidism or stress; may inhibit gonadal function & hormone secretions
Estradiol 20 - 25 (M) (W:21*st day of
menstrual cycle) Estrone (W:21stday of cycle) Progesterone (W:21st day of cycle)
Progesterone deficiency; (hypothyroidism, estrogen deficiency)
25 - 30 (M)
androgen, GH & cortisol deficiencies
Testosterone 6500 -7000(M) < 6000(M) Free testosterone Dihydrotestosterone 650 - 700(M) < 500 (M) Androstandiol 15 - 17 (M) glucuronide pregnenolone 24-HOUR URINE MUSCLE MASS creatinine DIET volume 24 St.Urine sodium Na+ potassium K+ magnesium
vegetable intake; excess loss (coffee intake),(hypopara-thyroidism(?))
phosphorus ENDOCRINE TESTS- Urine
GH 6-sulfatoxy- melatonin 1700-1900 Cortisol
(with urine loss of cortisol):Cushings disease or
17- OH- steroids
(with urine loss of cortisol); Cushings disease or syndrome
17- ketosteroids Aldosterone > 20 if sodium < pregnandiol Testosterone
M= men, W= women The suggested optimal and pathological values are only indicative and based on Dr. Hertoghe’s experience. They should always be submitted first to the physician’s own medical expertise and experience and adapted to each patient. These values are not intended to be used as strict dogmatic guidlines. Each patient is different and unique and in fact may need different optimal levels for his hormones than others, although many patients may benefit by having their hormone levels increased to the suggested „optimal“ levels.
Keystone/AmeriHealth Pharmacy & Therapeutic Committee Meeting Minutes December 8, 2009 Approval of Minutes 0 Against Old Business Committee requested in the October 2009 meeting to have a cardiologist/electrophysiologist to address efficacy, safety, and cost analysis of the Although several doctors were contacted, schedules did not permit them to attend the December
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