Microsoft word - newsletter_pain_and_inflammation2.doc

Greenstein Chiropractic & Health Management
954-938-5959
1919 NE 45th St., Suite 118. Fort Lauderdale FL 33308 Pain and Inflammation
No one wants to be in pain! We will do practically anything to not be in pain. Most people turn to prescription and non-prescription Non-Steroidal Anti-Inflammatory Drugs, also known as NSAIDS for pain relief. Why? People are very familiar with these drugs from the massive amount of advertising by the pharmaceutical companies. After reading this information, you will have a better understanding of NSAIDS, something pharmaceutical companies don’t want you to know. You will learn some troubling facts and adverse side effects caused by NSAIDS. Most important, you will learn about dietary and nutritional supplementation alternatives to NSAIDS. Greenstein Chiropractic & Health Management
954-938-5959
1919 NE 45th St., Suite 118. Fort Lauderdale FL 33308 Table of Contents
I. List of Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) II. The Trouble with NSAIDS III. Adverse Side Effects of NSAIDS and Published References IV. Effects on Inflammation V. Dietary and Nutrient Alternatives to NSAIDS Greenstein Chiropractic & Health Management
954-938-5959
1919 NE 45th St., Suite 118. Fort Lauderdale FL 33308 I. List of Non-Steroidal Anti-Inflammatory Drugs
(NSAIDS)
Oxycodone & Acetaminophen (Percocet, Tylox) Diflunisal (Dolobid) Piroxicam (Feldene) Greenstein Chiropractic & Health Management
954-938-5959
1919 NE 45th St., Suite 118. Fort Lauderdale FL 33308 II. The Trouble with NSAIDS
• Each year over 100,000 people are hospitalized with serious side effects from • Each year over 16,000 people die from the serious side effects from taking • More people die from NSAID side effects than from AIDS each year • More than 4 times as many people die from NSAID side effects as from • Only 1 in 5 people who have serious problems from taking NSAIDS have • 20% of all chronic NSAID users will develop a peptic ulcer. NSAID users have a greater risk, 3 to 4 times higher, to having upper gastrointestinal bleeding, perforation, or both • 81% of patients hospitalized with serious NSAID induced complications had • 21% of all adverse drug reactions in the United States are due to NSAID use • People over 60 years of age have a significantly higher probability to experiencing complications associated with NSAID use • In the United States, there are over 13 million regular users of NSAIDS, 70 million NSAID prescriptions written every year, and 30 billion over-the-counter NSAID tablets sold annually Greenstein Chiropractic & Health Management
954-938-5959
1919 NE 45th St., Suite 118. Fort Lauderdale FL 33308 III. Adverse Side Effects of NSAIDS
• Cause G.I. Hemorrhage • Encourage “Leaky Gut” • Destroy Vitamin C • Antagonize Folic Acid • Enhance Leukotrienes: Up to 1000 times as inflammatory as • Slow Fracture Healing • Create Muscle Imbalances • Increase Cardiovascular Risk • Decrease Sulfur Levels: Impairing Liver Detoxification (Phase 2) for many drugs and hormones (steroids); Impairing Cartilage Synthesis for Joint Repair, i.e. Glycosaminoglycans (GAGS) including chondroitin sulfate are the major structural component of articular cartilage • Interfere with Immune System (T-regulatory cells) Greenstein Chiropractic & Health Management
954-938-5959
1919 NE 45th St., Suite 118. Fort Lauderdale FL 33308 Increase gastrointestinal hemorrhage:
Gomes JA: Roth SA: Zech J: Bruyn GAW:Woods EM: Geis GS: Double-blind
comparison of efficacy and gastroduodenal safety of diclofenac/ misoprostol,
piroxicam, and napraxen in the treatment of osteoarthritis. Annals of Rheumatic
Diseases. 1993: 52: 881-885.
Decrease gut immunity and increase leaky gut:
Gomes reference above.
Decrease folic acid activity:
Baggott JE: Morgan SL: Ha T: Vaughn WH: Hine RJ: Inhibition of folate dependent
enzymes by non-Steroidal anti-inflammatory drugs. Biochem J 1992 Feb 15: 282 (pt
1). 197-202.
Enhance leukotrienes:
Vaananen PM: Keenam CM: Grisham MB: Wallace GL: Pharmacological
investigation of leukotrienes in the pathogenesis of experimental NSAID gastropathy.
Inflammation 1992 Jun: 16(3): 227-40.
Decrease bone healing (rats):
Varghese D, Kadakat S, Patel H. Non-steroidal anti-inflammatories should not be
used after orthopedic surgery. BMJ 1998; 316: 1390 (Letter).
Decrease availability of sulfates and interfere with gags synthesis:
Jung U. Yoo, Robert S. Popay, Charles J. Malemud. Suppression of proteoglycan
synthesis in chondrocyte cultures from canine disc. Spine, Vol. 17, No. 2, 1992. 221-
224.
P.M. van der Kraan, Elly L. Vitters, Bernard J. de Vries, Wim. B. van den Berg. High
susceptibility of human articular cartilage glycosaminoglycan synthesis to changes in
inorganic sulfate availability. J. Ortho Res. Vol. 8, No. 4, 1990. 565-571.
Increase cardiovascular risk:
Julia Hippisley-Cox, Carol Coupland, Risk of myocardial infarction in patients
taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory
drugs; population based nested case-control analysis. BMJ 2005; 330:1366 (11
June), doi:10.1136/bmj.330.7504.1366.
Greenstein Chiropractic & Health Management
954-938-5959
1919 NE 45th St., Suite 118. Fort Lauderdale FL 33308
Interfere with immune system:
Tricia M. McKeever, Sarah A. Lewis, Henriette A. Smit, Peter Burney, John R.
Britten and Patricia A. Cassano, The Association of Acetaminophen, Aspirin and
Ibuprofen with Respiratory Disease and Lung Function. Am J. Respir. Crit Care Med
2005, 171:966-971.
Animal studies have suggested that high doses of acetaminophen lower levels of the
important antioxidant glutathione in lung tissue. Therefore, regular users of
acetaminophen may, through depletion of glutathione, be at increased risk of lung
tissue damage and ultimately of respiratory disease. No similar association between
the use of either aspirin or ibuprofen and prevalence of either asthma or COPD.
Greenstein Chiropractic & Health Management
954-938-5959
1919 NE 45th St., Suite 118. Fort Lauderdale FL 33308 IV. Effects on Inflammation
NSAIDS function by inhibiting the conversion of pro-inflammatory fats
derived from milk, shellfish, mollusks and red meat into pro-inflammatory
hormones (PG2 family, i.e. hormones that promote inflammation). On the
surface, this sounds like a good idea, but NSAIDS also inhibit the
conversion of Omega-3 and Omega-6 fatty acids (EFAs) into their
respective anti-inflammatory hormones (PG1 and PG3), which in turn,
promotes inflammation.

All of these hormones (PG1, PG2 and PG3) are made from fats in your
diet. So, in a real sense, you are what you eat. Bottom line: If you respond
to NSAIDS for chronic pain, you have an EFA imbalance.
Anti-inflammatory PG hormones are made from Omega-3 fatty acids (e.g.
Flax Seed Oil, Fish Oil and Walnut Oil) and Omega-6 fatty acids (e.g.
Safflower Oil, Black Currant Seed Oil, Borage Oil and Primrose Oil). Pro-
inflammatory hormones (PG2 family) come from arachidonic acid (e.g.
fats in milk, shellfish, mollusks and red meat). Imbalances in dietary fats
promote inflammation.
Research suggests that the use of NSAIDS should be limited to three days
following acute trauma. Omega-6 and/or Omega-3 fatty acids and their
co-factors (vitamins and minerals that help them become PG1 and PG3,
respectively) are then more effective than NSAIDS in encouraging
increased anti-inflammatory activity and healing.
Greenstein Chiropractic & Health Management
954-938-5959
1919 NE 45th St., Suite 118. Fort Lauderdale FL 33308 V. Dietary and Nutrient Alternatives to NSAIDS
• Avoid Partially Hydrogenated (Trans) Fat • Decrease Saturated Fat (Animal and/or Vegetable) • Decrease Refined and/or Simple Carbohydrates • Flax Seed Oil • Fish Oil (Marine Lipids) Essential Fatty Acid Cofactor Considerations:

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