Curriculum vitae

Publications (Dr. Gijs H. Goossens)

Top 5 publications
1. Goossens GH, Petersen L, Blaak EE, Hul G, Arner P, Astrup A, Froguel P, Patel K, Pedersen O, Polak J, Oppert J-M, Martinez A, Sørensen TIA, Saris WHM, and the NUGENOB Consortium. Several gene polymorphisms but not FTO variants modulate resting energy expenditure and fat-induced thermogenesis in obese subjects: The NUGENOB Study Int J Obes Relat Metab Disord 2009; 33: 669-679. 2. Goossens GH, Jocken JWE, Blaak EE, Schiffers PM, Saris WHM, van Baak MA. Endocrine role of the renin-angiotensin system in human adipose tissue and muscle in vivo in humans: effect of β-adrenergic stimulation. Hypertension 2007; 3. Goossens GH, Blaak EE, Schiffers PM, Saris WHM, van Baak MA. Effect of short- term ACE inhibitor treatment on peripheral insulin sensitivity in obese insulin- resistant subjects. Diabetologia 2006; 49: 3009-3016. 4. Goossens GH, McQuaid SE, Dennis AL, van Baak MA, Blaak EE, Frayn KN, Saris WHM, Karpe F. Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans. J Physiol 2006;571:451-60. 5. Goossens GH, Blaak EE, Saris WHM, van Baak MA. Angiotensin II-induced effects on adipose and skeletal muscle tissue blood flow and lipolysis in normal-weight and obese subjects. J Clin Endocrinol Metab 2004; 89: 2690-2696.
International (refereed) journals

1. Van der Zijl NJ, Goossens GH, Moors CCM, van Raalte DH, Muskiet MHA, Pouwels
PJW, Blaak EE, Diamant M. Pancreatic and abdominal fat compartments in relation to clamp-measured beta-cell function in subjects with impaired glucose metabolism: evidence for lipotoxicity? J Clin Endocrinol Metab, in press. 2. Jocken JW, Moro C, Goossens GH, Hansen D, Mairal A, Hesselink MK, Langin D, van Loon LJ, Blaak EE. Skeletal Muscle Lipase Content and Activity in Obesity and Type 2 Diabetes. J Clin Endocrinol Metab, in press. 3. Van der Zijl NJ, Muskiet MHA, Tushuizen ME, Rijzewijk LJ, Schindhelm RK, Moors CCM, Goossens GH, Blaak EE, Pouwels PJ, Diamant M. C-reactive protein mediates the association of liver fat and carotid intima media thickness in healthy men and men with the metabolic syndrome and/or uncomplicated type 2 diabetes. Diabetes Metab Syndr 2010; 4: 160-4. 4. Goossens GH, Petersen L, Blaak EE, Hul G, Arner P, Astrup A, Froguel P, Patel K, Pedersen O, Polak J, Oppert J-M, Martinez A, Sørensen TIA, Saris WHM, and the NUGENOB Consortium. Several gene polymorphisms but not FTO variants modulate resting energy expenditure and fat-induced thermogenesis in obese subjects: The NUGENOB Study Int J Obes Relat Metab Disord 2009; 33: 669-679. 5. Goossens GH. The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol Behav 2008; 94: 206-218. 6. Franssen FME, O’Donnell DE, Goossens GH, Blaak EE, Schols AMWJ. Obesity and 7. Goossens GH, Jocken JWE, van Baak MA, Jansen EHJM, Saris WHM, Blaak EE. Short-term beta-adrenergic regulation of leptin, adiponectin and interleukin-6 secretion in vivo in lean and obese subjects. Diabetes Obes Metab 2008; 10: 1029-1038. 8. Jocken JWE, Roepstorff C, Goossens GH, van der Baan P, van Baak MA, Saris WHM, Kiens B, Blaak EE. HSL serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation. Diabetes 2008; 57: 1834-1841. 9. Jocken JWE, Smit E, Goossens GH, Essers Y, Mensink M, Saris WHM, Blaak EE. Adipose TriGlyceride Lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific. Histochem Cell Biol 2008; 129: 535-538. 10. Jocken JW, Goossens GH, van Hees AM, Frayn KN, van Baak M, Stegen J, Pakbiers MT, Saris WH, Blaak EE. Effect of beta-adrenergic stimulation on whole-body and abdominal subcutaneous adipose tissue lipolysis in lean and obese 11. Wang P, Smit E, Brouwers M, Goossens GH, Van der Kallen C, Van Greevenbroek M, Mariman E. Plasma pigment epithelium-derived factor is positively associated with obesity in Caucasian subjects, in particular with the visceral fat depot. Eur J Endocrinol 2008; 159: 713-718. 12. Goossens GH, Jocken JWE, Blaak EE, Schiffers PM, Saris WHM, van Baak MA. Endocrine role of the renin-angiotensin system in human adipose tissue and muscle in vivo in humans: effect of β-adrenergic stimulation. Hypertension 2007; 13. Goossens GH, Blaak EE, Arner P, Saris WHM, van Baak MA. Angiotensin II: a hormone that affects lipid metabolism in adipose tissue. Int J Obes Relat Metab 14. Boon N, Goossens GH, Blaak EE, Saris WHM. The effects of hydralazine on lipolysis in subcutaneous adipose tissue in humans. Metabolism 2007; 56: 1742-1748. 15. Goossens GH, Blaak EE, Schiffers PM, Saris WHM, van Baak MA. Effect of short- term ACE inhibitor treatment on peripheral insulin sensitivity in obese insulin-resistant subjects. Diabetologia 2006; 49: 3009-3016. 16. Goossens GH, McQuaid SE, Dennis AL, van Baak MA, Blaak EE, Frayn KN, Saris WHM, Karpe F. Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans. J Physiol 2006;571:451-60. 17. Goossens GH, Blaak EE, Saris WHM, van Baak MA. Angiotensin II-induced effects on adipose and skeletal muscle tissue blood flow and lipolysis in normal-weight and obese subjects. J Clin Endocrinol Metab 2004; 89: 2690-2696. 18. Tan GD, Goossens GH, Humphreys SM, Vidal H, Karpe F. Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans. Obes Res 2004; 12: 114-118. 19. Goossens GH, Blaak EE, van Baak MA. Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related
Books / Contributions to books
1. Goossens GH, Karpe F. Human Adipose Tissue Blood Flow and Micromanipulation
of Human Subcutaneous Blood Flow. In: Yang, K, ed. Methods Mol Biol, Adipose Tissue protocols, 2nd ed. Totowa, NJ: Humane Press; 456: 97-107. 2. Goossens GH, Saris WHM, Blaak EE. Microdialysis on Adipose Tissue. In: Tsai, T- H, ed. Applications of Microdialysis in Pharmaceutical Science. Hoboken, NJ: John Wiley & Sons, Inc., in press (will be published in 2010).
Case reports
1. Goossens GH, de Leeuw PW, van Baak MA. Management of obesity-related hypertension: reducing renin-angiotensin system activity. Renin Angiotensin System in Cardiovascular Medicine 2005; 1: 12-13. Popular publications
1. Goossens GH, Mensink M, Kooi, ME, Saris WHM, Blaak EE. De rol van vetten in de
spier bij type 2 diabetes mellitus. Chemisch2Weekblad 2002.
Abstracts (presented at international meetings)
1. Goossens GH, Moors CCM, Van der Zijl NJ, Cleutjens JP, Diamant M, Blaak EE. Long-term treatment with the angiotensin-receptor blocker valsartan improves adipose tissue function in normotensive subjects with impaired glucose metabolism. Diabetologia 2010; 53(1): S242. 2. Goossens GH, Bizzarri A, Cajlakovic M, Blaak EE. Adipose tissue hypoxia and insulin resistance: role for adipose tissue blood flow? Obes Rev 2010; 11(1): 28. 3. Van der Zijl NJ, Moors CCM, Goossens GH, Hermans MH, Blaak EE, Diamant M. Valsartan improves beta cell function and insulin sensitivity in normotensive subjects with impaired fasting glucose and/or impaired glucose tolerance. 4. Moors CCM, Van der Zijl NJ, Goossens GH, IJzerman RG, Blaak EE, Diamant M, Serné EH. Valsartan induced improvement of insulin sensitivity was not associated with improved microvascular function in subjects with impaired glucose metabolism. Diabetologia 2010; 53(1): S241. 5. Van Can J, Van Dijk J-W, Goossens GH, Jocken J, Hospers JJ, Blaak EE. A 3 day EGCG supplementation reduced lactate in skeletal muscle in overweight subjects. 6. Goossens GH, Petersen L, Blaak EE, Hul G, Arner P, Astrup A, Froguel P, Patel K, Pedersen O, Polak J, Oppert J-M, Martinez A, Sørensen TIA, Saris WHM, and the NUGENOB Consortium. Several gene polymorphisms but not FTO variants modulate resting energy expenditure and fat-induced thermogenesis in obese subjects: The NUGENOB Study. Int J Obes 2008; 32(1): S26. 7. Goossens GH, Jocken JWE, Blaak EE, Schiffers PM, Saris WHM, van Baak MA. Endocrine role of the renin-angiotensin system in adipose tissue and skeletal muscle in vivo in humans: effect of beta-adrenergic stimulation. Int J Obes 2007; 8. Goossens GH, Jocken JWE, van Baak MA, Jansen EHJM, Saris WHM, Blaak EE. Beta-adrenergic regulation of leptin, adiponectin and interleukin-6 secretion in vivo in lean and obese subjects. Int J Obes 2007; 31(1): S32. 9. Jocken JWE, Goossens GH, van Hees A, Frayn KN, van Baak MA, Pakbiers M, Saris WHM, Blaak EE. Effect of beta-adrenergic stimulation on whole-body and regional abdominal subcutaneous adipose tissue lipolysis in lean and obese men. 10. Jocken JWE, Goossens GH, van Baak MA, Saris WHM, Blaak EE. The effect of beta-adrenergic stimulation on abdominal subcutaneous adipose tissue substrate fluxes in lean and obese men. Obes Rev 2005; 6(1): 74. 11. Goossens GH, Blaak EE, Schiffers PM, Saris WHM, van Baak MA. ACE inhibition and insulin sensitivity in obese insulin resistant subjects: a double-blind placebo- controlled randomized trial to examine underlying mechanisms. Diabetologia 2006; 49(11): 455. 12. Goossens GH, McQuaid SE, Dennis AL, van Baak MA, Blaak EE, Frayn KN, Saris WHM, Karpe F. Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans. Int J Obes 2005; 29(3): S3. 13. Goossens GH, Jocken JW, Schiffers PM, Blaak EE, Saris WHM, van Baak MA. The effect of β-adrenergic stimulation on circulating angiotensin II concentration and angiotensin II release from adipose tissue and the forearm. Int J Obes 2005; 14. Goossens GH, Blaak EE, Schiffers PM, Saris WHM, van Baak MA. Does short-term ACE inhibitor treatment improve insulin sensitivity and hemodynamics in obese insulin resistant subjects? Int J Obes 2005; 29(3): S12. 15. Goossens GH, Jocken JW, Blaak EE, Saris WHM, Schiffers PM, van Baak MA. Angiotensin II release from adipose tissue and the forearm in lean and obese men: effect of beta-adrenergic stimulation. Obes Rev 2005; 6(1): 75. 16. Goossens GH, Blaak EE, Saris WHM, van Baak MA. Metabolic en hemodynamic effects of the ACE inhibitor ramipril in obese insulin resistant subjects. Obes Rev 17. Jocken JWE, Goossens GH, van Baak MA, Saris WHM, Blaak EE. The effect of beta-adrenergic stimulation on abdominal subcutaneous adipose tissue substrate fluxes in lean and obese men. Obes Rev 2005; 6(1): 74. 18. Goossens GH, van Baak MA, Saris WHM, Blaak EE. The effect of angiotensin II on abdominal subcutaneous adipose tissue lipolysis in normal-weight and obese subjects. Int J Obes 2004; 28(1): S83. 19. Goossens GH, Blaak EE, Saris WHM, van Baak MA. Ang II-induced effects on adipose and skeletal muscle tissue blood flow and lipolysis. Int J Obes 2003; 27: 20. Goossens GH, Tan GD, Humphreys SM, Vidal H, Karpe F. Upper and lower body adipose tissue function: a direct comparison of fat mobilization. Int J Obes 2003;

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