Life-assist.com

For acute relief or
acute prophylaxis
of angina pectoris
When every second counts,
count on NitroMist®
Delivers rapid relief in 60 seconds or less1
• Symptom relief in 60 seconds or less in 70% of patients
• 61% of patients taking tablets waited 1 to 5 minutes
and longer for symptom relief1
• Fewer, less severe headaches in patients treated with aerosol spray1*
* 58% of patients treated with aerosol spray had no headache vs 38% for tablets (P<.001); mild or moderate headache that did occur was also less numerous in patients treated with aerosol spray; 7% incidence vs 23% for patients treated with tablets (P<.001).
Priming NitroMist: After receiving a new prescription or refi ll, patients should remove the plastic cap, place forefi nger on actuator
button, and press 10 times. NitroMist is now primed for 6 weeks and ready to use. If not used for more than 6 weeks, the NitroMist bottle can be adequately reprimed with 2 sprays. Store at room temperature (25°C, 77°F); excursions permitted to 15-30°C (59-85°F). Important Safety Information: NitroMist should not be used in patients who are using phosphodiesterase type 5 inhibitors, such as
those used for the treatment of erectile dysfunction, which have been shown to potentiate the hypotensive effects of organic nitrates. NitroMist should not be used in patients with severe anemia, in patients with increased intracranial pressure, and in patients with a history of hypersensitivity to this or other nitrates or nitrites. Skin reactions consistent with hypersensitivity have been observed with organic nitrates. NitroMist should be used with caution if patients have low systolic blood pressure, are undergoing diuretic therapy, or are undergoing tissue-type plasminogen activator therapy. Co-administration of aspirin and nitroglycerin has been reported to increase nitroglycerin levels and intravenous nitroglycerin reduces the anticoagulant effect of heparin, so activated partial thromboplastin times should be monitored. Oral administration of nitroglycerin increases bioavailability of ergotamine, so concomitant use of ergotamine and related drugs should be avoided. Excessive use may lead to the development of tolerance. Severe hypotension, particularly with upright posture, may occur even with small doses of nitroglycerin. Hypotension induced by nitroglycerin may be accompanied by paradoxical bradycardia and increased angina pectoris. The benefi ts of NitroMist in patients with acute myocardial infarction or congestive heart failure have not been established. Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy. Nitroglycerin produces dose-related headaches, which may be severe. Tolerance to headaches occurs. The most common adverse reactions are headache, fl ushing, hypotension and syncope.
Please see Important Safety and full Prescribing Information at www.NitroMist.com
Reference: 1. Vandenburg MJ, Griffi ths GK, Brandman S. Sublingual nitroglycerin or spray in the treatment of angina. Br J Clin Pract. 1986;40(12):524-527.
2013 Akrimax Pharmaceuticals, LLC., Cranford, NJ 07016

Source: http://www.life-assist.com/CatalogImages/FullSize/Ad4.pdf