REPORT TO THE TWENTY-THIRD HAWAII STATE LEGISLATURE, 2005 IN ACCORDANCE WITH ACT 200, PART III, SECTION 36, SLH 2003, ON PRESCRIPTION DRUGS FOR FEE-FOR- SERVICE CLIENTS INCLUDING MENTAL HEALTH TREATMENT Department of Human Services Med-QUEST Division November 2004 REPORT ON PRESCRIPTION DRUGS FOR FEE-FOR-SERVICE CLIENTS INCLUDING MENTAL HEALTH TREATMENT FOR FY 2004, PURSUANT TO ACT 200, PART III, SECTION 36, SLH 2003
Act 200, Part III, Section 36, SLH 2003 appropriated funds to the Department for prescription drugs for fee-for-service clients. Section 36 requires the Department to submit a report that includes but not limited to, all expenditures made listed by prescription drugs, the number of recipients by type of drug prescribed, and possible cost containment measures for FY 2004.
1) Expenditures Listed by Prescription Drug
Attachment A shows a listing of the Top 100 Drugs by Amount Paid for FY 2004 in descending order. The expenditure total for the Top 100 drugs was $75,728,702.33. Expenditures for generic drugs and other drugs not as widely prescribed was $36,847,291.49 The total expenditures for all prescription drugs was $112,575,993.82 (see Attachment D.)
2) Number of Recipients by Type of Drug
Attachment B shows a listing of the Top 100 Drugs by Prescription Count for FY 2004 in descending order. Attachment C shows a Summary Listing of Unique Recipients by Therapeutic Drug Class for FY 2004. This listing provides a count of unique recipients by Drug Class (only counts each recipient once if they received multiple drugs within the same drug class).
3) Additional Reports on Expenditures, Recipient Counts, and Prescriptions
Attachment D shows the number of recipients by type of fee-for-service plan, the total number of prescriptions by plan, and the total amounts paid by plan for the prescriptions. Total expenditures for all prescription drugs: $112,575,993.82 Total number of claims paid: 1,748,937 Average prescription cost: $64.37 ($112,575,994/1,748,937) Total number of recipients unduplicated: 43,189 Attachment E shows the average number of recipients per month and the average number of prescriptions per recipient. Monthly average of utilizing recipients: 27,518 Average number of prescriptions per month: 5.2
4) Drugs Granted Prior Authorization
Attachment F shows a listing of the top drugs on the PDL that were granted prior authorization. Attachment G shows a listing of the top 25 other drugs that are not on the PDL but are granted prior authorization by the Medicaid program.
5)Cost Containment Measures for Fiscal Year 2004
The Department implemented these cost containment measures: a) Mandatory generic prescriptions savings
Summary of Mandatory Generic Drug Prescriptions for FY 2004
$1,933,196.45
b) Imposed quantity limits for certain medications that are over-utilized, requiring a prior
authorization to justify that large quantities are medically necessary and appropriate.
c) Imposed quantity limits to reduce overpayments to providers who bill for overstated
quantities, which leads to disputes with drug manufacturers on drug rebate amounts.
d) The pharmacy audit contractor audited the pharmacy fiscal agent and more pharmacies
The audit reports have shown problem areas that needed to be addressed such as incorrect provider billings, “lost” prescriptions, “lost” drug purchase invoices, etc. Also, the fiscal agent audit covering August 1, 2001 through December 31, 2002 showed deficiencies for which ACS and MQD are finalizing resolution in the clinical services area. ACS prepared a gap analysis to identify deficiencies and remedies and submitted outstanding deliverables on 11/12/04. A letter was submitted by ACS to MQD on 11/15/04 detailing additional services to be provided by Heritage (wholly owned subsidiary of ACS) and ACS will be holding telephone conferences with MQD to explain and validate outstanding clinical services being met. The goal is to have final resolution before November 30, 2004.
e) Additional prior authorizations for highly utilized medications or new very expensive
drugs were implemented to reduce inappropriate usage.
f) Certain outlier prescribers were targeted to receive “report cards” comparing their
prescribing practices to their peers. As a result, the utilization patterns for a number of the outliers changed after these report cards were issued. This was a small scale project that involved only prescribers of high dose Zyprexa.
g) A preferred drug list (PDL) was initially started in the fall of 2003 through a short-term
contract amendment with the current Pharmacy Fiscal Agent, Affiliated Computer Services (ACS). In 2004, a new contractor, First Health Services Corporation, was competitively awarded a 15 month contract with a one year extension provision for the PDL program. Attachment H shows savings of $261,652.47 for the Phase I PDL therapeutic class implementation and the therapeutic classes impacted. The Federal rebates for this period are still being collected. The State supplemental rebate contracts
are being finalized and the cost of implementing and maintaining the program was not included in this report.
6) Cost Containment Measures Proposed for Fiscal Year 2005
The MQD plans to implement or continue with the following: a) Expand the preferred drug list with supplemental rebates. b) Conduct audits of pharmacies and the pharmacy fiscal agent. c) Prior authorize high cost, highly utilized medications when appropriate. d) Place limits on various medications to encourage appropriate utilization. e) Consider revising the state maximum allowable cost program to increase savings on
f) Increase prescriber profiling to show more outliers how much they differ from their peers. Attachments
Top 100 Drugs by Amount Paid for FY 2004 (7/01/2003 - 6/30/2004) Top 100 Drugs by Rx Count for FY 2004 (7/01/2003 - 6/30/2004) Summary of Unique Recipients by Therapeutic Drug Class (7/01/03 through 6/30/04) Specific Thera Class
HYPOTENSIVES,ANGIOTENSIN RECEPTOR ANTAGONIST
ACE INHIBITOR/CALCIUM CHANNEL BLOCKER COMBINATION
PULMONARY ANTI-HTN, ENDOTHELIN RECEPTOR ANTAGONIST
NON-NARCOTIC ANTITUSSIVE AND EXPECTORANT COMB.
HYPOGLYCEMICS, INSULIN-RELEASE STIMULANT TYPE
HYPOGLYCEMICS, BIGUANIDE TYPE (NON-SULFONYLUREAS)
HYPOGLYCEMICS, ALPHA-GLUCOSIDASE INHIB TYPE (N-S)
HYPOGLYCEMICS, INSULIN-RESPONSE ENHANCER (N-S)
IV SOLUTIONS: DEXTROSE AND LACTATED RINGERS
ORAL MUCOSITIS/STOMATITIS ANTI-INFLAMMATORY AGENT
DRUGS TO TX CHRONIC INFLAMM. DISEASE OF COLON
IRRITABLE BOWEL SYND. AGENT,5HT-3 ANTAGONIST-TYPE
IRRITABLE BOWEL SYND. AGENT,5HT-4 PARTIAL AGONIST
DRUG TX-CHRONIC INFLAM. COLON DX,5-AMINOSALICYLAT
ALZHEIMER'S THERAPY, NMDA RECEPTOR ANTAGONISTS
SELECTIVE SEROTONIN REUPTAKE INHIBITOR (SSRIS)
TRICYCLIC ANTIDEPRESSANTS & REL. NON-SEL. RU-INHIB
TX FOR ATTENTION DEFICIT-HYPERACT(ADHD)/NARCOLEPSY
TRICYCLIC ANTIDEPRESSANT/PHENOTHIAZINE COMBINATNS
TRICYCLIC ANTIDEPRESSANT/BENZODIAZEPINE COMBINATNS
ANALGESICS NARCOTIC, ANESTHETIC ADJUNCT AGENTS
ALPHA-2 RECEPTOR ANTAGONIST ANTIDEPRESSANTS
SEROTONIN-NOREPINEPHRINE REUPTAKE-INHIB (SNRIS)
NOREPINEPHRINE AND DOPAMINE REUPTAKE INHIB (NDRIS)
SEROTONIN-2 ANTAGONIST/REUPTAKE INHIBITORS (SARIS)
MAOIS - NON-SELECTIVE & IRREVERSIBLE
ANTIPSYCHOTICS,DOPAMINE ANTAGONISTS,BUTYROPHENONES
ANTIPSYCHOTICS,DOPAMINE ANTAGONISTS, THIOXANTHENES
ANTIPSYCH,DOPAMINE ANTAG.,DIPHENYLBUTYLPIPERIDINES
ANTIPSYCHOTICS,DOPAMINE ANTAGONST,DIHYDROINDOLONES
ANTIPSYCHOTICS,ATYPICAL,DOPAMINE,& SEROTONIN ANTAG
ANTIPSYCHOTICS, DOPAMINE & SEROTONIN ANTAGONISTS
ANTIPSYCHOTICS, ATYP, D2 PARTIAL AGONIST/5HT MIXED
TX FOR ATTENTION DEFICIT-HYPERACT.(ADHD), NRI-TYPE
SSRI &ANTIPSYCH,ATYP,DOPAMINE&SEROTONIN ANTAG COMB
SMOKING DETERRENT AGENTS (GANGLIONIC STIM,OTHERS)
ADRENERGICS, AROMATIC, NON-CATECHOLAMINE
BETA-ADRENERGICS AND GLUCOCORTICOIDS COMBINATION
ANTIHYPERLIP(HMGCOA) & CALCIUM CHANNEL BLOCKER CMB
LHRH(GNRH) AGONIST ANALOG PITUITARY SUPPRESSANTS
LHRH(GNRH)AGNST PIT.SUP-CENTRAL PRECOCIOUS PUBERTY
BONE FORMATION STIM. AGENTS - PARATHYROID HORMONE
CALCIMIMETIC,PARATHYROID CALCIUM ENHANCER
OCULAR PHOTOACTIVATED VESSEL-OCCLUDING AGENTS
OPHTHALMIC ANTI-INFLAMMATORY IMMUNOMODULATOR-TYPE
RECTAL/LOWER BOWEL PREP.,GLUCOCORT. (NON-HEMORR)
CHRONIC INFLAM. COLON DX, 5-A-SALICYLAT,RECTAL TX
TOPICAL ANTINEOPLASTIC & PREMALIGNANT LESION AGNTS
TOPICAL ANTIBIOTICS/ANTIINFLAMMATORY,STEROIDAL
MIOTICS/OTHER INTRAOC. PRESSURE REDUCERS
NOSE PREPARATIONS, VASOCONSTRICTORS(OTC)
OTIC PREPARATIONS,ANTI-INFLAMMATORY-ANTIBIOTICS
BENIGN PROSTATIC HYPERTROPHY/MICTURITION AGENTS
URINARY TRACT ANTISPASMODIC/ANTIINCONTINENCE AGENT
POTASSIUM SPARING DIURETICS IN COMBINATION
URINARY TRACT ANESTHETIC/ANALGESIC AGNT (AZO-DYE)
ANTI-INFLAMMATORY/ANTIARTHRITICS AGENTS, MISC.
ANTI-INFLAMMATORY, PYRIMIDINE SYNTHESIS INHIBITOR
ANTI-INFLAMMATORY TUMOR NECROSIS FACTOR INHIBITOR
ANTI-FLAM. INTERLEUKIN-1 RECEPTOR ANTAGONIST
ANTI-ARTHRITIC, FOLATE ANTAGONIST AGENTS
NSAID, COX INHIBITOR-TYPE & PROTON PUMP INHIB COMB
ANTINEOPLAST EGF RECEPTOR BLOCKER RCMB MC ANTIBODY
ANTINEOPLASTICS ANTIBODY/ANTIBODY-DRUG COMPLEXES
SELECTIVE RETINOID X RECEPTOR AGONISTS (RXR)
ANTINEOPLASTIC LHRH(GNRH) AGONIST,PITUITARY SUPPR.
ANTINEOPLASTIC SYSTEMIC ENZYME INHIBITORS
SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERM)
ANTINEOPLAST EGF RECEPTOR BLOCKER RCMB MC ANTIBODY
ANTINEOPLAST HUM VEGF INHIBITOR RECOMB MC ANTIBODY
ANAEROBIC ANTIPROTOZOAL-ANTIBACTERIAL AGENTS
ANTIVIRALS, HIV-SPECIFIC, PROTEASE INHIBITORS
ANTIVIRALS, HIV-SPECIFIC, NUCLEOTIDE ANALOG, RTI
ANTIVIRALS, HIV-SPECIFIC, NUCLEOSIDE ANALOG, RTI
ANTIVIRALS, HIV-SPECIFIC, NON-NUCLEOSIDE, RTI
ANTIVIRALS, HIV-SPEC., NUCLEOSIDE ANALOG, RTI COMB
ANTIVIRALS, HIV-SPECIFIC, PROTEASE INHIBITOR COMB
ANTIVIRALS, HIV-SPECIFIC, FUSION INHIBITORS
TOXIN-PRODUCING BACILLI VACCINES/TOXOIDS
VACCINE/TOXOID PREPARATIONS,COMBINATIONS
MONOCLONAL ANTIBODIES TO IMMUNOGLOBULIN E(IGE)
Hawaii Report Of Unique Utilizers In FY 2004 By Plan
Total Unique Utilizers and Rx Counts for FY 2003
ATTACHMENT E Average Rxs Per Recipient Per Month For FY 2004 Plans100, 200, 300, 310, 500, & 600 Average: Top "PDL" Drugs Granted Prior Authorization Top 25 Other Drugs (not on the PDL) Granted Standing Prior Authorization $1,584,377.43 PDL Phase I Cost Savings Data
Feb 17 thru June 30, 2004 Comparison of 5 months prior to implementation of Phase I and 5 months after.
Cost Savings from Phase I PDL changes $261,652.47
Please note that this does not include supplemental rebates or federal rebates
Drug Classes included in PDL Phase I HYPOTENSIVES, ACE INHIBITORS HYPOTENSIVES,ANGIOTENSIN RECEPTOR ANTAGONIST ACE INHIBITOR/CALCIUM CHANNEL BLOCKER COMBINATION CALCIUM CHANNEL BLOCKING AGENTS GASTRIC ACID SECRETION REDUCERS BILE SALT SEQUESTRANTS ALPHA/BETA-ADRENERGIC BLOCKING AGENTS BETA-ADRENERGIC BLOCKING AGENTS LIPOTROPICS NSAIDS, CYCLOOXYGENASE INHIBITOR - TYPE II
Si mona (38 de ani) este o femeie, mama si sotie care in 5 iunie 2013, intr-o zi care a inceput ca oricare alta, avand grija de gospodaria ei a facut dintr-o data o hemoragie puternica, fara sa aiba vreo durere sau un semn dinainte ca ar fi bolnava. A mers cu sotul ei la spital, unde dupa niste investigatii a aflat un diagnostic socant : neoplasm rectal hemoragic cu metastaze. Medicii i- au spu
Chronic Daily Cannabis Smoking: Neuroadaptation, Residual Cannabinoid Excretion & Psychomotor Impairment Professor Dr. Dr. (h.c.) Marilyn A. Huestis Chief, Chemistry and Drug Metabolism Section, Intramural Research Program National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore USA, and Adjunct Professor, School of Medicine, University of Maryland