Microsoft word - mc_stockley_aug08_quarter_update.doc

What’s new in Stockley’s Drug Interactions
Changes for the August 2008 update

Stockley’s Drug Interactions is continually undergoing re-validation
and revision. Each quarter, new and revised sections will be
published on MedicinesComplete. This is a list of the changes made
since the last update.

Revised Chapters or Chapter Sections – the content has been
systematically re-validated and updated
Alcohol
Anorectics and Stimulants
New Monographs
Mifepristone + Miscellaneous
Paricalcitol + Miscellaneous
Sitaxentan + Miscellaneous
SNRIs; Venlafaxine + Atomoxetine
SNRIs; Venlafaxine + Sibutramine
SNRIs; Venlafaxine + Terbinafine
SSRIs + Methylphenidate
SSRIs + Terbinafine
Terbinafine + Miscellaneous
Selective Updates – monographs with some new, re-validated or
changed information (includes minor amendments)
5-HT3-receptor antagonists + Drugs that prolong the QT ACE inhibitors + Dialysis or Transfusion membranes ACE inhibitors + Diuretics; Potassium-sparing ACE inhibitors + NSAIDs ACE inhibitors and Angiotensin II receptor antagonists + Epoetin Alpha blockers + Aspirin or NSAIDs Alpha blockers + Beta blockers Alpha blockers + Calcium-channel blockers Alpha blockers + Cimetidine Alpha blockers + CYP3A4 or CYP2D6 inhibitors Alpha blockers + Diuretics Alpha blockers + Dutasteride or Finasteride Alpha blockers + Food Amfetamines and related drugs + Lithium Amfetamines and related drugs + Phenothiazines Amiodarone + Anaesthesia Amiodarone + Antihistamines Amiodarone + Beta blockers Amiodarone + Calcium-channel blockers Amiodarone + Disopyramide Amiodarone + Lithium Amiodarone + Macrolides Amiodarone + Oxygen Amiodarone + Protease inhibitors Amiodarone + Quinolones Amphotericin B + Antineoplastics Anaesthetics, general + Antihypertensives Anaesthetics, general + Methylphenidate Angiotensin II receptor antagonists + Aspirin or NSAIDs Angiotensin II receptor antagonists + Diuretics; Potassium-sparing Antidiabetics + Azoles; Miscellaneous Antidiabetics + Clonidine Antidiabetics + Disulfiram Antidiabetics + SSRIs Antiepileptics + Mefloquine Antiplatelet drugs + Aspirin Antiplatelet drugs + Food Antiplatelet drugs + NSAIDs Antipsychotics + SSRIs Azoles + Cola drinks Azoles + Food Azoles + H2-receptor antagonists Azoles + Proton pump inhibitors Azoles + Rifabutin Azoles + Rifampicin (Rifampin) and/or Isoniazid Benzodiazepines + Antiepileptics; Phenytoin Benzodiazepines + Modafinil Benzodiazepines + St John's wort (Hypericum perforatum) Benzodiazepines and related drugs + Protease inhibitors Benzodiazepines and related drugs + SNRIs Benzodiazepines and related drugs + SSRIs Beta blockers + Bupropion Beta blockers + Calcium-channel blockers; Verapamil Beta blockers + SSRIs Beta-agonist bronchodilators + Potassium-depleting drugs Bisphosphonates + Aspirin or NSAIDs Bisphosphonates + Polyvalent cations Bosentan + Azoles Bupropion + Antiepileptics Bupropion + Antiretrovirals Bupropion + Benzodiazepines and related drugs Bupropion + MAOIs and related drugs Bupropion + Miscellaneous Busulfan + Phenytoin Calcium-channel blockers + Diuretics Calcium-channel blockers + Grapefruit juice Calcium-channel blockers + Magnesium compounds Calcium-channel blockers + Protease inhibitors Calcium-channel blockers + Quinupristin/Dalfopristin Calcium-channel blockers + Rifampicin (Rifampin) Calcium-channel blockers + St John's wort (Hypericum perforatum) Calcium-channel blockers + Valproate Carbamazepine + Azoles Ciclosporin + Azoles Ciclosporin + Beta blockers Ciclosporin + Bosentan Ciclosporin + Fibrates Ciclosporin + Modafinil Ciclosporin + Protease inhibitors Ciclosporin + Sibutramine Ciclosporin + Terbinafine Clopidogrel + Miscellaneous Clozapine + Miscellaneous Corticosteroids + Azoles; Voriconazole Corticosteroids + Mifepristone Coumarins + Alpha blockers Coumarins + Antineoplastics; Fluorouracil and related prodrugs Coumarins + Antiplatelet drugs; Ticlopidine Coumarins + Azoles; Voriconazole Coumarins + Bosentan Coumarins + Broxuridine Coumarins + Calcium-channel blockers Coumarins + Foods; Mango fruit (Mangifera indica) Coumarins + Herbal medicines; St John's wort (Hypericum perforatum) Coumarins + Herbal medicines; Vitamin K1–rich Coumarins + Mefloquine Coumarins + Methylphenidate Coumarins + Phosphodiesterase type-5 inhibitors Coumarins + Protease inhibitors Coumarins + Proton pump inhibitors Coumarins + Sevelamer Coumarins + SNRIs Coumarins and related drugs + Antiplatelet drugs; Cilostazol Coumarins and related drugs + Antiplatelet drugs; Clopidogrel Coumarins and related drugs + Vitamin K substances Cyclophosphamide + Metronidazole Cycloserine + Ethionamide Digitalis glycosides + Alpha blockers Digitalis glycosides + Chinese herbal medicines Digitalis glycosides + Diuretics; Potassium-sparing Digitalis glycosides + Drugs that affect calcium Digitalis glycosides + Herbal medicines; St John's wort (Hypericum perforatum) Drugs that prolong the QT interval + Other drugs that prolong the QT interval Enteral feeds + Aluminium compounds and/or Sucralfate Eplerenone + CYP3A4 inducers Eplerenone + CYP3A4 inhibitors Eplerenone + Miscellaneous Ergot derivatives + Antidepressants Ergot derivatives + Macrolides Fibrates + Bile-acid binding resins Flecainide + Amiodarone Flecainide + SSRIs Furosemide + Sevelamer Halofantrine + Miscellaneous Haloperidol + Venlafaxine Heparin and LMWHs + Antiplatelet drugs Hormonal contraceptives + Modafinil Hormonal contraceptives + NNRTIs Hormonal contraceptives + Retinoids Hormonal contraceptives + St John's wort (Hypericum perforatum) Hormonal contraceptives + Terbinafine Hormonal contraceptives or HRT + Azoles Hormonal contraceptives or HRT + Bosentan Hormonal contraceptives or HRT + Protease inhibitors Hormonal contraceptives or HRT + Triptans Imatinib + CYP3A4 inducers Imatinib + CYP3A4 inhibitors Imatinib + Miscellaneous Inotropes and Vasopressors + Antimuscarinics Inotropes and Vasopressors + Ergometrine (Ergonovine) Inotropes and Vasopressors; Dopamine + Selegiline Irinotecan + Fluorouracil Isoniazid + Aminosalicylic acid Isoniazid + Disulfiram Isoniazid + Food Isoniazid + Rifamycins Levodopa + Antipsychotics Levodopa + MAO-B inhibitors Lithium + Antidepressants; SSRIs Lithium + Diuretics; Potassium-sparing Lithium + Herbal medicines Loop diuretics + Aspirin or other Salicylates Macrolides + H2-receptor antagonists Macrolides; Azithromycin + Food MAO-B inhibitors + Antidepressants MAO-B inhibitors + MAOIs or RIMAs MAO-B inhibitors + Pethidine (Meperidine) MAO-B inhibitors + Tyramine-rich foods MAO-B inhibitors; Selegiline + Hormonal contraceptives or HRT MAOIs + Opioids; Fentanyl and related drugs MAOIs + Opioids; Miscellaneous MAOIs or RIMAs + Benzodiazepines MAOIs or RIMAs + Dextromethorphan MAOIs or RIMAs + Opioids; Pethidine (Meperidine) MAOIs or RIMAs + Opioids; Tramadol MAOIs or RIMAs + SNRIs MAOIs or RIMAs + SSRIs MAOIs or RIMAs + Sympathomimetics; Directly-acting MAOIs or RIMAs + Sympathomimetics; Indirectly-acting MAOIs or RIMAs + Tyramine-rich foods Maraviroc + CYP3A4 inhibitors Mefloquine + Cardioactive drugs Mefloquine + Primaquine Mefloquine + Quinine and related drugs Mefloquine + Typhoid vaccine; Oral Mifepristone + Aspirin or NSAIDs Moclobemide + Cimetidine Nefazodone + Antidepressants Neuromuscular blockers + Antineoplastics NNRTIs + Antiepileptics; Enzyme-inducing NNRTIs + Azoles; Itraconazole NNRTIs + Azoles; Ketoconazole NNRTIs + Azoles; Voriconazole NNRTIs + Drugs that affect gastric pH NNRTIs + Food NNRTIs + Macrolides NNRTIs + NRTIs NNRTIs + Protease inhibitors NNRTIs + Rifamycins NRTIs + Atovaquone NRTIs + Co-trimoxazole or Trimethoprim NRTIs + Protease inhibitors NSAIDs or Aspirin + Prostaglandins Olanzapine + Miscellaneous Olanzapine + Quinolones Olanzapine + SSRIs Olanzapine + Tobacco Olanzapine + Tricyclic and related antidepressants Opioids + Antiepileptics; Enzyme-inducing Opioids + Baclofen Opioids + Glutethimide Opioids + Protease inhibitors Opioids + Quinidine Opioids; Fentanyl and related drugs + Azoles Opioids; Fentanyl and related drugs + Benzodiazepines Opioids; Fentanyl and related drugs + Macrolides Opioids; Fentanyl and related drugs + Protease inhibitors Opioids; Methadone + Protease inhibitors Paliperidone + Miscellaneous Parathyroid hormones; Teriparatide + Miscellaneous Phenobarbital + Azoles Phenytoin + Azoles Phenytoin + Calcium-channel blockers Phosphodiesterase type-5 inhibitors + Alpha blockers Phosphodiesterase type-5 inhibitors + Antihypertensives Phosphodiesterase type-5 inhibitors + Aspirin Phosphodiesterase type-5 inhibitors + Azoles Phosphodiesterase type-5 inhibitors + CYP3A4 inducers Phosphodiesterase type-5 inhibitors + Grapefruit juice Phosphodiesterase type-5 inhibitors + H2-receptor Phosphodiesterase type-5 inhibitors + Macrolides Phosphodiesterase type-5 inhibitors + Nitrates Phosphodiesterase type-5 inhibitors + Protease inhibitors Phosphodiesterase type-5 inhibitors; Sildenafil + Antidepressants Phosphodiesterase type-5 inhibitors; Sildenafil + Miscellaneous Phosphodiesterase type-5 inhibitors; Vardenafil + Miscellaneous Pimozide + SSRIs Potassium-sparing diuretics + NSAIDs Potassium-sparing diuretics + Potassium compounds Procainamide + Amiodarone Proguanil + Typhoid vaccine; Oral Propafenone + SSRIs Protease inhibitors + Antiepileptics; Carbamazepine Protease inhibitors + Antiepileptics; Phenytoin Protease inhibitors + Antiepileptics; Valproate Protease inhibitors + Atovaquone Protease inhibitors + Azoles; Fluconazole Protease inhibitors + Azoles; Itraconazole Protease inhibitors + Azoles; Ketoconazole Protease inhibitors + Azoles; Voriconazole Protease inhibitors + Drugs that affect gastric pH Protease inhibitors + Food Protease inhibitors + Grapefruit and other fruit juices Protease inhibitors + Macrolides Protease inhibitors + Miscellaneous Protease inhibitors + Protease inhibitors Protease inhibitors + Rifamycins Protease inhibitors + St John's wort (Hypericum perforatum) Protease inhibitors + Tenofovir Protease inhibitors; Fosamprenavir + Miscellaneous Proton pump inhibitors + Food or Drinks Quetiapine + CYP3A4 inducers Quetiapine + CYP3A4 inhibitors Quetiapine + Miscellaneous Quinidine + Amiodarone Quinolones + Opioids Raltegravir + Miscellaneous Ranolazine + Miscellaneous Reboxetine + Antidepressants Reboxetine + CYP3A4 inhibitors Reboxetine + Miscellaneous Risperidone + Lithium Risperidone + SSRIs Sirolimus + Azoles SNRIs + H2-receptor antagonists SNRIs + Propafenone SNRIs + St John's wort (Hypericum perforatum) SNRIs; Duloxetine + Antidepressants SNRIs; Duloxetine + Miscellaneous SNRIs; Venlafaxine + Antidepressants SNRIs; Venlafaxine + Miscellaneous Sodium oxybate + Miscellaneous SSRIs + Bupropion SSRIs + H2-receptor antagonists SSRIs + Nasal decongestants SSRIs + Protease inhibitors SSRIs + Rifampicin (Rifampin) SSRIs + Sibutramine SSRIs + SSRIs SSRIs + Tryptophan SSRIs; Fluoxetine + CYP2D6 substrates Statins + Azoles Statins + Protease inhibitors Sulphonylureas; Glibenclamide (Glyburide) + Bosentan Tacrolimus + Azoles Terbinafine + H2-receptor antagonists Tetracyclines + Sucralfate Thalidomide + Miscellaneous Theophylline + Sucralfate Theophylline + Tadalafil Thiazide diuretics + Calcium and/or Vitamin D Thyroid hormones + Amiodarone Ticlopidine + Miscellaneous Tizanidine + Antihypertensives Tizanidine + CYP1A2 inhibitors Tizanidine + Miscellaneous Trazodone + Antidepressants Tricyclic and related antidepressants + SSRIs Tricyclic antidepressants + Bupropion Tricyclic antidepressants + Modafinil Tricyclic antidepressants + Protease inhibitors Tricyclic antidepressants + SNRIs; Duloxetine Triptans + Beta blockers Triptans + Ergot derivatives Triptans + MAOIs Vaccines + Chloroquine or Hydroxychloroquine Vinca alkaloids + Azoles Vinca alkaloids + Macrolides Zolmitriptan + Cimetidine Zolmitriptan + Quinolones

Source: http://www.medicinescomplete.com/pdf/mc_stockley_Aug08_quarter_update.pdf