CURRICULUM VITAE __________________________________________________________________________________________
FULL NAME AND DEGREE/S:
EDUCATION: Institution
ACADEMIC APPOINTMENTS: 1995-1996 Research Assistant, M .S. Swaminathan Research Foundation, India 1996-1999 Teaching Assistant, School of Dietetics and Human Nutrition, McGill University, Canada 1999-2000 Research Scientist, School of Dietetics and Human Nutrition, McGill University, Canada 2000-2002 Postdoctoral Associate, JM USDA HNRCA, Tufts University, Boston, USA 2002-2004 Research Associate, JM USDA HNRCA, Tufts University, Boston, USA 2004-2008 Scientist III, JM USDA HNRCA, Tufts University, Boston, USA 2006-2007 Clinical Assistant Professor, Friedman School of Nutrition Science & Policy, Tufts University, USA 2007-present Assistant Professor, Friedman School of Nutrition Science & Policy, Tufts University, USA 2008-present Scientist II, JM USDA HNRCA, Tufts University, Boston, USA HONORS AND AWARDS 1993 Mary C. Jacob Endowment Prize for securing highest marks in part IV core (major) subjects, Womens Christian College, India 1993 Daisy Cornelius Prize for securing highest total marks in part IV core (major) and supporting (minor) subjects, Womens Christian College, India 1995 Department Rolling Shield for best thesis in Foods and Nutrition, Womens Christian College, India 1996-1999 Max Stern Fellowship, McGill University, Canada 1999 Alma Mater Student Award, McGill University, Canada 2003 Hamish N. Munro Award for Excellence in Postdoctoral Research, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 2005
First place, American Heart Association Scientific Sessions 2005 Poster Competition in
Population Science THESIS COMMITTE MEMBER: 2010- Nicole Spartano, (PhD candidate) Cardiovascular Nutrition Laboratory, Jean Mayer USDA HNRCA at Tufts University, Boston, MA 2008-present Lee Ann Honda, (PhD candidate) Cardiovascular Nutrition Laboratory, Jean Mayer USDA HNRCA at
Lisa Arsenault, (PhD candidate) Dietary Assessment and Epidemiology Program, Jean Mayer USDA HNRCA at Tufts University, Boston, MA
Jamie Lecker, Cardiovascular Nutrition Laboratory, Jean Mayer USDA HNRCA at Tufts University, Boston, MA
Shu Wang, Cardiovascular Nutrition Laboratory, Jean Mayer USDA HNRCA at Tufts University, Boston, MA
ACADEMIC ADVISOR: 2008-present Yiyi Ma, BMN Program, Friedman School of Nutrition Science & Policy, Tufts University, Boston, MA 2009-present Yu-Chi Lee, BMN Program, Friedman School of Nutrition Science & Policy, Tufts University, Boston, MA PROFESSIONAL SOCIETIES:
2000-Present: Nutrition, Metabolism and Physical Activity Council, American Heart Association 2002-Present American Society for Nutrition PEER REVIEWED PUBLICATIONS:
1. Matthan NR and Jones PJH. Differential effects of individual trans fatty isomers on lipoprotein assembly and
metabolism. Nutrition Reviews 1999; 57(9); 282-284.
2. Matthan NR, Ausman LH, Lichtenstein AH, and Jones PJH. Hydrogenated fat consumption affects
cholesterol synthesis in moderately hypercholesterolemic women. Journal of Lipid Research 2000; 41: 834-839.
3. Matthan NR, Raeini-Sarjaz M, Lichtenstein AH, Ausman LH, and Jones PJH. Deuterium uptake and plasma
cholesterol precursor levels correspond as methods for measurement of endogenous cholesterol synthesis. Lipids 2000; 35: 1037-1044.
4. Matthan NR, Cianflone K, Lichtenstein AH, Ausman LM, and Jones PJH. Hydrogenated fat consumption
affects acylation-stimulating protein levels and cholesterol esterification rates in moderately hypercholesterolemic women. Journal of Lipid Research 2001; 42: 1841-1848.
5. Matthan NR, Giovanni A, Schaefer EJ, Brown GB and Lichtenstein AH. Impact of simvastatin, niacin and/or
antioxidants on cholesterol metabolism in CAD patients with low HDL. Journal of Lipid Research 2003; 44:800-806.
6. Matthan NR and Lichtenstein AH. Approaches to measuring cholesterol absorption in humans. Matthan NR, Chung M, Balk E, Chew P, Kupelnick B, DeVine D, Lawrence A, Lichtenstein AH,
and Lau J. Effects of omega-3 fatty acids on arrhythmogenic mechanisms in animal and isolated organ or cell culture studies. cardio [March 2004].
8. Matthan NR, Welty FK, Barrett PHR, Harausz C, Dolnikowski GG, Parks JS, Eckel RH, Schaefer EJ and
Lichtenstein AH. Dietary hydrogenated fat increases HDL apoA-1 catabolism and decreases LDL apoB-100 catabolism in hypercholesterolemic women. Atherosclerosis, Thrombosis and Vascular Biology 2004; 24: 1092-1097.
9. Matthan NR, Jalbert SM, Lamon-Fava S, Dolnikowski GG, Welty FK, Barrett HR, Schaefer EJ, and
Lichtenstein AH. TRL, IDL, and LDL apolipoprotein B-100 and HDL apolipoprotein A-I kinetics as a function of age and menopausal status. Atherosclerosis, Thrombosis and Vascular Biology 2005; 25: 1691-1696.
10. Matthan NR, Jordan HS, Chung M, Lichtenstein AH, Lathrop D and Lau J. A systematic review and meta-
analysis of the impact of ω-3 fatty acids on selected arrhythmia outcomes in animal models. Metabolism 2005; 54: 1557-1565.
11. Lichtenstein AH, Matthan NR, Jalbert SM, Resteghini NA, Schaefer EJ and Ausman LM. Novel soybean oils
varying in fatty acid profile alter cardiovascular disease risk factors in moderately hyperlipidemic subjects. American Journal of Clinical Nutrition 2006; 84: 497-504.
12. Erkkilä AT, Matthan NR, Jalbert SM, Resteghini NA, Herrington DM and Lichtenstein AH. Higher plasma
docosahexaenoic acid is associated with reduced progression of coronary-artery atherosclerosis in women with established coronary artery disease. Journal of Lipid Research 2006; 47: 2814-2819.
13. Matthan NR, Jalbert SM, Ausman LM, Kuvin JT, Karas RH, Schaefer EJ and Lichtenstein AH. Impact of
different forms of soybean based foods on cardiovascular disease risk factors in hypercholesterolemic subjects. American Journal of Clinical Nutrition 2007; 85: 960-966.
14. Lichtenstein AH and Matthan NR. The effect of soybean-based foods on plasma lipid and lipoprotein
concentrations. American Journal of Clinical Nutrition 2007; 86:1253-1254.
15. Lamon-Fava S, Diffenderfer MR, Barrett PH, Buchsbaum A, Matthan NR, Lichtenstein AH, Dolnikowski GG,
Horvath K, Asztalos BF, Zago V, Schaefer EJ. Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism. Journal of Lipid Research 2007; 48:1746-1753.
16. Matthan NR, Jalbert SM, Dolnikowski GG, Barrett PHR, Schaefer EJ and Lichtenstein AH. Gender-specific
differences in the kinetics of nonfasting TRL, IDL and LDL apolipoprotein B-100 in men and premenopausal women. Atherosclerosis, Thrombosis and Vascular Biology 2008; 28: 1838-1843.
17. Lamon-Fava S, Diffenderfer MR, Barrett PH, Buchsbaum A, Nyaku M, Horvath K, Asztalos BF, Otokozawa S,
Ai M, Matthan NR, Lichtenstin AH, Dolnikowski GG, Schaefer EJ. Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and apo B-containing lipoproteins. Atherosclerosis, Thrombosis and Vascular Biology 2008; 28: 1672-1678.
18. Wang S, Wu D, Lamon-Fava S, Matthan NR, Honda KL, Lichtenstein AH. In vitro fatty acid enrichment of
macrophages alters inflammatory response and net cholesterol accumulation. British Journal of Nutrition 2009; 102: 497-501.
19. Wang S, Wu D, Matthan NR, Lamon-Fava S, Lecker JL, Lichtenstein AH. Reduction in dietary omega-6
polyunsaturated fatty acids:eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse Atherosclerosis. 2009; 204: 147-155.
20. Matthan NR, Dillard A, Lecker JL, Ip B, Lichtenstein AH. Effects of dietary palmitoleic acid on plasma
lipoprotein profile and aortic cholesterol accumulation are similar to those of other unsaturated fatty acids in the F1B golden Syrian hamster. Journal of Nutrition 2009; 139: 215-221.
21. van Himbergen TM, Matthan NR, Resteghini NA, Otokozawa S, Ai M, Stein EA, Jones PH, Schaefer EJ.
Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers. Journal of Lipid Research 2009; 50: 730-739. [PMCID: PMC2656667].
22. Vega-López S, Matthan NR, Ausman LM, Ai M, Otokozawa S, Schaefer EJ, Lichtenstein AH. Substitution of
vegetable oil for a partially-hydrogenated fat favorably alters cardiovascular disease risk factors in moderately hypercholesterolemic postmenopausal women. Atherosclerosis 2009; 207: 208-212.
23. Arsenault LN, Matthan NR, Scott TM, Dallal G, Lichtenstein AH, Folstein MF, Rosenberg I, Tucker KL.
Validity of estimated dietary eicosapentaenoic acid and docosahexaenoic acid intakes determined by interviewer-administered food frequency questionnaire among older adults with mild-to-moderate cognitive impairment or dementia. American Journal of Epidemiology 2009; 170: 95-103. [PMCID: PMC2733037].
24. Matthan NR, Pencina M, LaRocque JM, Jacques PF, D'Agostino RB, Schaefer EJ, Lichtenstein AH.
Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD. Journal of Lipid Research 2009; 50: 1927-1935. [PMCID: PMC2724787].
25. Wang S, Wu D, Lamon-Fava S, Matthan NR, Honda KL, Lichtenstein AH. In vitro fatty acid enrichment of
macrophages alters inflammatory response and net cholesterol accumulation. British Journal of Nutrition 2009; 102: 497-501.
26. van Himbergen TM, Otokozawa S, Matthan NR, Schaefer EJ, Buchsbaum A, Ai M, van Tits LJ, de Graaf J,
Stalenhoef AF. Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. Arteriosclerosis Thrombosis & Vascular Biology 2010; 30: 113-120.
27. Matthan NR, Resteghini N, Robertson M, Ford I, Shepherd J, Packard C, Buckley BM, Jukema JW,
Lichtenstein AH, Schaefer EJ: PROSPER group. Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: Insights from the PROSPER trial. Journal of Lipid Research 2010; 51: 202-209.
28. Willis LM, Bielinski DF, Fisher DR, Matthan NR, Joseph JA. Walnut Extract Inhibits LPS-induced Activation
of Bv-2 Microglia via Internalization of TLR4: Possible Involvement of Phospholipase D2. Inflammation. 2010 Mar 6. [Epub ahead of print]
29. Lecker JL, Matthan NR, Billheimer JT, Rader DJ, Lichtenstein AH. Impact of dietary fat type within the
context of altered cholesterol homeostasis on cholesterol and lipoprotein metabolism in the F1B hamster. Metabolism. 2010 Mar 1. [Epub ahead of print]
30. Vega-López S, Matthan NR, Ausman LM, Harding SV, Rideout TC, Ai M, Otokozawa S, Freed A, Kuvin JT,
Jones PJ, Schaefer EJ, Lichtenstein AH. Altering dietary lysine:arginine ratio has little effect on cardiovascular risk factors and vascular reactivity in moderately hypercholesterolemic adults. Atherosclerosis. 2009 Dec 5. [Epub ahead of print]
31. Matthan NR, Ip B, Resteghini, Ausman LM, Lichtenstin AH. Long term stability of fatty acids in human serum
cholesteryl ester, triglyceride and phospholipid fractions. Journal of Lipid Research 2010 May 6. [Epub ahead of print]
Las municipalidades, con el objeto de promover la salud y el desarrollo comunal, pueden implementar nuevas prestaciones de salud, insertas en planes comunales de esa naturaleza, en los casos en que no exista política pública ministerial, en la medida que tales prestaciones sean financiadas directamente por el paciente particular o haciéndose cargo el propio municipio de asumir su costo y no se