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Sleep Diagnosis and Therapy 2008; V3 N5, P19-20 K. Hansen
Care of Patients at Risk for Sleep Apnea Who Receive Sedation
Sleep apnea is the most widely known sleep disorder besides
patient for the effects of sedation, it is critical to differentiate
insomnia. Estimates are that more than 18 million people have
between sedation and sleepiness: does the patient need to be
sleep apnea, and it is more common in men than women. People
stimulated often to respond to your requests, and does the
of all ages and both sexes can have sleep apnea. Due to apneic
patient fall asleep easily without stimulation.2
events, restful sleep patterns are interrupted resulting in
Increased sedation also increases the patient’s risk for falls,
excessive sleepiness and next-day fatigue. Increasing preva-
especially later in the night when sedation and sleepiness
lence for sleep apnea requires the integration of a sleep apnea
management (SAM) program to reduce the risk of experiencingan adverse event after receiving sedation.1
Intervention to Prevent Adverse Events With the integration of a dedicated sleep apnea management What are the Consequences of Untreated Sleep Apnea?
program, continuous monitoring of oxygenation and ventila-
Patients with sleep apnea are four times as likely to have serious
tion reduces the possibility of adverse events. The post-
complications, two times as likely to have some post-surgical
operative or post-procedure management plan should take
and post-procedure complications and have significantly
into consideration the need for close observation by the
longer hospital stays. If you suspect your patient has sleep
clinical team and should be combined with the use of PAP
apnea, evaluation by a doctor specializing in sleep disorders
when sedated and asleep. Standing Orders used with patients
is recommended. A screening for sleep apnea should be done
diagnosed or at risk for sleep apnea receiving sedation, pain
prior to receiving pain medications, sedation, or anesthesia.
control, anxiolytics, and antiemetics provide a standardized
At a minimum, ask your patients who are preparing to receive
treatment plan to reduce the risk of a negative outcome when
a sedating drug: “Do you snore?” “Have you been noted to stop
caring for the patient with sleep apnea.3
breathing during your sleep?” and “Do you have difficultystaying awake when sitting quietly or while driving?”
Impact on Care Continuum of Sleep Apnea
Without proactive treatment of sleep apnea the patient
A sleep apnea management program requires a number of
receiving drugs that cause sedation has an increased risk for other
clinical services and a diverse care team to effectively reduce
health risk factors such as elevated blood pressure due to increased
effort to sustain adequate oxygenation and ventilation duringsleep. The risk for ischemic heart disease is elevated and atrial
• Anesthesia – risk for respiratory depression due to anes-
fibrillation is twice as likely to occur if sleep apnea is untreated.
Sleep deprivation contributes to elevated blood sugar and blood
• Operating Services and Surgeons – risk for adverse events
pressure plus weight gain. Left untreated, elevated insulin con-
tributes to diabetes. Also, with increased weight gain, sleep apnea
• Radiology – monitoring for over-sedation during invasive
becomes more severe, contributing to elevated blood pressure.
• Endoscopy – monitoring sedation used during procedure
Medications that Affect Sleep Apnea
• Emergency Department – management of pain control
Drugs, which create respiratory suppression, are commonly
• Heart Institute – monitoring for increased sedation
used in a perioperative and invasive procedural care plan:
benzodiazepines for relaxation, narcotics for pain control,
• Cardiology – management of ischemic heart disease
antiemetics (phenergan) for nausea, hypnotics for sleep and
• Pulmonology – treatment of pulmonary hypertension
antidepressants for mood or sleep. Close observation and con-
• Gastroenterology – treatment of acid reflux or GERD
tinuous respiratory monitoring is required when substantial
• Endocrinology – management of co-morbid diabetes
analgesia is required, especially when delivered intravenously
• Internal Medicine – management of co-morbid hypertension
with a Patient Controlled device. IV PCA used with patients at
• Psychiatry – depression from loss of sleep and reduced
risk for sleep apnea creates increased risk for over sedation by
the patient, who has increased need for pain control leading to
• Risk Management – impact of adverse events
increased sedation: increased somnolence from chronic sleep
• Administration – Support for equipment and staffing
deprivation coupled with drug induced sedation promotes risk
for an adverse event. To protect the patient, PAP therapy isrequired to sustain ventilation while managing pain control.
The evidence suggests that there is a significant and under-
Anesthesia may cause re-sedation in many patients 6–12
appreciated risk for serious injury from sedating agents, opioids,
hours after recovery. This creates a risk for an adverse event
and other drugs in the post-procedure or postoperative period.
and requires increased nursing assessment and continuous
These agents cause life-threatening respiratory depression in
respiratory monitoring. This is exacerbated by the presence of
the patients at risk for sleep apnea. To protect these patients from
excessive daytime sleepiness due to the accumulated sleep
an adverse event, and still maintain control of pain, monitoring
deprivation from untreated sleep apnea. When observing your
of ventilation and oxygenation with audible alarms and frequent
Sleep Diagnosis and Therapy ♦ Vol 3 No 5 September-October 2008
Sleep_19-20-V3N5 10/17/08 6:19 PM Page 20
assessment of vital functions is required. Treatment of sleep
management services for newly diagnosed sleep apnea
apnea with the use of positive air pressure implemented in
PACU and following a procedure with sedation will protectthe patient from experiencing an unexpected event.
We recommend that patient monitoring must continue after
discharge. The newly diagnosed patient must be encouraged
to be evaluated with a sleep study. They need to be educatedabout the dangers of ignoring treatment for sleep apnea and
References
they need to understand how the risks for respiratory and
1. Den Herder C, Risks of general anaesthesia in people with
cardiovascular complications are more serious for patients
obstructive sleep apnea. BMJ 2004; 329:955–9.
with sleep apnea. For example, their chance of having an auto
2. Practice Guidelines for the Perioperative Management of Patients
related accident due to sleepiness and fatigue is significantly
with Obstructive Sleep Apnea. A report by the American Society
of Anesthesiologists Task Force on Perioperative Management ofPatients with Obstructive Sleep Apnea. Anesthesiology 2006;
Implementing a sleep apnea monitoring program for
patients undergoing sedation for medical or surgical proce-
3. Preventing and managing the impact of anesthesia awareness.
dures will reduce patient health risks, reduce professional
Sentinel Event Alert Joint Commission on Accreditation of
medical liabilities and create new revenue streams for disease
Healthcare Organizations October 6, 2004; Issue 32. Sleep Diagnosis and Therapy ♦ Vol 3 No 5 September-October 2008
PAXIL AND IXEL TRADE-MARKS: NO RISK OF CONFUSION FOR THE ANGLOPHONE CONSUMER, FEDERAL COURT RULES 1001 Square-Victoria - Bloc E – 8th Floor Tel.: (514) 987 6242 - Fax: (514) 845 7874 Further to an appeal launched by the Appel ant pursuant to subsection 56(1) of Canada's Trade-marks Act , (R.S.C. 1985, c. T-13), the Trial Division of the Federal Court of Canada overturned the Registrar’s
Using BLAST and ExPASy for Genetic and Protein analysis of H1N1 variability, including mutations that confer resistance to antiviral medications. Objectives: •Students will become familiar with the online databases available to researchers including GenBank, BLAST and ESPy utilities. •Students will analyze normal and mutant strains of H1N1 viruses to look for nucleotide mutations