Material Safety Data Sheet 1. PRODUCT AND COMPANY IDENTIFICATION
Sigma-Aldrich 3050 Spruce Street SAINT LOUIS MO 63103 USA
2. COMPOSITION/INFORMATION ON INGREDIENTS
N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Chloroquine bis(phosphate) 50-63-5 200-055-2 3. HAZARDS IDENTIFICATION Emergency Overview OSHA Hazards
Harmful by ingestion. Target Organs HMIS Classification Health Hazard: 1 Chronic Health Hazard: * Flammability: 0 Physical hazards: 1
NFPA Rating Health Hazard: 1 Fire : 0 Reactivity Hazard: 1 Potential Health Effects Sigma-Aldrich Corporation
Sigma - C6628 Inhalation
May be harmful if inhaled. May cause respiratory tract irritation.
May be harmful if absorbed through skin. May cause skin irritation.
Ingestion 4. FIRST AID MEASURES General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing give artificial respiration Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 5. FIRE-FIGHTING MEASURES Flammable properties Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for fire-fighters Wear self contained breathing apparatus for fire fighting if necessary. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Environmental precautions Do not let product enter drains. Methods for cleaning up Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal. 7. HANDLING AND STORAGE Handling Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. Storage Keep container tightly closed in a dry and well-ventilated place. Sigma-Aldrich Corporation
Sigma - C6628
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Contains no substances with occupational exposure limit values.
Personal protective equipment Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Hand protection For prolonged or repeated contact use protective gloves. Handle with gloves. Eye protection Safety glasses Skin and body protection Choose body protection according to the amount and concentration of the dangerous substance at the work place. Hygiene measures Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Safety data 10. STABILITY AND REACTIVITY Storage stability Stable under recommended storage conditions. Conditions to avoid Light. Materials to avoid Strong oxidizing agents Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx), Phosphorous oxides, Hydrogen chloride gas 11. TOXICOLOGICAL INFORMATION Sigma-Aldrich Corporation
Sigma - C6628 Acute toxicity Irritation and corrosion Sensitisation Chronic exposure
No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH.
No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.
No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.
Genotoxicity in vitro - rat - Liver Sister chromatid exchange
Signs and Symptoms of Exposure
May cause permanent eye injury., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Potential Health Effects Inhalation
May be harmful if inhaled. May cause respiratory tract irritation.
May be harmful if absorbed through skin. May cause skin irritation.
Ingestion Target Organs 12. ECOLOGICAL INFORMATION Elimination information (persistence and degradability) Ecotoxicity effects
EC50 - Daphnia magna (Water flea) - 49.52 mg/l - 24 h
Further information on ecology 13. DISPOSAL CONSIDERATIONS Product Observe all federal, state, and local environmental regulations.
Contaminated packaging Dispose of as unused product. Sigma-Aldrich Corporation
Sigma - C6628
14. TRANSPORT INFORMATION DOT (US) Not dangerous goods IMDG Not dangerous goods IATA Not dangerous goods 15. REGULATORY INFORMATION OSHA Hazards Target Organ Effect, Harmful by ingestion. TSCA Status Not On TSCA Inventory DSL Status All components of this product are on the Canadian DSL list. SARA 302 Components SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302. SARA 313 Components SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313. SARA 311/312 Hazards Acute Health Hazard, Chronic Health Hazard Massachusetts Right To Know Components No Components Listed Pennsylvania Right To Know Components New Jersey Right To Know Components California Prop. 65 Components This product does not contain any chemicals known to State of California to cause cancer, birth, or any other reproductive defects. 16. OTHER INFORMATION Further information Copyright 2008 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Co., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Sigma-Aldrich Corporation
Sigma - C6628
Cellular and Molecular Neurobiology [cemn] Cellular and Molecular Neurobiology, Vol. 23, No. 2, April 2003 ( C 2003) Rapid Communication A Novel Method of Eliminating Non-Neuronal Proliferating Cells From Cultures of Mouse Dorsal Root Ganglia Parker L. Andersen,1 J. Ronald Doucette,2 and Adil J. Nazarali1,3 Received November 5, 2002; accepted December 18, 2002 1. We hypothes
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