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Material Safety Data Sheet
Doxepin hydrochloride MSDS
Section 1: Chemical Product and Company Identification
Product Name: Doxepin hydrochloride
Contact Information:
Catalog Codes: SLD1378
Sciencelab.com, Inc.
14025 Smith Rd.
CAS#: 1229-29-4
US Sales: 1-800-901-7247
RTECS: HQ4375000
International Sales: 1-281-441-4400
TSCA: TSCA 8(b) inventory: No products were found.
CI#: Not available.
CHEMTREC (24HR Emergency Telephone), call:
1-800-424-9300
Synonym: N.N-dimethyldibenz(b,e)oxepin-delta(sup
11(6H),gamma)propylamine hydrochloride
International CHEMTREC, call: 1-703-527-3887
Chemical Name: Not available.
For non-emergency assistance, call: 1-281-441-4400
Chemical Formula: C19H21CO,HCl
Section 2: Composition and Information on Ingredients
Composition:
% by Weight
Toxicological Data on Ingredients: Doxepin hydrochloride: ORAL (LD50): Acute: 147 mg/kg [Rat]. 180 mg/kg [Mouse].
Section 3: Hazards Identification
Potential Acute Health Effects:
Very hazardous in case of ingestion. Hazardous in case of skin contact (irritant), of eye contact (irritant), of
inhalation. Slightly hazardous in case of skin contact (permeator). Severe over-exposure can result in death.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in
one or many human organs.
Section 4: First Aid Measures
Eye Contact: Check for and remove any contact lenses. Do not use an eye ointment. Seek medical attention.
Skin Contact:
After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin
with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated
clothing before reusing.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate
medical attention.
Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation:
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Seek medical attention.
Ingestion:
Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible
indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen
tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Seek immediate medical attention.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Large Spill: Use a shovel to put the material into a convenient waste disposal container.
Section 7: Handling and Storage
Precautions:
Keep locked up Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk,
evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not
breathe dust. Wear suitable protective clothing In case of insufficient ventilation, wear suitable respiratory
equipment If ingested, seek medical advice immediately and show the container or the label. Avoid contact with
skin and eyes
Storage:
Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly
closed. Keep in a cool, well-ventilated place. Highly toxic or infectious materials should be stored in a separate
locked safety storage cabinet or room.
Section 8: Exposure Controls/Personal Protection
Engineering Controls:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection:
Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid.
Odor: Not available.
Taste: Not available.
Molecular Weight: 315.87 g/mole
Color: Not available.
pH (1% soln/water): Not available.
Boiling Point: Decomposes.
Melting Point: 186°C (366.8°F)
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: Not available.
Solubility: Not available.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Not available.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: No.
Section 11: Toxicological Information
Routes of Entry: Eye contact. Inhalation. Ingestion.
Toxicity to Animals: Acute oral toxicity (LD50): 147 mg/kg [Rat].
Chronic Effects on Humans: Not available.
Other Toxic Effects on Humans:
Very hazardous in case of ingestion.
Hazardous in case of skin contact (irritant), of inhalation.
Slightly hazardous in case of skin contact (permeator).
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans: Not available.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products of Biodegradation: The products of degradation are more toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:
Section 14: Transport Information
DOT Classification: CLASS 6.1: Poisonous material.
Identification: : Toxic solid, organic, n.o.s. (Doxepin hydrochloride) : UN2811 PG: III
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations: TSCA 8(b) inventory: No products were found.
Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Classifications:
WHMIS (Canada): CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
DSCL (EEC):
R25- Toxic if swallowed.
R36/38- Irritating to eyes and skin.
HMIS (U.S.A.):
Health Hazard: 3
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 3
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/09/2005 05:25 PM
Last Updated: 11/06/2008 12:00 PM
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